个人基本简介:
职称：教授，博士生导师
学位：博士
电子邮件：liulixin@mail.sysu.edu.cn
科研项目
主持国家自然科学基金（**，**）；广东省科技厅社会发展领域项目；中国科学院重要方向性项目集群项目子课题：新型艾滋病和病毒性肝炎灵长类动物模型的创建（KSCX2-EW-R-13）；中国科学院知识创新工程重要方向项目（生命科学领域“十二五”基础前沿专项）子课题：微流控纳米及顺磁生物新技术研究（KSCX2-EW-J-29）；“十二五”国家科技支撑计划课题：“亚健康状态的评价指标及城市人口亚健康监测网络与数据库的建立”子课题：亚健康状态产生的分子学机制研究；省纳米创新团队项目主要成员，国家自然科学资金重点项目主要成员。

主要经历:
教育经历
1994年于吉林医学院预防医学专业毕业，获医学学士学位
1999年于中国科学院微生物研究所研究生毕业，获理学硕士学位
2002年于德国杜塞尔多夫大学儿童血液肿瘤研究所，获得医学博士学位
工作经历
2002 -2005 中国科学院微生物研究所工作 ? ??科研工作 助理研究员
2005-2007 ?中国科学院大学生命科学院?? ??教学与科研工作 讲师
2007-2014 ?中国科学院大学生命科学院???? 教学与科研工作 副教授
2014-2021? 中山大学材料科学与工程学院 ? ? 教学与科研工作 副教授
2021至今? ? 中山大学材料科学与工程学院? ? ?教学与科研工作 教授

学科方向:
纳米材料做为疫苗佐剂及载体的研究，纳米材料在自身免疫性疾病治疗中应用研究。

荣誉获奖:
2006-2007学年，《分子病毒学》获得中国科学院研究生院优秀课程
2007-2008学年，《分子病毒学》获得中国科学院研究生院优良课程
2008学期，《分子病毒学》获得中国科学院教学成果二等奖，排名第一

代表论著:
Bo Peng, Huiyi Liang, Yuyan Li, Cong Dong, Jun Shen, Hai-Quan Mao, Kam W. Leong, Yongming Chen, and Liu, L.X.*Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment, Angew. Chem. Int. Ed. 2019, 58:4254-4259.
Huiyi Liang, Bo Peng, Cong Dong, Liu, L.X.*, Jiaji Mao, Song Wei, Xinlu Wang, Hanshi Xu, Jun Shen*, Hai-Quan Mao, Xiaohu Gao, Kam W. Leong*, Yongming Chen*, Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation, Nature Communication, 2018, 9:4291-4305.
Qiao, D.D.; Liu, L.X.*; Chen, Y.; Xue, C.B.; Gao, Q.; Mao, H.Q.*; Leong, K.W.*; Chen, Y.M., Potency of a Scalable Nanoparticulate Subunit Vaccine. Nano Letters. 2018, 18 (5), 3007-3016.
Li, Z.Y; Zhou, F.; Li, Z.Y.; Lin, S.Y.; Chen, L.; Liu, L.X.; Chen, Y.M.*, Hydrogel Cross-Linked with Dynamic Covalent Bonding and Micellization for Promoting Burn Wound Healing. ACS applied materials & interfaces. 2018, 10 (30), 25194-25202.
Chen, Y.; Zhou, H.B.; Sun, Z.Y.; Li, H.A.; Huang, H.U.; Liu, L.X.*; Chen, Y.M.*, Shell of amphiphilic molecular bottlebrush matters as unimolecular micelle. Polymer. 2018, 149, 316-324.
He, Z.Y.; Liu, Z.J.; Tian, H.K.; Hu, Y.Z.; Liu, LX..; Leong, K.W.*; Mao, H. Q.*; Chen, Y.M.*, Scalable Production of Core-Shell Nanoparticles by Flash Nanocomplexation to Enhance Mucosal Transport for Oral Delivery of Insulin. Nanoscale. 2018, 10 (7), 3307-3319.
Plummer, C. M.; Zhou, H.B.; Zhu, W.; Huang, H.H.; Liu, L.X.; Chen, Y.M.*, Mild Halogenation of Polyolefins Using An N-haloamide Reagent. Polymer Chemistry 2018, 9 (11), 1309-1317.
Hu, Z.T.; Chen, Y.; Huang, H.H.; Liu, L.X.; Chen, Y.M.*, Well-Defined Poly(α-amino-δ-valerolactone) via Living Ring-Opening Polymerization. Macromolecules. 2018, 51 (7), 2526-2532.
Zeng, Z.P.; Zhao, P.F.; Liu, L.X.*; Gao, X.H.; Mao, H.Q.; Chen, Y.M.*, Lipid Stabilized Solid Drug Nanoparticles for Targeted Chemotherapy. ACS applied materials & interfaces. 2018, 10 (30), 24969-24974.
Li, H.A.; Liu, H.; Nie, T.Q.; Chen, Y.; Wang, Z.Y.*; Huang, H.H.; Liu, L.X.*; Chen, Y.M.*, Molecular Bottlebrush as A Unimolecular Vehicle with Tunable Shape for Photothermal Cancer Therapy. Biomaterials. 2018, 178, 620-629.
Wu, X.L.; Wu, Y.D.; Wang, Z.Y.; Liu, L.X. *; Sun, C.X.; Chen, Y.M.; Wang, C.*, A Cascade-Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition. Advanced Healthcare Materials. 2018, 7 (11), e**.
Chu, Y.H.; Li, H.A.; Huang, H.H.; Zhou, H.B.; Chen, Y.; Andreas, B.; Liu, L.X.*; Chen, Y.M.*, Uni-Molecular Nanoparticles of Poly(2-Oxazoline) Showing Tunable Thermoresponsive Behaviors. Journal of Polymer Science Part A-Polymer Chemistry. 2018, 56(2), 174-183.
He, Z.Y.; Santos, J.L.; Tian, H.K.; Huang, H.H.; Hu, Y.Z.; Liu, L.X.; Leong, K.W.*; Chen, Y.M.*; Mao, H.Q.*, Scalable Fabrication of Size-Controlled Chitosan Nanoparticles for Oral Delivery of Insulin. Biomaterials. 2017, 130, 28-41.
Peng, B.; Lai, X.Y.; Chen, L.; Lin, X.M.; Sun, C.X.; Liu, L.X.*; Qi, S.H.; Chen, Y.M.*; Leong, K.W.*, Scarless Wound Closure by a Mussel-Inspired Poly(amidoamine) Tissue Adhesive with Tunable Degradability. ACS Omega. 2017, 2(9), 6053?6062.
Sun, Z.Y.; Huang, H.H.; Li, L.; Liu, L.X.*; Chen, Y.M.*, Polythioamides of High Refractive Index by Direct Polymerization of Aliphatic Primary Diamines in the Presence of Elemental Sulfu. Macromolecules. 2017, 50(21), 8505-8511.
Yan, Y.C.; Huang, H.H.*; Zhu, W.; Liu, L.X.; Zhang, K.; Chen, Y.M.*, Synthesis of Amphiphilic Polymer Brushes with Mixed Side Chains and Their Emulsifying Function. Acta Polymerica Sinica. 2017, 9, 1531-1537.
Xing Y.X.; Chu Q.Y.; Feng R.; Wang W.; Liu L.X.*; Lu Z.B*., hCLP46 Increases Smad3 Protein Stability via Inhibiting Its Ubiquitin-Proteasomal Degradation. Protein & Cell. 2015, 6(10), 767-770.
Yang, G.L.; Zhang, R.; Huang, H.H.*; Liu, L.X.; Wang, L.*; Chen, Y.M.*, Synthesis of Novel Biobased Polyimides Derived from Isomannide with Good Optical Transparency, Solubility and Thermal Stability. RSC Advances. 2015, 5 (83), 67574-67582.
Bai, R.; Zhang, X.J.; Li, Y.L.; Liu, J.P.; Zhang, H.B.; Xiao, W.L.; Pu, J.X.; Sun, H.D.; Zheng, Y.T.*; Liu, L.X*;., SJP-L-5, A Novel Small-Molecule Compound, Inhibits HIV-1 Infection by Blocking Viral DNA Nuclear Entry. BMC Microbiology. 2015, 15, 274-287.
Zhang S.; Bai R.; Feng R.; Zhang H.; Liu L.X.* Detection and Evolutionary Analysis of Picobirnaviruses in Treated Wastewater. Microb Biotechnol. 2015, 8(3), 474-482.
Wang, J.; Zhu, W.*; Liu, L.X*.; Chen, Y.M*.; Wang, C., Synthesis and Cellular Internalization of Spindle Hematite/Polymer Hybrid Nanoparticles. ACS Applied Materials & Interfaces. 2015, 7(9), 5454-5461.
Wang, J.; Liu, L.X.*; Zhu, W.; Chen, Y.M.*; Wang, C.*, Cancer Cell Uptake of Polymer Hydrogel Nanotubes. J. Biomed. Nanotechnol. 2014, 10, 3329-3336.
Zhu, W.; Peng, B.; Wang, J.; Zhang, K.; Liu, L. X.*; Chen, Y. M.* Bamboo Leaf-Like Micro-Nano Sheets Self-Assembled by Block Copolymers as Wafers for Cells. acromolecular Bioscience. 2014, 14, 1764-70.
Chu, Q.; Liu, L.X.*; Wang, W*., Overexpression of hCLP46 Enhances Notch Activation and Regulates Cell Proliferation in A Cell Type-Dependent Manner. Cell Prolif. 2013, 46 (3), 254-62.
Cui, Y.; Wu, Y. S.; Liu, Y.; Yang, G. M.; Liu, L. X.; Fu, H. B.; Li, Z, B.; Wang, S.; Wang, Z. H.*; Chen, Y. M.*, PEGylated Nanoparticles of Diperylene Bisimides with High Efficiency of O-1(2) Generation. Dyes and Pigments. 2013, 97129-33.
Zhao, P.; Yan, Y. C.; Feng, X. Q.; Liu, L.X.*; Wang, C.; Chen, Y. M.*, Highly Efficient Synthesis of Polymer Brushes with PEO and PCL as Side Chains via Click Chemistry. Polymer, 2012, 53, 1992-2000.
Zhao, P.; Liu, L.X.*; Feng, X. Q.; Wang, C.*; Shuai, X. T.; Chen, Y. M.*, Molecular Nanoworm with PCL Core and PEO Shell as Non-Spherical Carrier for Drug Delivery. Macromol. Rapid Commun. 2012,33, 1351-5
Zhu, W.; Li, Y. L.; Liu, L X.*; Chen, Y. M.*; Xi, F., Supramolecular Hydrogels as A Universal Scaffold for Stepwise Delivering Dox and Dox/cisplatin Loaded Block Copolymer Micelles. International Journal of Pharmaceutics. 2012, 437, 9-11.
Zhu,?W.; Li,?Y. L.; Liu, L.X.;*?Chen, Y. M.;*?Wang,?C.; Xi, F., Biamphiphilic Triblock Copolymer Micelles as A Multifunctional Platform for Anticancer Drug Delivery. J. Biomed. Mater. Res. Part A. 96A .2011, 330-340.
Zhang, W. L.; Li, Y. L.; Liu, L.X.*; Sun, Q.; Shuai, X. T.; Zhu, W.; Chen, Y. M.*, Amphiphilic Toothbrush-like Copolymers Based on Poly(ethylene glycol) and Poly(ε-caprolactone) as Drug Carriers with Enhanced Properties. Biomacromolecules. 2010, 11, 1331-1338.
Zhu, W.; Li, Y. L; Liu, L.X.*; Zhang, W.; Chen, Y. M.*; Xi, F., Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and α-Cyclodextrins with a Stepwise Delivery Property. Biomacromolecules. 2010, 11, 3086-3092.
Li, Z.Q.; Liu, L.X.; Lv, F.X.; Ma, J.; Gao, G.X.*, Fusing ZAP to HIV RNA Binding Proteins to Inhibit HIV. Progress in Biochemistry and Biophysics. 2007, 34, 50-56.
Ye, J.; Liu, L.X.; Gao, G.X.;* Fang, R.X.* Inhibition of SARS by Small Interfering RNAs Targeting the Leader RNA. Progress in Biochemistry and Biophysics 2007, 34, 1092-1100. (共为第一作者)
Borrowski, A.; Dirkson, U.*; Liu, L.X. Shi, R. L; Goebal, U. Structure and Function of ETAA-16: A Novel Cell Surface Antigen in Ewing Tumors. Cancer Immunology Immunotherapy. 2006, 55, 363-374.
Liu, L.X.; Chen, G.F.; Ji, X.; Gao, G.X.* ZAP is a CRM1 dependent protein. Biochemical and Biophysical Research Communications. 2004, 321, 517-523.
Lan, J.?; Song, M.S.?; Pan, C.H.?; Zhuang, G.Q.?; Wang, Y.X.?; Ma, W.Z.?; Chu, Q.Y.?; Lai, Q.X.?; Xu, F.?; Li, Y.L.?; Liu, L.X.?; Wang,W., Association between Dopaminergic Genes (SLC6A3 and DRD2) and Stuttering among Han Chinese. Journal of Human Genetics (Nature Publishing Group). 2009,54, 457-460.
Ma, W.Z.?; Du, J.?; Chu, Q.Y.?; Wang, Y.X.?; Liu, L.X.?; Song, M.S.?; Wang, W., hCLP46 Regulates U937 Cell Proliferation via Notch Signaling Pathway. Biochemical and Biophysical Research Communication. 2011,408, 84-88.
Wang, Y.X.; Chang, N.B.; Zhang, T.; Liu, H.; Ma, W.Z.; Chu, Q.Y.; Lai, Q.X.; Liu, L.X.; Wang, W., Overexpression of Human CAP10-like Protein 46 KD in T-acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia. Genetic Testing and Molecular Biomarkers. 2010, 14, 127-33.
Sheng A.; Lan J.; Wu H.; Lu J.; Wang Y.; Chu Q.; Jia Z.; Song M.; Liu L.X.; Wang W., A Clinical Case Control Study on the Association between Mannose-binding Lectin and Susceptibility to HIV-1 Infection among Northern Han Chinese population. International Journal of Immunogentics. Int J Immunogenet. 2010, 37, 445-54.
刘利新*，刘树峰等。人Dcp2(脱帽酶2)克隆表达、多克隆抗体的制备及其应用。《中国科学院研究生院学报》2007,24: 362-367。
张恬，王有信，王嵬，刘利新*。人CD34＋干/祖细胞异常表达新基因hCLP46 的克隆，表达与功能分析。《中国科学院研究生院学报》2007,4:520-52
盛艾娟，刘利新，吴昊，王友信，彭晓霞，王嵬。中国北方汉族人群MBL与HIV易感性的研究。《南方医科大学学报》2008,4:567-571。
盛艾娟；吴昊；兰洁；路甲鹏；王友信；宋曼殳；武晶晶；刘利新；王嵬, 甘露糖结合凝集素与人类免疫缺陷病毒感染的关联性研究(英文), 中国病毒病杂志, 02期, pp 92-98, 2011.
张文娟，杜杰，常乃柏，张恬，王嵬，刘利新*。酵母双杂交技术筛选与hCLP46蛋白相互作用的蛋白。《中国生物工程杂志》2008,6:23-27。
李艳丽，郑友唐，王嵬，刘利新﹡。利用假病毒技术研究抗HIV-1药物的作用机制 。《微生物学通报》，2011,10:1507-1517。
徐峰，穆昕，王嵬，刘利新﹡ 。串联亲和纯化技术筛选hCLP46的相互作用蛋白 。《中国科学院研究生院学报》2011,2:210-217（通讯作者）。
冯晓琴，徐峰，王嵬，刘利新﹡。通过对免疫共沉淀技术优化验证蛋白质弱相互作用的研究。《中国科学院研究生院学报》，2013,30:18-23。
会议获奖
Li, Y. L.; Gao, G. X.; Zheng, Y. T.; Liu, L. X.;* A simple method?for?exploring the mechanisms for anti-HIV compounds. Abstract of 4th Ditan International Conference on Infectious Diseases. 2010 (获得大会议AGD奖).
会议论文
Ru Bai, Shiwei Zhang, Hongxun Zhang, Lixin Liu. Ultracentrifugation as a direct method to concentrate viruses in sewage, 中国生态学学会微生物生态专业委员会2013年年会会议论文集，P71，成都，2013.11.15-18
Shiwei Zhang, Ru Bai, Lixin Liu. Treated Wastewater from Poultry Farms Harbours Diverse Picobirnavirus Population，中国生态学学会微生物生态专业委员会2013年年会会议论文集，P70，成都，2013.11.15-18
杨金龙，张士伟，张洪勋，刘利新。玻璃棉滤器浓缩水体病毒方法的建立与优化。中国生态学学会微生物生态专业委员会2013年年会会议论文集，P86，成都，2013.11.15-18
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专 利
Therapeutic protein-loaded nanoparticle and method for preparing the same，申请号：PCT/US17/14080.
孙成新、刘利新、陈永明。一种鼠尾静脉精准注射仪(ZL4.0)
刘利新、高光侠。抗HIV病毒的多肽及其编码基因与应用(4.X).
参编教材
《抗病毒天然免疫》（舒红兵主编）第三章内源性免疫：宿主限制因子。科学出版社，2009。