出生年月:1969.11
籍贯:广西
学历:博士
职称:教授
专业:无机化学
---教育和主要工作经历--- 陈振锋博士1969年11月生于广西北流市。2001年6月毕业于南京大学无机化学专业,获理学博士学位。2001年晋升副教授,2003年被破格晋升教授。2004年被评为广西新世纪“百千万人才工程”第二层次人选,教育部“新世纪优秀人才支持计划”人选。2006-2007到加拿大UniversityofBritishColumbia化学系ChrisOrvig教授实验室作访问研究。2011年被聘为广西首批“八桂学者”(药物化学)。现任化学与药学学院副院长、药用资源化学与药物分子工程教育部重点实验室常务副主任,广西药用资源化学与药物分子工程实验室----省部共建国家重点实验室培育基地常务副主任。主要承担本科生《无机化学》和研究生的《现代配位化学》等课程的教学工作。作为硕士生导师,已指导或合作硕士研究生40多名,独立或合作指导博士研究生8名。先后主持973计划前期研究专项1项,国家自然科学基金项目3项,教育部”创新团队发展计划”项目1项,教育部重点项目2项,教育部“新世纪优秀人才支持计划”资助项目1项,广西自然科学基金项目4项。作为第二成员参与国家自然科学基金地区基金联合资助项目1项,973计划前期研究专项各3项。近年来已在《Chem.Eur.J.》,《Chem.Commun.》,《AnalyticalChemistry》,《Inorg.Chem.》,《Organometallics》,《CrystEngComm》,《DaltonTrans.》,《J.Biol.Inorg.Chem.》,《J.Inorg.Biochem.》,《Eur.J.Med.Chem.》《Bioorg.&Med.Chem.Lett.》,《Anti-CancerAgentsinMedicinalChemistry》《Eur.J.Inorg.Chem.》等国际、国内刊物正式发表SCI收录论文120余篇,他人引用1100余次。作为第一完成人2012年获广西自然科学奖三等奖1项,作为第二完成人2003年获广西科技进步一等奖1项。现任广西自然科学基金委员会常务委员,《广西师范大学学报》编委和《Crystal&GrowthDesign》,《CrystEngComm》,《DaltonTrans.》,《EvidenceBasedComplementaryandAlternativeMedicine》,《Mini-ReviewsinMedicinalChemistry》,《Eur.J.Med.Chem.》《Bioorg.&Med.Chem.Lett.》,《InorganicChemistryCommunications》,《Inorg.Chim.Acta》,《Appl.Organometal.Chem.》,《J.Coord.Chem.》,《中国科学》,《化学学报》,《结构化学》,《有机化学》等近20种刊物的审稿人。
------研究领域-----
主要研究和感兴趣的领域:
基于中药活性成分金属抗肿瘤药物、抗糖尿病药物的研究。
------近年研究项目-----
目前主持的主要科研项目:
1.国家自然科学基金面上项目:雌激素靶向配体调控的高活性卤代喹啉-镧系系列抗肿瘤配合物(21271051),2013/1-2016/12,78万元。
2.教育部创新团队项目:天然活性物质的发现、结构改造与功能(IRT1225),2013/1-2015/12,450万元。
3.广西首批八桂学者项目:药物化学,2011/11-2016/10,500万元。
4.广西自然科学基金重点项目:基于中药活性成分氧化阿朴菲生物碱抗肿瘤金属药物前期研究(2012GXNSFDA053005),2012/4-2014/3,25万元。
---代表性成果---
1.PeiLiu,Heng-shanWang,Ying-mingPan,*Wei-longDai,HongLiangandZhen-FengChen*.Thefirstpalladium-catalyzed1,4-additionofterminalalkenestoacrylateesters.Chem.Commoun.,2013,49,5295-5297.
2.Yan-ChengLiu,Zhen-FengChen*,Xiao-YanSong,YanPeng,Qi-PinQin,HongLiang*.Synthesis,crystalstructure,cytotoxicityandDNAinteractionof5,7-dibromo-8-quinolinolato-lanthanides.EuropeanJournalofMedicinalChemistry,2013,59,168-175.
3.Zhen-FengChen*,Yun-QiongGu,Xiao-YanSong,Yan-ChengLiu,YanPeng,HongLiang*.Synthesis,crystalstructure,cytotoxicityandDNAinteractionof5,7-dichloro-8-quinolinolato-lanthanides.EuropeanJournalofMedicinalChemistry,2013,59,194-202.
4.Zhen-FengChen*,YanPeng,Yun-QiongGu,Yan-ChengLiu,MeiLiu,Ke-BinHuang,KunHuandHongLiang*.Highantitumoractivityof5,7-dihalo-8-quinolinolatotin(IV)complexes.EuropeanJournalofMedicinalChemistry,2013,2013,62,51-58.
5.Ke-BinHuang,Zhen-FengChen*,Yan-ChengLiu,Zhu-QuanLi,Jian-HuaWei,MengWang,Guo-HaiZhang,HongLiang*.Platinum(II)complexeswithmono-aminopho-sphonateestertargetinggroupthatinduceapoptosisthroughG1cell-cyclearrest:Synthesis,crystalstructureandantitumouractivity.EuropeanJournalofMedicinalChemistry,2013,63,76-84.
6.Ke-BinHuang,Zhen-FengChen,*Yan-ChengLiu,Zhu-QuanLi,Jian-HuaWei,MengWang,Xiao-LiXie,andHongLiang*.Platinum(II)complexescontainingaminophosphonateesters:synthsis,characterization,cytotoxicityandactionmechanism.EuropeanJournalofMedicinalChemistry,2013,64,554-561.
7.YanPeng,Min-MinZhang,Zhen-FengChen,*KunHu,Yan-ChengLiu,XiaChenandHongLiang*.Synthesis,characterizationandinteractionwithbiomoleculesofplatinum(II)complexeswithshikimicacid-basedligands.BioinorganicChemistryandApplications,Volume2013,ArticleID565032,12pages.
8.Zhen-FengChen*,Yan-FangShi,Yan-ChengLiu,XueHong,BoGeng,YanPeng,HongLiang*,TCMactiveingredientoxoglaucinemetalcomplexes:Crystalstructure,cytotoxicityandinteractionwithDNA.InorganicChemistry,2012,51,1998-2009.
9.HuangTang,Hai-TaoZhao,Shu-MingZhong,Zhi-YuWang,Zhen-FenChen*,HongLiang*,Noveloxoisoaporphine-basedinhibitorsofacetyl-andbutyrylcholinesteraseandacetylcholinesterase-inducedbeta-amyloidaggregation.Bioorganic&MedicinalChemistryLetters,2012,22,2257-2261.
10.Zhen-FengChen*,Yan-ChengLiu,YanPeng,XueHong,Hong-HongWang,Min-MinZhang,HongLiang.Synthesis,characterization,andinvitroantitumorpropertiesofgold(III)compoundswiththetraditionalChinesemedicine(TCM)activeingredientliriodenine.J.Biol.Inorg.Chem.,2012,17(2),247-261.
11.Zhen-FengChen*,LiMao,Li-MinLiu,Yan-ChengLiu,YanPeng,XueHong,Hong-HongWang,Hua-GangLiu,HongLiang*.PotentialnewinorganicantitumouragentsfromcombiningtheanticancertraditionalChinesemedicine(TCM)matrinewithGa(III),Au(III),Sn(IV)ions,andDNAbindingstudies.J.Inorg.Biochem.,2011,105,171-180.
12.Zhen-FengChen*,Xiao-YanSong,YanPeng,XueHong,Yan-ChengLiu,HongLiang.Highcytotoxicityofdihalo-substituted8-quinolinolato-lanthanides.DaltonTrans.,2011,40,1684-1692.
13.Zhen-FengChen*,Ming-XiongTan,Yan-ChengLiu,YanPeng,Hong-HongWang,Hua-GangLiuandHongLiang*.Synthesis,CharacterizationandPreliminaryCytotoxicityEvaluationofFiveLanthanide(III)-PlumbaginComplexes.J.Inorg.Biochem.,2011,105,308-316.
14.HuangTang,Li-ZhenZhao,Hao-TaoZhao,Shi-LiangHuang,Shu-MingZhong,Jiang-KeQin,Zhen-FengChen,*Zhi-ShuHuang,HongLiang.Hybridsofoxoisoaporphine-tacrinecongeners:Novelacetylcholinesteraseandacetylcholinesterase-inducedb-amyloidaggregationinhibitors.EuropeanJournalofMedicinalChemistry,2011,46,4970-4979.
15.Zhen-FengChen*,HongLiang*,ProgressesinTCMMetal-BasedAntitumourAgents,Anti-CancerAgentsinMedicinalChemistry,2010,10,412-423.
16.Zhen-FengChen*,Yan-ChengLiu,Li-MinLiu,Heng-ShanWang,San-HaiQin,Bo-LongWang,He-DongBian,BinYang,Hoong-KunFun,Hua-GangLiu,HongLianandChrisOrvig,PotentialnewinorganicantitumouragentsfromcombiningtheanticancertraditionalChinesemedicine(TCM)liriodeninewithmetalions,andDNAbindingstudies,DaltonTrans.,2009,(2):262-272.
17.Yan-ChengLiu,Zhen-FengChen*,Li-MinLiu,YanPeng,XueHong,BinYang,Hua-GangLiu,HongLiangandChrisOrvig,Divalentlatertransitionmetalcomplexesofthetraditionalchinesemedicine(TCM)liriodenine:coordinationchemistry,cytotoxicityandDNAbindingstudies,DaltonTrans.,2009,(48):10813-10823.
18.Zhen-FengChen*,Ming-XiongTan,Li-MinLiu,Yan-ChengLiu,Heng-ShanWang,BinYang,YanPeng,Hua-GangLiu,HongLiangandChrisOrvig,Cytotoxicityofthetraditionalchinesemedicine(TCM)plumbagininitscopperchemistry,DaltonTrans.,2009,(48):10824-10833.
19.MerynL.Bowen,Zhen-FengChen,AdrienneM.Roos,RipenMisri,UrsHafeli,MichaelJ.AdamandChrisOrvig,Long-chainrheniumandtechnetiumglucosamineconjugates,DaltonTrans.,2009,9228-9236.
20.Zhen-FengChen*,Shu-FengZhang,Hai-ShengLuo,BrendanF.AbrahamsandHongLiang.Ni2(R*COO)4(4,4’-bipy)2----arobusthomochrialquartz-likenetworkwithlargechiralchannels.CrystEngComm,2007,9,7-29.
21.Zhen-FengChen*,Zhi-LiZhang,Yu-HuiTan,Yun-ZhiTang,Hoong-KunFun,Zhong-YuanZhou,BrendanF.AbrahamsandHongLiang.Coordinationpolymersconstructedbylinkingmetalionswithazodibenzoateanions.CrystEngComm,2008,10,17-231.
22.Zhi-RongQu,Zhen-FengChen*,etal.Thefirsthighlystablehomochiralolefin-copper(I)2Dcoordinationpolymergridbasedonquinineasabuildingblock.Organometallics,2003,22,2814-2816.
23.Zhen-FengChen,Ren-GenXiong,JingZhang,Xue-TaiChen,Zi-LingXue,Xiao-ZengYou.2Dmolecularsquaregridwithstrongbluefluorescentemission:acomplexofnorfloxacinwithZinc(II).InorganicChemistry,2001,40(16),4075-4077.
24.Zhen-FengChen,Ren-GenXiong,AbrahamsBrendanF.,Xiao-ZengYou,Chi-MingChe.Anunprecedentedsix-foldanion-typechiraldiamondoid-likeeight-coordinateCd(II)coordinationpolymerwithasecond-ordernonlinearopticaleffect.DaltonTrans,2001,(17),2453-2455.
---联系方式---
Tel:(0773)2120998(o),E-mail:chenzfgxnu@yahoo.comorchenzf@gxnu.edu.cn.(2013年7月1日更新)