陈　巧
职务/职称：副教授/硕导
研 究 所：药物化学研究所
联系电话：
电子邮件：chenqiao@lzu.edu.cn
办 公 室：

个人简介
研究成果
研究项目

【基本情况】2011-2016年于兰州大学获得理学博士学位；2016年10月至2019年9月在新加坡南洋理工大学从事博士后研究。2019年9月至今在兰州大学药学院工作。
【研究方向】具有药物活性的小分子的设计与合成，药物分子的结构修饰及生物活性研究。
【主讲课程】《有机化学实验》
【获奖情况】暂无


发明专利一项：
1. 许兆青，陈巧，于红梅，王国强，一种芳炔的合成方法. 专利号: ZL 6.2 (2017-01-18).
共参与发表SCI论文十余篇：
1. Q. Chen, T. Zhu, P. K. Majhi, C. Mou, H. Chai, J. Zhang, S. Zhuo, Y. R. Chi, Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes, Chem. Sci. 2018, 9, 8711-8715. (SCI一区, IF 9.063)
2. Q. Chen, J. Zhou, Y. Wang, C. Wang, X. Liu, Z. Xu, L. Lin, R. Wang, Transition-Metal-Free Dehydrosilylative Difluoroamidation of Tetrahydroisoquinolines under Mild Conditions, Org. Lett. 2015, 17, 4212–4215. (SCI一区, IF 6.492)
3. Q. Chen, G. Wang, X. Jiang, Z. Xu, L. Lin, R. Wang, Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters, Org. Lett. 2014, 16, 1394–1397. (SCI一区, IF 6.492)
4. Q. Chen, J. Liang, S. Wang, D. Wang, R. Wang, An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst, Chem. Commun. 2013, 49, 1657–1659. (SCI一区, IF 6.29)
5. Q. Chen, Y. Lei, Y. Wang, C. Wang, Y. Wang, Z. Xu, H. Wang, R. Wang, Direct thiocyanation of ketene dithioacetals under transition-metal-free conditions, Org. Chem. Front. 2017, 4, 369–372. (SCI二区, IF 5.455)
6. Q. Chen, C. Wang, J. Zhou, Y. Wang, Z. Xu, R. Wang, CuSO4-Mediated Decarboxylative Difluoroacetamidation of α,β-Unsaturated Carboxylic Acids, J. Org. Chem. 2016, 81, 2639–2645. (SCI二区, IF 4.805)
7. Q. Chen, H. Yu, Z. Xu, L. Lin, X. Jiang, R. Wang, Development and Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes, J. Org. Chem. 2015, 80, 6890–6896. ( SCI二区, IF 4.805)
8. C. Wang+,Q. Chen+,Q. Guo,H. Liu,Z. Xu,Y. Liu,M. Wang,R. Wang, Silver-Catalyzed Difluoroamidation of Activated Alkenes for the Construction of Difluorinated 3,3-Disubstituted Oxindoles, J. Org. Chem.2016,81, 5782–5788. (并列第1作者, SCI二区, IF 4.805)
9. Y. Liu, Q. Chen, C. Mou, L. Pan, X. Duan, X. Chen, H. Chen, Y. Zhao, Y. Lu, Z. Jin, Y. R. Chi, Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs. (Nat. Commun. https://doi.org/10.1038/s41467-019-09445-x, SCI一区, IF 12.353)
10. J. Liang, Q. Chen, L. Liu, X. Jiang, R. Wang, An organocatalytic asymmetric double Michael cascade reaction of unsaturated ketones and unsaturated pyrazolones: highly efficient synthesis of spiropyrazolone derivatives, Org. Biomol. Chem. 2013, 11, 1441–1445.
11. X. Liu, Q. Chen, W. Li, Y. Liang, R. Wang, Synthesis of 3-Aroyl-4-hydroxy-4-arylpiperidine Derivatives by DBU-Catalyzed Reactions of Amines with Vinyl Ketones, Synlett 2012, 23, 1691–1695.
12. Y. Zhu, X. Li, Q. Chen, J. Su, F. Jia, S. Qiu, M. Ma, Q. Sun, W. Yan, K. Wang, R. Wang, Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-Containing Chromanes, Org. Lett. 2015, 17, 3826–3829. (SCI一区, IF 6.492)
13. X. Liu, H. Song, Q. Chen, W. Li, W. Yin, M. Kai, R. Wang, An Asymmetric Organocatalytic Approach to Michael Reactions of Thiazolones and Nitroalkenes: Preparation of Compounds with Anti-Cancer Potency, Eur. J. Org. Chem. 2012, 2012, 6647–6655.
14. L. Zhu, H. Yu, Q. Guo, Q. Chen, Z. Xu, R. Wang, C–H Bonds Phosphorylation of Ketene Dithioacetals, Org. Lett. 2015, 17, 1978–1981. (SCI一区, IF 6.492)
15. W. Li, X. Liu, Z. Mao, Q. Chen, R. Wang, New approach to the preparation of bicycle octane derivatives via the enantioselective cascade reaction catalyzed by chiral diamine-Ni(OAc)2 complex, Org. Biomol. Chem. 2012, 10, 4767–4773.