李陈龙

Submitted on 周一, 10/30/2017 - 20:25


性别
男

电子邮件
lichlong3@mail.sysu.edu.cn

职称
教授

导师类型
博士生导师

学历
博士

学科方向
0710生物学-01植物学
0710生物学-10生物化学与分子生物学
0710生物学-Z1生物信息学


研究方向
1. 植物表观遗传的生物信息学分析。
2. 植物基因表达调控的表观遗传机制。
3. 染色体重塑因子识别靶标基因的分子机理。
4. 种子寿命与活力的表观遗传调控。
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本实验室成立于2017年，已完成实验室的建设，实验室PI已经以独立通讯作者在Nature Plants（2020）, Nucleic Acids Research (2021), Molecular Plant?(2021),?Plant Physiology（2020, 2021）杂志上发表论文。实验室正招收博士后或专职研究员1名（2020年10月更新）。2021年实验室硕士招生方向为植物学(1个)，生化与分子生物学(1个)，欢迎感兴趣同学联系lichlong3@mail.sysu.edu.cn
应聘条件：
1）植物学，分子生物学, 生物信息学相关专业领域已毕业博士或即将毕业的博士在读生；
2）撰写的研究论文已在高水平国际学术期刊发表或接收发表者优先考虑；
3）有NGS测序数据分析经验优先考虑；
4）有植物相关研究经历优先考虑。

个人经历
2017年-至今 中山大学生命科学学院 教授
2017年-至今 有害生物控制与资源利用国家重点实验室 PI
2015-2017? 加拿大农业部 伦敦研发中心 研究科学家
2015-2015? 加拿大the University of? Western Ontario生物系 博士后
2010-2014? 加拿大the University of? Western Ontario生物系 博士
2006-2009? 中山大学生命科学学院 硕士
2001-2005? 南昌大学生命科学与食品学院 本科

讲授课程
1. 诺贝尔生理学或医学奖史话（主讲，2018-）
2. 生命科学导论实验（2018-）
3. 现代生命科学进展（2019-）
4. 专业科技文献阅读和理解（2018-）
5. 科技论文写作 （2020-）

学术成就
多年来在植物表观遗传学、发育生物学和逆境生物学领域进行研究，近期的研究集中在染色体重塑因子及组蛋白去甲基化酶的作用机理及其在植物生长发育与逆境反应的作用，以第一作者身份在Nature Genetics, Nature Plants, PLoS Genetics, The Plant Cell, Plant Biotechnology Journal, Journal of Experimental Botany 等刊物上发表系列研究论文。入选中组部高层次人才计划，广东省珠江人才计划,?现任中国植物学会种子科学与技术专业委员会主任，中国植物生理与植物分子生物学青年工作委员会委员，广东省植物生理学会理事。

承担课题
1. 国家自然科学基金，面上项目，2021/01-2024/12，58万，在研，主持
2. 国家自然科学基金，面上项目，**，拟南芥染色体重塑酶BRAHMA相互作用蛋白BRIP1/2调节植物发育的分子机理研究，2019/01-2022/12，60万，在研，主持
3. 国家自然科学基金，面上项目，**，水稻种子老化相关lncRNA与染色体重塑蛋白调控种子活力的作用机制研究，2019/01-2022/12，59万，在研，参与
4. 中山大学****，中山大学，2018/01-2020/12, 300万，在研，主持
5. 中组部“高层次人才计划”，2018/01-2020/12，200万，在研，主持
6. 中央高校基本业务费青年教师重点培育项目、18lgzd12、植物种子寿命的表观遗传机理研究、2018/01-2019/12，30万，已结题，主持
7. 国家自然科学基金应急管理项目，**，lncRNA在水稻种子老化过程的功能及其作用机制，2017/01-2017/12，15万，已结题，参加

论文专著
# co-first author, * corresponding author

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1.????? Yaoguang Yu, Wei Fu, Jianqu Xu, Yawen Lei, Xin Song, Zhenwei Liang, Tao Zhu, Yuhui Liang, Yuanhao Hao, Liangbing Yuan, Chenlong Li*. (2021) Bromodomain-containing Proteins BRD1, BRD2, and BRD13 are Core Subunits of SWI/SNF Complexes and are Vital for their Genomic Targeting in Arabidopsis. Molecular Plant.

2.????? Jiuxiao Ruan^#, Huhui Chen^#, Tao Zhu^#, Yaoguang Yu, Yawen Lei, Liangbing Yuan, Jun Liu, Zhi-Yong Wang, Jian-Fei Kuang, Wang-Jin Lu, Shangzhi Huang, Chenlong Li^*. (2021) Brassinosteroids repress the seed maturation program during the seed-to-seedling transition. Plant Physiology. doi:10.1093/plphys/kiab089
3.????? Fu-Yu Hung^#, You-Cheng Lai^#, Jianhao Wang^#, Yun-Ru Feng, Yuan-Hsin Shih, Jian-Hao Chen, Hua-Chung Sun, Songguang Yang^*, Chenlong Li^*, Keqiang Wu^*. (2021) The Arabidopsis histone demethylase JMJ28 regulates CONSTANS by interacting with FBH transcription factors. Plant Cell doi:10.1093/plcell/koab014
25 January 2021 IF2021 =
4.????? Jie Shu, Chen Chen, Chenlong Li, Raj K Thapa, Jingpu Song, Xin Xie, Vi Nguyen, Shaomin Bian, Jun Liu, Susanne E Kohalmi, Yuhai Cui^*.? (2021) Genome-wide occupancy of Arabidopsis SWI/SNF chromatin remodeler SPLAYED provides insights into its interplay with its close homolog BRAHMA and Polycomb proteins. Plant Journal 11 January 2021 doi: 10.1111/tpj.15159
5.????? Liangbing Yuan, Xin Song, Lu Zhang, Yaoguang Yu, Zhenwei Liang, Yawen Lei, Jiuxiao Ruan, Bin Tan, Jun Liu, Chenlong Li^*. (2021) The transcriptional repressors VAL1 and VAL2 recruit PRC2 for genome-wide Polycomb silencing in Arabidopsis. Nucleic Acids Research. 49(1): 98-113.???? doi: 10.1093/nar/gkaa1129，11 January 2021?? IF2020 = 11.501
6.????? Huhui Chen, Jianhua Tong, Wei Fu, Zhenwei Liang, Jiuxiao Ruan, Yaoguang Yu, Xin Song, Liangbing Yuan, Langtao Xiao, Jun Liu, Yuhai Cui, Shangzhi Huang, Chenlong Li^*. (2020) The H3K27me3 demethylase RELATIVE OF EARLY FLOWERING6 suppresses seed dormancy by inducing Abscisic Acid catabolism. Plant Physiology. 184(4):1969-1978. https://doi.org/10.1104/pp.20.01255, 30 September 2020.? IF2020 = 6.902
7.????? Yaoguang Yu, Zhenwei Liang, Xin Song, Wei Fu, Jianqu Xu, Yawen Lei, Liangbing Yuan, Jiuxiao Ruan, Chen Chen, Wenqun Fu, Yuhai Cui, Shangzhi Huang, Chenlong Li^*. (2020) BRAHMA-interacting proteins BRIP1 and BRIP2 are core subunits of Arabidopsis SWI/SNF complexes. Nature Plants. 6(8):996-1007.?? 10.1038/s41477-020-0734-z, 03 August 2020. IF2020 = 13.256
8.????? Jie Shu, Chen Chen, Chenlong Li, Yuhai Cui^*. (2020) The complexity of PRC2 catalysts CLF and SWN in plants. Biochemical Society Transactions. 48(6):2779-2789.
9.????? Fu-Yu Hung, Chen Chen, Ming-Ren Yen, Jo-Wei Allison Hsieh, Chenlong Li, Yuan-Hsin Shih, Fang-Fang Chen, Pao-Yang Chen^*, Yuhai Cui^*, Keqiang Wu^*. (2020) The expression of long non-coding RNAs is associated with H3Ac and H3K4me2 changes regulated by the HDA6-LDL1/2 histone modification complex in Arabidopsis. NAR Genomics and Bioinformatics. 2(3): lqaa066.?? 10.1093/nargab/lqaa066, 21 September 2020
10.?? Huhui Chen, Jiuxiao Ruan, Pu Chu^*, Wei Fu, Zhenwei Liang, Yin Li, Jianhua Tong, Langtao Xiao, Jun Liu, Chenlong Li, Shangzhi Huang^*. (2020) AtPER1 enhances primary seed dormancy and reduces seed germination by suppressing the ABA catabolism and GA biosynthesis in Arabidopsis seeds. Plant Journal. 101(2):310-323.
11.?? Chen Chen, Jie Shu, Chenlong Li, Raj K Thapa, Vi Nguyen, Kangfu Yu, Ze-Chun Yuan, Susanne E Kohalmi, Jun Liu, Frédéric Marsolais, Shangzhi Huang, Yuhai Cui^*. (2019) RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis. Nucleic Acids Research. 47(13):6714-6725.
12.?? Fu-Yu Hung, Fang-Fang Chen, Chenlong Li, Chen Chen, Jian-Hao Chen, Yuhai Cui^*, Keqiang Wu^*. (2019) The LDL1/2-HDA6 histone modification complex interacts with TOC1 and regulates the core circadian clock components in Arabidopsis. Frontiers in Plant Science. 10:233.
13.?? Chenlong Li^#，*, Vi Nguyen^#, Jun Liu^#, Wenqun Fu, Chen Chen, Kangfu Yu, Yuhai Cui^*. (2019) Mutagenesis of seed storage protein genes in Soybean using CRISPR/Cas9. BMC Research Notes. 12(1):176.
14.?? Jie Shu, Chen Chen, Raj Kumar Thapa, Shaomin Bian, Vi Nguyen, Kangfu Yu, Ze-Chun Yuan, Jun Liu, Susanne E. Kohalmi, Chenlong Li^*, Yuhai Cui^*. (2019) Genome-wide occupancy of histone H3K27 methyltransferases CURLY LEAF and SWINGER in Arabidopsis seedlings. Plant Direct. 3(1):e00100.
15.?? Fu-Yu Hung, Fang-Fang Chen, Chenlong Li, Chen Chen, You-Cheng Lai, Jian-Hao Chen, Yuhai Cui^*, Keqiang Wu^*. (2018) The Arabidopsis LDL1/2-HDA6 histone modification complex is functionally associated with CCA1/LHY in regulation of circadian clock genes. Nucleic Acids Research. 46(20): 10669-10681
16.?? Chenlong Li ^{#, *}, Chen Chen^#, Huhui Chen, Suikang Wang, Xuemei Chen, and Yuhai Cui. (2018) Verification of DNA motifs in Arabidopsis using CRISPR/Cas9 mediated mutagenesis. Plant Biotechnology Journal. 16(8):1446-1451.?? IF2018 = 6.84
17.?? Chen Chen^#, Chenlong Li ^#, Ying Wang, Gang Tian, Behnaz Saatian, Vi Nguyen, Abdelali Hannoufa, Ryan S. Austin, Susanne E. Kohalmi, Keqiang Wu, Shangzhi Huang and Yuhai Cui^*. (2017) Cytosolic acetyl-CoA promotes histone acetylation predominantly at H3K27 in Arabidopsis. Nature Plants. 3(10):?814-824.
18.?? Chenlong Li ^*, Yuhai Cui ^*. (2016) A DNA element that remembers winter. Nature Genetics 48(12): 1451-1452.
19.?? Chenlong Li,Lianfeng Gu, Lei Gao, Chen Chen,Chuang-Qi Wei, Qi Qiu, Chih-Wei Chien, Suikang Wang, Lihua Jiang, Lian-Feng Ai, Chia-Yang Chen, Songguang Yang,Vi Nguyen, Yanhua Qi, Michael P Snyder, Alma L Bulingame, Susanne E Kohalmi, Shangzhi Huang, Xiaofeng Cao, Zhi-Yong Wang, Keqiang Wu, Xuemei Chen, Yuhai Cui^*. (2016) Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis. Nature Genetics. 48(6): 687-693.
Featured by “News and Views” in Nature Genetics

Recommended by Faculty of 1000
20.?? Yunmin Xu, Changkui Guo, Bingying Zhou, Chenlong Li, Huasen Wang, Ben Zheng, Han Ding, Zhujun Zhu, Angela Peragine, Yuhai Cui, Scott Poethig, Gang Wu^*. (2016) Regulation of vegetative phase change by SWI2/SNF2 chromatin remodeling ATPase BRAHMA in Arabidopsis. Plant Physiology. 172(4)::2416-2428.
21.?? Chenlong Li, Chen Chen,Lei Gao, Songguang Yang, Vi Nguyen, Xuejiang Shi, Katherine Siminovitch, Susanne E Kohalmi, Shangzhi Huang, Keqiang Wu, Xuemei Chen, Yuhai Cui^*. (2015) The Arabidopsis SWI2/SNF2 chromatin remodeler BRAHMA regulates polycomb function during vegetative development and directly activates the flowering repressor gene SVP. PLoS Genetics 11(1): e**.
22.?? Songguang Yang^#, Chenlong Li^#, Linmao Zhao^#, Sujuan Gao, Jingxia Lu, Minglei Zhao, Chia-Yang Chen, Xuncheng Liu, Ming Luo, Yuhai Cui, Chengwei Yang, Keqiang Wu^* (2015) The Arabidopsis SWI2/SNF2 chromatin remodeling ATPase BRAHMA targets directly to PINs and is required for root stem cell niche maintenance. Plant Cell. 27(6):1670-1680.
23.?? Minglei Zhao^#, Songguang Yang^#, Chia-Yang Chen, Chenlong Li, Wei Shan, Wangjin Lu, Yuhai Cui, Xuncheng Liu^*, Keqiang Wu^* (2015) Arabidopsis BREVIPEDICELLUS interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA to regulate KNAT2 and KNAT6 expression in control of inflorescence architecture. PLoS Genetics. 11(3): e**.
24.?? Yi Zhou^#, Bin Tan^#, Ming Luo^#, Yin Li, Chen Liu, Chen Chen, Chun-Wei Yu, Songguang Yang, Shuai Dong, Jiuxiao Ruan, Liangbin Yuan, Zhou Zhang, Linmao Zhao, Chenlong Li, Huhui Chen, Yuhai Cui, Keqiang Wu^#, Shangzhi Huang^#,*. (2013) HISTONE DEACETYLASE19 interacts with HSL1 and participates in the repression of seed maturation genes in Arabidopsis seedlings. Plant Cell. 25(1):134-148.
25.?? Mohamed Elhiti, Kim H Hebelstrup, Aiming Wang, Chenlong Li, Yuhai Cui, Robert D Hill, Claudio Stasolla^*. (2013) Function of type-2 Arabidopsis hemoglobin in the auxin-mediated formation of embryogenic cells during morphogenesis. Plant Journal. 74(6): 946-958.
26.?? Guohua Fu^#, Yujuan Zhong^#, Chenlong Li, Yin Li, Xiaodong Lin, Bin Liao, Edward W. T. Tang, Keqiang Wu^*, Shangzhi Huang^*. (2010) Epigenetic regulation of peanut allergen gene Ara h 3 in developing embryos. Planta. 231 (5):1049-1060.
27.?? Chenlong Li^#, Keqiang Wu^#, Guohua Fu, Yin Li, Yujuan Zhong, Xiaodong Lin, Yi Zhou, Lining Tian, Shangzhi Huang^*. (2009) Regulation of oleosin expression in developing peanut (Arachis hypogaea L.) embryos through nucleosome loss and histone modifications. Journal of Experimental Botany 60(15): 4371-4382.