教师个人信息表
姓名王勉性别女

出生年月 政治面貌中共党员
籍贯广西玉林职称副教授
学历研究生学位
联系电话邮政编码530004
Emailmianwang23@163.com
QQ微信
通讯地址广西南宁市大学东路100号
所在学院化学化工学院导师类型校内导师
导师类别硕士研究生导师
指导学科一
指导学科二
学习和工作经历王勉，女，制药工程专业硕士生导师，广西大学化学化工学院制药工程教研室教师
2009年7月至今在广西大学工作
2011年3月-11月于中国科学院上海药物研究所新药设计与发现中心访学
2015年-2016年 哈佛医学院访学
目前主要从事新型药物制剂制备与评价、药物分子设计、蛋白质结构与功能等方面的研究
现主持1项广西自然科学基金项目，参与1项国家自然科学基金
学术兼职
主讲课程
主要研究方向1 新型药物制剂的制备及评价 2 分子模拟在生物大分子结构和功能、药物设计和药物传递系统的应用
主持（或参与）的主要科研项目1基于β-榄香烯的肝癌治疗剂的设计与合成
2 乳糖基小分子肝靶化合物的设计、合成物的设计、合成及生物学评价 糖缀杂环肝靶向化学载体的设计与合成
3 基于NHS-Diazirine 的光点击化学对松香基天然活性萜烯分子改性研究
4 源于广西莪术的β-榄香烯的肝靶向抗肿瘤化合物的设计、合成与生物学评价
取得的主要成果1.Mian Wang, Marc Baaden, Zhiqun Liang*, Jianyi Wang*. A Cooperative Mechanism of Clotrimazoles in P450 revealed by the Dissociation Picture of Clotrimazole from P450. Journal of Chemical Information and Modeling, 2014, 54, 1218-1225.
2.Mian Wang, Yun Du, Jianyi Wang, Xiaomin Luo, Hualiang Jiang, Naixia Zhang*, Yechun Xu*. Dynamic behavior of ubiquitin receptor S5a in free and complex with K48-linked diubiquitin. Molecular Simulation 2012, 38(12), 1015–1021.
3.Wenhao Sheng, Mian Wang, Matthias Lein, Linbin Jiang, Wanxing Wei, Jianyi Wang*. Mechanism of Copper(I)-Catalyzed Allylic Alkylation of Phosphorothioate Esters: Influence of the Leaving Group on α Regioselectivity. Chemistry: A European journal 2013, 19, 14126–14142. (co-first author)
4.Mian Wang, Jipeng Yang, Jianyi Wang*, Xiaojuan Wang. Structural effects of L16Q, S20G, and L16Q-S20G mutations on hIAPP: a comparative molecular dynamics study. Chinese Journal of Chemistry 2012, 30, 241–248.
5.Jingxi Wu, Mian Wang, Lisheng Wang, Jianyi Wang*, Linbin Jiang*. How the bicyclo[4.1.0] substrate isomerizes into 4, 5-dihydrobenzo[b]furan: the contribution from W(CO)5 and NEt3. The Journal of Organic Chemistry 2013, 78, 10812?10820.
6.Jianyi Wang*, Dinglong Cai, Min Zhang, Mian Wang. The addition mechanism of TMSCN into N-acetylpyridinum to give 2-cyanoacetylpyridinum: the roles of TpW(NO)(PMe3) and DABCO. Journal of Organometallic Chemistry 2013, 724, 117-128.
7.Dinglong Cai, Mian Wang, Jianyi Wang*, Wengui Duan. DFT study on the mechanism of intramolecular cyclization of 2-benzyloxyphenyl trimethylsilyl ketone to give the benzofuran derivatives. Journal of Physical organic Chemistry 2011, 25, 400-408.
8.Yanchun Yin, Mian Wang, Jianyi Wang*, et al. Mechanism of Gold(Ι)-Catalyzed Conia-ene Reaction of β-Ketoesters with Alkynes: A DFT Study. Chinese Journal of Chemistry 2011, 29, 2320-2326.
9.Mian Wang, Jianyi Wang*. Conformational changes of the wild-type hIAPP and the S20P mutant in water revealed by molecular dynamics simulations. Advanced Materials Research 2012, 396-398, 1554-1557.
10.Jianyi Wang, Mian Wang. Molecular Dynamics Simulations in Pharmaceutics. Chinese Journal of Pharmaceuticals (Chinese edition) 2010, 41, 863-868.
11.Mian Wang, Jiabi Zhu, Yue Tang. Advances in pulmonary delivery systems. Chinese Journal of New Drugs (Chinese edition) 2009, 18, 694-698.
12 Mian Wang, Hao Luo, Min Zhang, and Jianyi Wang. Why trans- or cis-Dimethyl Fumarate Addition to 2,5-Dimethylpyrrole Gives Exclusively trans-7-Azanorbornane.J. Phys. Chem. A, 2015, 119, 6563-73.
13 Mian Wang, Hao Luo, Lisheng Wang, Jianyi Wang. What factors cause the complete substrate-controlled selectivity in Rh2(Piv)4-catalyzed cycloadditions of 1,2,3-triazoles with isocyanates or isothiocyanates.J. Organomet. Chem. 2015, 788, 58-67.
13 Xuesong Wu, Mian Wang, Guangwu Zhang,Yan Zhao, Jianyi Wang and Haibo Ge. Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Cyclization of Hydrazones via sp3 C?H Functionalization. Chem. Sci., 2015, 6, 5882-5890.
数据更新日期2016-02-01填报责任人王勉
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