闻晓波


男，博士，教授，博士研究生导师
邮箱：wenxiaobo1977@163.com
通讯地址：海南省海口市人民大道58号 邮政编码570228

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研究领域
预防兽医学

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教育背景
2003年9月-2006年6月 中国农业科学院哈尔滨兽医研究所 预防兽医专业 博士
2000年9月-2003年6月 黑龙江八一农垦大学 预防兽医专业 硕士
1996年9月-2000年6月 黑龙江八一农垦大学 动物医学专业 学士

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工作经历
2006年7月- 2008年8月 黑龙江八一农垦大学动物科技学院 讲师
2008年9月- 2008年12月 黑龙江八一农垦大学动物科技学院 副教授
2009年1月- 2012年6月 美国国立卫生研究院（NIH） 博士后
2012年7月- 2017年9月 黑龙江八一农垦大学动物科技学院 副教授
2017年9月-2019年10月 黑龙江八一农垦大学动物科技学院 教授
2019年11月- 海南大学动物科技学院 教授

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讲授课程：
兽医传染病学、兽医微生物学

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科研项目
1.牛UK株轮状病毒拮抗Ⅰ型IFN信号转导通路机制的研究、国家自然科学基金青年项目，2013/01-2015/12、24万元、已结题、主持。
2.博士后研究人员落户黑龙江科研启动资助项目、Caco-2细胞网格蛋白表达对轮状病毒侵入的影响、2014/1-2016/12、5万元、已结题、主持。
3.异源宿主细胞内牛轮状病毒NSP1蛋白调控IFN免疫应答机制、黑龙江省科学基金面上项目，2015/7-2018/7、10万元、已结题、主持。
4. 猪塞内卡病毒3C蛋白调控IFN信号转导通路的关键结构域及其作用机制、海南省自然科学基金，2020/12-2023/12、7万元，在研，主持。

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发表论文
[1] Yang Y, Teng Z, Lu Y, Luo X, Mu S, Ru J, Zhao X, Guo H, Ran X, Wen X*, Sun S*. Enhanced immunogenicity of foot and mouth disease DNA vaccine delivered by PLGA nanoparticles combined with cytokine adjuvants [J]. Res Vet Sci, 2021, 136: 89-96.
[2] Wen X, Tong X, Wang M, Wang J, Ni H, Ran X*. Protective immunity following vaccination with a recombinant multiple-epitope protein of bovine herpesvirus type I in a rabbit model [J]. Appl Microbiol Biotechnol, 2020, 104(7): 3011-3023.
[3] Mu S, Abdullah S W, Zhang Y, Han S, Guo H, Li M, Dong H, Xu J, Teng Z, Wen X, Sun S. Development of a novel SYBR green I-based quantitative RT-PCR assay for Senecavirus A detection in clinical samples of pigs [J]. Mol Cell Probes, 2020, 53: 101643.
[4] Lu Y, Dong H, Li J, Li L, Wang M, Liu H, Teng Z, Zhang Y, Jin Y, Guo H, Yang Y, Wen X*, Sun S*. Enhanced protective immune response of foot-and-mouth disease vaccine through DNA-loaded virus-like particles [J]. Microb Pathog, 2020, 143: 104130.
[5] Wang X, Bi Y, Ran X, Tong X, Ni H*, Wen X*. Mapping a highly conserved linear neutralizing epitope on gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. J Vet Med Sci, 2019, 81(5): 780-786.
[6] Ran X, Yang Z, Bai M, Zhang Y, Wen X, Guo H, Sun S. Development and validation of a competitive ELISA based on bacterium-original virus-like particles of serotype O foot-and-mouth disease virus for detecting serum antibodies [J]. Appl Microbiol Biotechnol, 2019, 103(7): 3015-3024.
[7] Ran X, Meng X Z, Geng H L, Chang C, Chen X, Wen X*, Ni H*. Generation of porcine Pasteurella multocida ghost vaccine and examination of its immunogenicity against virulent challenge in mice [J]. Microb Pathog, 2019, 132: 208-214.
[8] Ran X, Cheng J, Wang M, Chen X, Wang H, Ge Y, Ni H, Zhang X X*, Wen X*. Brucellosis seroprevalence in dairy cattle in China during 2008-2018: A systematic review and meta-analysis [J]. Acta Trop, 2019, 189: 117-123.
[9] Ran X, Chen X, Wang S, Chang C, Wen X, Zhai J, Ni H*. Preparation of porcine enterotoxigenic Escherichia coli (ETEC) ghosts and immunogenic analysis in a mouse model [J]. Microb Pathog, 2019, 126: 224-230.
[10] Ran X, Chen X, Ma L, Wen X, Zhai J, Wang M, Tong X, Hou G, Ni H. A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China [J]. Acta Trop, 2019, 190: 296-303.
[11] Ni H, Jia X X, Wang J, Ran X, Wen X*. Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. Microb Pathog, 2019, 138(103815.
[12] Ran X, Chen X, Wang M, Cheng J, Ni H, Zhang X X*, Wen X*. Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis [J]. BMC Vet Res, 2018, 14(1): 393.
[13] Chen X, Wang X, Qi Y, Wen X, Li C, Liu X, Ni H. Meta-analysis of prevalence of bovine herpes virus 1 in cattle in Mainland China [J]. Acta Trop, 2018, 187: 37-43.
[14] Wen X, Sun J, Zhang Y, Cao S, Ran X, Ni H. Identification and genetic characterization of bovine parainfluenzavirus type 3 genotype c strain isolated from cattle in western China [J]. Turkish Journal of Veterinary and Animal Sciences, 2017, 41(180-186.
[15] Wen X B, Jiang H T, Zhang Y L, Lang X Y, Liu J, Ni H B. Rapid and Sensitive Diagnosis of Cattle Anaplasmosis by Loop-Mediated Isothermal Amplification (LAMP) [J]. Pakistan Veterinary Journal, 2016, 36(2): 174-178.
[16] Wen X, Wei X, Ran X, Ni H, Cao S, Zhang Y. Immunogenicity of porcine P[6], P[7]-specific truncated VP8* rotavirus subunit vaccines with a tetanus toxoid universal T cell epitope [J]. Vaccine, 2015, 33(36): 4533-4539.
[17] Wen X, Cao D, Jones R W, Hoshino Y, Yuan L. Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic [J]. Hum Vaccin Immunother, 2015, 11(10): 2483-2489.
[18] Ma Y, Wen X, Hoshino Y, Yuan L. Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains [J]. Vet Microbiol, 2015, 176(1-2): 172-178.
[19] Wen X, Wen K, Cao D, Li G, Jones R W, Li J, Szu S, Hoshino Y, Yuan L. Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus DeltaVP8* subunit parenteral vaccines [J]. Vaccine, 2014, 32(35): 4420-4427.
[20] Wen X, Cao D, Jones R W, Li J, Szu S, Hoshino Y. Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates [J]. Vaccine, 2012, 30(43): 6121-6126.