张海文


男，博士，副教授，硕导。
邮 箱：hwzhang@hainu.edu.cn

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研究领域
动物营养与免疫学、动物肠道营养调控、新型非常规饲料添加剂研发、植物提取物及其功能

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教育背景
2010年9月-2015年6月 浙江大学动物科技学院 饲料科学研究所 博士（硕博连读）
2006年9月-2010年6月 四川农业大学动物科技学院 动物科学专业 学士

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工作经历
2015年7月-2018年12月 海南大学动物科技学院 讲师
2018年12月-至今 海南大学动物科技学院 副教授

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讲授课程
本科生课程：《实验动物学》《专业英语》《畜牧业经济管理》
研究生课程：《专业前沿讨论课程》《动物营养与饲料学》《生物信息学》

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科研项目
主持项目：
1. 海南省自然科学基金项目：抗菌肽对断奶仔猪肠道免疫的作用及调控机制，2016-01-01—2017-12-31
2. 海南省科协青年科技英才学术创新计划项目：基于畜禽减抗的动物源抗菌肽筛选及其作用机理研究，2018-05-01—2020-12-31
3. 海南省林业局项目：海南省农业遗传资源调查，2020-01-01—2021-01-01
4. 海南省教育厅教改项目：以实验动物学课程为介导搭建畜牧兽医专业学生多元化知识架构，2020-01-01—2022-12-30
参与项目:
1.国家自然科学基金项目：中性粒细胞的浸润对减毒鼠伤寒沙门氏菌介导犬乳腺肿瘤治疗的影响及其机理研究，2017-01-01—2020-12-31
2.国家自然科学基金项目：基于融合串联抗原表位的新型疫苗治疗热带无爪螨过敏症及其作用机理研究，2019-01-01—2022-12-31
3.海南省重点研发项目：海南特种野猪肉质关键基因筛选及分子辅助育种研究及应用， 2017-01-01—2018-12-31
4.海南省重点研发项目：鸭疫里默氏杆菌通用型抗体制备、性能检测及应用研究，2018-01-01—2019-12-31
5.海南省科学青年科技英才项目：鸭疫里默氏杆菌保守性外膜蛋白筛选、重组表达纯化及免疫机理研究，2016-01-01—2018-12-31
6.海南省重大科技专项：海南黑山羊规模化健康养殖关键技术研究与集成应用， 2017-01-01—2018-12-31

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发表论文
1. Zhang Haiwen, Hua Rui, Zhang Bingxi, Guan Qingfeng, Zeng Jifeng, Wang Xuemei, Wang Beibei. Oral Administration of Bovine Lactoferrin-Derived Lactoferricin(Lfcin) B Could Attenuate Enterohemorrhagic Escherichia coli O157:H7 Induced Intestinal Disease through Improving Intestinal Barrier Function and Microbiota.J. Agric. Food Chem.DOI: 10.1021/acs.jafc.9b00861. IF=4.192
2. Haiwen Zhang, Rui Hua, Qingfeng Guan, Kebang Wu. iTRAQ-based proteomic analysis of the reproductive cycle characteristics of Hainan Black Goat, the unique species in China, Hainan Province. Emirates Journal of Food and Agriculture. 2018. 30(10): 839-850. IF=0.74
3. Haiwen Zhang, Bingxi Zhang, Xiaomeng Zhang, Xuemei Wang, Kebang Wu, Qingfeng Guan. Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets. Vet Immunol Immunopathol. 2017, Oct; 192:41-53. doi: 10.1016/j. IF=1.718
4. Zhang haiwen, Hua rui, Zhang bingxi, Guan qingfeng, Wang Beibei, Zeng jifeng, Wang xuemei, Wu kebang. Cathelicidin-derived PR39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine. Sci Rep. 2019 Jul 1;9(1):9456. IF=4.011
5. Zhang haiwen, Hua rui, Zhang bingxi, Zhang xiaomeng, Yang hui, Zhou xihong. Serine Alleviates Dextran Sulfate Sodium-Induced Colitis and Regulates the Gut Microbiota in Mice. Front Microbiol. 2018 Dec 10;9:3062. IF=4.235
6. Haiwen, Zhang, Xi Xia, Feifei Han, Qin Jiang, Yili Rong, Deguang Song, and Yizhen Wang. Cathelicidin-BF, a novel antimicrobial peptide from Bungarus fasciatus, attenuates disease in a dextran sulfate sodium model of colitis. Mol Pharm. 2015, 12 (5): 1648–1661. IF=5.603
7. Feifei Han, Haiwen Zhang (co-first author), Xi Xia, Haitao Xiong, Deguang Song, Xin Zong, and Yizhen Wang. Porcine beta-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol. 2015, 194(4): p. 1882-93. IF=5.57
8. Tao Chen, Shihui Hu, Haiwen Zhang*（co-corresponding author）, Qingfeng Guan, Yuhui Yang, Xuemei Wang*. 2017. Anti-inflammatory effects of Dioscorea alata L.anthocyanins in a TNBS-induced colitis model. Food & Function. DOI: 10.1039/c6fo01273f. IF=2.686
9. He, L., H. Zhang, and X. Zhou. 2018. Weanling Offspring of Dams Maintained on Serine-Deficient Diet Are Vulnerable to Oxidative Stress. Oxidative medicine and cellular longevity 2018: **. IF=4.936
10. Zhou, X., H. Zhang, L. He, X. Wu, and Y. Yin. 2018. Long-Term l-Serine Administration Reduces Food Intake and Improves Oxidative Stress and Sirt1/NFkappaB Signaling in the Hypothalamus of Aging Mice. Frontiers in endocrinology 9: 476. IF=3.519
11. Chao Luan, Haiwen Zhang, Deguang Song, Yonggang Xie, Jie Feng, and Yizhen Wang. Expressing antimicrobial peptide cathelicidin-BF in Bacillus subtilis using SUMO technology. Appl Microbiol Biotechnol. 2014, 98(8):p.3651-58. IF=4.138
12. Deguang Song, Xin Zong, Haiwen Zhang, Tenghao Wang, Hongbo Yi, Chao Luan, and Y. Wang. Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia. Int Immunopharmacol. 2015, 25(1): p. 141-7. IF=2.722
13. Hongbo Yi, Caihua Yu, Haiwen Zhang, Denghu Jiang, Yizhen Wang. Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets. Int Immunopharmacol. 2015, 28 (1) : p. 61–69 IF=2.722
14. Yonggang Xie, Chao Luan, Haiwen Zhang, Feifei Han, Jie Feng, Y.J. Choi, D. Groleau, and Yizhen Wang. Effects of thioredoxin: SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli. Protein Pept Lett. 2013, 20(1): p. 54-60. IF=1.994
15. Yonggang Xie, Feifei Han, Chao Luan, Haiwen Zhang, Jie Feng, Choi YJ, Groleau D, Yizhen Wang. High-Yield Soluble Expression and Simple Purification of the Antimicrobial Peptide OG2 Using the Intein System in Escherichia coli. BioMed Research International. 2013: 754319. IF=2.88
16. Chao Luan, Yonggang Xie, Yutian Pu , Haiwen Zhang, Feifei Han, Jie Feng, and Yizhen Wang. Recombinant expression of antimicrobial peptides using a novel self-cleaving aggregation tag in Escherichia coli. Can J Microbiol. 2014, 60(3): p. 113-20. IF=1.316
17. Yili Rong, Zeqing Lu, Haiwen Zhang, Yizhen Wang*. Effects of Casein glycomacropeptide supplementation on Escherichia coli K88 challenged piglets. Animal nutrition. 2015.
18. Xinxia Wang, Yizhen Wang, Yongjin Li, Ming Huang, Yang Gao, Xianfeng Xue, Haiwen Zhang. Responses of yellow catfish (Pelteobagrus fulvidraco) to different dietary concentrations of aflatoxin B1 (AFB1) and evaluation of an aflatoxin binder in offsetting its negative effects. Ciencias Marinas. 2016. IF=0.684.
19. Qin Jiang, Haiwen Zhang, Yonggang Xie, Yizhen Wang. Recombinant expression of porcine lactoferrin peptide LF-6 with intein technology and its immunomodulatory function in ETEC K88-infected mice. Int Immunopharmacol. 2016, 39(1): p. 181-191. IF=2.722.
20. Feifei Han, Zeqing Lu, Yifan Liu, Xi Xia, Haiwen Zhang, Yizhen Wang. Cathelicidin-BF ameliorates lipopolysaccharide-induced intestinal epithelial barrier disruption in rat. Life Science. 2016, 152(1): p. 199-209. IF=2.685.
另以第一或通讯作者发表中文核心期刊20篇（略）。

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出版著作
1.《动物营养与免疫学概论》，中国农业科学技术出版社，10万字；
2.《生物技术与工程原理及应用》，中国原子能出版社，参编，7万字。