贾爱群


1.基本情况
贾爱群 男 理学博士 教授 博士生导师
联系方式：海南大学药学院，海口，570228，电话：**，邮箱：ajia@hainanu.edu.cn。
2.教育背景
2001.1-2004.7 中国科学院昆明植物研究所，理学博士（植物化学-天然药物化学）；
1998.9-2001.1 无锡轻工大学（今江南大学），工学硕士（应用化学-天然产物化学）；
1989.9-1993.7 河南师范大学，理学学士（化学）。
3.教学情况
主讲《海洋药物学》、《制药工艺学》、《发酵与生物分离工程》、《生物医学基础》等。
4.科研情况
先后获得资助项目13项（主持11项，参与2项），其中主持国家级5项，主持省部级4项。
代表性项目：
海洋生物体中细菌群体感应信号分子的发现与非经典抗菌，海南大学高层次人才引进启动基金（C类），（2017-2022）
基于C-H活化策略的海洋二酮哌嗪的衍生化及其细菌群体感应信号传导，国家自然科学基金（地区），（2018-2021）
微生物源活性代谢物库的构建，国家重点研发计划（子课题），（2017-2020）
广西珍稀药食同源植物金花茶花叶中功能因子的研究与保健食品的开发，国家863计划（课题），（2014-2016）
以RNA-seq策略探索新型QSI破坏耐药细菌生物被膜的分子作用机制，国家自然科学基金（面上），（2012-2015）
3种中国药用植物中细菌群体感应抑制剂的发现及其抗菌评价，国家自然科学基金（面上），（2011-2013）
以Quorum Sensing 为探针的3 种中国药用植物抗菌及抗耐药性研究，教育部（博士点基金-新教师类），（2009-2011）
以细菌群体感应为探针的3 种中国药用植物抑菌信号分子研究，教育部（留学回国启动基金），（2009-2011）
5.研究兴趣
（海洋）药食化学——有重要药学活性天然产物的研究与开发。
特色（海洋）药（食）用生物资源中（新颖结构）有机化合物的发现与以非经典抗菌为主的重要药学活性评价与机制研究；
基于新合成方法的有重要生理活性天然有机化合物的化学修饰；
功能天然有机小分子的化学生态学或化学生物学行为研究。
6.社会兼职
中国化学会永久会员；中国植物学会永久会员；The Overseas Chinese Society for Microbiology member；
Medicinal Research Reviews, Journal of Medicinal Food, Journal of Agricultural and Food Chemistry, Materials Science & Engineering C, Bioorganic Chemistry, Pharmaceutical Biology, APMIS, The Journal of Medicinal Plant Research, Plos One, Bioorganic & Medicinal Chemistry Letters, Natural Product Research, Scientific Reports, Chinese Journal of Catalysis, Food Chemistry, Chemosphere等国际期刊审稿人；BMC Complementary & Alternative Medicine（SCI）副主编；Frontiers in Cellular and Infection Microbiology（SCI）编委；
国家自然科学基金函评专家；教育部研究生学位授权点函评专家；教育部研究生学位论文抽检函评专家。
7.代表性成果
先后在Angewandte Chemie、Chemical Communications、Journal of Agriculture and Food Chemistry (ACS)、Food Chemistry、Scientific Reports等学术期刊发表论文80余篇，国内外学术会议交流论文（含报告）25篇，申请中国专利6项。2015年入选江苏省六大人才高峰，2014年获得江苏省优秀硕士生指导教师，2012年入选江苏高校“青蓝工程”中青年学术带头人培养对象，2007年获得云南省自然科学一等奖（排名第五）。
近五年代表性文章：
Liu, J. S., Zeng Y. X., Bi, S. Y., Zhou, J. W.*, Cheng, R., Li, J., Jia, A. Q.*, (2021), Characterization and chemical modification of PLN-1, an exopolysaccharide from Phomopsis liquidambari NJUSTb1, Carbohydrate Polymers, 253, 117197. 10.1016/j.carbpol.2020.117197.
Luo, H. Z., Zhou, J. W., Sun, B., Jiang, H., Tang, S., Jia, A. Q.*, (2021), Inhibitory Effect of norharmane on Serratia marcescens NJ01 quorum sensing-mediated virulence factors and biofilm formation, Biofouling. 37(2), 1-16.
Quan-Bing Wang, Shi Tang*, Ying-Jie Wang, Yue Yuan, Ai-Qun Jia*, (2021), PhI(OAc)2-Mediated Intramolecular Oxidative C-N Coupling and Detosylative Aromatization: an Access to Indolo[2,3-b]quinolines, RSC advances, 11, 17206 - 17211.
Cheng, W. J., Zhang, P. P., Luo, Q. Q., Deng, S. M., Jia, A. Q.*, (2020), The Chemosensitizer Ferulic Acid Enhances Epirubicin-induced Apoptosis in MDA-MB-231 Cells, Journal of Functional Foods, https://doi.org/10.1016/j.jffff.2020.104130.
Chen, X. D. Liu Y., Yang, L. M.*, Hu, X. Y.*, Jia, A. Q.*, (2020), Hydrogen sulfide signaling protects Chlamydomonas reinhardtii against allelopathic damage from cyanobacterial toxin microcystin-LR, Frontier in Plant Science, doi: 10.3389/fpls.2020.01105.
Wang, W. X., Yang, R., Chen, H. J., Wu, Y., Lin, S. S., Yuan, S. T., Pan, W. D.*, Jia, A. Q.*, (2020), Chemical Constituents of Smilax riparia and their Tumoral Cytotoxicities, Chemistry of Natural Compounds, 56 (2), 228-234, DOI: 10.1007/s10600-020-02994-4.
Cheng, W. J., Zhou, J. W., Zhang, P. P., Luo, H. Z., Tang, Shi., Li, J. J., Deng, S. M., Jia A. Q.*, (2020), Quorum sensing inhibition and tobramycin acceleration in Chromobacterium violaceum by two natural cinnamic acid derivatives, Applied Microbiology and Biotechnology, 104, 5025-5037, DOI: 10.1007/s00253-020-10593-0.
Luo, H. Z., Guan, Y., Yang, R., Qian, G. L., Wang, J. S., Yang, X. H.*, Jia, A. Q.*, (2020), Growth inhibition and metabolomic analysis of Xanthomonas oryzae pv. oryzae treated with resveratrol, BMC Microbiology. 20(1):117. doi: 10.1186/s12866-020-01803-w.
Wang, Z. N., Yang, R., Guan, Y., Zhao, W. L., Xu, Y., Pan, W. D., Wang, J. S., Jia, A. Q.*, (2020), Anti-inflammatory activity of Kaempferol 3-O-(3'',6''-di-O-E-p-coumaroyl)-β-D-glucopyranoside and its metabolomic analysis in LPS-induced RAW 264.7 cells, BMC Complementary Medicine and Therapies (BMC Complementary and Alternative Medicine). 10.1186/s12906-020-03115-y.
Zhou, J. W., Jia, A. Q.*, Tan, X. J.*, Chen, H., Sun, B., Huang, T. Z., He, Y., Li, P. L., Liu, E. Q.*, (2020), 1-(4-amino-2-hydroxyphenyl)ethenone suppresses Agrobacterium tumefaciens virulence and metabolism, Frontier in Microbiology. https://doi.org/10.3389/fmicb.2020.584767.
Zhou, J. W., Jia, A. Q.*, Jiang, H., Li, P. L., Chen, H., Tan, X. J.*, Liu, E. Q.*, (2020), 1-(4-Amino-2-hydroxyphenyl)ethanone from Phomopsis liquidambari showed quorum sensing inhibitory activity against Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 105, 341-352. DOI: https://doi.org/10.1007/s00253-020-11013-z.
u Zhou, J. W., Ruan, L. Y., Chen, H. J.; Luo, H. Z., Jiang, H., Wang, J. S., Jia, A. Q.*, (2019), Inhibition of quorum sensing and virulence in Serratia marcescens by hordenine, J. Agri. Food Chem., 67(3), 784-795. u Zhou, J. W., Muhammad, J., Sun, B., Yang, R., Wadood, A., Wang, J. S.*, Jia, A. Q.*, (2019), Metabolomic analysis of quorum sensing inhibitor hordenine on Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 103(15):6271-6285，3.340. Wang, W. X., Yao, H., Yang, R., Wu, Y., Pan, W., Jia, A. Q.*, (2019), Inhibiting the formation of advanced glycation end-products by three stilbenes and the identification of their adducts, Food Chem., 295, 10-15.
Liu, Y., Xie, F., Jia, A. Q. *, Li, X. W. *, (2018), Cp*Co(III)-Catalyzed amidation of olefinic and aryl C-H bonds: Highly selective synthesis of enamides and pyrimidones, Chemical Communications, 54, 4345-4348.
Zhou, J. W., Luo, H. Z., Jiang, H., Jian, T. K., Chen, Z. Q., Jia, A. Q.*, (2018), Hordenine, a novel quorum sensing inhibitor and anti-biofilm agent against Pseudomonas aeruginosa, J. Agri. Food Chem., 66(7):1620-1628.
Yang, R., Guan, Y., Wang, W. X., Chen, H.J., He, Z.C., Jia, A. Q.*, (2018), Antioxidant capacity of phenolics in Camellia nitidissima Chi flowers and their identification by HPLC Triple TOF MS/MS, PlosOne, 13(4), e**.
Zhou, J. W., Chen, T. T., Tan, X. J., Sheng, J. Y., Jia, A. Q.*, (2018), Can resveratrol, a quorum sensing inhibitor, function as an aminoglycoside antibiotic-mate against Pseudomonas aeruginosa? International Journal of Antimicrobial Agents, 52(1), 35-41.
Yang, R., Zhou, J. W., Sun, B., Wang, Z. N., Chen, H. J., He, Z. C., Jia, A. Q.*, (2018), Phytochemicals from Camellia nitidissima Chi flowers reduce the pyocyanin production and motility of Pseudomonas aeruginosa PAO1, Frontiers in Microbiology, 8, 2640-2653.
Yang, R., Wang, W.X., Chen, H.J., He, Z.C., Jia, A.Q.*, (2018), The inhibition of advanced glycation end-products by five fractions and three main flavonoids from Camellia nitidissima Chi flowers, Journal of Food and Drug Analysis, 26, 252-259.
Zhou, J. W., Bi, S. Y., Chen, H. J., Chen, T. T., Yang, R., Li, M. H., Fu, Y. H., Jia, A. Q.*, (2017), Anti-Biofilm and Antivirulence Activities of Metabolites from Plectosphaerella cucumerina against Pseudomonas aeruginosa, Frontiers in Microbiology, 8, 769-786.
Chen, T. T., Sheng, J. Y., Fu, Y. H., Li, M. H., Wang, J. S.*, Jia, A. Q.*, (2017), ¹H-NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol, Journal of Proteome Research, 16 (2), 824-830.
Chen, X. D., Tian, D. G., Abeer, H Allah EF, A, Hu, X. Y. *, Jia, A. Q.*, (2016), The role of nitric oxide signaling in response to salt stress in Chlamydomonas reinhardtii, Planta, 244 (3), 651-69.
Wang, W. X., Liu, H. Y., Wang, Z. N., Qi, J., Yuan, S. T., Zhang, W. J., Chen, H. J., Finley, J. W, Gu, L. W.*, Jia, A. Q.*, (2016), Phytochemicals from Camellia nitidissima Chi inhibited the formation of advanced glycation end-products by scavenging methylglyoxal, Food Chem, 205, 204-211.
Sheng, J. Y., Chen, T. T., Tan, X. J., Chen, T., Jia, A. Q.*, (2015), The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship, Bioorganic & Medicinal Chemistry Letters, 25(22), 5217-20.
Xu, H. D., Wang, J. S.*, Li, M. H., Liu, Y., Chen, T., Jia, A. Q.*, (2015), ¹H NMR based metabolomics approach to study the toxic effects of herbicide butachlor on goldfish (Carassius auratus). Aquatic Toxicology, 159, 69-80.
Wang, W. X., Qi, Y. J., Rocca, J, Sarnoski, P., Jia, A. Q.*, Gu, L. W. *, (2015), Scavenging of Toxic Acrolein by Resveratrol and Hesperetin and Identification of Adducts, J. Agri. Food Chem, 63(43), 9488-95.
Chen, J. H., Lin, S. S., Yuan, S. T., Shi, J. S.*, Jia, A. Q.*, (2015), The extract, LXB-1, from the barks of Liriodendron × hybrid, induced apoptosis via Akt, JNK and ERK1/2 pathways in A549 lung cancer cells, Zeitschrift für Naturforschung C (ZNC), 70 (11-12), 305-311.
Yang, D. T, Lin, S. S., Chen, J. H., Yuan, S. T., Shi, J. S.*, Wang, J. S., Jia, A. Q.*, (2015), (+)- and (?)-liriodenol, a pair of novel enantiomeric lignans fromLiriodendron hybrid, Bioorganic & Medicinal Chemistry Letters, 25 (9), 1976-8.
Tan, X. J., Qin, N., Sheng, J. Y., Peng, X. H.*, Jia, A. Q.* (2015), Transcriptome analysis of the biofilm formed by methicillinsusceptible Staphylococcus aureus, Scientific Reports, 5, 11997.
近五年专利：
苯丙素糖苷Smiglaside A在制备治疗脓毒症的药物中的应用，贾爱群，庞涛，袁胜涛，徐渊，汪玮鑫，ZL2017 1 **.2；
大麦芽碱或其联合抗生素的抗感染制药用途，贾爱群，周金伟，ZL2017 1 **.5；
一种枫香拟茎点霉属内生真菌及其应用，贾爱群，毕士媛，周金伟，3.6。