徐晓鹏

Submitted on 周一, 10/30/2017 - 21:09


性别
男

工作电话


电子邮件
xuxpeng@mail.sysu.edu.cn

职称
副教授

导师类型
博士生导师

学历
博士

学科方向
0710生物学-04水生生物学


研究方向
海洋生物病原分子生物学、海洋动物分子免疫学。包括病毒功能基因及其致病机理、病毒与宿主的相互作用、病毒疫苗开发、模式动物抗病毒免疫、先天免疫调控机制、microRNA调控网络等。

个人经历
毕业于中山大学生命科学学院获博士学位，2018-2019年在美国哈佛医学院做公派访问****。

讲授课程
本科生：《分子生物学》、《分子生物学实验》、《鱼类转基因实验技术》
研究生：《模式动物实验操作技术》、《海洋生物免疫学》

承担课题
1. 国家自然科学基金面上项目，**，细胞膜NF-κB（mNF-κB）信号通路及其介导的凡纳滨对虾抗真菌免疫调控机制，2018.01-2021.12， 主持。
2. 国家自然科学基金面上项目，**，凡纳滨对虾Vago信号通路的调控机制及其在抗病毒免疫中的作用，2016.01-2019.12， 主持。
3. 国家自然科学基金面上项目，**，肿大细胞病毒感染细胞的膜外贴附内皮细胞现象的机制和功能，2013.01-2016.12， 主持。
4. 国家自然科学青年基金项目，**，肿大细胞病毒VP23R和VP48R基因的致病机理， 2010.01-2012.12，主持。
5. 973计划项目（子课题），2012CB**，海水养殖动物主要病毒性疫病爆发机理与免疫防治的基础研究，2012.01-2016.12，主持。
6. 广东省自然科学基金，2017A，伪基底膜结构（VMBM）诱导肿大细胞病毒感染鱼类脉管系统病变的分子机制，2017.05-2020.05, 主持。
7. 广东省自然科学基金, 2014A，凡纳滨对虾类干扰素调节因子（IRF-like）在核酸诱导抗病毒免疫反应中的作用, 2015.01-2018.01, 主持。???????
8. 中国博士后科学基金特别资助，，传染性脾肾坏死病毒VP23R和VP48R基因的致病机理，2010.10-2012.10，主持。
9. 中国博士后基金，，传染性脾肾坏死病毒（ISKNV）VP48R基因的致病机理， 2008.12-2010.12，主持。
10. 广州市产学研重大专项，，草鱼出血症血清抗体免疫监控平台技术研究与应用， 2015.01-2017.12，主持。
11. 珠江科技新星专项，2011J**, 鱼类疫苗自动注射机的研发与应用，2011.11-2014.10，主持。
12. 高校基本科研业务费青年教师重点培育项目，17lgzd27，对虾细胞膜NF-κB（mNF-κB）信号通路的鉴定及其调控机制，徐晓鹏，2017.05-2018.12，主持。
13. 高校基本科研业务费青年教师培育项目，传染性脾肾坏死病毒VP15R和VP008R的致病机理，编号：11lgpy24，2010.12-2013.12，主持。

论文专著
近年来以通讯作者和第一作者在病毒学或免疫学领域知名期刊J. Virol., J. Immunol.和Virology上发表多篇论文，包括一篇Virology杂志的封面文章。
1.?Linwei Yang, Shengwen Niu, Jiefeng Gao, Hongliang Zuo, Jia Yuan, Shaoping Weng, Jianguo He*, Xiaopeng Xu*.A single WAP domain (SWD)-containing protein with antiviral activity from Pacific white shrimp Litopenaeus vannamei Fish Shellfish Immunol. 2018,73:167-174. （通讯作者）
2.?Hongliang Zuo, Jia Yuan, Shengwen Niu, Linwei Yang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A molting-inhibiting hormone-like protein from Pacific white shrimp Litopenaeus vannamei is involved in immune responses. Fish Shellfish Immunol. 2018,72:544-551. （通讯作者）
3.?Qianhui Liang, Jiefu Zheng, Hongliang Zuo, Chaozheng Li, Shengwen Niu, Linwei Yang, Shaoping weng, Jianguo He, Xiaopeng Xu*. Identification and characterization of an interleukin-16-like gene from pacific white shrimp Litopenaeus vannamei. Dev Comp Immunol. 2017, 74:49-59. （通讯作者）
4.?Wei Qiu, Jianhui He, Hongliang Zuo, Shengwen Niu, Chaozheng Li, Shuang Zhang, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Identification, characterization, and function analysis of the NF-kappaB repressing factor (NKRF) gene from Litopenaeus vannamei. Dev Comp Immunol. 2017, 76:83-92.（通讯作者）
5.?Jian-Hui He, Muting Yan, Hongliang Zuo, Shengwen Niu, Jia Yuan, Shao-Ping Weng, Jianguo He, Xiaopeng Xu*, High reduced/oxidized glutathione ratio in infectious spleen and kidney necrosis virus-infected cells contributes to degradation of VP08R multimers. Veterinary Microbiology 2017, 207: 19-24. （通讯作者）
6.?Jiefeng Gao, Hongliang Zuo, Linwei Yang, Jian-Hui He, Shengwen Niu, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Long-term influence of cyanobacterial bloom on the immune system of Litopenaeus vannamei. Fish Shellfish Immunol. 2017,61:79-85. （通讯作者）
7.?Hongliang Zuo, Jiefeng Gao,? Jia Yuan, Hengwei Deng, Linwei Yang, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection. Fish Shellfish Immunol. 2017, 60:282-288. （通讯作者）
8.?Xiaopeng Xu, Jia Yuan, Linwei Yang, Shaoping Weng, Jianguo He*, Hongliang Zuo*. The Dorsal/miR-1959/Cactus feedback loop facilitates the infection of WSSV in Litopenaeus vannamei. Fish Shellfish Immunol. 2016, 56:397-401.
9.?Hongliang Zuo, Jia Yuan, Yonggui Chen, Sedong Li, Ziqi Su, Erman Wei, Chaozheng Li, Shaoping Weng, Xiaopeng Xu*, Jianguo He*. A microRNA-mediated positive feedback regulatory loop of the NF-κB pathway in Litopenaeus vannamei. Journal of Immunology.2016, 196:3842-3853. （通讯作者）
10.?Muting Yan, Jianhui He, Weibin Zhu, Jing Zhang, Qiong Xia, Shaoping Weng, Jianguo He, Xiaopeng Xu*. A microRNA from infectious spleen and kidney necrosis virus modulates expression of the virus-mock basement membrane component VP08R. Virology 2016, 492, 32-37.（通讯作者）
11.?Muting Yan, Lihong Liu, ?Qianhui Liang, Jianhui He, Shaoping Weng, Jianguo He, Xiaopeng Xu*. A mitochondrial outer membrane-localized protein encoded by White spot syndrome virus. Virus Genes. 2016, 52(2):290-293.（通讯作者）
12.?Chaozheng Li, Haoyang Li, Yixiao Chen, Yonggui Chen, Sheng Wang, Shaoping Weng, Xiaopeng Xu*, Jianguo He*. Activation of Vago by interferon regulatory factor (IRF) suggests an interferon system-like antiviral mechanism in shrimp. Scientific Reports 2015, 5:15078.（通讯作者）
13.?Muting Yan, Junliang Tang, Qianhui Liang, Guohua Zhu, Haoyang Li, Chaozheng? Li, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Daxx from Pacific white shrimp Litopenaeus vannamei is involved in activation of NF-κB pathway. Fish Shellfish Immunol. 2015, 45 (2): 443-453. （通讯作者）
14.?Muting Yan, Chaozheng? Li, Ziqi Su, Qianhui Liang, Haoyang Li, Shizhong Liang, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei. Fish Shellfish Immunol. 2015, 44(1):26-32. （通讯作者）
15.?Hongliang Zuo, Haoyang Li, Erman Wei, Ziqi Su, Jieyao Zheng, Chaozheng Li,Yonggui Chen, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. Identification and functional analysis of a Hemolin like protein from Litopenaeus vannamei. Fish Shellfish Immunol. 2015, 43(1):51-59. （通讯作者）
16.?Xiaopeng Xu, Muting Yan, Rui Wang, Ting Lin, Junliang Tang, Chaozheng Li, Shaoping Weng, Jianguo He. VP08R from infectious spleen and kidney necrosis virus is a novel component of the virus-mock basement membrane. J. Virol. 2014, 88(10): 5491-5501.
17.?Ming Li, Chaozheng Li, Chunxia Ma, Haoyang Li, Hongliang Zuo, Shaoping Weng, Xiaohan Chen,Digang Zeng, Jianguo He, Xiaopeng Xu*. Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei. Dev Comp Immunol. 2014，46:231-240.（通讯作者）
18.?Rui Wang, Yang Yi, Lihong Liu, Yanghong Lu, Shaoping Weng,Jianguo He, Xiaopeng Xu*. ORF005L from infectious spleen and kidney necrosis virus is located in the inner? mitochondrial membrane and induces apoptosis. Virus Genes. 2014, doi:10.1007/s11262-014-1088-2.（通讯作者）
19.?Chaozheng Li, Jiaoting Chai, Haoyang Li, Hongliang Zuo, Sheng Wang, Wei Qiu, Shaoping Weng, Jianguo He, Xiaopeng Xu*. Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-kappaB activation. Dev Comp Immunol. 2014 44:341-350. （通讯作者）
20.?Chaozheng Li, Yixiao Chen,Shaoping Weng,Sedong Li, Hongliang Zuo, Xiaoqiang Yu, Haoyang Li, Jianguo He, Xiaopeng Xu*. Presence of Tube isoforms in Litopenaeus vannamei suggests various regulatory patterns of signal transduction in invertebrate NF-kappaB pathway. Dev Comp Immunol. 2014 42:174-185. （通讯作者）
21.?Chaozheng Li, Yi-xiao Chen, Shuang Zhang, Ling Lü, Yi-Hong Chen, Jiaoting Chai, Shaoping Weng, Yong-gui Chen, Jianguo He, Xiaopeng Xu*. Identification, Characterization, and Function Analysis of the Cactus Gene from Litopenaeus vannamei. PLOS ONE, 2012, 7(11): e49711. （通讯作者）
22.?Chaozheng Li, Shaoping Weng, Yonggui Chen, Xiaoqiang Yu, Ling Lü, Haiqing Zhang, Jianguo He, Xiaopeng Xu*. Analysis of Litopenaeus vannamei transcriptome using the next-generation DNA sequencing technique. PLOS ONE, 2012, 7(10): e47442. （通讯作者）
23.?Xiaopeng Xu, Ting Lin, Lichao Huang, Zhongsheng Li, Qiong Xia, Shaoping Weng ,Ling Lv, Zhongsheng Li, Junliang Tang, Jianguo He. VP15R from infectious spleen and kidney necrosis virus (ISKNV) is a non-muscle myosin II (NM II)-binding protein. Arch. Virol. 2011, 156:53–61.
24.?Xiaopeng Xu, Shaoping Weng, Ting Lin, Junliang Tang, Lichao Huang, Jing Wang, Xiaoqian Yu, Ling Lu, Zhijian Huang, and Jianguo He. VP23R of infectious spleen and kidney necrosis virus mediates formation of virus-mock basement membrane to provide attaching sites for lymphatic endothelial cells. J. Virol. 2010, 84(22):11866-11875.
25.?Xiaopeng Xu, Lichun Zhang, Shaoping Weng, Zhijian Huang, Jing Lu, Dongming Lan, Xuejun Zhong, Xiaoqiang Yu, Anlong Xu, and Jianguo He. A zebrafish (danio rerio) model of infectious spleen and kidney necrosis virus (ISKNV) infection. Virology,2008,376(1): 1-12. (封面文章)
26.?Xiaopeng Xu, Lichao Huang, Shaoping Weng, Jing Wang, Junliang Tang, Ting Lin, Zhongsheng Li, Qingxia Lu, Qiong Xia, Xiaoqiang Yu, and Jianguo He, Tetraodon nigroviridis as a non-lethal model of infectious spleen and kidney necrosis virus (ISKNV) infection. Virology 2010, 406(2):167-175.
27.?Xiaopeng Xu, Qingxia Lu, Rui Wang, Ting Lin, Shaoping Weng, Ling Lu, Zhongsheng Li, Xiaoqiang Yu, Junliang Tang, Jianguo He, Identification of the VP92R gene from infectious spleen and kidney necrosis virus. Virus Genes 2010, 41(2):210-217.
28.?Xiaopeng Xu, Jing Lu, Qingxia Lu, Hui Zhong, Shaoping Weng, Jianguo He. Characterization of a membrane protein (VP001L) from infectious spleen and kidney necrosis virus (ISKNV). Virus Genes. 2008, 36(1):157-167.
29.?Zi-Liang Wang&, Xiao-Peng Xu&, Bai-Liang He, Shao-Ping Weng, Jia Xiao, Li Wang, Ting Lin, Xi Liu, Qing Wang, Xiao-Qiang Yu, and Jian-Guo He. Infectious spleen and kidney necrosis virus ORF48R functions as a new viral vascular endothelial growth factor. J Virol. 2008, 82(9): 4371-4383.（共同第一）
30.?Ruiwen Ren&, Xiaopeng Xu&, Ting Lin, Shaoping Weng, Huafang Liang, Mengli Huang, Chuanfu Dong, Yongwen Luo, and Jianguo He. Cloning, characterization, and biological function analysis of the SidT2 gene from Siniperca chuatsi. Dev Comp Immunol. 2011, 35: 692-701. (共同第一)
31.?Zhongsheng Li&, Xiaopeng Xu&, Lichao Huang, Jianmin Wu, Qingxia Lu, Zhiming Xiang, Jingjing Liao, Shaoping Weng, Xiaoqiang Yu, Jianguo He. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & Shellfish Immunology，2010, 29(3):399-406. (共同第一)
32.?Zhi-Ying Zhao, Zhi-Xin Yin, Xiao-Peng Xu, Shao-Ping Weng, Xia-Yu Rao, Zong-Xian Dai, Yong-Wen Luo, Gan Yang, Zong-Sheng Li, Hao-Ji Guan, Se-Dong Li, Siu-Ming Chan, Xiao-Qiang Yu, and Jian-Guo He. A novel C-type lectin from the shrimp Litopenaeus vannamei possesses anti-WSSV activity. J. Virol.2009, 83(1):347-356.
33.?Xiao-Peng Xiong, Chuan-Fu Dong, Xiaopeng Xu, Shao-Ping Weng, Zhao-Yu Liu, Jian-Guo He, Proteomic analysis of zebrafish (Danio rerio) infected with infectious spleen and kidney necrosis virus. Dev Comp Immunol. 2011, 35: 431–440.
34.?Xian-De Huang, Li Zhao, Hai-qing Zhang, Xiao-peng Xu, Xiao-ting Jia, Yi-hong Chen，Pei-Hui Wang, Shao-Ping Weng, Xiao-Qiang Yu, Zhi-Xin Yin, Jian-Guo He, Shrimp NF-?B Binds to the Immediate-Early Gene ie1 Promoter of White Spot Syndrome Virus and Upregulates Its Activity. Virology 2010, 406(2):176-180.
35.?Chuanfu Dong, Shaoping Weng, Xiujuan Shi, Xiaopeng Xu, Nan Shi, Jian-guo He, Development a mandarin fish Siniperca chuatsi fry cell line suitable for the study of infectious spleen and kidney necrosis virus (ISKNV). Virus Research, 2008,135: 273-281.
36.?Wei Qiu, Shuang Zhang, Yong-gui Chen, Pei-hui Wang, Xiao-peng Xu, Chao-zheng Li, Yi-Hong Chen, Wen-Zhou Fan, Hui Yan, Shao-Ping Weng, Siuming Francischan, Jian-Guo He. Litopenaeus vannamei NF-kappaB is required for WSSV replication. Dev Comp Immunol. 2014 45:156-162.
专利：
1. 汤俊良，徐晓鹏，何建国，翁少萍，严慕婷，一种鱼类疫苗自动化连续注射装置，专利号：CNU,授权日期：2016.8.17
2.黄志坚，徐晓鹏，唐晶晶，张飓，何建国；一种利用线粒体DNAD-loop控制区进行鱼类遗传信息分析的方法，专利号：1，授权日期：2010.5
3. 黄志坚，徐晓鹏，唐晶晶，张飓，何建国；鱼类线粒体DNA控制区扩增引物及其设计方法和应用，专利号：2，授权日期：2010.6
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