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硕士研究生导师
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王勉，女，硕士研究生导师，广西大学生命科学与技术学院教师本科、硕士毕业于中国药科大学,博士毕业于广西大学（期间于哈佛大学进行一年的博士课题研究）2009年7月至今在广西大学工作2011年 中国科学院上海药物所新药设计与发现中心，生物大分子结构和功能及药物设计的课题研究2015年-2016年 哈佛大学医学院，抗肿瘤化合物评价、肿瘤细胞/干细胞3D培养及3D打印的课题研究
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1.药学分子生物学2.分子生物学3.免疫学
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（1）抗肿瘤、抗病毒前药及药物递送系统（2）抗肿瘤、抗病毒药物的筛选、作用机制研究及药物靶点确证（3）化学生物学
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1 靶向HCC和TAFs的共载氯化两面针碱和阿霉素脂质体用于肝癌化学免疫治疗的研究2 针对广西高发肝癌的双靶修饰氯化两面针碱脂质体的构建、评价及协同靶向机理研究
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28) Honghui Liu, Yan Wang, Mingxia Lv, Yi Luo, Bu-Ming Liu, Yan Huang, Mian Wang*,Jianyi Wang*. Flavonoid analogues as urease inhibitors: Synthesis, biological evaluation, molecular docking studies and in-silico ADME evaluation. Bioorganic Chemistry, 2020,105, 104370-104380.(IF 4.831，SCI 二区)27) Ruihua Ding, Zhenjie Li, Jianyi Wang*, Xueyan Zhu, Zhuang Zhao, Mian Wang*, Design and synthesis of galactose-biotin lipid materials for liposomes to promote the hepatoma cell-targeting effect, Journal of Pharmaceutical Sciences, 2019, 108,3074-3081, (IF 3.2，JCR 三区)26) Hongping Zhang，Xueyan Zhu，Mian Wang*，Bu-Ming Liu，Yan Huang，Jianyi Wang*，A theoretical study of Fe(PMe3)4-catalyzed anti-Markovnikov addition of aromatics to alkenes to provide linear alkylation products，Transition Metal Chemistry，2019，doi.org/10.1007/s11243-019-00338-y25) Liang Yi，Yan Wang，Tingrong Luo，Wei Hu，Mian Wang*，Jianyi Wang*，Design, synthesis and evaluation of a novel hepatocyte-targeting fluorescent probe to accurately detect H2S in mitochondria, Dyes and Pigments, 2019，166，460-466 (IF 4.0，JCR 二区，Top)24）Yamin Zhang, Zhenjie Li, Haibo Ge, Xueyan Zhu, Zhuang Zhao, Zhong-quan Qi, Mian Wang*, Jianyi Wang*，Dual Hepatocyte-Targeting Fluorescent Probe with High Sensitivity to Tumorous pH: Precise Detection of Hepatocellular Carcinoma Cells，Sensors & Actuators: B. Chemical，2019，285，584-589 ( SCI一区，Top）23）Hui Zhang, Zhenjie Li, Mian Wang,* Tingrong Luo, Liang Yi and Jianyi Wang *, Novel Hepatocyte-Targeting Fluorescent Probes for Detection of Hypochlorous Acid: Synergistic Effect of Phosphate and Galactose, Sensors & Actuators: B. Chemical, 2019，279，102–110 (SCI一区，Top）22）Heng Li, Wen-Juan Hao, Mian Wang, Xue Qin, Shu-Jiang Tu*, Peng Zhou, Guigen Li, Jianyi Wang,* and Bo Jiang*，Catalytic Double [2+2] Cycloaddition Relay Enabled C-C Triple Bond Cleavage of Yne−Allenones, Organic Letters, 2018, 20, 4362-4366 (IF 6.7, SCI一区，Top）21）Wei Hu, Zhengjun Chen, Mian Wang, Tingrong Luo, Jianyi Wang*, Design, synthesis and evaluation of HepDirect fluorescence probes mediated by asialoglycoprotein receptor, Dyes and Pigments, 2018，159，471–478 (IF 3.7，SCI 二区，Top)20）Lujuan Liao, Zhenjie Li, Wei Hu, Yan Huang, Bu-min Liu, Lisheng Wang, Mian Wang*, Jianyi Wang*. Design, synthesis and evaluation of a novel fluorescent probe to accurately detect H2S in lysosomes.Tetrahedron Letters, 2018,59(27),2683-2687.(SCI)19) Feiyang Liu,Piaoping Tang, Ruihua Ding, Lujuan Liao, Lisheng Wang,Mian Wang*,Jianyi Wang*. A glycosylation strategy to develop a low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium. Dalton Trans., 2017,46,7515–7522. （SCI大类二区, 小类一区, top）18) Jianyi Wang, Qing Chen, Mian Wang*, Cheng Zhong. The opening/closure of the P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib. Phys. Chem. Chem. Phys., 2017,19,22444--22453.（SCI 二区, top）17) Mian Wang, Marc Baaden, Zhiqun Liang*, Jianyi Wang*. A Cooperative Mechanism of Clotrimazoles in P450 revealed by the Dissociation Picture of Clotrimazole from P450. Journal of Chemical Information and Modeling, 2014,54,1218-1225. （SCI 二区）16) Wenhao Sheng, Mian Wang, Matthias Lein, Linbin Jiang, Wanxing Wei, Jianyi Wang*. Mechanism of Copper(I)-Catalyzed Allylic Alkylation of Phosphorothioate Esters: Influence of the Leaving Group on α Regioselectivity. Chemistry: A European journal 2013,19,14126–14142. (co-first author)（SCI 二区, top）15) Xuesong Wu, Mian Wang, Guangwu Zhang,Yan Zhao, Jianyi Wang and Haibo Ge. Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Cyclization of Hydrazones via sp3 C−H Functionalization. Chem. Sci., 2015,6,5882-5890.（SCI 一区，top）14) Jingxi Wu, Mian Wang, Lisheng Wang, Jianyi Wang*, Linbin Jiang*. How the bicyclo[4.1.0] substrate isomerizes into 4, 5-dihydrobenzo[b]furan: the contribution from W(CO)5 and NEt3. The Journal of Organic Chemistry 2013,78,10812-10820.（SCI 二区，top）13) Jingzhou Yang*, Yu Shrike Zhang*, Pengfei Lei, Xiaozhi Hu, Mian Wang, Haitao Liu, Xiulin Shen, Kun Li, Zhaohui Huang, Juntong Huang, Jie Ju, Yihe Hu*, and Ali Khademhosseini*. “Steel–Concrete” Inspired Biofunctional Layered Hybrid Cage for Spine Fusion and Segmental Bone Reconstruction. ACS Biomaterials Science & Engineering. 2017, 3,637-647. （SCI ）12) Mian Wang, Hao Luo, Min Zhang, and Jianyi Wang. Why trans- or cis-Dimethyl Fumarate Addition to 2,5-Dimethylpyrrole Gives Exclusively trans-7-Azanorbornane. J. Phys. Chem. A, 2015,119,6563-73.（SCI ）11) Mian Wang, Hao Luo, Lisheng Wang, Jianyi Wang. What factors cause the complete substrate-controlled selectivity in Rh2(Piv)4-catalyzed cycloadditions of 1,2,3-triazoles with isocyanates or isothiocyanates. J. Organomet. Chem. 2015,788,58-67.（SCI ）10) Jianyi Wang*, Dinglong Cai, Min Zhang, Mian Wang*. The addition mechanism of TMSCN into N-acetylpyridinum to give 2-cyanoacetylpyridinum: the roles of TpW(NO)(PMe3) and DABCO. Journal of Organometallic Chemistry. 2013,724,117-128.（SCI ）9) Cuicui Jiang, Mian Wang, Yanxiu Wang, Xiuneng Tang, Yamin Zhang, Hui Zhang, Lin Ma, Jianyi Wang*. Synthesis and evaluation of two novel rhodamine-based fluorescence probes for specific recognition of Fe3+ ion. Tetrahedron Letters. 2017,58,2560-2565.（SCI ）8) Mian Wang, Yun Du, Jianyi Wang, Xiaomin Luo, Hualiang Jiang, Naixia Zhang*, Yechun Xu*. Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin. Molecular Simulation 2012,38,1015–1021.（SCI ）7) Mian Wang, Jipeng Yang, Jianyi Wang*, Xiaojuan Wang. Structural effects of L16Q, S20G, and L16Q-S20G mutations on hIAPP: a comparative molecular dynamics study. Chinese Journal of Chemistry 2012,30,241–248.（SCI ）6) Zhengjun Chen, Wei Hu, Mian Wang, Lisheng Wang, Guifa Su, Jianyi Wang*. Synthesis and evaluation of a water-solubility glycosyl-rhodamine fluorescent probe detecting Hg2+. Carbohydrate Research. 2016,429,81-86.（SCI ）5) Mian Wang, Jianyi Wang*. Conformational changes of the wild-type hIAPP and the S20P mutant in water revealed by molecular dynamics simulations. Advanced Materials Research 2012,396-398,1554-1557.4) Dinglong Cai, Mian Wang, Jianyi Wang*, Wengui Duan. DFT study on the mechanism of intramolecular cyclization of 2-benzyloxyphenyl trimethylsilyl ketone to give the benzofuran derivatives. Journal of Physical organic Chemistry 2011,25,400-408.（SCI ）3) Yanchun Yin, Mian Wang, Jianyi Wang*, et al. Mechanism of Gold(Ι)-Catalyzed Conia-ene Reaction of β-Ketoesters with Alkynes: A DFT Study. Chinese Journal of Chemistry 2011, 29, 2320-2326.（SCI ）2) Jianyi Wang, Mian Wang. Molecular Dynamics Simulations in Pharmaceutics. Chinese Journal of Pharmaceuticals (Chinese edition) 2010,41,863-868.1) Mian Wang, Jiabi Zhu, Yue Tang. Advances in pulmonary delivery systems. Chinese Journal of New Drugs (Chinese edition) 2009,18,694-698.
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