张晓辉


男，博士，高聘副教授，硕士生导师
邮箱：zhangxiaohuiwxw@163.com


研究领域
热带动物抗热性状
兽医分子病理学和免疫病理学
动物病理诊断


教育背景
2011/09- 2016/06 南京农业大学 基础兽医学 博士（硕博连读，兽医病理学）
2007/09- 2011/06 河北北方学院 动物医学专业 学士


工作经历
2021/11月- 至今 海南大学动物科技学院 高聘副教授
2018/01- 2021/06 南京农业大学动物医学院 博士后/助理研究员


科研项目
1. 海南大学高层次人才引进科研启动项目，2021/11-2026/11， 在研, 主持
2. 国家自然科学基金青年项目(**)，2019/01-2021/12， 在研, 主持
3. 家畜疫病病原生物学国家重点实验室开放基金课题(SKLVEB2020KFKT010)，2020/11-2022/11，在研, 主持
4. 江苏省博士后科研资助计划项目(2018K206C)，2018/09-2020/08，结题, 主持
5. 中央高校基本科研业务费专项资金项目(KJQN201931)，2019.01-2019.12，结题, 主持


研究论文
1. Xiaohui Zhang, Bixia Chen, Jiaxin Wu, Junzhou Sha, ...... , Endong Bao*. Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways. Cells, 2020.01.
2. Bixia Chen, Bo Yang, Jie Zhu, Jiaxin Wu, ...... , Xiaohui Zhang*. Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling. International Journal of Molecular Science, 2020.02.
3. Xiaohui Zhang, Jie Zhu, Bo Yang, Bixia Chen, ...... , Endong Bao*, Transcriptomic investigation reveals toxic damage due to tilmicosin and potential resistance against tilmicosin in primary chicken myocardial cells, Poultry Science, 2020.12.
4. Xiaohui Zhang, Xiangdong Lei, Lifang Ma, Jiaxin Wu, Endong Bao*. Genetic and pathogenic characteristics of newly emerging avian reovirus from infected chickens with clinical arthritis in China. Poultry Science, 2019.11.
5. Xiaohui Zhang, Jiaxin Wu, Junzhou Sha, Bo Yang, ...... , Endong Bao*. Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating target PI3K-Akt and PKM2 signaling in vivo. International Journal of Molecular Medicine, 2020.06.
6. Bixia Chen?, Xiaohui Zhang?, Jie Zhu, Lijing Liao, Endong Bao*. Molecular Epidemiological Survey of Canine Parvovirus Circulating in China from 2014 to 2019, Pathogens, 2021.05.
7. Xiaohui Zhang, Miao Zhang, Jiaxin Wu, Yubao Li, ...... , Endong Bao*. Gingko biloba extract EGB761 alleviates heat-stress injury in chicken heart tissues by stimulating Hsp70 expression in vivo in vascular endothelial cells. British Poultry Science, 2020.04.
8. Xiaohui Zhang, Miao Zhang, Yanan Su, Zhe Wang, ...... , Endong Bao*. Inhibition of heat stress-related apoptosis of chicken myocardial cells through inducing Hsp90 expression by aspirin administration in vivo. British Poultry Science, 2018.06.
9. Xiaohui Zhang?, Miao Zhang?, Endong Bao*. Ginkgo biloba extract EGB761 improved anti-heat stress responses in chickens in vivo via regulation of heat-shock protein expression and distribution.Turkish Journal of Veterinary and Animal Science, 2020.04.
10. Xiaohui Zhang, Jinzhe Pan, Ning Wu, Shu Tang, ...... , Endong Bao*. Investigation of the efficiency and safety of tilmicosin phosphate in treating experimental mycoplasmal infections in pigs. Turkish Journal of Veterinary and Animal Science, 2018.10.
11. Xiaohui Zhang, Hong Wu, Shu Tang, Qiaoning Li, ...... , Endong Bao*. Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro. Journal of Veterinary Science, 2017.06.
12. Xiaohui Zhang, Zhe Wang, Bin Yin, Hong Wu, ...... , Endong Bao*. A complex of trypsin and chymotrypsin effectively inhibited growth of pathogenic bacteria inducing cow mastitis and showed synergistic antibacterial activity with antibiotics. Livestock Science, 2016.03.
13. Xiaohui Zhang, Huaisen Zhu, Zhuang Qian, Shu Tang, ...... , Endong Bao*. The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells. Journal of Veterinary Science, 2016.03.
14. Xiaohui Zhang, Zhuang Qian, Huaisen Zhu, Shu Tang, ...... , Endong Bao*. HSP90 gene expression induced by aspirin is associated with damage remission in a chicken myocardial cell culture exposed to heat stress. British Poultry Science. 2016.08.


奖励和荣誉
1. 张晓辉(4/5)；应激性心肌损伤及诱导表达热休克蛋白抗应激损伤的分子机制，国家教育部，自然科学奖（二等奖），2017.
2. 张晓辉(4/5)；应激性心肌损伤及诱导表达热休克蛋白抗应激损伤的分子机制, 江苏省教育厅, 自然科学奖（二等奖），2016.
3. 张晓辉(1/1)；糜蛋白酶和胰蛋白酶体外微生物敏感性研究，中国畜牧兽医学会兽医病理学分会学术研讨会，优秀青年论文奖，2014.
4. 张晓辉(1/1)；The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells，中国畜牧兽医学会兽医病理学分会学术研讨会，优秀青年论文奖，2015.
5. 南京农业大学优秀博士毕业生，2016. 06
6. 江苏省优秀学生干部，2014. 05


课程建设
1.《家禽养殖中的应激与防控》，江苏省科技厅“助力乡村振兴，千门优课下乡”省级在线开放课程，主持
2.《高级兽医病理学》，科学出版社，研究生教材（整理出版中），参编
3.《兽医病理生理学》，国家林业和草原局“十四五规划教材”，本科生教材（编写中），参编


学术兼职
担任Current Medicinal Chemistr、BMC Endocrine Disorders、3 Biotech、Life Science、Acta Biochimica et Biophysica Sinica等SCI期刊审稿人