姓名： 柳军玺 性别： 男
学科类别： 化学 职务：
学历： 博士 职称： 研究员
电话： 传真：
电子邮件： liujx@licp.cas.cn
通讯地址： 兰州市天水中路18号


简　　历：
1997年兰州大学药学院药学专业本科毕业；1997-2001年先后在中国农科院兰州畜牧与兽药研究所和中国农科院上海兽医研究所工作，从事化学药物的合成研究；2006年中科院兰州化学物理研究所分析化学专业博士研究生毕业留所工作，从事天然产物化学研究，副研究员，硕士生导师。

研究方向：
天然产物化学及中药化学的提取分离、结构鉴定及天然产物结构衍生和药理活性化合物筛选以及基于天然产物的药物分析研究。

获奖及荣誉：
获得甘肃省科技进步奖一等奖2项，二等奖1项，三等奖1项，甘肃省药学会药学发展奖一等奖1项，二等奖1项。

承担科研项目：
承担包括国家自然基金、中科院西部之光、甘肃省科技支撑在内的多项科研项目。

代表论著：
[1] Yali Chen, Ruxia Li, Rongrong Gao, Qian Yan, Mei Zhong, Junxi Liu*, Quanyi Zha, Duolong Di. Total content determination for the effective fraction of the alkaloids in Dicranostigma leptopodum (Maxim.) Fedde by highperformance liquid chromatography and ultraviolet-visible spectrophotometry. Anal. Methods, 2016, 8: 2645-2652.
[2] Lijuan Chen, Hua Tian, Meng Li, Chao Ge, Fangyu Zhao, Lixing Zhang, Hong Li, Junxi Liu, Tingpu Wang, Ming Yao, Jinjun Li*，Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis, Tumour Biol, 2016, 37: 5951-5961.
[3] Meng Li, Lixing Zhang, Chao Ge, Lijuan Chen, Tao Fang, Hong Li, Hua Tian, Junxi Liu, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li*, An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma. Oncotarget, 2015, 6(28): 25149-25160.
[4] Mei Zhong, Yunbin Jiang, Yali Chen, Qian Yan, Junxi Liu*, Duolong Di, Asymmetric total synthesis of (S)-isocorydine, Tetrahedron: Asymmetry, 2015, 26(20): 1145-1149.
[5] Yali Chen, Min Li, Jianjun Liu, Qian Yan, Mei Zhong, Junxi Liu*, Duo long Di, Jinxia Liu. Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection. Journal of Separation Science, 2015, 38(1): 9-17.
[6] Yali Chen, Qian Yan, Mei Zhong, Quanyi Zhao, Junxi Liu*, Duolong Di, Jinxia Liu. Study on pharmacokinetics and tissue distribution of the isocorydine derivative (AICD) in rats by HPLC-DAD method. Acta Pharm Sin B, 2015, 5(3): 238-245.
[7] Yanjuan Liu, Xiaofen Chen, Junxi Liu, Duolong Di*, Three-phase solvent systems for the comprehensive separation of a wide variety of compounds from Dicranostigma leptopodum by high-speed counter-current chromatography. Journal of Separation Science, 2015, 38(12): 2038-2045.
[8] Mei Zhong, Yanjuan Liu, Junxi Liu*, Duolong Di, Mengrou Xu, Yaya Yang, Wenguang Li, Yali Chen, Jinxia Liu, Isocorydine derivatives and their anticancer activities. Molecules, 2014, 19(8): 12099-12115.
[9] Mei Zhong, Yuxi Ma, Junxi Liu*, Duolong Di, A new quaternary protoberberine alkaloid isolated from Dicranostigma leptopodum (Maxim) Fedde, Natural Product Research, 2014, 28(8): 507-510.
[10] Yanjuan Liu, Junxi Liu*, Duolong Di, Min Li, Yan Fen, Structural and mechanistic bases of the anticancer activity of natural aporphinoid alkaloids. Current Topics in Medicinal Chemistry, 2013, 13(17): 2116-2126.
[11] Yun Liu, Junxi Liu, Xiaoming Sun, Duolong Di, Evaluation of polydopamine supported nano-polytetrafluoroethylen as novel material for solid phase extraction, New J. Chem., 2012, 36(11): 2376-2382.
[12] Dong Pei, Dahu Liu, Junxi Liu, Duolong Di, Chemical investigation of the pollen of Brassica napus, Chemistry of Natural Compounds, 2012, 48(2): 310-312.
[13] Mingrui Shi, Dong Pe, Junxi Liu, Duolong Di, Chemical constituents from Sphallerocarpus gracilis, Biochemical Systematics and Ecology, 2012, 40:1-3.


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