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中山大学珠海校区化学工程与技术学院导师教师师资介绍简介-宋化灿

本站小编 Free考研考试/2021-05-15

教授
副教授
研究员
博士后
历任教师



宋化灿?[教授]
基本情况
宋化灿(Hua-Can Song),男,博士、教授,有机化学专业博士生导师。
E-mail: yjhxhc@mail.sysu.edu.cn
国籍:中国? 出生地:山东? 出生日期:1959年4月? 职业:博士、教授
毕业院校:山东大学(本科)、中山大学(博士)
代表作品:《物理有机化学》
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联系方式
邮箱:yjhxhc@mail.sysu.edu.cn
通讯地址:广东省珠海市唐家湾中山大学珠海校区中山大学化学工程与技术学院
邮编:519082
教育经历
1978年2月-1982年1月,山东大学化学系有机化学专业,本科;
1993年9月-1996年7月,中山大学化学系有机化学专业,博士。
工作经历
1996年6月中山大学有机化学专业博士毕业留校任教至今,先后任讲师、副教授、教授。先后于1998和1999年赴美国Brigham Young University和2001—2002年赴台湾大学做博士后研究各一年。主讲过《有机化学》、《有机分析》、《有机化学实验》、《物理有机化学》等课程。公开发表研究论文60余篇。
1982年1月—1993年8月,郑州轻工业学院化工系任教;
1996年7月—1998年8月,中山大学化学系,副教授;
1998年9月—1999年8月,美国Brigham Young University,博士后;
1999年8月—2001年9月,中山大学化学院,副教授;
2001年9月—2002年8月,台湾大学化学系,博士后;
2002年8月—2004年3月,中山大学化学院,副教授;
2004年4月—2016年2月,中山大学化学院,教授,博士生导师。
2016年2月—至今,中山大学化学工程与技术学院,教授,博士生导师。
学术任职
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讲授课程
《物理有机化学》(本科生,36学时);?
《物理有机化学》(研究生,60学时)。
科研方向
药物设计与合成,有机光电材料设计与合成
科研项目
1. 广东省科技厅重点引导项目(2004B**)。
2、顺德科技局产学研结合项目“水基喷柒产品技术的研究与应用”,2007-2009;
3、广东省教育部产学研结合项目“高性能氯化聚丙烯改性树脂的研发” 2009-2010;
4、广东省教育部产学研结合项目“低硫低碳制革工艺和助剂的研究开发”,2010-2011;
5、广东中烟公司项目“主要烟用香料转移行为对卷烟品质的影响及其应用研究” 2009-2011;
6、广东省科技计划重点项目“广东凉茶的数字化质量控制技术研究”,2011-2012;
7、长江生命科技国际有限公司项目(香港)“用于抗癌药物活性测试的化合物的合成”,2010-2012;
8、广东省科技计划重点项目“环保型有机硅表面活性剂关键技术开发及产业化”,2013-2016;
9、惠州大亚湾科技局重点项目“高效、环保新型光引发剂推广应用关键技术的研发”,2012-2015。
获奖情况
暂无内容。
论著一览
《物理有机化学》英柏宁、宋化灿,化学工业出版社,2010年。
相关成果
1. 1-(1-Arylethylidene)Thiosemicarbazide derivatives: A new class of tyrosinase inhibitors,?Bioorganic and Medicinal Chemistry, 2008, 1096;
2. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives,?Bioorganic & Medicinal Chemistry Letters, 2008, 6558;
3. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives,?European Journal Medicinal Chemistry,2008, 533;
4. Synthesis and biological evaluation of helicid analoguesas novel acetylcholinester as einhibitors,?European Journal Medicinal Chemistry, 2008, 166;
5. The synthesis and preliminary optical study of 1-alkyl-2,4,5-triphenylimidazole derivatives,?Dyes and Pigments, 2008, 17;
6. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors,?Bioorganic & Medicinal Chemistry Letters, 2008, 6490;
7. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds,?European Journal Medicinal Chemistry, 2009, 1773;
8. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,?European Journal Medicinal Chemistry, 2009, 1737;
9. Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors,?Bioorganic & Medicinal Chemistry Letters, 2009, 6157;
10.Synthesis and biological evaluation of novel4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors,?European Journal of Medicinal Chemistry, 2009, 1737;
11. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors,?Bioorganic & Medicinal Chemistry Letters, 2009, 4055;
12. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities,?European Journal of Medicinal Chemistry, 2009, 4235;
13. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives,?European Journal of Medicinal Chemistry, 2009, 1737;
14. Synthesis and optical behaviors of 2-(9-phenanthrenyl)-, 2-(9-anthryl)-, and 2-(1-pyrenyl)-1-alkylimidazole homologues,?Spectrochimica Acta Part A, 2009, 233;
15. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants,?Food Chemistry, 2009, 381;
16. Synthesis of 4-[(diethylamino)methyl]phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyryl cholinesterase,?Bioorganic & Medicinal Chemistry Letters,2010, 3254;
17. Synthesis and cytotoxic evaluation of ?N-benzylatedquaternary b-carboline amino acid ester conjugates,?European Journal of Medicinal Chemistry, 2010, 1515;
18. Synthesis and preliminary optical study of 1,3,4-oxadiazole derivatives containing imidazole units,?Dyes and Pigments, 2010, 249;
19. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity,?Bioorganic & Medicinal Chemistry Letters, 2010, 3876;
20. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents,?European Journal of Medicinal Chemistry, 2010,2503;
21. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives,?European Journal of Medicinal Chemistry, 2010, 4740;
22. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines,?European Journal of Medicinal Chemistry, 2010, 5513;
23.Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors,?European Journal of Medicinal Chemistry, 2010, 639;
24. α-Glucosidase and α-amylase inhibitory activities of guava leaves,?Food Chemistry, 2010, 6;
25. Design, synthesis and biological evaluation of 3-(4-halophenyl)-3-oxopropanal and their derivatives as novel antibacterial agents,?Chem. Pharm. Bull. 2010, 1127;
26. Rational design and synthesis of 4-O-substituted phenylmethylene thiosemi- carbazones as novel tyrosinase inhibitors,?Chem. Pharm. Bull. 2010, 752;
27. ?Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors,?Chem. Pharm. Bull. 2010, 1216;
28. Synthesis and biological evaluation of novelB-Carbolines as potent cytotoxic and DNA intercalatingagents,Chem. Pharm. Bull. 2010, 901;
29. Synthesis and cytotoxicity of A-homo-lactam derivatives of cholic acid and 7-deoxycholic acid, Steriods, 2011, 76,690;
30. Synthesis and cytotoxicity of 17a-aza-D-homo-androster-17-one derivatives, Bioorganic & Medicinal Chemistry Letters, 2011, 21,3641;
31. Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase, European Journal of Medicinal Chemistry, 2011, 46, 4330;
32. Synthesis and biological evaluation of 1,9-disubstituted b-carbolines as potent DNA intercalating and cytotoxic agents, European Journal of Medicinal Chemistry, 2011, 46, 5127;
33. Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines, European Journal of Medicinal Chemistry, 2013, 60, 10;
34. Synthesis and Neuroprotective Action of Xyloketal Derivatives in Parkinson’s Disease Models,?Marine Drugs?2013,?11, 5159;
35. Design, Synthesis and Evaluation of N13-SubstitutedEvodiamine Derivatives against Human Cancer Cell Lines,?Molecules?2013,?18, 15750;
36. Rational design, synthesis and structure–activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23, 924;
37. Structure-based modification of 3-/4-aminoacetophenones giving a profound change of activity on tyrosinase: From potent activators to highly efficient inhibitors, European Journal of Medicinal Chemistry, 2015, 93, 255;
38. Rh(III)-catalyzed and alcohol-involved carbenoid C–H insertion into N-phenoxyacetamides using a-diazomalonates, Chemcal Communication, 2015, 51, 5868;
39. A new and efficient ZnCl2-catalyzed synthesis and biological evaluation of novel 2-amino-3,5-dicyano-4-aryl-6-arylaminopyridines as potent antibacterial agents against Helicobacter pylori (HP), Tetrahedron, 2015, 71, 8628.
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