周非凡（博士），教授、博士生导师，全国百篇优秀博士学位论文获得者，国家海外高层次人才青年项目获得者。获华南师范大学光学专业博士学位；2010.06-2013.12 华南师范大学 历任助理研究员、副研究员；2014.01-2018.06 美国俄克拉荷马中央大学 历任研究助理、研究助理教授、研究副教授；2018.07-2020.07深圳大学 ****；2020.08 海南大学 教授。
从事光学技术在肿瘤诊疗和神经免疫调控中的应用基础研究，主要研究方向有：1) 肿瘤光学精准诊疗技术研发；2) 神经免疫可视化及诊疗技术研究。
学术论文
在Nano Letter、 Clinical Cancer Research等国际知名学术期刊上发表SCI论文40余篇，被引3000余次；获批中国、美国专利各1项。主要工作如下：阐明了激光肿瘤治疗的抗肿瘤免疫新机制，开发了肿瘤光免疫协同治疗技术和成像引导监控的诊疗一体化技术，发展新型激光免疫疗法成功治疗晚期黑色素瘤病人；探究神经免疫调控可视化技术，发展针对神经疾病的诊疗技术。
代表性论文
1、Feifan Zhou#*, Meng Wang#, Teng Luo, Junle Qu*, Wei R. Chen*. Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem. Biomaterials 2020. DOI: https://doi.org/10.1016/j.biomaterials.2020.120421. (JCR工程技术1区)
2、Feifan Zhou#, Jingxuan Yang#, Yuqing Zhang, Mingyang Liu, Mark L Lang, Min Li*, Wei R Chen*, Local phototherapy synergizes with immunoadjuvant for treatment of pancreatic cancer through induced immunogenic tumor vaccine. Clinical Cancer Research 2018;24(21):5335-5346. (JCR医学1区)
3、Mark F. Naylor, Feifan Zhou*, Brian V. Geister, Robert E. Nordquist, Wei R. Chen, Treatment of advanced melanoma with laser immunotherapy and ipilimumab. J Biophotonics 2017, 10(5), 618-622. (JCR光学2区)
4、Feifan Zhou#, Xiaosong Li#, Mark F. Naylor, Tomas Hode, Robert E. Nordquist, Luciano Alleruzzo, Joseph Raker, Samuel S.K. Lam, Nan Du, Lei Shi, Xiuli Wang, Wei R. Chen*. InCVAX - A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity. Cancer Lett. 2015, 395, 169-177. (JCR医学1区)
5、Feifan Zhou, Shengnan Wu, Sheng Song, Wei R. Chen, Daniel E. Resasco, Da Xing*, Antitumor immunologically modified carbon nanotubes for photothermal therapy. Biomaterials 2012, 33, 3235-3242. (JCR工程技术1区) (cited 128)
6、Sheng Song, Feifan Zhou*, Wei R. Chen, Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases, J Neuroinflam 9, 219, 2012. (JCR医学2区) (cited 73)
7、Feifan Zhou#, Shengnan Wu#, Yi Yuan, Wei R. Chen, Da Xing*, Mitochondria targeting photoacoustic therapy using single-walled carbon nanotubes. Small 2012, 8, 1543–1550. (JCR工程技术1区) (cited 81)
8、Feifan Zhou#, Shengnan Wu#, Baoyan Wu, Wei R. Chen, Da Xing*, Mitochondria-targeting single-walled carbon nanotubes for cancer photothermal therapy, Small 2011, 7, 2727–2735. (JCR工程技术1区) (cited 143)
9、Feifan Zhou, Da Xing*, Baoyan Wu, Shengnan Wu, Zhongmin Ou, Wei R. Chen, New insights of transmembranal mechanism and subcellular localization of non covalently modified single-walled carbon nanotubes, Nano Lett. 2010, 10, 1677-1681. (JCR工程技术1区) (cited 142)
10、Feifan Zhou, Da Xing, ZhongminOu, Baoyan Wu, Daniel E. Resasco, Wei R. Chen, Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes, J. Biomed. Opt. 14(2), 021009, 2009. (JCR光学3区) (cited 276)
获批专利：
中国发明专利 一种手持介入装置以及手持介入装置的使用方法 2.9
美国发明专利 A device and a method for imaging-guided photothermal laser therapy for cancer treatment 2018 US9,987,089 B2.
主持科研项目
1、广东省科技厅计划项目，肿瘤靶向性多功能纳米探针构建及应用研究，2011.09-2014.08，8万，已结题。
2、广东省自然科学基金项目，功能纳米探针介导的肿瘤激光免疫疗法应用基础研究，2012.10-2014.10，5万，已结题。
3、国家自然科学青年基金，线粒体靶向碳纳米管介导的肿瘤激光治疗应用基础研究，2012.01-2014.12，22万，已结题。
4、广东省科技厅重点研发项目，基于光声成像的鼻咽癌激光免疫精准诊疗技术研究，2019.01-2022.12，300万，在研。
获奖与荣誉称号
1、2011 FEBS J 学术期刊高引用奖;
2、2012 教育部科学技术奖二等奖 (骨干);
3、2012 广东省优秀博士学位论文；
4、2013 全国百篇优秀博士学位论文；
5、2017国家海外高层次人才青年项目入选者。
学术兼职
国际光学工程学会（SPIE）Photonics West “Biophotonics and Immune Responses”会议的委员会成员（Program Committee Member），中国生物医学工程学会生物医学光子学分会委员，中国抗癌协会肿瘤光动力治疗分会青年委员。
招生需求
招收生物、医学、光学、生物医学工程及相关专业的硕士生、博士生、博士后和预聘教师。
邮箱：zhouff@hainanu.edu.cn



Feifan Zhou, PhD.
Professor, PhD supervisor
School of Biomedical Engineering
Hainan University, Haikou, China
Email: zhouff@hainanu.edu.cn
Professor Feifan Zhou was the gainer of Excellent Doctoral Thesis Award of China and National Overseas High-level Talents Youth Program. She have published more than 50 peer-reviewed papers with more than 3000 citations. She also received several research grants, delivered several invited talks in international conferences, and served as members in many academic organizations.
Research Interests
Optical technology in tumor theranostics and neuroimmune regulation
Nanomaterials based theranostics for cancer and neurodegenerative diseases
Synergized phototherapy and immunotherapy for metastatic cancer
Education
09/2000-07/2004 Bioscience B.S. Henan University, China
09/2005-06/2010 Optics Ph.D. South China Normal University, China

Positions
07/2010-12/2011 Assistant Professor of Research, South China Normal University
01/2012-12/2013 Associate Professor of Research, South China Normal University
01/2014-09/2015 Research Associate, University of Central Oklahoma
10/2015-05/2017 Assistant Professor of Research, University of Central Oklahoma
06/2017-06/2018 Associate Professor of Research, University of Central Oklahoma
07/2018-07/2020 Professor, Shenzhen University
08/2020- present Professor, Hainan University
Awards
2017 High-level Youth Talents Program
2013 Excellent Doctoral Thesis Award of China
2012 Excellent Doctoral Thesis Award of Guangdong, China
2012 Ministry of Education Science and Technology Progress Award, China
2011 Academic Journal High Citation Award in 2011, FEBS J
Patents
A device and a method for imaging-guided photothermal laser therapy for cancer treatment, 2018 US9,987,089 B2, US Patent.
A hand-held intervention device and using method of hand-held intervention device, 2.9, China Patent
Relevant Peer-Reviewed Publications
? Feifan Zhou#*, Meng Wang#, Teng Luo, Junle Qu*, Wei R. Chen*. Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem. Biomaterials 2021; 265, 120421.
? Feifan Zhou#, Jingxuan Yang#, Yuqing Zhang, Mingyang Liu, Mark L Lang, Min Li*, Wei R Chen*, Local phototherapy synergizes with immunoadjuvant for treatment of pancreatic cancer through induced immunogenic tumor vaccine. Clinical Cancer Research 2018;24(21):5335-5346.
? Mark F. Naylor, Feifan Zhou*, Brian V. Geister, Robert E. Nordquist, Wei R. Chen, Treatment of advanced melanoma with laser immunotherapy and ipilimumab. J Biophotonics 2017, 10(5), 618-622.
? Feifan Zhou#, Xiaosong Li#, Mark F. Naylor, Tomas Hode, Robert E. Nordquist, Luciano Alleruzzo, Joseph Raker, Samuel S.K. Lam, Nan Du, Lei Shi, Xiuli Wang, Wei R. Chen*. InCVAX - A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity. Cancer Lett. 2015, 395, 169-177.
? Feifan Zhou, Shengnan Wu, Sheng Song, Wei R. Chen, Daniel E. Resasco, Da Xing*, Antitumor immunologically modified carbon nanotubes for photothermal therapy. Biomaterials 2012, 33, 3235-3242.
? Sheng Song, Feifan Zhou*, Wei R. Chen, Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases, J Neuroinflam 9, 219, 2012.
? Feifan Zhou#, Shengnan Wu#, Yi Yuan, Wei R. Chen, Da Xing*, Mitochondria targeting photoacoustic therapy using single-walled carbon nanotubes. Small 2012, 8, 1543–1550.
? Feifan Zhou#, Shengnan Wu#, Baoyan Wu, Wei R. Chen, Da Xing*, Mitochondria-targeting single-walled carbon nanotubes for cancer photothermal therapy, Small 2011, 7, 2727–2735.
? Feifan Zhou, Da Xing*, Baoyan Wu, Shengnan Wu, Zhongmin Ou, Wei R. Chen, New insights of transmembranal mechanism and subcellular localization of non covalently modified single-walled carbon nanotubes, Nano Lett. 2010, 10, 1677-1681.
? Feifan Zhou, Da Xing, ZhongminOu, Baoyan Wu, Daniel E. Resasco, Wei R. Chen, Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes, J. Biomed. Opt. 14(2), 021009, 2009.
Research Support
Key R&D Project of Guangdong Provincial, Photoacoustic guided photo-immunotherapy for nasopharyngeal carcinoma, 2019.01-2021.12, 3 million yuan.
National Natural Science Foundation of China (Youth Talents Program) , Basic research on the application of photoimmunotherapy, 2020.01-2022.12, 2 million yuan.
National Natural Science Foundation of China, Basic research on mitochondria targeting carbon nanotubes mediated cancer laser therapy, 2012.01-2014.12, 220 thousands yuan.
Academic Service
Program committee member, Biophotonics and Immune Responses Branch, Photonics West of Society of Photo-Optical Instrumentation Engineers (SPIE)
Committee member, Biomedical Photonics Branch, Chinese Society of Biomedical Engineering
Youth committee member, Photodynamic Therapy Branch, Chinese Anti-Cancer Association
Current Opening
Opening for Master students/PhD students/Post-doctoral Fellows/Pre-employed teachers in biology, medicine, optics, biomedical engineering and other related areas.