朱惠莲 教授

营养学系




办公电话



电子邮件
zhuhl@mail.sysu.edu.cn



学术简历
2009.12-至今：中山大学公共卫生学院教授、博士生导师
2002.6-2009.12：中山大学公共卫生学院副教授
2001.10-2002.7 ：KUOPIO大学（芬兰）访问****
1997.1-2002.6：中山大学公共卫生学院讲师
1991.7-1996.12：中山医科大学公共卫生学院助教
社会兼职
中国营养学会，常务理事
中国营养学会老年营养分会，副主任委员
广东省食品安全专家委员会，委员
广东省营养学会，副理事长兼秘书长
广东省食品安全学会，副会长
中国老年医学保健研究会老年健康科技创新分会 副秘书长
国家健康科普专家
主要承担或参与的课题
　　主持国家自然科学基金面上项目7项；广东省自然科学基金重点项目1项、广州市产学研协同创新重大专项1项；省自然、省、市科技计划项目共4项；国家重点研究计划子课题1项，获得行业及企业的纵项课十几项；此外，还获得1项广东省教育厅精品资源共享课程建设等。
甜菜碱的甲基供体作用对mRNA m6A甲基化修饰的影响及其与原发性肝癌关系的研究（主持，2019年批准，NO.**）
甜菜碱的甲基供体作用及其对中老年人肌肉衰减的影响和机制探讨。国家自然科学基金（主持，2017年批准，NO.**）
基于移动健康管理的慢病风险评估及综合干预技术。广州市产学研协同创新重大专项（民生科技研究专题）（主持，2016年批准。NO. 5）
非酒精性脂肪肝病与胆碱依赖肠道细菌的代谢物-氧化三甲胺的相关性研究。广东省自然科学基金重点项目（主持，2015年批准，NO. 2015A）
胆碱肠道菌群依赖代谢物-氧化三甲胺与非酒精性脂肪肝病的关系研究及机制探讨。国家自然科学基金（主持，2014年批准，NO.**）
甲基供体对非酒精性脂肪肝脂质代谢的影响及表观遗传学机制探讨. 国家自然科学基金（主持，2012年批准，NO. **）
膳食甲基供体及其代谢酶基因多态性对非酒精性脂肪肝的影响及交互作用。国家自然科学基金（主持，2010年批准，NO.**）
甜菜碱干预对非酒精性脂肪肝作用的研究及其作为甲基供体机制的探讨。国家自然科学基金（主持，2008年批准，NO.**）
甜菜碱的多甲基供体作用及其抗动脉粥样硬化的研究。国家自然科学基金（主持，2006年批准，NO.**）
以通讯作者发表的主要文章
Zhong RH#, Long JA#, Wang F, Chen S, Luo Y, Lu XT, Yishake D, Chen YM, Fang AP*, Zhu HL*.Association between serum choline and betaine concentrations and longitudinal changes of body composition in community-dwelling middle-aged and older Chinese adults. Appl Physiol Nutr Metab. 2020 Jan 9. doi: 10.1139/apnm-2019-0778. [Epub ahead of print]
Zhang DM#, Luo Y#, Yishake D, Liu ZY, He TT, Luo Y, Zhang YJ, Fang AP* and Zhu HL*. Prediagnostic dietary intakes of vitamin A and β-carotene are associated with hepatocellular-carcinoma survival. Food & Function. 2020;29;11(1):759-767.
Lai Z, Chen J, Ding C, Wong K, Chen X, Pu L, Huang Q, Chen X, Cheng Z, Liu Y, Tan X, Zhu H*, Wang L*. Association of hepatic global DNA methylation and serum one-carbon metabolites with histological severity in NAFLD patients. Obesity. 2020 Jan;28(1):197-205.
Huang ZP#, Huang BX#, Zhang H, Zhu MF, Zhu HL*. Waist-to-height ratio is a better predictor of hyperuricemia than body mass index and waist circumference in Chinese. Ann Nutr Metab. 2019;75(3):187-19
Fang AP, Long JA, Zhang YJ, Liu ZY, Li QJ, Zhang DM, Luo Y, Zhong RH, Zhou ZG, Xu YJ, Xu XJ, Ling WH, Chen MS, Zhu HL*.Serum bioavailable, rather than total, 25-hydroxyvitamin D levels are associated with hepatocellular carcinoma survival..Hepatology. 2019 Nov 2. doi:10.1002/hep.31013. [Epub ahead of print]
Tan X, Liu Y, Long J, Chen S, Liao G, Wu S, Li C, Wang L, Ling W, Zhu H*.Trimethylamine N-Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease. Mol Nutr Food Res. 2019;63(17):e**.
Fang AP, Liu ZY, Liao GC, Chen PY, Wang XY, Zhang DM, Luo Y, Long JA, Zhong RH, Zhou ZG, Xu YJ, Xu XJ, Ling WH, Chen MS, Zhang YJ, Zhu HL*. Serum folate concentrations at diagnosis are associated with hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort study.Br J Nutr. 2019;121(12):1376-1388
Li CY, Fang AP, Ma WJ, Wu SL, Li CL, Chen YM and Zhu HL*. Amount rather than source of dietary protein intake is associated with skeletal muscle mass in middle-aged and older Chinese adults: results from the Guangzhou Nutrition and Health Study. J Acad Nutr Diet. 2019 ;119(9):1501-1510
Wang L, Ding C, Zeng F, Zhu H*. Low Levels of Serum β-Carotene and β-Carotene/Retinol Ratio Are Associated with Histological Severity in Nonalcoholic Fatty Liver Disease Patients. Ann Nutr Metab. 2019 ;74(2):156-164.
Fang AP, Chen PY, Wang XY, Liu ZY, Zhang DM, Luo Y, Liao GC, Long JA, Zhong RH, Zhou ZG, Xu YJ, Xu XJ, Ling WH1, Chen MS, Zhang YJ, Zhu HL*. Serum Copper and Zinc levels at Diagnosis and Hepatocellular Carcinoma Survival in the Guangdong Liver Cancer Cohort. International journal of cancer. 2019;144(11):2823-2832
Liu ZY; Tan XY; Li QJ; Liao GC; Fang AP; ZhangDM; Chen PY; Wang XY; Luo Y; Long JA; Zhong RH; Zhu HL*.Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study. Nutrition & Metabolism [Epub ahead of print]
Wang XY, Fang AP, Chen PY, Liao GC, Zhang YJ, Nitin Shivappa, James R. Hébert, Chen YM and Zhu HL*.High dietary inflammatory index scores are associated with an elevated risk of hepatocellular carcinoma in a case-control study.Food & Function.2018 Nov 14;9(11):5832-5842. doi: 10.1039/c8fo01190g
Chen PY, Fang AP, Wang XY, Lan QY, Liao GC, Liu ZY, Zhang DM, Zhang YY, Chen YM, Zhu HL*.Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study.Nutrients. 2018 Aug 17;10(8). pii: E11 doi: 10.3390/nu**.
Chen JB, Fang AP, Chen MS, Yiminjiang Tuoheti, Zhou ZG, Xu L, Chen JC, Pan YX, Wang JC, Zhu HL*, Yaojun Zhang.A novel inflammation-based nomogram system to predict survival of patients with hepatocellular carcinoma. Cancer Medicine.2018 Oct;7(10):5027-5035. doi: 10.1002/cam4.1787. Epub 2018 Sep 27.
Wu SL , Ding D , Fang AP, Chen PY, Chen S, Jing LP, Chen YM, Zhu HL*. Growth, gastrointestinal tolerance and stool characteristics of healthy term infants fed an infant formula containing hydrolyzed whey protein: a randomized clinical trial. Nutrients. 2017 16;9(11). pii: E1254.
Zhou RF, Chen XL, Zhou ZG, Zhang YJ, Lan QY, Liao GC, Chen YM,?Zhu HL*.?Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study.?Sci Rep.?. 2017;7(1):679.
?Wang HL, Zhang H,Wu SL, Liao GC,Fang AP, Zhu MF,?Zhu HL*.?Red blood cell count has an independent contribution to the prediction of ultrasonography-diagnosed fatty liver disease.?PLOS ONE?2017 Feb 10;12(2):e**.
Lan QY, Zhang YJ, Liao GC, Zhou RF, Zhou ZG, Chen YM and?Zhu HL*. The Association between Dietary Vitamin A and Carotenes and the Risk of Primary Liver Cancer: A Case–Control Study.?Nutrients?2016, 8(10), 624;
Huang BX, Zhu YY, Tan XY, Lan QY, Li CL, Chen YM,Zhu HL*.Serum betaine is inversely associated with low lean mass mainly in men in a Chinese middle-aged and elderly community-dwelling population.British Journal of Nutrition. 2016 ;115(12):2181-8
Chen YM, Liu Y, Zhou RF, Chen XL, Wang C, Tan XY, Wang LJ,? Zheng RD, Zhang HW Ling WH,Zhu HL*,Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults.?Sci Rep. 2016 Jan 8;6:19076. doi: 10.1038/srep19076.
?Zhu CH, Wu T, Jin Y, Huang BX, Zhou RF, Wang YQ, Luo XL,?Zhu HL*.Prenatal choline supplementation attenuates spatial learning deficits of offspring rats exposed to low-protein diet during fetal period.?The Journal of Nutritional Biochemistry .2016;32:163-70
Huang BX, Zhu MF, Wu T, Zhou JY, Liu Y, Chen XL, Zhou RF,? Wang LJ,? Chen YM,?Zhu HL*.? Neck circumference, along with other anthropometric indices, has an independent and additional contribution in predicting fatty liver disease.?PLOS ONE? 2015. 10(2): e**.doi:10.1371
?Ma WJ, Huang ZH, Huang BX, Qi BH, Zhang YJ, Xiao BX, Li YH, Chen L,?Zhu HL*?.? Intensive low glycemic load dietary intervention for the management of glycaemia and serum lipids among women with gestational diabetes: a randomized control trial.?Public Health Nutrition?. 2015;18(8):1506
?Chen YM, Liu Y, Liu YH, Wang X, Guan K and?Zhu HL*. Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults.?International Journal of Obesity. 2015;39(3):465-71.?
Zeng FF, Xue WQ, Cao WT, Wu BH, Xie HL, Fan F,?Zhu HL*, Chen YM.Diet-quality scores and risk of hip fractures in elderly urban Chinese in Guangdong, China: a case-control study.?Osteoporos Int.? 2014;25: 2131-2141
Wang LJ, Zhang HW,Zhoua JY,Liu Y, Yang Y, Chen XL, Zhu CH,Zheng RD, Ling WH,?Zhu HL*.?Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high fat diet.The Journal of Nutritional Biochemistry, 2014,25,329-336
Wang L, Chen L, Tan Y, Wei J, Chang Y, Jin T,?Zhu HL*. Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter.?Lipids Health and Diseases. 2013;12:34-42.
Chen L, Chen Y, Wang L, Wei J, Tan Y, Zhou J, Yang Y, Ling W,?Zhu HL*. Higher homocysteine and lower betaine increases the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C.?Diabetes Metabolism Research and Reviews. 2013.29:607-617
Zhou JY, Ge H, Zhu MF, Wang LJ, Chen L, Tan YZ, Chen YM,?Zhu HL*. Neck circumference as an independent predictive contributor to cardio-metabolic syndrome.?Cardiovascular Diabetology. 2013; 12:76-82
Tan Y, Huang W, Chen F, Li J, Zhou J, Wang L, Chen L,?Zhu HL*.?n‐3 polyunsaturated fatty acids enhance the antitumor effect of 5‐fluorouracil by inhibiting bcl‐2 and mutant‐p53.?European Journal of Lipid Science and Technology. 2013..115(12), 1483-1491
Xie H, Wu B, Xue W, He M, Fan F, Ouyang W, Tu S,?Zhu HL*, Chen Y.Greater intake of fruit and vegetables is associated with a lower risk of osteoporotic hip fractures in elderly Chinese: a 1: 1 matched case–control study.?Osteoporosis International. 2013:2827-2836.
Zeng F, Wu B, Fan F, Xie H, Xue W,?Zhu HL*, Chen Y. Dietary patterns and the risk of hip fractures in elderly Chinese: A matched case-control study.?J Clin Endocrino Metab. 2013;98(6):2347-2355.
Wang J, Luo X, Xu B, Wei J, Zhang Z, Zhu HL*. Elevated oxidative damage in kitchen workers in Chinese restaurants. J Occup Health. 2011;53(5):327-3
Wang L, Zhang Z, Chang Y, Wang X, Hou M, Wei J, Ling W, Zhu HL*. Comparison of dietary habits between migrant and local adolescents in Shenzhen, China.?Asia Pac J Clin Nutr. 2011;20(4):624-631.
Du Y, Peng J, Sun A, Tang Z, Ling W, Zhu HL*. Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model.?BMC Cancer. 2009;9(1):261-270.
Lv S, Fan R, Du Y, Hou M, Tang Z, Ling W,?Zhu HL*.Betaine supplementation attenuates atherosclerotic lesion in apolipoprotein E-deficient mice. Eur J Nutr 2009;48:205-212.
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研究生培养及人才招聘
1. 营养与食品卫生学（硕士与博士）
2. 公共卫生硕士（MPH）
3. 博士后
4. 特聘研究员和副研究员

获奖情况
广东省科技进步奖二等奖（2020年，排名第1）
中国营养学会科学技术奖二等奖（2019年，排名第1）
华夏医学科技奖三等奖（2019年，排名第1）
中国营养学会百名英才-全国营养行业先进工作者（2015年）
广东省南粤教坛新秀（2000年）