基本情况姓名：徐亮
性别：男
出生年月：1985-10
籍贯：湖北黄冈
职位：教授，博士生导师
教育经历2003年9月?2007年6月，武汉大学，本科，化学基地班
2007年9月?2012年6月，武汉大学，博士，有机化学
工作经历2012年7月?2017年3月，加州大学圣地亚哥分校药学院，博士后
2017年3月?至今，中山大学化学学院，教授，博士生导师
科研方向核酸化学生物学，围绕核酸修饰展开，主要研究内容包括：
(1) 核酸修饰对转录响应等生物学过程的分子机制研究；
(2) 发展针对核酸修饰的化学工具，以调控和监测核酸修饰的转化和功能；
(3) 利用修饰核酸研究核酸结合蛋白的作用机制并发展基因调控的化学工具
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论著一览?
??Liang Xu, Wei Wang, Jiabin Wu, Ji Hyun Shin, Pengcheng Wang, Ilona Christy Unarta, Jenny Chong, Yinsheng Wang*, and Dong Wang*. Mechanism of DNA alkylation-induced transcriptional stalling, lesion bypass, and mutagenesis.?Proc. Natl. Acad. Sci.,?2017,?114, E7082–E7091. (*Co-corresponding authors.)
??Wei Wang#,?Liang Xu#, Lulu Hu, Jenny Chong, Chuan He, and Dong Wang* Epigenetic DNA Modification N6?Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing.?J. Am. Chem. Soc.?2017,?139, 14436-14442. (#Co-first authors.)
??Liang Xu#, Wei Wang#, Deanna Gotte, Fei Yang, Alissa A. Hare, Timothy R. Welch, Benjamin C. Li, Ji Hyun Shin, Jenny Chong, Jeffrey N. Strathern*, Peter B. Dervan*, and Dong Wang*. RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif.?Proc. Natl. Acad. Sci., 2016, 113, 12426-12431.?
??Lin-Tai Da#, Fatima Pardo#,?Liang Xu#, Daniel-Adriano Silva, Lu Zhang, Xin Gao, Dong Wang*, and Xuhui Huang*.?Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue.?Nature Commun., 2016,?7, 11244.
??Candy Hwang#,?Liang Xu#, Wei Wang, Sébastien Ulrich, Lu Zhang, Jenny Chong, Ji Hyun Shin, Xuhui Huang, Eric Kool, Charles McKenna*, and Dong Wang*. Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution.?Nucleic Acids Res.?2016,?44, 3820-3828.
??Lanfeng Wang#, Yu Zhou#,?Liang Xu#, Rui Xiao#, Xingyu Lu, Liang Chen, Jenny Chong, Hairi Li, Chuan He, Xiang-Dong Fu*, and Dong Wang*. Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex.?Nature, 2015,?523, 621-625.
??Liang Xu, Wei Wang, Lu Zhang, Jenny Chong, Xuhui Huang and Dong Wang*.?Impact of template backbone heterogeneity on RNA polymerase II transcription.?Nucleic Acids Res.?2015, 43, 2232-2241.
??Liang Xu, Ying-Chu Chen, Jenny Chong, Andrea Fin, Lisa S. McCoy, Jun Xu, Chao Zhang, and Dong Wang*. Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation.?Angew. Chem. Int. Ed.?2014,?53,?11223-11227.
??Liang Xu, Lu Zhang, Jenny Chong, Jun Xu, Xuhui Huang, and Dong Wang*. Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.?Proc. Natl. Acad. Sci.?2014,?111,?E3269-76.
??Liang Xu, Kyle Vincent Butler, Jenny Chong, Jesper Wengel, Eric T. Kool*?and Dong Wang*. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.?Nucleic Acids Res.?2014,?42, 5863-5870.
??Liang Xu, Ying-Chu Chen, Satoshi Nakajima, Jenny Chong, Lanfeng Wang, Li Lan, Chao Zhang*, and Dong Wang*. A chemical probe targets DNA 5-formylcytosine sites and inhibits TDG excision, polymerases bypass, and gene expression.?Chem. Sci.?2014,?5, 567-574.
??Liang Xu#, Steven W. Plouffe#, Jenny Chong, Jesper Wengel, and Dong Wang*. A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids.?Angew. Chem. Int. Ed.?2013,?52, 12341-12345.