----个人基本信息----
姓名:王恒山
出生年月：1965.4
籍贯：浙江
学历：博士
职称：教授
专业：有机化学
---教育和主要工作经历---2000年毕业于兰州大学，获理学博士学位，
2004任广西师范大学化学化工学院教授，
2007年获广西“新世纪十百千人才工程”第二层次人选。
讲授的课程：天然药物化学、波谱解析---研究领域---主要研究和感兴趣的领域：手性化合物分离分析、天然药物的提取分离与结构改造。---近年研究项目---目前主持的主要科研项目：1、973计划前期研究专项(No.2011CB512005)：基于广西主产中药活性成分的手性氨基膦酸酯基抗肿瘤和抗病毒药物的前期研究。
2、广西自然科学基金重点项目(No.2011GXNSFD018010):松香基手性冠醚和衍生试剂的合成及其在手性分离中的应用。
3、广西新世纪十百千人才工程人选资助项目（2007228）:源于松香酸的手性核磁共振识别试剂的设计、合成和应用。科研奖励
王恒山、潘英明、赵书林、梁英、王凯、何春欢，特色桂药抑制活性氧自由基损伤功效物质基础及作用机制的研究与应用，广西自然科学奖三等奖，2012年
赵书林、叶芳贵、卢 昕、田建袅、李舒婷、王恒山，微流控芯片和毛细管电泳新方法及其在单细胞和体液分析中的应用研究，广西自然科学奖二等奖，2010年
赵书林、李舒婷、王恒山等，毛细管电泳新技术及其在生物和药物分析中的应用研究，广西科技进步奖二等奖，2007年
---代表性成果---
1.Xiao-ChaoHuang,MengWang,Ying-MingPan,Gui-YangYao,Heng-ShanWang*,Xiao-YanTian,Jiang-KeQin,YeZhang*.Synthesisandantitumoractivitiesofnovelthioureaα-aminophosphonatesfromdehydroabieticacid.EuropeanJournalofMedicinalChemistry.2013,69:508–520.
2.Gui-yangYao,Man-yiYe,Ri-zhenHuang,Ya-junLi,Ying-mingPan,QingXu,Zhi-XinLiao*,Heng-shanWang*.Synthesisandantitumoractivitiesofnovelrheinα-aminophosphonatesconjugates.Bioorganic&MedicinalChemistryLetters.2014,24(2):501–507
3.Ying-ChunWang,Heng-ShanWang*,Guo-BaoHuang,Fu-PingHuang,KunHu,Ying-MingPan*.Aone-potapproachto4,5-dihydropyrazolesfromketones,arylacetylenes,andhydrazines.Tetrahedron.2014,70(8):1621–1628
4.Xiao-ChaoHuang,MengWang,Ying-MingPan,Xiao-YanTian,Heng-ShanWang*,YeZhang*.Synthesisandantitumoractivitiesofnovelα-aminophosphonatesdehydroabieticacidderivatives.Bioorganic&MedicinalChemistryLetters.2013,23(19):5283–5289
5.Xiao-ChaoHuang,MengWang,Heng-ShanWang*,Zhen-FengChen,YeZhang*,Ying-MingPan.Synthesisandantitumoractivitiesofnoveldipeptidederivativesderivedfromdehydroabieticacid.Bioorganic&MedicinalChemistryLetters.2014,http://dx.doi.org/10.1016/j.bmcl.2014.02.001
6.Gui-yangYao,Man-yiYe,Ri-zhenHuang,Ya-junLi,Yong-taoZhu,Ying-mingPan,Zhi-XinLiao*,Heng-shanWang*.SynthesisandantitumoractivityevaluationofmaleopimaricacidN-arylimideatropisomers.Bioorganic&MedicinalChemistryLetters.2013,23(19):5283–5289
7.GuiyangYao,YajunLi,YongtaoZhu,YingmingPan,FupingHuang,HengshanWang*andZhixinLiao*.Protonation-controlledaxialchiralityinmaleopimaricimides.NewJ.Chem.,2014,38,693-699
8.PingtanLin,ShulinZhao*,XinLu,FangguiYe,HengshanWang*.Preparationofadual‐enzymeco‐immobilizedcapillarymicroreactorandsimultaneousscreeningofmultipleenzymeinhibitorsbycapillaryelectrophoresis,JournalofSeparationScience,2013,36(15):2538–2543
9.Man-YiYe,Gui-YangYao,Jing-ChenWei,Ying-MingPan*,Zhi-XinLiaoandHeng-ShanWang*.Synthesis,Cytotoxicity,DNAbindingandApoptosisofRheinPhosphonateDerivativesasAntitumorAgents.Int.J.Mol.Sci.2013,14,9424-9439;
10.XuWang,Ying-mingPan*,Xiao-chaoHuang,Zhong-yuanMaoandHeng-shanWang*Anovelmethodologyforsynthesisofdihydropyrazolederivativesaspotentialanticanceragents,Org.Biomol.Chem.,2014,10.1039/C3OB42432D
11.Yan-liXu,Ying-mingPan*,QiangWu,Heng-shanWang*andPei-zhenLiu.RegioselectiveSynthesisof1,3,5-SubstitutedBenzenesviatheInCl3/2-Iodophenol-CatalyzedCyclotrimerizationofAlkynes.J.Org.Chem.2011,76(20):8472–8476.
12.HengshanWang*,XiaoyanTian,DaYang,YingmingPan,QiangWu,ChunhuanHeSynthesisandenantiomericrecognitionabilityof22-crown-6ethersderivedfromrosinacidandBINOLTetrahedron:Asymmetry,2011,22:381–386
13.Ming-xiongTan,Dian-huaGan,Liu-xinWei,Ying-mingPan,Shao-qingTang,Heng-shanWang*IsolationandcharacterizationofpigmentfromCinnamomumburmannii’peel.FoodResearchInternational,2011,44:2289-2294
14.HengshanWang*,ChunhuanHe,YingmingPan,GuiyangYao,QiangWuandHongguiDeng.Synthesisandaminesenantiomericrecognitionabilityofbinaphthyl-appended22-crown-6ethersderivedfromrosinacid.JInclusionPhenomenaandMacrocyclicChemistry,2011,DOI10.1007/s10847-011-0040-5
15.ShiwenHuang,YingmingPan,DianhuaGan,XilinOuyang,ShaoqingTang,StephenI.N.Ekunwe,HengshanWang*.AntioxidantactivitiesandUV-protectivepropertiesofMelaninfromtheberryofCinnamomumburmanniiandOsmanthusfragrans.Medicinalchemistryresearch,2011,20:475–481
16.X.L.OUYANG,X.M.FANG,Y.M.PAN,L.X.WEI,ANDH.S.WANG*,DevelopmentofHPLCFingerprintfortheQualityControlofEuonymusfortuneiandDistinguishingfromRelatedSpecies.ActaChromatographica,2011,inpress.
17.YingchunWang,ChunhuaSu,FangyaoLi,LuzhiLiu,YingmingPan,XiurongWu,HengshanWang*.Syntheses,characterizationandfluorescentpropertiesoftwoseriesofdehydroabieticacidC-ringderivatives.SpectrochimicaActaPartA,2010,76:328–335
18.HengshanWang*,DianhuaGan,XiaopuZhang,YingmingPan.AntioxidantcapacityoftheextractsfrompulpofOsmanthusfragransanditscomponents,LWT-FoodScienceandTechnology,2010,43:319–325
19.FangguiYe*,HengshanWang,BaojunHuang,ShulinZhao.Maleopimaricacidanhydride-bondedsilicamonolithaschiralstationaryphaseforseparationsofphenylthiocarbamylaminoacidsbyCEC.Electrophoresis,2010,31,1488–1492
20.YeZhang,ShaoboFeng,QiangWu,KaiWang,XianghuiYi,HengshanWang*,YingmingPan.Microwave-assistedsynthesisandevaluationofnaphthalimidesderivativesasfreeradicalscavengers.Medicinalchemistryresearch,2010，DOI10.1007/s00044-010-9384-4
21.YingmingPan*,ChunhuanHe,HengshanWang*,XiaowenJi,KaiWang,PeizhenLiu.Antioxidantactivityofmicrowave-assistedextractofBuddleiaofficinalisanditsmajoractivecomponent.FoodChemistry,2010,121:497-502
22.YingmingPan,*,ZhirenZhu,ZhiliHuang,HengshanWang*,YingLiang,KaiWang,QianLei,MinLiang.CharacterisationandfreeradicalscavengingactivitiesofnovelredpigmentfromOsmanthusfragrans’seeds.FoodChemistry,2009,112：909–913
23.MingxiongTan,JinchanZhu,YingmingPan,ZhenfengChen,HongLiang,HuagangLiu,HengshanWang*,Synthesis,CytotoxicActivity,andDNABindingPropertiesofCopper(II)Complexeswithhesperetin,naringeninandapigenin.BioinorganicChemistryandApplications,2009,doi:10.1155/2009/347872
24.Heng-ShanWang*,Ying-ChunWang,Ying-MingPan,Shu-LinZhaoandZhen-FengChen.Simultaneousreductionofnitro-toaminogroupinthepalladium-catalyzedSuzukicross-couplingreaction.TetrahedronLett,2008,49(16):2634–2637
25.Yi-ZhengLi,Ying-MingPan,Xiao-YanHuang,Heng-ShanWang*.WithanolidesfromPhysalisalkekengivar.francheti.HelveticaChimicaActa.2008,91：2284－2291
26.HengshanWang,ShulinZhao*,MinHe,ZhicaiZhao,YingmingPan,QianLiang.Sodiummaleopimaricacidaspseudostationaryphaseforchiralseparationsofaminoacidsderivativesbyapillarymicellarelectrokineticchromatography.JournalofSeparationScience,2007,30:2748-2753
27.ShulinZhao,HengshanWang,YingmingPan,MinHe,ZhicaiZhao.3-[(3-Dehydroabietamidopropyl)dimethylammonio]-1-propane-sulfonateasanewtypeofchiralsurfactantforenantiomerseparationinmicellarelectrokineticchromatography.JournalofChromatographyA,2007,1145:246–249
28.Hengshan.Wang,RongcanZhang,ShulinZhao*,LidongTangandYingmingPan.Synthesisandapplicationofdehydroabietylisothiocyanteasanewchiralderivatizingagentfortheenantiomericseparationofchiralcompoundsbycapillaryelectrophoretic.AnalyticaChimicaActa2006,560:64–68
29.ShulinZhao*,RongcanZhang,HengshanWang*,LidongTangandYingmingPan.Capillaryelectrophoresisenantioselectiveseparationofvigabatrinenantiomersbyprecolumnderivatization.JournalofChromatographyB,2006,833:186–190
30.ShulinZhao,HengshanWang,RongcanZhangandYimingLiu*.Degradingdehydro-abietylisothiocyanateasachiralderivatizingreagentforenantiomericseparationsbycapillaryelectrophoresis,Electrophoresis,2006,27,3428–3433
发明专利
1．从罗汉果残渣中提取多种成分，ZL02133627.X，2004，中国专利授权
2．松香基吖啶类化合物的合成、其制造方法及其用途，ZL**4.1，2006，中国专利授权
3．脱氢松香酸甲酯呋咱衍生物，其合成方法及其用途，申请号：**6.3，2004，中国专利
4.王恒山,戴伟龙,潘英明,姚贵阳,程克光,陈振锋,田小艳.茜素二氧杂环己烷衍生物及其制备方法和应用.专利号:**4.5.
5.王恒山;潘英明;黄卫根;谭恒;刘志芳;刘陆智.脱氢松香基硫脲衍生物及其制备方法和应用专利号:**7
---联系方式---Email：hshwang2002@126.com
电话：**
