兰州大学生命科学学院 教授、博导 苟小平

学习经历

    1998.09-2001.07：四川大学生命科学学院植物学专业，理学博士
    1995.09-1998.07：四川大学生命科学学院植物学专业，理学硕士
    1991.09-1995.07：四川大学生物系植物学专业，理学学士

    1998.09-2001.07:  Ph.D., Botany, College of Life Sciences, Sichuan University
    1995.09-1998.07:  M.S., Botany, College of Life Sciences, Sichuan University
    1991.09-1995.07:  B.S., Botany, Department of Biology, Sichuan University

工作经历

    2009.10－目前：      兰州大学萃英特聘教授，博士生导师，兰州大学生命科学学院
    2001.10－2009.09：博士后，The University of Oklahoma，USA

    2009.10-Present:      Professor of plant biology, School of Life Sciences, Lanzhou University, China
    2001.10-2009.9:       Postdoctoral research associate, Department of Microbiology and Plant Biology, University of Oklahoma, USA

教学及指导研究生情况

    1、研究生招生（Masters and Ph.D. Programs）：

    硕士研究生招生  专业：植物学（071001）；方向：植物分子生物学、植物分子发育生物学、植物细胞信号转导

    博士研究生招生  专业：植物学（071001）；方向：植物分子遗传学、植物分子发育生物学、植物生殖生物学

    目前指导博士研究生8人，硕士研究生6人。

    欢迎报考博士、硕士研究生，合作开展博士后研究工作。

    Major for master students: Plant Biology (Plant Molecular Biology, Plant Developmental Biology, Plant Cell Signaling)

    Major for Ph.D. students: Plant Biology (Plant Molecular Genetics, Plant Developmental Biology, Plant Reproductive Biology)

    2、教学（Teaching）：

    植物生殖与发育生物学（秋季，本科生）／Plant Reproductive & Developmental Biology (Fall, Undergraduate)

    植物生殖生物学（秋季，研究生）／Plant Reproductive Biology (Fall, Graduate)

    分子克隆与基因工程（秋季，研究生）／Molecular Cloning & Genetic Engineering (Fall, Graduate)

    本科生科研训练（本科生）／Independent Study Courses in Plant Biology (Spring/Fall, Undergraduate)

发表论文及专著

    Du J, Gao Y, Zhan Y, Zhang S, Wu Y, Xiao Y, Zou Bo, He K, Gou X, Li G, Lin H, Li J. (2016). Nucleocytoplasmic trafficking is essential for BAK1 and BKK1-mediated cell-death control. Plant Journal, doi: 10.1111/tpj.13125.

    Zhang J, Yuan T, Duan X, Wei X, Li J, Russell SD, Gou X. (2016). Cis-regulatory elements determine germline specificity and expression level of an isopentenyltransferase gene in sperm cells of Arabidopsis. Plant Physiology, doi:10.1104/pp.15.01510.

    Yue J, Qin Q, Meng S, Jin H, Gou X, Li J, Hou S. (2016). TOPP4 regulates the stability of phytochrome interacting factor 5 during photomorphogenesis in Arabidopsis. Plant Physiology, doi:10.1104/pp.15.01729.

    Wu Y, Xun Q, Guo Y, Zhang J, Cheng K, Shi T, He K, Hou S, Gou X, Li J. (2016) Genome-wide expression pattern analyses of the Arabidopsis leucine-rich repeat receptor-like kinases. Molelular Plant, 10.1016/j.molp.2015.12.011.

    Shi T, Dimitrov I, Zhang Y, Tax FE, Yi J, Gou X, Li J. (2015). Accelerated rates of protein evolution in barley grain and pistil biased genes might be legacy of domestication. Plant Molecular Biology, 89: 253-261.

    Anderson S, Johnson C, Jones D, Conrad L, Gou X, Russell SD, Sundaresan V. (2013). Transcriptomes of isolated rice gametes characterized by deep sequencing: Evidence for distinct sex-dependent chromatin and epigenetic states before fertilization. Plant Journal, 76: 729-741.

    Russell SD, Gou X, Wong CE, Wang XK, Yuan T, Wei XP, Bhalla PL, Singh MB. (2012). Genomic profiling of rice sperm cell transcripts reveals conserved and distinct elements in the flowering plant male germ lineage. New Phytologist, 195: 560-573.

    Du J, Yin H, Zhang S, Wei Z, Zhao B, Zhang J, Gou X, Lin H, Li J. (2012). Somatice embryogenesis receptor kinases control root development mainly via brassinosteroid-independent actions in Arabidopsis thaliana. Journal of Integrative Plant Biology, 54: 388-399.

    Gou X, Li J. (2012). Activation tagging. Methods in Molecular Biology, 876. DOI: 10.1007/978-1-61779-809-2_9.

    Gou X, Yin H, He K, Du J, Yi J, Xu S, Lin H, Clouse SD, Li J. (2012). Genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling. PLoS Genetics, 8: e1002452.

    Li J, Du J, He K, Gou X. (2011). Control of cell death by Receptor Kinases in Arabidopsis thaliana. In "Receptor-like Kinases in Plants: From Development to Defense (eds Birgit Kemmerling and Frans Tax)". Signaling and Communication in Plants (ed. Frantisek Baluska, Springer Publisher), Volume 13, pp79-91.

    An J, Guo Z, Gou X, Li, J. (2011) TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana. Plant Signaling & Behavior, 6: 1117-1118.

    Ge L, Gou X, Yuan T, Strout GW, Nakashima J, Blancaflor EB, Tian HQ, Russell SD. (2010). Migration of sperm cells during pollen tube elongation in Arabidopsis thaliana: behavior during transport, maturation and upon dissociation of male germ unit associations. Planta, 233:325-332.

    Guo Z, Fujioka S, Blancaflor EB, Miao S, Gou X, Li J. (2010). TCP1 controls brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana. Plant Cell 22, 1161-1173.

    Russell SD, Gou X, Wei X, Yuan T. (2010). Male gamete biology in flowering plants. Biochemical Society Transactions 38, 598-603.

    Yang H, Gou X, He K, Xi D, Du J, Lin H, Li J. (2010). BAK1 and BKK1 in Arabidopsis thaliana confer reduced susceptibility to turnip crinkle virus. European Journal of Plant Pathology 127, 149-156.

    Gou X, He K, Yang H, Yuan T, Clouse SD, Li J. (2010). Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana. BMC Genomics 11, 19.

    Gou X, Yuan T, Wei X, Russell SD. (2009). Gene expression in the dimorphic sperm cells of Plumbago zeylanica: Transcript profiling, diversity, and relationship to cell type. Plant Journal 60, 33-47.

    He K, Gou X, Powell RA, Yang H, Yuan T, Guo Z, Li J. (2008). Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaling & Behavior 3: 813-815.

    Li J, Gou X. (2007). Brassinosteroids. In Handbook of plant science (Roberts, K., ed). John Wiley & Sons, Ltd, pp. 395-404.

    He K, Gou X, Yuan T, Lin H, Asami T, Yoshida S, Russell SD, Li J. (2007). BAK1 and BKK1 regulate brassinosteroid-dependent growth and brassinosteroid-independent cell-death pathways. Current Biology 17, 1109-1115.

    Yuan T, Fujioka S, Takatsuto S, Matsumoto S, Gou X, He K, Russell SD, Li J. (2007). BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. Plant Journal 51, 220-233.

    Wei X, Gou X, Yuan T, Russell SD. (2006). A highly efficient in vitro plant regeneration system and Agrobacterium-mediated transformation in Plumbago zeylanica. Plant Cell Rep 25, 513-521.

研究方向

    （1）受体激酶介导的细胞信号转导。受体激酶（RLKs）分布在细胞表面，从胞外环境获取信号并传递到细胞内启动下游的基因表达和调控，从而让植物体对各种信号作出正确的反应。在拟南芥中有600个以上的受体激酶，到目前为止只对其中很少一部分基因的功能有所了解。我们克隆了其中绝大部分受体激酶的全长cDNA，并转化野生型拟南芥进行了超表达，目前正致力于解析这些受体激酶的生物学功能。

    Functional Analysis of Receptor Kinases

    There are more than 600 receptor-like kinases (RLKs) in Arabidopsis that locate on the surface of cells to perceive and transduce chemical signals into cells, regulating downstream gene expression and responding to a variety of biotic or abiotic stimuli. So far, biological functions have been defined for only a handful of RLKs that play crucial roles in many physiological processes in plant. My research is focusing on revealing the functions of these RLKs. Preliminary studies showed that gene members of a couple of RLK subfamilies regulate anther and ovary development, and zygotic embryogenesis, which is under intensive investigation.

    （2）植物生殖生物学。被子植物双受精是一个复杂的过程，一个精细胞与卵细胞融合形成合子，发育成胚胎，是下一代植物的雏形；另一个精细胞与中央细胞融合形成胚乳，为胚胎发育提供营养。双受精的成败关系到植物种群的延续，同时也关系到绝大部分农作物的产量与质量。实验室目前的工作主要是利用模式植物拟南芥研究雌雄生殖器官以及性细胞发育调控的分子机理，以及早期胚胎发育调控的信号途径。

    Plant Reproductive Biology

    Double fertilization is a very complex biological process of angiosperms. After transferred into embryo sac by pollen tube, one sperm cell fuses with the egg cell, forming the zygote that will develop into the embryo, and the other sperm cell fuses with the center cell to generate the endosperm that provides nutrients for embryo development. Successful double fertilization is critical for the survival and development of every species, and is also crucial for the quantity and quality of the production of many crops. Plants have complex regulatory systems to regulate the development of sexual organs to achieve successful double fertilization and embryogenesis. My current research is focusing on those genes involved in anther, ovule and embryo development.

项目成果

    实验室得到国家自然科学基金委员会、教育部、科技部和兰州大学的经费支持。

    1、主持项目：

    国家自然科学基金面上项目《拟南芥富含亮氨酸重复类受体激酶调控合子胚胎发育的分子机理》（No.31070283）

    国家自然科学基金面上项目《拟南芥珠被发育的信号网络与调控机理》（No.31270229）

    国家自然科学基金面上项目《PzIPT1在拟南芥精细胞中表达的分子机理研究》（No.31471402）

    教育部新世纪优秀人才支持计划项目《受体激酶调控花药发育的分子机理》（No. NCET-12-0249）

    教育部科学技术项目《受体激酶SERKs调控拟南芥胚胎发育的信号通路》（No.113058A）

    2、参加项目：

    国家自然科学基金重大研究计划重点项目《一类植物特有的转录因子TCP在油菜素内酯生物合成及信号转导中的调控机理》（No.90917019）

    教育部“长江学者和创新团队发展计划”创新团队项目《植物多重抗逆的分子机理》（Nos.IRT0924, IRT_13R25）

    科技部重大科学研究计划课题《植物蛋白的修饰的重要过程与调控机理》（No.2011CB9154001）

荣誉、获奖

    教育部新世纪优秀人才支持计划（2012）

社会工作

其它信息