王少华
职务/职称：院长/三级教授/博导
研 究 所：药物化学研究所
联系电话：
电子邮件：wangshh@lzu.edu.cn
办 公 室：

个人简介
研究成果
研究项目

【基本情况】
　　兰州大学药学院药物化学研究所教师。2001年、2006年在兰州大学化学与化工学院分别获得学士及博士学位，导师涂永强教授；2006-2011年在美国梅奥医学中心做博士后研究；2011年至今在兰州大学药学院工作。
【研究方向】
　　主要针对具有生物（药物）活性的小分子的设计与合成，以及天然药物分子全合成和相关合成方法学研究。
【主讲课程】
　　本科生《仪器分析》，《化学制药工艺学》，研究生《专业英语》
【获奖情况】
　　2015年教育部自然科学一等奖（第四完成人）
2015年兰州大学医学院本科实践教学优秀指导教师
2016年国家自然科学二等奖（第四完成人）
2016年兰州大学本科毕业论文优秀指导教师
2016年兰州大学创新创业行动计划“优秀指导教师”
2017年甘肃省青年教师成才奖
2017年兰州大学青年五四奖章
2017年兰州大学本科毕业论文优秀指导教师
2018年“****奖励计划”青年****
2019年兰州大学隆基教学新秀奖
2019年兰州大学本科毕业论文优秀指导教师
2020年江苏省双创人才
　　1.Hou, S.-H.; Tu, Y.-Q.*; Liu, L.; Zhang, F.-M.; Wang, S.-H.*; Zhang, X.-M., Divergent and Efficient Syntheses of the Lycopodium Alkaloids (?)-Lycojaponicumin?C, (?)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine.Angewandte Chemie International Edition2013,52(43), 11373-11376.
　　2.Chen, Z.-M.; Zhang, Z.; Tu, Y.-Q.*; Xu, M.-H.; Zhang, F.-M.; Li, C.-C.; Wang, S.-H.*, A Mn(iii)/TEMPO-co-mediated tandem azidation-1,2-carbon migration reaction of allylic silyl ethers.Chemical Communications2014,50(74), 10805-10808.
　　3.Peng Rui, Y. B., Chen Zhimin, Xu Li, Wang Shaohua*, Copper-Catalyzed Trifluoromethylation of Enol Ether.Chinese Journal of Organic Chemistry2014,34(5), 980-984.
　　4.Tian, J.-M.; Zhao, X.; Tu, Y.-Q.*; Gong, W.; Zhang, F.-M.; Zhang, S.-Y.; Wang, S.-H.*, A Synthetic Approach for Constructing the 3/6/6/5-Fused Tetracyclic Skeleton of Tenuipesine A.Chemistry – An Asian Journal2014,9(3), 724-727.
　　5.Wang, S. H.; Tu, Y. Q.; Tang, M., 3.16 The Semipinacol Rearrangements. InComprehensive Organic Synthesis II (Second Edition), Knochel, P., Ed. Elsevier: Amsterdam, 2014; pp 795-852.
　　6.Wang, S.-H.; Li, B.-S.; Tu, Y.-Q.*, Catalytic asymmetric semipinacol rearrangements.Chemical Communications2014,50(19), 2393-2408.
　　7.Xu, L.; Mou, X.-Q.; Chen, Z.-M.; Wang, S.-H.*, Copper-catalyzed intermolecular azidocyanation of aryl alkenes.Chemical Communications2014,50(73), 10676-10679.
　　8.Mou, X.-Q.; Xu, L.; Wang, S.-H.*; Yang, C., Copper-catalyzed dicyanation of N,N-disubstituted formamide.Tetrahedron Letters2015,56(21), 2820-2822.
　　9.Mou, X.-Q.; Xu, Z.-L.; Wang, S.-H.*; Zhu, D.-Y.; Wang, J.; Bao, W.; Zhou, S.-J.; Yang, C.; Zhang, D., An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole.Chemical Communications2015,51(60), 12064-12067.
　　10.Yang, C.; Xu, Z.-L.; Shao, H.; Mou, X.-Q.; Wang, J.; Wang, S.-H.*, A Tin(IV) Chloride Promoted Tandem C??O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes.Organic Letters2015,17(21), 5288-5291.
　　11.Zhu, D.-Y.; Xu, M.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Wang, S.-H.*, Catalytic Asymmetric Construction of α-Quaternary Cyclopentanones and Its Application to the Syntheses of (?)-1,14-Herbertenediol and (?)-Aphanorphine.Chemistry – A European Journal2015,21(44), 15502-15505.
　　12.Zhu, D.-Y.; Zhang, Z.; Mou, X.-Q.; Tu, Y.-Q.*; Zhang, F.-M.; Peng, J.-B.; Wang, S.-H.*; Zhang, S.-Y., Gold(I)/Copper(II)-Cocatalyzed Tandem Cyclization/Semipinacol Reaction: Construction of 6-Aza/Oxa-Spiro[4.5]decane Skeletons and Formal Synthesis of (±)-Halichlorine.Advanced Synthesis & Catalysis2015,357(4), 747-752.
　　13.徐力,王.,李辉,阿托伐他汀的合成.有机化学2015,35(7), 1559-1564.
　　14.Dou, Q.-Y.; Tu, Y.-Q.*; Zhang, Y.; Tian, J.-M.; Zhang, F.-M.; Wang, S.-H.*, Spiro-Pyrrolidine-Catalyzed Asymmetric Conjugate Addition of Hydroxylamine to Enals and 2,4-Dienals.Advanced Synthesis & Catalysis2016,358, 874.
　　15.Mou, X.-Q.; Xu, Z.-L.; Xu, L.; Wang, S.-H.*; Zhang, B.-H.; Zhang, D.; Wang, J.; Liu, W.-T.; Bao, W., The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction.Organic Letters2016,18(16), 4032-4035.
　　16.Wang, J.; Mou, X.-Q.; Zhang, B.-H.; Liu, W.-T.; Yang, C.; Xu, L.; Xu, Z.-L.; Wang, S.-H.*, A metal-free addition/dearomatizationΓ??cyclization/decarboxylation cascade of aryl 3-arylpropiolate toward the synthesis of 1,1-diaryl-2-alkyl-substituted ethylenes.Tetrahedron Letters2016,57(11), 1239-1242.
　　17.Xu, X.-T.*; Mou, X.-Q.; Xi, Q.-M.; Liu, W.-T.; Liu, W.-F.; Sheng, Z.-J.; Zheng, X.; Zhang, K.; Du, Z.-Y.; Zhao, S.-Q.; Wang, S.-H.*, Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice.Bioorganic & Medicinal Chemistry Letters2016,26(21), 5334-5339.
　　18.Liu, W.-T.; Xu, Z.-L.; Mou, X.-Q.; Zhang, B.-H.; Bao, W.; Wang, S.-H.*; Lee, D.; Lei, L.-S.; Zhang, K., The synthesis of cycloalka[b]furans via an Au(i)-catalyzed tandem reaction of 3-yne-1,2-diols.Organic & Biomolecular Chemistry2017,15(30), 6333-6337.
　　19.Zhang, B.-H.; Lei, L.-S.; Liu, S.-Z.; Mou, X.-Q.; Liu, W.-T.; Wang, S.-H.*; Wang, J.; Bao, W.; Zhang, K., Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.Chemical Communications2017,53(61), 8545-8548.
　　20.Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H.*, Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis.Chemical Society Reviews2017,46(8), 2272-2305.
　　21.Shao, H.; Bao, W.; Jing, Z.-R.; Wang, Y.-P.; Zhang, F.-M.; Wang, S.-H.*; Tu, Y.-Q.*, Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction.Organic Letters2017,19(17), 4648-4651.
　　22.Liu, L.; Cheng, H.-L.; Ma, W.-Q.; Hou, S.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.*, Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization.Chemical Communications2018,54(2), 196-199.
　　23.吕卉,徐.,黄丹颖,吴盼盼,盛钊君,刘文锋,李冬利, Njud S. Alharbi,张焜,王少华,内质网荧光探针研究进展.有机化学2018,38(12), 3165-3175
　　24.Bao, W.; Wang, J.-Q.; Xu, X.-T.; Zhang, B.-H.; Liu, W.-T.; Lei, L.-S.; Liang, H.; Zhang, K.; Wang, S.-H.*, Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines.Chemical Communications2018,54(59), 8194-8197.
　　25.Liu, L.; Lei, L.-S.; Zhan, Z.-S.; Liu, S.-Z.; Wang, Y.-X.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Ma, A.-J.; Wang, S.-H.*, A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton.Chem. Commun.2019,55(26), 3789-3792[1]
　　26.Lei, L.-S.; Xue, C.-G.; Xu, X.-T.; Jin, D.-P.; Wang, S.-H.*; Bao, W.; Liang, H.; Zhang, K.; Asiri, A. M., The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles.Organic & Biomolecular Chemistry2019,17(15), 3723-3726.
　　27.Xu, X.; Chen, J.; Lin, Z.; Li, D.; Zhang, K.; Sheng, Z.; Wang, S.*; Zhu, S.; Abdullah M. A. Synthesis and Anti-inflammatory Effects of Oxaprozin-Paeonol Ester[J]. Chinese Journal of Organic Chemistry,2019,39(10): 2958-2964.
　　28.Zhang, Y.; Zheng, T.-L.; Cheng, F.; Dai, K.-L.; Zhang, K.; Ma, A.-J.; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.*; Tu, Y.-Q.* Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence.Chemical Science2020,11, 3878-3884.
　　29.Bao, W.; Gao, Z.-P.; Jin, D.-P.; Xue, C.-G.; Liang, H.; Lei, L.-S.; Xu, X.-T.; Zhang, K.; Wang, S.-H.*, Direct synthesis of 2-substituted benzonitriles via alkylcyanation of arynes with N,N-disubstituted aminomalononitriles.Chem. Commun.2020,56(55), 7641-7644.
　　30.Lei, L.-S.; Wang, B.-W.; Jin, D.-P.; Gao, Z.-P.; Huan, L.; Wang, S.-H.*; Xu, X.-T.; Zhang, K.; Zhang, X.-Y.*, Al(Otf)3-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues≠.Advanced Synthesis & Catalysis2020,362(14), 2870-2875.
　　31.Xu, X.-T.; Deng, X.-Y.; Chen, J.; Liang, Q.-M.; Zhang, K.; Li, D.-L.; Wu, P.-P.; Zheng, X.; Zhou, R.-P.; Jiang, Z.-Y.; Ma, A.-J.; Chen, W.-H.*; Wang, S.-H.*, Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors.European Journal of Medicinal Chemistry2020,189, 112013.
　　32.Zheng, T.-L.; Zhang, Y.; Gou, A. L.; Cheng, F.; Liu, S.-Z.; Yu, L.*; Cui, M.-Y.; Xu, X.-T.; Zhang, K.; Wang, S.-H.*, Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds.Organic Letters2020,22(18), 7073-7077.
　　33.Liang, H.; Gou, A.; Gao, Z.; Lei, L.; Wang, B.; Yu, L.*; Xu, X.; Wang, S.*, A New Strategy for the Synthesis of Tertiary Amides via a Copper-Catalyzed Decyanation Reaction of N,N-Disubstituted 2-Aminomalononitriles.Acta Chim. Sinica2020,78, 1064.
　　34.Wang Shaohua, Z. B., Chen Jie, Zheng Yingying, Feng Na, Ma Aijun, Xu Xuetao, Abdullah M. Asiri, Recent Progress in Synthesis of Polysubstituted Pyrazoles.Chinese Journal of Organic Chemistry2020,40(1), 15-27.
　　35.Zheng, T.-L.; Liu, S.-Z.; Huo, C.-Y.; Li, J.; Wang, B.-W.; Jin, D.-P.; Cheng, F.; Chen, X.-M.*, Zhang, X.-M.; Xu, X.-T.; Wang, S.-H.*, Au-Catalyzed 1,3-Acyloxy Migration/Cyclization Cascade: A Direct Strategy toward the Synthesis of Functionalized Abietane-Type Diterpenes.CCS Chem.2020,2, 2795-2802.
　　36.Liu, S.-Z.;Li, J.; Xue, C.-G.; Xu, X.-T.; Lei, L.-S.; Huo, C.-Y.;Wang, Z.;Wang, S.-H.*, Copper-promoted cyanation of aryl iodides with N,N-dimethyl aminomalononitrile.Tetrahedron Lett.2021,65, 152749.


【1】国家自然科学基金面上项目，**，负责人；
【2】国家自然科学基金面上项目，**，负责人；
【3】国家自然科学基金青年基金项目，**，负责人；
【4】甘肃省自然科学基金项目，20JR10RA608，负责人；
【5】国家“重大新药创制”科技重大专项子课题，2012ZX09201-101 -003，参与。