叶芳贵　[教授]
联系方式办公电话：**
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电子邮箱：fgye@mailbox.gxnu.edu.cn
办公地址：化学楼410
基本介绍叶芳贵，男，福建建瓯人，1974年生，博士，教授，博士生导师，广西自然科学****基金获得者。主要从事纳米酶及纳米多孔分离材料研究。先后主持国家自然科学基金4项、广西自然科学基金5项，科研成果获广西自然科学一等奖(第四完成人)及二等奖(第二完成人)各一项。迄今，以第一作者或通讯作者在Anal. Chem., ACS Appl. Mater. Interfaces,Chem. Commun., Chem. Eur. J., ACS Sustainable Chem. Eng., J. Mater. Chem.B, J. Chromatogr. A, Anaylst, Sensors Actuat. B-Chem.,等国内外权威刊物上发表SCI收录论文六十余篇,已获授权中国发明专利5项。
研究兴趣1. 纳米酶的设计合成及其生物传感分析
2. 纳米酶的抗菌及抗肿瘤机理与应用
3. 多孔分离材料（MOF/COF）在样品前处理中的应用

学历背景2001.09～2006.07福州大学化学化工学院分析化学专业硕博连读，博士
1993.09～1997.07南开大学化学学院化学专业，本科
工作经历2011.01～至今 广西师范大学化学与药学学院，教授
2007.01～2010.12 广西师范大学化学化工学院，副教授
2006.07～2006.12 广西师范大学化学化工学院，讲师
1997.07～2001.08福州福抗药业集团股份有限公司，助理工程师
讲授课程主讲分析化学、仪器分析、药物分析、分析化学前沿、表征技术及药物分析化学等课程。
论著专利60. Ying Sun, TianranLin*, Cuihong Zeng, Gaoyan Jiang, Xuanhan Zhang, Fanggui Ye*and Shulin Zhao. A self-correcting fluorescent assay of tyrosinase based onFe-MIL-88B-NH2 nanozyme. Microchim. Acta2021, 188, 158
59. Xueting Fang, Xiaoting Zhang, Zhihua Zhang, Shengqiang Hu*, Fanggui Ye*and Shulin Zhao. Complementary atomic flame/molecular colorimetry dual-mode assayfor sensitive and wide-range detection of cancer cells. Chem. Commun.2021, 57, 3327-3330
58. Ling Liang, Zhenghong Zhao, Fanggui Ye*and Shulin Zhao. Rapid andsensitive colorimetric detection of dopamine based on the enhanced-oxidasemimicking activity of cerium (Ⅳ). New J. Chem.2021, 45, 6780-6786
57. Wei Tan, XiaohaiWu, Wenren Liu, Fanggui Ye*and Shulin Zhao. Synchronous constructionof hierarchical porosity and thiol functionalization in COFs for selective extraction of cationic dyes in water samples.ACS Appl. Mater. Interfaces2021, 13, 4352-4363.
56. Xiaohai Wu, Siyu Si, Wei Tan, Xin Lu^?, Fanggui Ye*and Shulin Zhao. Preparation of magnetic mesoporous metal-phenolic coordination spheres for extraction of crystal violet and leuco-metabolites in fish. J. Chromatogr. A2021, 1636, 461776.
55.Wei Tan, Tao Chen,Wenren Liu, Fanggui Ye*and Shulin Zhao. Design and fabrication of boric acid functionalized hierarchical porous metal-organic frameworks for specific removal of cis-diol containing compounds from aqueous solution. Appl. Surf. Sci.2021, 53, 147714.
54. Ling Liang, Yaojing Huang, Wenren Liu, Weiyuan Zuo, Fanggui Ye*and Shulin Zhao. Colorimetric detection of salicylic acid in aspirin using MIL-53(Fe) nanozyme. Front. Chem. 2020, 8, 671.
53. Li Hou, Yuemei Qin, Tianran Lin*, Ying Sun, Fanggui Ye*and Shulin Zhao. Michael reaction-assisted fluorescent sensor for selective and one step determination of catechol via bifunctional Fe-MIL-88NH₂nanozyme. Sensors Actuat. B-Chem. 2020, 321, 128547.
52. Zhenghong Zhao, Yaojing Huang, Wenren Liu, Fanggui Ye*and Shulin Zhao. Immobilized glucose oxidase on boronic acid-functionalized hierarchically porous MOF as an integrated nanozyme for one-step glucose detection. ACS Sustainable Chem. Eng. 2020, 8, 4481-4488.
51. Wenqian Wu, Feng Lin, Xiaohan Yang, Bin Wang, Xin Lu*, Qiuxia Chen, Fanggui Ye*andShulin Zhao. Facile synthesis of magnetic carbon nanotubes derived from ZIF-67 and application to magnetic solid-phase extraction of profens from human serum. Talanta2020, 207, 120284
50. Kun Hu, Yuanxia Lv, Fanggui Ye*, Tao Chen and Shulin Zhao*. Boric-acid-functionalized covalent organic framework for specific enrichment and direct detection of cis-diol-containing compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal. Chem.2019, 91, 6353-6362.
49. Zhenghong Zhao, Junhong Pang, Wenren Liu, Tianran Lin, Fanggui Ye*, Shulin Zhao. A bifunctional metal organic framework of type Fe(III)-BTC for cascade (enzymatic and enzyme-mimicking) colorimetric determination of glucose. Microchim. Acta2019, 186, 295
48.Zhenghong Zhao, Tianran Lin*, Wenren Liu, Li Hou, Fangui Ye*, Shulin Zhao. Colorimetric detection of blood glucose based on GOx@ZIF-8@Fe-polydopamine cascade reaction. Spectrochim. Acta. A Mol. Biomol. Spectrosc.2019, 219, 240-247.
47. Yuanlin Huang, Guangzhao Liang, Tianran Lin*,Li Hou, Fanggui Ye*, Shulin Zhao. Magnetic Cu/Fe₃O₄@FeOOH with intrinsic HRP-like activity at nearly neutral pH for one-step biosensing. Anal. Bioanal. Chem.2019, 411, 3801-3810.
46. Yuanlin Huang, Tianran Lin*, Li Hou,Fanggui Ye*, Shulin Zhao. Colorimetric detectionof thioglycolic acid based on the enhanced Fe³⁺ions Fenton reaction. Microchem. J.2019, 144, 190-194.
45. Yan Duan, Fanggui Ye*, Yuanlin Huang, Yuemei Qin, Caimei He, Shulin Zhao*. One-pot synthesis of metal-organic framework-based drug carrier for intelligent glucose-responsive insulin delivery. Chem. Commun.2018, 54, 5377-5380.
44. Tianran Lin, Yuemei Qin, Yuanlin Huang, Ruitao Yang, Li Hou, Fanggui Ye*, Shulin Zhao. A label-free fluorescence assay for hydrogen peroxide and glucose based on the bifunctional MIL-53(Fe) nanozyme.Chem. Commun. 2018, 54, 1762-1765
43. Haiguan Yang, Ruitao Yang, Peng Zhang, Yuemei Qin, Tao Chen, Fanggui Ye*. A bimetallic (Co/2Fe) metal-organic framework with oxidase and peroxidase mimicking activity for colorimetric detection of hydrogen peroxide. Microchim. Acta2017, 184, 4629-4635
42. Tao Chen, Cong Zhang, Yuemei Qin, Haiguan Yang, Peng Zhang, Fanggui Ye*. Preparation of cationic MOFs with mobile anions by anion stripping to remove 2,4-D from water. Materials2017, 10, 879-890
41. Yuhao Xiong, Yuemei Qin, Linjing Su, Fanggui Ye*. Bioinspired synthesis of Cu²⁺-modified covalent triazine framework: A new highly efficient and promising peroxidase mimic. Chem. Eur. J.2017,23, 11037-11045
40. Jiannan Wang, Shufen Shen, Xin Lu, Fanggui Ye*. One-pot preparation of an organic polymer monolith by thiol-ene click chemistry for capillary electrochromatography. J. Sep. Sci.2017, 40, 3144-3152
39. Haiguan Yang, Junqi Zha, Peng Zhang, Yuemei Qin, Tao Chen, Fanggui Ye*. Fabrication of CeVO4 as nanozyme for facile colorimetric discrimination of hydroquinone from resorcinol and catechol. Sensor Actuat. B-Chem. 2017, 247, 469-478
38. Fan Nie, Jiannan Wang, Xin Lu*, Fanggui Ye*. Preparation of bifunctional magnetic nanoparticles with octadecyl and phosphate group by thiol-ene click chemistry for extraction and enrichment of organophosphorus pesticides in tea drink. Anal. Methods2017, 9, 2069-2075
37.Tao Chen, Yuhao Xiong, Yuemei Qin, Haiguan Yang, Peng Zhang, Fanggui Ye*. Facile synthesis of low-cost biomass-based γ-Fe2O3/C for efficient adsorption and catalytic degradation of methylene blue in aqueous solution. RSC Adv.2017, 7, 336-343
36. Peng Zhang, Haiguan Yang, Tao Chen, Yuemei Qin, Fanggui Ye*. Facile one-pot preparation of a novel imidazolium-based monolith by thiol–ene click chemistry for capillary liquid chromatography. Electrophoresis 2017, 38, 3013-3019
35. Junyu Lu, Fanggui Ye*, Xiuxiang Huang, Lianqiang Wei, Dongmei Yao, Shengying Li, Miao Ouyang, Hongfang Lai. Ionic liquid-modified magnetic nanoparticles as solid phase extraction adsorbent coupled with HPLC for determination of linear alkylbenzene sulfonates in water samples. J. Sep. Sci.2017, 40, 1133-1341
34. Haiguan Yang, Junqi Zha, Peng Zhang, Yuhao Xiong, Linjing Su, Fanggui Ye*. Sphere-like CoS with nanostructures as peroxidase mimics for colorimetric determination of H₂O₂and mercury ions. RSC Adv.2016, 6, 66963-66970
33. Peng Zhang, Jiannan Wang, Haiguang Yang, Linjing Su, Yuhao Xiong, Fanggui Ye*. Facile one-pot preparation of chiral monoliths with a well-defined framework based on thiol–ene click reaction for capillary liquid chromatography. RSC Adv.2016, 6, 24835-24842
32. Linjing Su, Yuhao Xiong, Haiguan Yang, Peng Zhang, Fanggui Ye*. Prussian blue nanoparticles encapsulated inside a metal-organic framework via in situ growth as promising peroxidase mimetics for enzyme inhibitor screening. J. Mater. Chem. B2016,4, 128-134
31. Junyu Lu, Yuhao Xiong, Chunjin Liao, Fanggui Ye*. Colorimetric detection of uric acid in human urine and serum based on peroxidase mimetic activity of MIL-53(Fe). Anal. Methods 2015, 7, 9894-9899
30. Yuhao Xiong, Linjing Su, Haiguan Yang, Peng Zhang, Fanggui Ye*. Fabrication of copper sulfide using a Cu-based metal organic framework for colorimetric determination and efficient removal of Hg²⁺in aqueous solutions. New J. Chem.2015, 39, 9221-9227
29. Haiguan Yang, Yuhao Xiong, Peng Zhang, Linjing Su, Fanggui Ye*. Colorimetric detection of mercury ions using MnO₂nanorods as enzyme mimics. Anal. Methods2015, 7, 4596-4601
28. Yuhao Xiong, Siheng Chen, Fanggui Ye*, Lingjing Su, Cong Zhang, Shufen Shen, Shulin Zhao. Synthesis of mixed valence state Ce-MOF as oxidase mimetics for colorimetric detection of biothiols. Chem. Commun.2015, 51, 4635-4638
27. Shengchao Yang, Fanggui Ye*, Cong Zhang, Shufen Shen, Shulin Zhao. In situ synthesis of metal-organic frameworks in porous polymer monolith as stationary phase for capillary liquid chromatography. Analyst2015, 140, 2755-2761
26. Cong Zhang, Fanggui Ye*, Shufen Shen, Yuhao Xiong, Linjing Su, Shulin Zhao. From metal-organic frameworks to magnetic nanostructured porous carbon composites: Towards highly efficient dye removal and degradation. RSC Adv.2015, 5, 8228-8235
25. Yuhao Xiong, Fanggui Ye*, Cong Zhang, Shufen Shen, Linjing Su, Shulin Zhao. Synthesis of magnetic porous γ-Fe₂O₃/C@HKUST-1 composites for efficient removal of dyes and heavy metal ions from aqueous solution. RSC Adv.2015, 5, 5164-5172
24. Yuhao Xiong, Siheng Chen, Fanggui Ye*, Linjing Su, Cong Zhang, Shufen Shen, Shulin Zhao. Preparation of magnetic core-shell nanoflowers Fe₃O₄@MnO₂as reusable oxidase mimetics for colorimetric detection of phenol. Anal. Methods2015, 7, 1300-1306
23. Shufen Shen, Fanggui Ye*, Cong Zhang, Yuhao Xiong, Linjing Su, Shulin Zhao. Preparation of polyhedral oligomeric silsesquioxane based hybrid monoliths by thiol-ene click chemistry for capillary liquid chromatography. Analyst2015, 140, 265-271
22. Shengchao Yang, Fanggui Ye*, Qinghui Lv, Cong Zhang, Shufen Shen, Shulin Zhao. Incorporation of metal-organic framework HKUST-1 into porous polymer monolithic capillary columns to enhance the chromatographic separation of small molecules. J. Chromatogr. A 2014, 1360, 143-149
21. Wei Yu, Chen Xia, Yang Sheng-Chao, LV Qing-Hui, Ye Fang-Gui*, Zhao Shu-Lin. Preparation and characterization of polymer solid-phase extraction monolith immobilized metal affinity ligands. Chin. J. Anal. Chem.2014, 42, 495-500
20.Fanggui Ye, Jinwen Liu, Yong Huang, Shutin Li, Shulin Zhao*. Competitive immunoassay of progesterone by microchip electrophoresis with chemiluminescence detection. J. Chromatogr. B2013, 936, 74-79
19. Fanggui Ye, Tinzhen Yang, Yong Huang, Shutin Li, Shulin Zhao*. Homogeneous immunoassay of cortisol based on microchip electrophoresis with chemiluminescence detection. Anal. Methods2013, 5, 5657-5661
18. Aizhu Zhang, Fanggui Ye*, Junyu Lu, Shulin Zhao. Screening α-glucosidase inhibitor from natural products by capillary electrophoresis with immobilised enzyme onto polymer monolith modified by gold nanoparticles. Food Chem.2013, 141, 1854-1859
17. Junyu Lu, Fanggui Ye*, Aizhu Zhang, Xia Chen, Yu Wei, Shulin Zhao. Preparation and evaluation of ionic liquid-gold nanoparticles functionalized silica monolithic column for capillary electrochromatography. Analyst2012, 137, 5860-5865
16. Chen Xia, Wei Yu, Lu Jun-Yu, Zhang Ai-Zhu, Ye Fang-Gui*, Zhao Shu-Lin. Preparation and evaluation of C18 modified capillary open-tubular column based on thiol-ene click chemistry for capillary electrochromatography. Chin. J. Anal. Chem.2012, 40, 1584-1588.
15. Junyu Lu, Fanggui Ye*, Aizhu Zhang, Zong Wei, Yan Peng, Shulin Zhao. Preparation and characterization of silica monolith modified with bovine serum albumin-gold nanoparticles conjugates and its use as chiral stationary phases for capillary electrochromatography. J. Sep. Sci.2011, 34, 2329-2336
14. Zhang Ai-Zhu, Ye Fang-Gui*, Lu Jun-Yu, Wei Zong, Peng Yan, Zhao Shu-Lin. preparation and characterization of polymer solid-phase microextraction monolith modified with gold nanoparticle. Chin. J. Anal. Chem.2011, 39, 1247-1250
13. Ye Fang-Gui*, Lu Jun-Yu, Wang Yuan, Zhang Ai-Zhu, Tian Jian-Niao, Zhao Shu-Lin. Preparation and characterization of gold nanoparticle-modified silica monolith for capillary electrochromatography. Chin. J. Anal. Chem.2011, 39, 341-345
12. Fanggui Ye*, Baojun Huang, Shun Wang, Shulin Zhao. Electrochromatographic performance of conventional and polar-embedded C16 silica monolithic stationary phases. J. Sep. Sci.2010, 33, 3386-3392
11. Fanggui Ye*, Hengshan Wang, Baojun Huang, Shulin Zhao. Maleopimaric acid anhydride-bonded silica monolith as chiral stationary phase for separations of phenylthiocarbamyl amino acids by capillary electrochromatography. Electrophoresis2010, 31, 1488-1492
10. Fanggui Ye, Yong Huang, Qing Xu, Ming Shi, Shulin Zhao*. Quantification of taurine and amino acids in mice single fibrosarcoma cell by microchip electrophoresis coupled with chemiluminescence detection. Electrophoresis2010, 31, 1630-1636
9. Fanggui Ye, Ming Shi, Yong Huang, Shulin Zhao*. Noncompetitive immunoassay for carcinoembryonic antigen in human serum by microchip electrophoresis for cancer diagnosis. Clin. Chim. Acta2010, 411, 1058-1062
8. Ye Fang-gui*, Han Yan-yan, Wang Shun, Huang Bao-jun, Zhao Shu-lin. Preparation and characterization of butylaminopropyl silica monolithic column for capillary electrochromatography. Chin. J. Anal. Chem.2010, 38, 192-196
7. Fanggui Ye*, Shun Wang, Shulin Zhao. Preparation and characterization of mixed-mode monolithic silica column for capillary electrochromatography. J. Chromatogr. A2009, 1216, 8845-8850
6. Fanggui Ye, Shuting Li, Shulin Zhao*. Electrochromatographic evaluation of diol-bonded silica monolith capillary column for separation of basic compounds. J. Chromatogr. Sci.2009, 47, 492-496
5. Fanggui Ye, Shuting Li, Shulin Zhao*. Development of a new C14 monolithic silica column containing embedded polar groups for pressurized capillary electrochromatography. J. Sep. Sci.2007, 30, 3027-3034
4. Fanggui Ye, Zenghong Xie*, Xiaoping Wu, Xucong Lin. Determination of pyrethroid pesticide residues in vegetables by pressurized capillary electrochromatography. Talanta2006, 69, 97-102
3. Fanggui Ye, Zenghong Xie*, Kwok-Yin Wong.Monolithic silica columns with mixed mode of hydrophilic interaction and weak anionexchange stationary phase for pressurized capillary electrochromatography. Electrophoresis2006, 27, 3373-3380
2. Fanggui Ye, Zenghong Xie*, Xiaoping Wu, Xucong Lin, Guonan Chen. Separation of polar and basic compounds in hydrophilic interaction pressurizedCEC using diethylenetriaminopropyl silica monolithic columns. Chromatographia2006, 64, 267-272
1. Fanggui Ye, Zenghong Xie*, Xiaoping Wu, Xucong Lin, Guonan Chen*. Phenylaminopropyl silica monolithic column for pressure assisted capillary electrochromatography. J. Chromatogr. A 2006, 1117, 170-175
专利申请
1. 叶芳贵,王恒山,赵书林,黄保军.硅胶毛细管整体手性固定相及其制备方法.中国发明专利，授权专利号：ZL4.0
2. 叶芳贵,陆俊宇,张爱珠,赵书林.离子液体硅胶毛细管整体柱固定相的制备方法.中国发明专利，授权专利号：ZL1.4
3. 叶芳贵,张爱珠,陆俊宇,赵书林.一种多孔整体柱固定化酶微反应器的制备方法.中国发明专利，授权专利号：ZL8.9
4. 叶芳贵,沈淑芬,张聪,赵书林.POSS杂化毛细管整体柱固定相及其制备方法，中国发明专利，授权专利号：ZL4.X
5. 赵书林,黄勇,叶芳贵,石明,李向堂.微流控芯片化学发光测定人单个血红细胞内物质的方法.中国发明专利,授权专利号：ZL3.8
科研项目1. 国家自然科学基金：合理设计集成样品前处理功能的纳米酶及其比色传感应用(**), 2021.1～2024.12，主持；
2. 国家自然科学基金：点击反应制备分级孔金属-有机框架材料整体柱及其在富集和电色谱分离中的应用(**), 2018.1～2021.12, 主持；
3. 国家自然科学基金：基于金属-有机骨架材料的磁性纳米粒子和整体柱的制备及用于多环芳烃电色谱分析研究(**)，2014.1～2017.12, 主持(已结题)；
4. 国家自然科学基金：在线亲和预富集芯片手性整体柱电色谱技术用于生物体内及单细胞中手性物质的分析研究(**), 2011.1～2013.12,主持(已结题)；
5. 广西自然科学基金重点项目：基于MOF纳米酶的荧光传感平台构建及其用于有机磷农药残留分析(2017GXNSFDA198044), 2017.9～2021.9,主持；
6.广西自然科学基金联合资助培育项目：单原子合金纳米酶的设计合成及肿瘤化学动力学疗法研究(2019GXNSFAA245014)，2020.1～2022.1，主持；
7. 广西自然科学****基金：基于功能化MOFs膜涂层的磁性纳米粒子和电色谱整体柱的制备及其应用研究(2014GXNSFGA118002), 2014.6～2017.5，主持(已结题)；
8.广西自然科学基金面上项目：MOFs聚合物毛细管固相微萃取整体柱的制备及其应用研究(2012GXNSFAA053024)，2012.1～2014.12，主持(已结题)；
9.广西自然科学基金应用基础专项：新型硅胶基质毛细管整体柱的制备及应用研究(**)，2007.5～2010.4，主持(已结题)；

获奖情况1. 2014年广西自然科学奖一等奖(排名第四)
2. 2010年广西自然科学奖二等奖(排名第二)
3. 2014年广西自然科学****基金获得者
4. 2013年入选广西师范大学拨尖人才