副高级职称人员 副教授
电子邮件 hexin59@mail.sysu.edu.cn
性????? 别： 男?
导??? 师：硕士导师
学科专业：分子医学；微生物学
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现任中山大学中山医学院副教授，硕士生导师。2009年毕业于中国药科大学制药工程专业，获工学学士学位。2009 年至 2014 年在中山大学中山医学院攻读博士学位，从事抗HIV药物研发和微小RNA的分子生物学研究。2014年至2020年在美国宾夕法尼亚大学医学院(University of Pennsylvania School of Medicine)从事博士后研究工作。2020年获聘中山大学“****”引进人才。
研究方向：（1）HIV潜伏感染激活的研究以及特异性抗病毒的免疫治疗策略；（2）嵌合抗原受体T细胞免疫治疗的研发，包括细胞免疫治疗特异性标志物的鉴定、抗体筛选以及嵌合抗原受体结构优化的研发；（3）抗病毒药物研发，包括HIV、HBV等高致病性病毒。
代表性学术论著：
He X #, Feng Z #, Ma J, Ling S, Cao Y, Gurung B, Wu Y, Katona BW, O’Dwyer K, Siegel DL, June CH, Hua X*. Bi-specific and Split CAR T Cells Targeting CD13 and TIM3 Eradicate Acute Myeloid Leukemia. Blood. 2020 Jan 17. (IF= 17.5)
He X#, Chen X#, Zhang X#, Duan X, Pan T, Hu Q, Zhang Y, Zhong F, Liu J, Zhang H, Luo J, Wu K, Peng G, Luo H, Zhang L, Li X*, Zhang H*. An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Nucleic acids research. 2015;43(7):3712-25. (IF= 11.5)
He X, Wang L, Yan J, Yuan C, Witze ES, Hua X*. Menin localization in cell membrane compartment. Cancer biology & therapy. 2016;17(1):114-22.? (IF=6.5)
Pan T#, He X#, Chen B, Chen H, Geng G, Luo H, Zhang H*, Bai C*. Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein. European journal of medicinal chemistry. 2015;95:500-13. (IF= 8.3)
Ma J#, He X#, Cao Y, O'Dwyer K, Szigety KM, Wu Y, Gurung B, Feng Z, Katona BW, Hua X*. Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice. J Endocrinol. 2020;244(1):41-52. (IF=4.38)
Zhang X, He X, Liu C, Liu J, Hu Q, Pan T, Duan X, Liu B, Zhang Y, Chen J, Ma X, Zhang X*, Luo H, Zhang H. IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells. J Immunol. 2016;196(4):1591-603. (IF=4.71)
Ma J, Matkar S, He X, Hua X*. FOXO family in regulating cancer and metabolism. Semin Cancer Biol. 2018;50:32-41. (IF= 9.65)
Ling S, Shan Q, Zhan Q, Ye Q, Liu P, Xu S, He X, Ma J, Xiang J, Jiang G, Wen X, Feng Z, Wu Y, Feng T, Xu L, Chen K, Zhang X, Wei R, Zhang C, Cen B, Xie H, Song P, Liu J, Zheng S, Xu X*. USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1alpha/USP22 positive feedback loop upon TP53 inactivation. Gut. 2019. Epub 2019/11/30. doi: 10.1136/gutjnl-2019-319616. PubMed PMID: ** (IF= 17.94)
Katona BW, Glynn RA, Paulosky KE, Feng Z, Davis CI, Ma J, Berry CT, Szigety KM, Matkar S, Liu Y, Wang H, Wu Y, He X, Freedman BD, Brady DC, Hua X*. Combined Menin and EGFR Inhibitors Synergize to Suppress Colorectal Cancer via EGFR-Independent and Calcium-Mediated Repression of SKP2 Transcription. Cancer Research. 2019;79(9):2195-207. (IF= 8.37)
Pan T, Ding Y, Wu L, Liang L, He X, Li Q, Bai C*, Zhang H*. Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors. European journal of medicinal chemistry. 2019;166:480-501.