性 ? ?别： 男?? ?
导 ? ?师： 博士导师,硕士导师
学科专业： 分子生物学，免疫学?? ?
?
个人简介：
? ? 中山大学中山医学院人类病毒学研究所副教授。2003年毕业于中国科学院遗传与发育生物学研究所，获遗传学博士学位。2004年美国伊利诺大学医学院微生物与免疫系做博士后；2009年起在美国农业部Jean Mayer 营养老化研究所营养免疫实验室担任助理研究员；2010年3月中山大学“****”引进。研究领域分子生物学和免疫学。目前研究方向：1）T 细胞发育、分化和免疫功能调节的重要基因功能研究；2) T细胞免疫调节和抗自免疫疾病药物及免疫细胞治疗技术研究；3）细胞发育的表观遗传学机制和环境影响。
学术论著与教材：
1. ? ? ? ?Yu B, Qi Y, Liu D, Gao X, Chen H, Bai C, Huang Z. Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm. Fertil Steril. 2013 Oct 7. doi:pii: S0015-0282(13)03050-1. 10.1016/j.fertnstert.2013.09.001. [Epub ahead of print] ?(通讯作者)
2. ? ? ? ?Chen J, Yang L, Huang Z. The N-terminal 33 amino acid sequence ?of Siva-1 is
sufficient for nuclear localization. Brazilian Journal of Medical and Biological Research (已接收)(通讯作者)
3. ? ? ? ?Yu B, Chen J, Liu D, Zhou H, Xiao W, Xia X, Huang Z. Cigarette smoking is associated with human semen quality in synergy with functional NRF2 polymorphisms. Biol Reprod. 2013 Jul 5;89(1):5. doi: 10.1095/biolreprod.113.109389.(通讯作者)
4. ? ? ? ?Bolan Yu, Zixin Mai, Xuxiang Liu, Zhaofeng Huang. Selective estrogen receptor modulator BC-1 activates antioxidant signaling pathway in vitro via formation of reactive metabolites. Acta Pharmacol Sin. 2013 Mar;34(3):373-9. doi: 10.1038/aps.2012.168. Epub 2013 Jan 21 (通讯作者)
5. ? ? ? ?杨丽霞，黄朝峰. RORgt基因启动子的鉴定和特征分析. 免疫学杂志，2013， 29（1）：28-32. (通讯作者)
6. ? ? ? ?Molano A, Huang Z, Marko MG, Azzi A, Wu D, Wang E, Kelly SL, Merrill AH Jr, Bunnell SC, Meydani SN. Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. PLoS One. 2012;7(10):e47650. doi: 10.1371/journal.pone.**. Epub 2012 Oct 26
7. ? ? ? ?Bolan Yu, Huanlan Lin, Lixia Yang, Kang Chen, Haihua Luo , Jianqiao Liu, Xinchen Gao, Xuefeng Xia, Zhaofeng Huang. Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans. J Mol Med (Berl). 2012 Nov;90(11):1333-42. doi: 10.1007/s00109-012-0914-z. ?(通讯作者)
8. ? ? ? ?Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Jian Ma, Xianfeng Fang, Yan Ding and Zuoming Sun. TCF-1 Regulates Thymocyte Survival via a RORγt-dependent Pathway. J Immunol. 2011,187(11):5964-73
9. ? ? ? ?RuiqingWang, Huimin Xie, Zhaofeng Huang, Weirong Shang and Zuoming Sun. Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL. Clinical and Developmental Immunology. 2012, Article ID 632837, doi:10.1155/2012/632837
10. ? ?Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Jian Ma, Xianfeng Fang, Yan Ding and Zuoming Sun. Transcription factor network regulating CD4+CD8+ thymocyte survival. Critical Review in Immunology 2011;31(6):447-58.
11. ? ?Huang Z, Wang R, Xie H, Shang W, Manicassamy S and Sun Z. Stabilized β-catenin potentiates peripheral T cell apoptosis by up-regulating Fas. ?Journal of Immunology 2008; 180: 6586- 6592.
12. ? ?Manicassamy S, Gupta S, Huang Z, Molkentin J, Shang W and Sun Z. Requirement of Calcineurin A β for the survival of Na?ve T cells. Journal of Immunology 2008; 180:106-112
13. ? ?Huang Z, Xie H, Wang R, and Sun Z. Retinoid-related orphan receptor γt is a potential therapeutic target for controlling inflammatory autoimmunity. Expert Opinion on Therapeutic Targets 2007, 11(6):737-743
15. ? ?Xie H, Huang Z, Wang R, and Sun Z. Regulation of thymocyte survival by transcriptional coactivators. Critical reviews in Immunology 2006; 26(6): 475-486
16. ? ?Huang Z, Xie H, Ioannidis V, Held W, Clevers H, Sadim M, and Sun Z. Transcriptional Regulation of CD4 Gene Expression by T Cell Factor-1/β-Catenin Pathway. Journal of Immunology 2006; 176: 4880–4887
17. ? ?Manicassamy S, Gupta S, Huang Z, and Sun Z. Protein Kinase C-θ-Mediated Signals Enhance CD4 T Cell Survival by Up-Regulating Bcl-xL. Journal of Immunology 2006; 176: 6709–6716
18. ? ?Xie H, Huang Z, Sadim SM and Sun Z. Stabilized β-Catenin extends thymocyte survival by up-Regulating Bcl-xL. Journal of Immunology 2005; 175: 7981–7988
?
科研项目研究课题：
1. ?b-catenin在Th17细胞分化和自免疫疾病发生中的作用： 黄朝峰
负责人：黄朝峰 参与人： 经费：3.0000 万元 年份：2012
2. ?b-Catenin调节T细胞激活后凋亡的分子机制： 黄朝峰
负责人：黄朝峰 参与人： 经费：60.0000 万元 年份：2011