吴锡龙，教授（高聘），博士生导师。2015年获中国科学院长春应用化学研究所高分子化学与物理博士学位，师从陈学思院士，同年12月至2017年12月在中山大学开展博士后研究。2018年1月以“海南大学C类高层次引进人才计划”入职海南大学，主要从事多功能纳米药物，生物响应性水凝胶和纳米分子影像技术相关领域的研究，相关研究成果发表在Advanced Functional Materials、Biomaterials、Journal of Controlled Release等相关领域国际著名期刊上，获得多项国家发明专利授权，并主持国家自然科学基金面上项目、地区科学基金项目、青年科学基金项目、海南省自然科学基金高层次人才项目、武汉光电国家研究中心开放基金、中国博士后科学基金面上项目、海南大学C类高层次人才启动基金等基金项目。
代表性学术论文
1、Wu X, He C, Wu Y, Chen X, Cheng J. Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo–protein combination therapy. Advanced Functional Materials, 2015, 25(43): 6744. (IF=16.836，中科院JCR工程技术一区)；
2、Wu X, He C, Wu Y, Chen X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials, 2016, 75: 148. (IF=10.317，中科院JCR工程技术一区)；
3、Wu X, Wu Y, Ye H, Yu S, He C, Chen X. Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy. Journal of Controlled Release, 2017, 255: 81. (IF=7.727，中科院JCR医学一区)；
4、 Wu X, Wu Y, Wang Z, Liu L, Sun C, Chen Y, Wang C. A cascade targeting nanocapsule for enhanced photothermal tumor therapy with aid of autophagy inhibition. Advanced Healthcare Materials, 2018, 7(11): **. (IF=7.367，中科院JCR工程技术一区)；
5、Wu X, Hou J, Li M, Wang J, Kaplan DL, Lu S. Sodium dodecyl sulfate-induced rapid gelation of silk fibroin. Acta Biomaterialia. 2012, 8(6): 2185. (IF=7.242，中科院JCR工程技术一区)；
6、 Li Z, Yu Z, Wu Y, Wu X^*, Wan Y, Yan Y, Wang N. Self-sterilizing diblock polycation-enhanced polyamidoxime shape-stable blow-spun nanofibers for high-performance uranium capture from seawater. Chemical Engineering Journal, 2020, 390(15): 124648. (IF=10.652，中科院JCR工程技术一区)；
部分主持科研项目
1.国家自然科学基金面上项目，2021.01-2024.12，主持，在研；
2.国家自然科学基金地区科学基金项目，2021.01-2024.12，主持，在研；
3.国家自然科学基金青年科学基金项目，2018/01-2020/12，主持，已结题；
4.海南省自然科学基金高层次人才项目，2020/01-2022/12，主持，在研；
5.武汉光电国家研究中心开放基金，2021/01-2023/12，主持，在研；
6.海南大学C类高层次人才启动基金，2018/01-2022/12，主持，在研；
7.中国博士后基金面上项目，2016/01-2017/12，主持，已结题
招生需求
招收生物医学工程、化学、材料学、医学、药学或生命科学等相关专业背景的硕士生、博士生、博士后和预聘教师。
联系方式：wuxilong@hainanu.edu.cn











Xilong Wu, Ph.D.
Professor, Hainan University
No 58, Renmin Avenue, Haikou, 570228, China
Mobile Phone: (+86)173-8460-0130
Email: xilongwu@foxmail.com
OVERVIEW OF RESEARCH INTERESTS
Organic Synthetic Polymer Chemistry, Functional Biodegradable Polymers;
Nanomedicine, Biological Hydrogels, Biomaterials, Drug Delivery, Molecular Imaging;
Nano-Probes for Whole-Brain Multimodal Imaging;
Three-Dimensional Culture of Cerebral Organoids for Drug Screening, Regenerative Medicine and Precision Medicine;
EDUCATION AND RESEARCH EXPERIENCE
Dr. Wu obtained Ph.D. degree from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) in 2015 under the supervision of Prof. Xuesi Chen. During 2015?2017, he worked in Sun Yat-sen University as a postdoctoral research fellow. He joined Hainan University in 2018. His research focuses on the synthesis of nanometer-sized controlled drug delivery systems and biological hydrogels, the development of nano-probes for whole-brain multimodal imaging and three-dimensional culture of cerebral organoids for drug screening, regenerative medicine and precision medicine.
SELECTED PUBLICATIONS
? Wu X, He C, Wu Y, Chen X, Cheng J. Nanogel-incorporated physical and chemical hybrid gels for highly effective chemo–protein combination therapy. Advanced Functional Materials, 2015, 25(43): 6744.
? Wu X, He C, Wu Y, Chen X. Synergistic therapeutic effects of Schiff's base cross-linked injectable hydrogels for local co-delivery of metformin and 5-fluorouracil in a mouse colon carcinoma model. Biomaterials, 2016, 75: 148.
? Wu X, Wu Y, Ye H, Yu S, He C, Chen X. Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy. Journal of Controlled Release, 2017, 255: 81.
? Wu X, Wu Y, Wang Z, Liu L, Sun C, Chen Y, Wang C. A cascade targeting nanocapsule for enhanced photothermal tumor therapy with aid of autophagy inhibition. Advanced Healthcare Materials, 2018, 7(11): **.
? Wu X, Hou J, Li M, Wang J, Kaplan DL, Lu S. Sodium dodecyl sulfate-induced rapid gelation of silk fibroin. Acta Biomaterialia. 2012, 8(6): 2185.
? Li Z, Yu Z, Wu Y, Wu X*, Wan Y, Yan Y, Wang N. Self-sterilizing diblock polycation-enhanced polyamidoxime shape-stable blow-spun nanofibers for high-performance uranium capture from seawater. Chemical Engineering Journal, 2020, 390(15): 124648.
SELECTED PAPER TO ACADEMIC CONFERENCES
? Wu X, Wu Y, Liu L, Chen Y, "Cellular protease-mediated antitumor drug delivery by hierarchical targeting and pH-sensitive nanosystems", the 2nd International Conference on Nanomedicine, China, Oct 2016, Wuhan, P.R. China.
? Wu X, Chu Y, Wu Y, Liu L, Mao H, Chen Y, "Well-defined peptide-conjugated intracellular-acidity-sensitive nanoassemblies for tumor-targeted anticancer drug delivery", 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD), Sep 2016, Suzhou, P.R. China.
? Wu X, He C, Wu Y, Chen X, "Schiff's base cross-linked in situ hydrogels for localized and sustained delivery of anticancer drugs", 2015 National Polymer Academic Report, Oct 2015, Suzhou, P.R. China.
? Wu X, He C, Chen X, "Injectable synthetic polypeptide-based hydrogels for biomedical applications", International Symposium on Translational Nanomedicine, Jan 2015, Guangzhou, P.R. China.
? Wu X, He C, Chen X, "In situ cross-linking hybrid hydrogels based on naturally-derived polysaccharides and protein", 3rd International Symposium on Polymer Ecomaterials (PEM2014), Aug 2014, Kunming, P.R. China.
? Wu, X, Mao L, Lu S, "Preparation and Mechanism of Injectable Silk Hydrogel", The 9th World Biomaterials Congress (WBC), Jun, 2012, Chengdu, P.R. China.
SELECTED PATENTS
? China Authorized Patent No. CN B: Synthesis and preparation of a kind of novel hydrogel.
? China Authorized Patent No. CN B: Preparation of a modified dextran-based micelle or drug-carrying nanogel.
? China Authorized Patent No. CN B: A kind of preparing method of silk fibroin aqueous solution.
?China Authorized Patent No. CN B: A novel injectable silk fibroin hydrogel and its preparation process and application.
? China Patent Application No. CN A: Design and preparation of anti-shrinkage and antibacterial nanocomposite fibers for extracting uranium from seawater.
CURRENT SUPPORT
? General Program of National Natural Science Foundation of China (Grant No. **), Period: 2021.01-2024.12;
? Regional Program of National Natural Science Foundation of China (Grant No. **), Period: 2021.01-2024.12;
? Youth Program of National Natural Science Foundation of China (Grant No. **), Period: 2018.01-2020.12;
? Hainan Provincial Natural Science Foundation of China for High-level Talents (Grant No. 2019RC125), Period: 2020.01-2022.12;
?Open Project Program of Wuhan National Laboratory for Optoelectronics (Grant NO. 2020WNLOKF020), Period: 2021.01-2023.12;
? The Start-up Scientific Research Foundation from Hainan University (Grant No. KYQD(ZR)1828), Period: 2018.01-2022.12;
? China Postdoctoral Science Foundation (Grant No. 2016M602578), Period: 2016.01-2017.12;