教授
副教授
研究员
博士后
历任教师



胡文浩（兼）?[教授]
?
基本情况
姓名：胡文浩
性别：男
籍贯：
职位：
联系方式
联系电话：?
传真：
邮箱：huwh9@mail.sysu.edu.cn?
地址：广东省广州市广州大学城外环东路132号中山大学药学院
教育经历
1995-1998年：香港理工大学应用生物及化学科技学系????????????????????? ? ?博士学位
1987-1990年：中国科学院成都有机化学研究所??????????????????????????????????? ?硕士学位
1983-1987年：四川大学化学系?? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ???? ?学士学位
工作经历
2016.08-至今：中山大学药学院教授；中山大学药学院院长；
2006-2016：华东师范大学化学系教授；上海市高校“****”?****（2009-）；华东师范大学小分子药物研究所所长（2010-2011）；上海分子治疗与新药创制工程技术研究中心主任（2011-2016）；
2003-2006年：美国施贵宝制药公司，高级研究员（制药工艺），美国新泽西；
2002-2003年：美国GeneSoft制药公司，研究员（药物化学），美国旧金山；
1998-2001年：美国亚利桑那大学化学系博士后；
1993-1998年：中国科学院成都有机化学研究所先后任实习研究员（1990），助理研究员（1993），副研究员（1997）。不对称合成联合开放实验室副主任（1992），课题组长（1992），其间公派到香港理工大学攻读博士学位。
学术任职
上海市药物化学专门委员会委员
化学学报编委
化学快报编委
中国化学会手性化学专业委员会委员
讲授课程
暂无资料
科研方向
暂无资料
科研项目
暂无资料
获奖情况
2016年国务院特殊津贴专家；
2015年国家百千****才工程人选，有突出贡献中青年专家；
2014年?教育部“****”?****；
2011年?国家****基金获得者；
2010年?教育部自然科学二等奖；
2010年?Asian Core Program Lectureship Award；
2009年?上海市高校“****”****；
2009年?“上海市优秀学科带头人”；
2008年?Thieme Chemistry Journal Award；?
2007年?上海市“浦江计划”；
2006年?上海市“曙光****”；?
2005年?“四川省学术和技术带头人”；
2002年?四川省科学技术进步一等奖；?
2000年?中国科学院“****”入选者；?
1994年?四川省科学技术进步二等奖。
论著一览
发表研究论文152篇?
代表性论文
1. Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and?Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun.?2015, 6, 5801.
2. Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and?Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed.?2014, 53, 13136-13139.
3. Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and?Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed.?2013, 125, 13598-13602.
4. Shikun Jia, Dong Xing, Dan Zhang, and?Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed.?2014, 53, 13098-13101.
5. Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and?Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed.?2013, 52, 9289-9292.
6. Xin Guo, and?Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Res.?2013, 46, 2427-2440.
7. Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and?Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed.?2013, 52, 1539-1542.
8. Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and?Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nature Chem.?2012, 4, 733-739.
9. Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and?Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc.?2011, 133, 8428-8431.
10. Xiaoyu Guan, Liping Yang, and?Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed.?2010, 49, 2190-2192.
11. Xu Zhang, Haoxi Huang, Xin Guo, Xiaoyu Guan, Liping Yang, and?Wenhao Hu*, Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh-II/Zr-IV-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes, Angew. Chem. Int. Ed.?2008, 47, 6647–6649.
12.?Wenhao Hu*, Xinfang Xu, Jing Zhou, Wei-Jun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liu-Zhu Gong*, Cooperative Catalysis with Chiral Br?nsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, J. Am. Chem. Soc.?2008, 130, 7782-7783.
13. Haoxi Huang, Xin Guo, and?Wenhao Hu*, Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters, Angew. Chem. Int. Ed.?2007, 46, 1337-1339.
14. Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu,?Wenhao Hu*, and Yushe Yang*, Design, Synthesis, and Structure-Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility, J. Med. Chem.?2014, 57, 3687-3706.
15. Brendan Frett, Robert V. Brown, Mingliang Ma,?Wenhao Hu, Haiyong Han, and Hong-yu Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem.?2014, 57, 5835-5844.
16. Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao,** Fengping Lv, Liping Yang, Yushe Yang,** andWenhao Hu*, Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria, Eur. J. Med. Chem.?2014, 86, 133-152.
17. Wei Shi, Haikun Ma, Yuejiao Duan, Kelly Aubart, Yuhong Fang, Rimma Zonis, Liping Yang,?Wenhao Hu*, Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett.?2011, 21, 1060-1063.
18. Wei Shi, Yuejiao Duan, Yu Qian, Ming Li, Liping Yang, and?Wenhao Hu*, Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett.?2010, 20, 3592-3595.
其他论文（详见附件页）
·参与撰写的专著
1.?
《Multicomponent Reactions in Organic Synthesis》
2.?
3.?
《实用有机合成工艺研发手册》
4.?
5.?
《有机化学学科前沿与展望》
6.?
7.?
《高速发展的中国化学》
8.?
9.?
《不对称催化反应进展》
10.?
?
附件页:论文清单
2016年
1. Jian-Bei Xi, Ming-Liang Ma, and?Wenhao Hu*, Rh2(OAc)4 and InCl3 co-catalyzed diastereoselective trapping of carbamate ammonium ylides with aldehydes for the synthesis of β-hydroxyl-α-amino acid derivatives, Tetrahedron?2016, 72, 579-583.
2. Mingfeng Li, Xin Guo, Weifeng Jin,Qing Zheng, Shunying Liu,* and?Wenhao Hu*, Enantioselective Three-component Reaction of Diazoacetates with Indoles and Enals by Iridium/Iminium Co-catalysis, Chem. Commun.?2016, 52, 2736-2739.
3. Jiuwei Che, Dong Xing,* and?Wenhao Hu*, Metal-Catalyzed Cross-Coupling of Terminal Alkynes with Different Carbene Precursors, Current Organic Chemistry,?2016, 20, 41-60.
4. Min Tang, Yong Wu, Yuan Liu, Maoqiang Cai, Fei Xia, Shunying Liu,* and?Wenhao Hu*, One-pot Enantioselective Multi-component Cascade Reactions for Synthesis of Chiral Functionalized Hydro-epoxyisochromenes: A Rapid Access to Molecular Complexity, Acta Chim. Sinica?2016, 74, DOI: 10.6023/A**.
2015年
5. Changcheng Jing, Dong Xing,* Lixin Gao, Jia Li, and?Wenhao Hu*, Divergent Synthesis of Multisubstituted Tetrahydrofurans and Pyrrolidines via Intramolecular Aldol-type Trapping of Onium Ylide Intermediates, Chem. Eur. J.?2015, 21, 19202-19207.
6. Catalytic Asymmetric Four-Component Reaction for the Rapid Construction of 3,3'-Disubstituted 3-Indol-3'-yloxindoles, Changcheng Jing, Dong Xing,* and?Wenhao Hu*, Org. Lett.?2015, 17, 4336-4339.
7. Taoda Shi, Xin Guo, Shenghan Teng, and?Wenhao Hu*, Pd(II)-catalyzed formal [4+1] cycloaddition reactions of diazoacetates and aryl propargyl alcohols to form 2,5-dihydrofurans, Chem Commun.?2015, 51, 5204-5207.
8. Dan Zhang, Jun Zhou, Fei Xia, Zhenghui Kang, and?Wenhao Hu*, Bond cleavage, fragment modification and reassembly in enantioselective three-component reactions, Nat Commun.?2015, 6, 5801.
9. Fengping Lv , Zhi-fang Li,?Wenhao Hu*, and Xiaohua Wu*, Small molecules enhance functional O-mannosylation of α-dystroglycan, Bioorg. Med. Chem.?2015, 23, 7661-7670.
10. Divergent Synthesis of Chiral Heterocycles via Sequencing of Enantioselective Three-Component Reactions and One-Pot Subsequent Cyclizations, Min Tang, Dong Xing,* Haoxi Huang, and?Wenhao Hu*, Chem Commun.?2015, 51, 10612-10615.
11. Changcheng Jing, Dong Xing,* Chengjin Wang, and?Wenhao Hu*, Synthesis of 3-(hydroxymethyl)-3-indol-3'-yloxindoles via Rh(II)-catalyzed three-component reaction of 3-diazooxindoles, indoles and formalin, Tetrahedron?2015, 71, 3597-3602.
2014年
12. Min Tang, Dong Xing, Maoqiang Cai, and?Wenhao Hu*, Diazo Compounds-Involved Catalytic Asymmetric Multicomponent Reactions, Chin. J. Org. Chem.?2014, 34, 1268-1276.
13. Changwei Zhai, Dong Xing, Yu Qian, Jingjing Ji, Chaoqun Ma, and?Wenhao Hu*, Trapping of Carboxylic Oxonium Ylides with N-Boc Imines for the Facile Synthesis of β-Amino Alcohol Derivatives, Synlett?2014, 25, 1745-1750.
14. Changcheng Jing; Dong Xing, Yu Qian, and?Wenhao Hu*, Rh2(OAc)4 and Chiral Phosphoric Acid Cocatalyzed Highly Diastereo- and Enantioselective Four-Component Reactions: Facile Synthesis of Chiral α,β-Diamino Acid Derivatives, Synthesis-Stuttgart?2014, 46, 1348-1354.
15. Xufeng Cao, Zhaoshuan Sun, Yongbing Cao, Ruilian Wang, Tongkai Cai, Wenjing Chu,?Wenhao Hu*, and Yushe Yang*, Design, Synthesis, and Structure-Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility, J. Med. Chem.?2014, 57, 3687-3706.
16. Changwei Zhai, Dong Xing*, Changcheng Jing, Jun Zhou, Chengjin Wang, Dongwei Wang, and?Wenhao Hu*, Facile Synthesis of 3Aryloxindoles via Br?nsted Acid Catalyzed Friedel?Crafts Alkylation of Electron-Rich Arenes with 3Diazooxindoles, Org. Lett.?2014, 16, 2934-2937.
17. Hua-Dong Xu,* Mao-Qiang Cai, Wei-Jie He,?Wen-Hao Hu?and Mei-Hua Shen*, Interception of benzyne with thioethers: a facile access to sulfur ylides under mild conditions, RSC Adv.?2014, 4, 7623-7626.
18. Dong Xing, and?Wenhao Hu*, Recent advances in metal carbenoid mediated nitrogen-containing zwitterionic intermediate trapping process, Tetrahedron Lett.?2014, 55, 777-783.
19. Shikun Jia, Dong Xing, Dan Zhang, and?Wenhao Hu*, Catalytic Asymmetric Functionalization of Aromatic C-H Bonds by Electrophilic Trapping of Metal-Carbene-Induced Zwitterionic Intermediates, Angew. Chem. Int. Ed.?2014, 53, 13098-13101.
20. Jun Zhou, Liping Yang, and?Wenhao Hu*, Stereoselective Synthesis of a Sulfated Tetrasaccharide Corresponding to a Rare Sequence in the Galactofucan Isolated from Sargassum polycystum, J. Org. Chem.2014, 79, 4718-4726.
21. Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao,** Fengping Lv, Liping Yang, Yushe Yang,** andWenhao Hu*, Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria, Eur. J. Med. Chem.?2014, 86, 133-152.
22. Chengjin Wang, Dong Xing,* Dongwei Wang, Xiang Wu, and?Wenhao Hu*,Synthesis of 3Amino-3-hydroxymethyloxindoles and 3Hydroxy-3-hydroxymethyloxindoles by Rh2(OAc)4Catalyzed Three-Component Reactions of Diazooxindoles with Formaldehyde and Anilines or Water, J. Org. Chem.?2014, 79, 3908-3916.
23. Brendan Frett, Robert V. Brown, Mingliang Ma,?Wenhao Hu, Haiyong Han, and Hong-yu Li*, Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition, J. Med. Chem.?2014, 57, 5835-5844.
24. Lin Qiu, Lixin Gao, Jixing Tang, Dongwei Wang, Xin Guo, Shunying Liu *, Liping Yang, Jia Li,?Wenhao Hu*, Regio- and Diastereoselective Construction of α-Hydroxyl-δ-Amino Esters Derivatives via 1,4-Conjugate Addition of β,γ-Unsaturated N-Sulfonyl Imines, J. Org. Chem.,?2014, 79, 4142-4147.
25. Xin Guo, Wei Liu, and?Wenhao Hu*, A Facile Access to Polyfunctional Oxygen-containing Heterocycles via Intramolecularly Formed Protic Oxonium Ylide Trapping Processes, Chem. Asian J.?2014, 9, 117-120.
26. Changcheng Jing, Dong Xing, and?Wenhao Hu*, Highly diastereoselective synthesis of 3-hydroxy-2,2,3-trisubstituted indolines via intramolecular trapping of ammonium ylides with ketones, Chem. Commun.?2014, 50, 951-953.
27. Jun Jiang, Xiaochu Ma, Changge Ji, Zhengqiu Guo, Taodao Shi, Shunying Liu*, and?Wenhao Hu*, Ruthenium(II)/Chiral Br?nsted Acid Co-Catalyzed Enantioselective Four-Component Reaction/Cascade Aza-Michael Addition for Efficient Construction of 1,3,4-Tetrasubstituted Tetrahydroisoquinolines, Eur. Chem. J.?2014, 20, 1505-1509.
28. Yi Ni, Xin Guo,?Wenhao Hu, and Shunying Liu*, Asymmetric N-H Insertion Reaction of α-Diazoesters and Carbamates through Co-catalyzed by Dirhodium Acetate, Sufonic Acid and Chiral Sul-fonamide Urea, Chin. J. Org. Chem.?2014, 34, 107-111.
29. Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu,* Fei Xia, and?Wenhao Hu*, An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three-Component Reaction through Trapping of Rhodium(I)-Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed.?2014, 53, 13136-13136.
30. Lin Qiu, Xin Guo, Chaoqun Ma, Huang Qiu, Shunying Liu,* Liping Yang and?Wenhao Hu*. Efficient synthesis of chiral cyclic acetals by metal and Br?nsted acid co-catalyzed enantioselective four-component cascade reactions, Chem. Commun.?2014, 50, 2196-2198.
31. Lin Qiu, Dongwei Wang, Fengping Lv, Xin Guo,?Wenhao Hu, Liping Yang, and Shunyin Liu*, Three-component reactions based on trapping ammonium ylides with N-sulfonyl aldimines via cooperative catalysis of squaramides and Rh2(OAc)4, Tetrahedron?2014, 70, 1471-1477.
32. Xin Guo, Wei Liu, and?Wenhao Hu*, A Facile Access to Polyfunctional Oxygen-containing Heterocycles via Intramolecularly Formed Protic Oxonium Ylide Trapping Processes, Chem. Asian J.?2014, 9, 117-120.
2013年
33. Dan Zhang, Huang Qiu, Liqin Jiang,* Fengping Lv, Chaoqun Ma, and?Wenhao Hu*,. Enantioselective Palladium(II) Phosphate Catalyzed Three-Component Reactions of Pyrrole, Diazoesters, and Imines. Angew. Chem. Int. Ed.?2013, 125, 13598-13602.
34. Chaoqun Ma, Dong Xing,* Changwei Zhai, Jiuwei Che, Shunying Liu, Jue Wang, and?Wenhao Hu*, Iron Porphyrin-Catalyzed Three-Component Reaction of Ethyl Diazoacetate with Aliphatic Amines and β,γ-Unsaturated α-Keto Esters, Org. Lett.?2013, 15, 6140-6143.
35. Chengjin Wang, Shunying Liu*; Dong Xing, Xin Wang, Xiang Wu, and?Wenhao Hu*, Efficient synthesis of α-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde, Tetrahedron?2013, 69, 11203-11208. Lin Qiu, Xin Guo, Jun Zhou, Shunying Liu*; Liping Yang, Xiang Wu, and?Wenhao Hu*, A stereoselective synthesis of fully substituted tetrahydrofurans through 1,3-dipolar cycloaddition with cinnamaldehydes: an easy access to chroman derivatives, RSC Adv.?2013, 3, 20065-20070.
36. Liqin Jiang, Dan Zhang, Zhongqing Wang, and?Wenhao Hu*, Highly Enantioselective Three-Component Reactions of tert-Butyl Diazoacetate with Arylamines and Imines: An Efficient Synthesis of α,β-Bis(arylamino) Acid Derivatives, Synthesis-Stuttgart,?2013, 45, 452-458.
37. Fengping Lv, Shunying Liu, and?Wenhao Hu*, Recent Advances in the Use of Chiral Br?nsted Acids as Cooperative Catalysts in Cascade and Multicomponent Reactions, Asian J. Org. Chem.?2013, 2, 824-836.
38. Yu Qian, Peter Y. Zavalij,?Wenhao Hu*, and M. P. Doyle*, Bicyclic Pyrazolidinone Derivatives from Diastereoselective Catalytic [3+3]-Cycloaddition Reactions of Enoldiazoacetates with Azomethine Imines, Org. Lett.?2013, 15, 1564-1567.?
39. Hua-Dong Xu,* Ren-Wei Zhang, Xiaoxun Li, Suyu Huang, Weiping Tang, and?Wen-Hao Hu*, Rhodium-Catalyzed Chemo- and Regioselective Cross-Dimerization of Two Terminal Alkynes, Org. Lett.?2013, 15, 840-843.
40. Xinfang Xu, Peter Y. Zavalij,?Wenhao Hu, and Michael P. Doyle*, Vinylogous Reactivity of Enol Diazoacetates with Donor-Acceptor Substituted Hydrazones. Synthesis of Substituted Pyrazole Derivatives, J. Org. Chem.?2013, 78, 1583-1588.
41. Manas M. Sarmah, Dipak Prajapati,* and?Wenhao Hu, Synthesis of Novel and Complex Tetrahydroquinazolinedione and Dihydropyrido[2,3-d]pyrimidine Derivatives via a One-Pot [4+2]-Cycloadddition Strategy, Synlett?2013, 4, 471-474.
42. Manas M. Sarmah, Rupam Sarma, Dipak Prajapati,* and?Wenhao Hu, Efficient synthesis of dihydropyrido[4,3-d]pyrimidines by microwave-promoted three-component aza-Diels-Alder reaction. Tetrahedron Lett.?2013, 54, 267-271.
43. Xin Guo, and?Wenhao Hu*, Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles, Acc. Chem. Soc.?2013, 46, 2427-2440.
44. Changcheng Jing, Dong Xing, Yu Qian, Taoda Shi, Yun Zhao, and?Wenhao Hu*, Diversity-Oriented Three-Component Reactions of Diazo Compounds with Anilines and 4-Oxo-Enoates. Angew. Chem. Int. Ed.?2013, 52, 9289-9292.
45. Dong Xing,* Changcheng Jing, Xinfeng Li, Huang Qiu, and?Wenhao Hu*, Highly Efficient Synthesis of Mixed 3,3-Bisindoles via Rh(II)-Catalyzed Three-Component Reaction of 3-Diazooxindoles with Indoles and Ethyl Glyoxylate, Org. Lett.?2013, 15, 3578-3581.
46. Changcheng Jing, Taoda Shi, Dong Xing, Xin Guo, and?Wen-Hao Hu*, CuSO4 catalyzed three-component reaction of α-diazo ester, water and isatin: an efficient and green approach to oxindole derivatives. Green Chem.?2013, 15, 620-624.
47. Jun Jiang, Xiaochu Ma, Shunying Liu, Yu Qian, Fengping Lv, Lin Qiu, and?Wenhao Hu*, Enantioselective Trapping of Phosphoramidate Ammonium Ylides with Imino Esters for Synthesis of 2,3-Diaminosuccinic Acid Derivatives, Chem. Commun.?2013, 49, 4238-4240.
48. Yu Qian, Changcheng Jing, Shunying Liu, and?Wenhao Hu*, A Highly Enantioselective Four-Component Reaction for the Efficient Construction of Chiral ?-Hydroxy-α-Amino Acid Derivatives, Chem. Commun.?2013, 49, 2700-2702.
49. Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and?Wenhao Hu*, Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols, Angew. Chem. Int. Ed.?2013, 52, 1539-1542.
2012年
50. Huang Qiu, Dan Zhang, Shun-ying Liu, Lin Qiu, Jun Zhou, Yu Qian, Chang-wei Zhai,?Wen-hao Hu*, Asymmetric C-H functionalization of indoles via enantioselective protonation, Acta Chim. Sinica?2012, 70, 2484-2488. ?
51. Huang Qiu, Ming Li, Li-Qin Jiang, Feng-Ping Lv, Li Zan, Chang-Wei Zhai, Michael P. Doyle, and?Wen-Hao Hu*, Highly enantioselective trapping of zwitterionic intermediates by imines, Nature Chem.?2012, 4, 733-739.
52. Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij,?Wenhao Hu, and Michael P. Doyle*, Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways, Angew. Chem. Int. Ed.?2012, 51, 5900-5903.
53. Yu Qian, Changcheng Jing, Changwei Zhai, and?Wen-hao Hu*, A Novel Method for Synthesizing N-Alkoxycarbonyl Aryl α-Imino Esters and Their Applications in Enantioselective Transformations, Adv. Synth. Catal.?2012, 354, 301-307.
54. Xinfang Xu, Peter Y. Zavalij,?Wenhao Hu, and Michael P. Doyle*, Efficient synthesis of oxazoles by dirhodium(II)-catalyzed reactions of styryl diazoacetate with oximes, Chem. Commun.?2012, 48, 11522-11524.
55. Jingjing Ji, Xia Zhang, Liqing Jiang, and?Wenhao Hu*, InBr catalyzed three-component reactions of an aryldiazoacetate, an alcohol, and a carbonyl compound, Tetrahedron Lett.?2012,53,182-185.
56. Xia Zhang, Jingjing Ji, Yingguang Zhu, Changcheng Jing, Ming Li, and?Wenhao Hu*, Highly diastereoselective three-component tandem 1,4-conjugated addition/cyclization reaction to multisubstituted pyrrol, Org. Biomol.Chem.?2012, 10, 2133-2138.
57. Ming Li, Li Zan, Dipak Prajapatib, and?Wenhao Hu*, Rhodium(II) catalyzed diastereoselective reactions of diazoacetamides with isatins: an efficient approach to 3-hydroxy-3,3′-bioxindoles, Org. Biomol. Chem.2012, 10, 8808-8813.
58. Xiao-na Chen,?Wen-hao Hu, Xiao-Liu Li and Hua-dong Xu, Synthesis of β-Diazo-α-ketoamides and their cyclopropanation reaction with alkenes, Chin. J. Syn Chem.?2012, 20, 19-22.?
59. Ying-Guang Zhu, Hong-Zhu Kan, Li-Qin Jiang, and?Wen-Hao Hu*, Practical and Scalable Synthesis of Ethyl (R)-Piperidine-3-acetate, Syn. Commun.?2012, 42, 1137-1145.
60. Yu Qian, Xinfang Xu, Xiaochen Wang, Peter J. Zavalij,?Wenhao Hu, and Michael P. Doyle*, Rhodium(II)- and Copper(II)-Catalyzed Reactions of Enol Diazoacetates with Nitrones: Metal Carbene versus Lewis Acid Directed Pathways, Angew. Chem. Int. Ed.?2012, 51, 5900-5903.
2011年
61. Xinfang Xu,?Wen-Hao Hu, and Michael P. Doyle*, Highly Enantioselective Catalytic Synthesis of Functionalized ChiralDiazoacetoacetates, Angew. Chem. Int. Ed.?2011, 50, 6392-6395.
62. Jun Jiang, Hua-Dong Xu, Jian-Bei Xi, Bai-Yan Ren, Feng-Ping Lv, Xin Guo, Li-Qin Jiang, Zhi-Yong Zhang, and?Wenhao Hu*, Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines, J. Am. Chem. Soc.?2011, 133, 8428-8431.
63. Xinfang Xu,?Wen-Hao Hu*, Peter Y. Zavalij, and Michael P. Doyle*, Divergent Outcomes of Carbene Transfer Reactions from Dirhodiumand Copper-Based Catalysts Separately or in Combination, Angew. Chem. Int. Ed.?2011, 50, 11152-11155.
64. Yu Qian, Changcheng Jing, Taoda Shi, Jingjing Ji, Min Tang, Jing Zhou, Changwei Zhai, and?Wenhao Hu*, Dual Catalysiisn Highly Enantioselectiv Multicomponent Reactionw with Water:A n Efficient Approach to Chiral β-Amino-α-Hydroxy acid Derivative, ChemCatChem?2011, 3, 653-656.
65. Jingjing Ji, Xia Zhang, Yingguang Zhu, Yu Qian, Jing Zhou, Liping Yang, and?Wenhao Hu*, Diastereoselectivity Switch in Cooperatively Catalyzed Three-Component Reactions of an Aryldiazoacetate, an Alcohol, and a β,γ-Unsaturated α-Keto Ester, J. Org. Chem.?2011, 76, 5821-5824.
66. Wei Shi, Haikun Ma, Yuejiao Duan, Kelly Aubart, Yuhong Fang, Rimma Zonis, Liping Yang,?Wenhao Hu*, Design, synthesis and antibacterial activity of 3-methylenepyrrolidine formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett.?2011, 21, 1060-1063.
67. Xingchun Han, Liqing Jiang, Min Tang, and?Wenhao Hu*, Diastereoselective three-component reactions of aryldiazoacetates with alcohols/water and alkynals: application to substituted enelactones, Org. Biomol. Chem.?2011, 9, 3839-3843.
68. Xingchun Han, Minghua Gan, Huang Qiu, Jingjing Ji, Xia Zhang, Liqing Jiang, and?Wenhao Hu*, Trapping of Oxonium Ylides with Michael Acceptors: Highly Diastereoselective Three-Component Reactions of Diazo Compounds with Alcohols and Benzylidene Meldrum's Acid/4-Oxo-enoate, Synlett?2011, 1717-1722.
69.?Wenhao Hu*, Jing Zhou, Xinfang Xu, Weijun Liu, and Liuzhu Gong*, (R)-33'-Bis(9-phenanthryl)-1,1'-binaphthalene-2,2'-diylhydrogen Phosphate, Org. Synth.?2011, 88, 406-417.
70. Jing Zhou, Xinfang Xu, and?Wenhao Hu*, Enantioselective three-component reaction for the preparation of β-amino-α-hydroxy esters, Org. Synth.?2011, 88, 418-426.
2010年
71. Qinyao Xu, Jianghui Yu and?Wenhao Hu*, Liping Yang, A New Route for the Preparation of Orlistat, Chinese Journal of Organic Chemistry,?2010, 30, 1175-1179.
72. Yu Qian, Xinfang Xu, Liqin Jiang, Dipak Prajapati, and?Wenhao Hu*, A Strategy to Synthesize Taxol Side Chain and (-)-epi Cytoxazone via Chiral Br?nsted Acid-Rh2(OAc)4 Co-catalyzed Enantioselective Three-Component Reactions, J. Org. Chem.?2010, 75, 7483-7486.
73. Yingguang Zhu, Changwei Zhai, and?Wenhao Hu*, Asymmetric Multicomponent Reactions, Progress in Chemistry,?2010, 22, 1380-1396.
74. Xiaoyu Guan, Liping Yang, and?Wenhao Hu*, Cooperative Catalysis in Multicomponent Reactions: Highly Enantioselective Synthesis of γ-Hydroxyketones with a Quaternary Carbon Stereocenter, Angew. Chem. Int. Ed.?2010, 49, 2190-2192.
75. Yingguang Zhu, Changwei Zhai, Liping Yang, and?Wenhao Hu*, Copper(II)-catalyzed highly diastereoselective three-component reactions of aryl diazoacetates with alcohols and chalcones: an easy access to furan derivatives, Chem. Commun.?2010, 46, 2865-2867.
76. Wei Shi, Yuejiao Duan, Yu Qian, Ming Li, Liping Yang, and?Wenhao Hu*, Design, synthesis, and antibacterial activity of 2,5-dihydropyrrole formyl hydroxyamino derivatives as novel peptide deformylase inhibitors, Bioorg. Med. Chem. Lett.?2010, 20, 3592-3595.
77. Zhenqiu Guo, Mei Cai, Jun Jiang, Liping Yang, and?Wenhao Hu*, Rh2(OAc)4-AgOTf Cooperative Catalysis in Cyclization/Three-Component Reactions for Concise Synthesis of 1,2-Dihydroisoquinolines, Org. Lett.?2010, 12, 652-655.
78. Xin Guo, Jingjing Wang, Liping Yang, and?Wenhao Hu*, Rh(II) Catalyzed Three-Component Reactions of Diazoacetates with Benzenemethanol and Indane-1,2,3-Triones, Lett. Org. Chem.?2010, 7, 106-109.
2009年
79. Zhenqiu Guo, Taoda Shi, Jun Jiang, Liping Yang, and?Wenhao Hu*, Component match in rhodium catalyzed three-component reactions of ethyl diazoacetate, H2O and aryl imines: a highly diastereoselective one-step synthesis of β-aryl isoserine derivatives, Org. Biomol. Chem.?2009, 7, 5028-5033.
80. Xinfang Xu, Xingchun Han, Liping Yang,* and?Wenhao Hu*, Highly Diastereoselective Synthesis of Fully Substituted Tetrahydrofurans by a One-Pot Cascade Reaction of Aryldiazoacetates with Allyl Alcohols, Chem-Eur. J.?2009, 15, 12604-12607.
81. Xiao-Yu Guan, Zhang-Qin Liu, Hao-Xi Huang, Li-Ping Yang, Liao Jian,* and?Wen-Hao Hu*, Novel C-S Bond Formation Through α’,β-Elimination of tert-Butyl Sulfoxonium Ylides: A Facile Approach to Chiral Sulfoxides, Synlett.?2009, 13, 2183-2187.
82. Dongyin Dong, Liping Yang, and?Wenhao Hu*, Organic Reactions with Carbon Dioxide, Prog. Chem.?2009, 6, 1217-1228.
83. Xu Zhang, Xin Guo, Liping Yang, and Wenhao Hu*, Rh(II) and Zn(II) co-catalyzed multi-component reaction for the synthesis of vicinal diols, Chinese Chem. Lett.?2009, 20, 1299-1302.
84. Xu Zhang, Na Zhang, Xin Guo, Liping Yang, and?Wenhao Hu*, Rhodium(II) catalyzed multi-component reactions of aryldiazoacetates with titanium(IV) isopropoxide and imines, Tetrahedron?2009, 39, 8277-8282.
85. Xin Guo, Yongli Yue, Guoliang Hu, Jing Zhou, Yiqing Zhao, Liping Yang, and?Wenhao Hu*, Trapping of an Ammonium Ylide with Activated Ketones: Synthesis of β-Hydroxy-α-Amino Esters with Adjacent Quaternary Stereocenters, Synlett?2009, 13, 2109-2144.
2008年
86. Xu Zhang, Haoxi Huang, Xin Guo, Xiaoyu Guan, Liping Yang, and?Wenhao Hu*, Catalytic enantioselective trapping of an alcoholic oxonium ylide with aldehydes: Rh-II/Zr-IV-co-catalyzed three-component reactions of aryl diazoacetates, benzyl alcohol, and aldehydes, Angew. Chem. Int. Ed.?2008, 47, 6647–6649.
87.?Wenhao Hu*, Xinfang Xu, Jing Zhou, Wei-Jun Liu, Haoxi Huang, Juan Hu, Liping Yang, and Liu-Zhu Gong*, Cooperative Catalysis with Chiral Br?nsted Acid-Rh2(OAc)4: Highly Enantioselective Three-Component Reactions of Diazo Compounds with Alcohols and Imines, J. Am. Chem. Soc.?2008, 130, 7782-7783.
88. Yongli Yue, Xin Guo, Zhiyong Chen, Liping Yang, and?Wenhao Hu*, Copper(?) hexafluorophosphate: a dual functional catalyst for three-component reactions of methyl phenyldiazoacetate with alcohols and aldehydes or α-ketoesters, Tetrahedron Letters.?2008, 49, 6862-6865.
89. Xinfang Xu, Jing Zhou, Liping Yang, and?Wenhao Hu*, Selectivity control in enantioselective four-component reactions of aryl diazoacetates with alcohols, aldehydes and amines: an efficient approach to synthesizing chiral β-amino-α-hydroxyesters, Chem. Commun.?2008, 44, 6564-6566.
2007年
90. Haoxi Huang, and?Wenhao Hu*, An efficient route for the construction of cyclopenta[b]quinoline derivatives via intramolecular cyclopropanation, Tetrahedron?2007, 63, 11850-11855.
91. Haoxi Huang, Xin Guo, and?Wenhao Hu*, Efficient Trapping of Oxonium Ylides with Imines: A Highly Diastereoselective Three-Component Reaction for the Synthesis of β-Amino-α-hydroxyesters with Quaternary Stereocenters, Angew. Chem. Int. Ed.?2007, 46, 1337-1339.
92. Yongli Yue, Huayuan Wang, and?Wenhao Hu*, Regioselectivity in Lewis acids catalyzed X-H (O, S, N) insertions of methyl styryldiazoacetate with benzyl alcohol, benzyl thiol, and aniline, Tetrahedron Lett.?2007, 48, 3975-3977.
93. Haoxi Huang, and?Wenhao Hu*, Rhodium-catalyzed reaction of diazoacetates, thiols and azodicarboxylates: An unusual 1,2-aza shift from a sulfonium ylide, Synlett?2007, 8, 1314 -1316.
94. Xin Guo, Haoxi Huang, Liping Yang, and?Wenhao Hu*, Trapping of Oxonium Ylide with Isatins:? Efficient and Stereoselective Construction of Adjacent Quaternary Carbon Centers, Org. Lett.?2007, 9, 4721-4723.
2006年
95. Zhenqiu Guo, Haoxi Huang, Hingyuan Hu, and?Wenhao Hu*, Facile synthesis of aryl α-keto esters via the reaction of aryl diazoacetate with H2O and DEAD, Synlett 2006, 15, 2486-2488.
2005年
96. Haoxi Huang, Yuanhua Wang, Zhiyong Chen, and?Wen-Hao Hu*, A Novel Synthesis of Aryl α-Imino Esters from Aryl Diazoacetate., Synlett?2005, 16, 2498-2500.
97. Wei-Jun Liu, Zhen-Liang Chen, Zhi-Yong Chen, and?Wen-Hao Hu*, Dirhodium catalyzed intramolecular enantioselective C–H insertion reaction of N-cumyl-N-(2-p-anisylethyl) diazoacetamide: synthesis of (-)-Rolipram. Tetrahedron: Asymmetry?2005, 16, 1693-1698.
98. Zhi-Cheng Li, Zhi-Yong Chen,?Wen-Hao Hu*, and Xiao-Qi Yu*, Rh(II) Catalyzed Aziridination of Diazobenzylphosphonate with Arylimines, Acta Chimica Sinica?2005, 12, 1136-1140.
99. Zhi-Cheng Li, Ji Zhang, and?Wen-Hao Hu*, Zhi-Yong Chen, and Xiao-Qi Yu*, Rhodium Acetate-Mediated Epoxidation from the Reaction of Diazobenzyl-phosphonates with Aldehydes and a Ketone: A Convenient and Highly Stereoselective Synthetic Method of cis-1,2-Epoxypropylphosphonates, Synlett?2005, 11, 1711-1715.
100. Haoxi Huang, Yuanhua Wang, Zhiyong Chen, and?Wenhao Hu*, Rhodium-Catalyzed, Three-Component Reaction of Diazo Compounds with Amines and Azodicarboxylates, Adv. Synth. Catal.?2005, 347, 531-534.
101. Chong-Dao Lu, Hui Liu, Zhi-Yong Chen,?Wen-Hao Hu*, and Ai-Qiao Mi*, The rhodium catalyzed three-component reaction of diazoacetates, titanium(IV) alkoxides and aldehydes. Chem. Commun.?2005, 2624-2626.
102. Zhenliang Chen, Zhiyong Chen, Yaozhong Jiang, and?Wenhao Hu*, The synthesis of baclofen and GABOB via Rh(II) catalyzed intramolecular C–H insertion of α-diazoacetamides. Tetrahedron,?2005, 61, 1579–1586.
103. Chong-Dao Lu, Hui Liu, Zhi-Yong Chen,?Wen-Hao Hu*, and Ai-Qiao Mi. Three-Component Reaction of Aryl Diazoacetates, Alcohols, and Aldehydes (or Imines):? Evidence of Alcoholic Oxonium Ylide Intermediates, Org. Lett.?2005, 7, 83-86.
104. Yan-Xin Zhu, Yuan-Hua Wang, Zhi-Yong Chen, and?Wen-Hao Hu*, Unexpected Side Reaction in the Intermolecular N-H Insertion of Phenyl Diazoacetates with Arylamines. Chinese Chem. Lett.?2005, 16, 307-310.
2004年
105. Chong-Dao Lu, Zhi-Yong Chen, Hui Liu,?Wen-Hao Hu*, and Ai-Qiao Mi, A Facile Three-Component One-Pot Synthesis of Structurally Constrained Tetrahydrofurans That Are t-RNA Synthetase Inhibitor Analogues, J. Org. Chem.?2004, 69, 4856-4859.
106. Zhenliang Chen, Zhiyong Chen, Yaozhong Jiang, and?Wenhao Hu*, Cumyl: A Better N-Protecting Group of α-Diazo Acetamides for Intra-molecular C-H Insertion Reaction and its Application in the Synthesis of Pregabalin and 3-Benzyloxy Pyrrolidine, Synlett?2004, 10, 1763-1764.
107. Zhenjun Du, Zhenliang Chen, Zhiyong Chen, Xiaoqi Yu, and?Wenhao Hu*, Dirhodium-catalyzed enantioselective C–H insertion of N-(2-benzyloxyethyl)-N-(tert-butyl)diazoacetamide and its application for the synthesis of chiral GABOB, Chirality?2004, 16, 516-519.
108. Roland W. Bürli, Dustin McMinn, Jacob A. Kaizerman,?Wenhao Hu, Yigong Ge, Quinn Pack, Vernon Jiang, Matthew Gross, Martin Garcia, Richard Tanaka, and Heinz E. Moser*, DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives, Bioorg. Med. Chem. Lett.?2004, 14, 1253-1257.
109.?Wenhao Hu, Roland W. Bürli, Jacob A. Kaizerman, Kirk W. Johnson, Matthew I. Gross, Mari Iwamoto, Peter Jones, Denene Lofland, Stacey Difuntorum, Hsiu Chen, Bülent Bozdogan, Peter C. Appelbaum, and Heinz E. Moser*, DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus, J. Med. Chem.?2004, 47, 4352-4355.
110. Roland W. Burli, Jacob A. Kaizerman, Jian-Xin Duan, Peter Jones, Kirk W. Johnson, Mari Iwamoto, Kiet Truong,?Wenhao Hu, Timothy Stanton, Alfred Chen, Sofia Touami, MatthewGross, Vernon Jiang, Yigong Ge, and Heinz E. Moser*, DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids. Bioorg. Med. Chem. Lett.?2004, 14, 2067-2072.
111. Chong-Dao Lu, Zhi-Yong Chen, Hui Liu,?Wen-Hao Hu*, and Ai-Qiao Mi, Highly Chemoselective 2,4,5-Triaryl-1,3-dioxolane Formation from Intermolecular 1,3-Dipolar Addition of Carbonyl Ylide with Aryl Aldehydes. Org. Lett.?2004, 6, 3071-3074.
112. Marcela Valenzuela, Michael P. Doyle,* Christine Hedberg,?Wenhao Hu, and Alexandra Holmstrom, Influence of the Diene in the Hetero-Diels-Alder Reaction Catalyzed by Dirhodium(II) Carboxamidates, Synlett?2004, 13, 2425-2428.
113. Yuanhua Wang, Zhiyong Chen, Aiqiao Mi, and?Wenhao Hu*, Novel C–C bond formation through addition of ammonium ylides to arylaldehydes: a facile approach to β-aryl-β-hydroxy α-amino acid frameworks. Chem. Commun.?2004, 2486-2487.
114. Ming Yan, Neil Jacobsen,?Wenhao Hu, Luisa S. Gronenberg, Michael P. Doyle,* John T. Colyer, and Darren Bykowski, Stereoselective Synthesis of Bicyclic Pyrrolidines by a Rhodium-Catalyzed Cascade Process, Angew. Chem. Int. Ed.?2004, 43, 6713-6716.
2003年
115. Zhenliang Chen, Zhiyong Chen, Yaozhong Jiang, and?Wenhao Hu*, A Concise Synthesis of Gabapentin via Intramolecular C-H Insertion Reaction. Synlett?2003, 13, 1965-1966.
116. Yuanhua Wang, Yanxin Zhu, Zhiyong Chen, Aiqiao Mi,?Wenhao Hu*, and Michael P. Doyle*, A Novel Three-Component Reaction Catalyzed by Dirhodium(II) Acetate:? Decomposition of Phenyldiazoacetate with Arylamine and Imine for Highly Diastereoselective Synthesis of 1,2-Diamines, Org. Lett.?2003, 5, 3923-3926.
117. Michael P. Doyle,*?Wenhao Hu, and Thomas M. Weathers Jr. Comparative enantiocontrol with allyl phenyldiazoacetates in asymmetric catalytic intramolecular cyclopropanation, Chirality?2003, 15, 369-373.
118. Jacob A. Kaizerman, Matthew I. Gross, Yigong Ge, Sarah White,?Wenhao Hu, Jian-Xin Duan, Eldon E. Baird, Kirk W. Johnson, Richard D. Tanaka, Heinz E. Moser, and Roland W. Bürli*, DNA Binding Ligands Targeting Drug-Resistant Bacteria:? Structure, Activity, and Pharmacology, J. Med. Chem.?2003, 46, 3914-3929.
119. Michael P. Doyle,* and?Wenhao Hu, Enantioselectivity for catalytic cyclopropanation with diazomalonates, ARKIVOC?2003, 7, 15-22.
120. Michael P. Doyle,* Ming Yan,?Wenhao Hu, and Luisa S. Gronenberg, Highly Selective Catalyst-Directed Pathways to Dihydropyrroles from Vinyldiazoacetates and Imines, J. Am. Chem. Soc.?2003, 125, 4692-4693.
2002年
121. Michael P. Doyle,* and?Wenhao Hu, Enantioselective carbon--hydrogen insertion is an effective and efficient methodology for the synthesis of (R)-(-)-baclofen, Chirality?2002, 14, 169-172.
122.?Wenhao Hu, Daren J. Timmons, and Michael P. Doyle*, In Search of High Stereocontrol for the Construction of cis-Disubstituted Cyclopropane Compounds. Total Synthesis of a Cyclopropane-Configured Urea-PETT Analogue That Is a HIV-1 Reverse Transcriptase Inhibitor. Org. Lett.?2002, 4, 901-904.
123. Michael P. Doyle,*?Wenhao Hu, and Marcela V. Valenzuela, Total Synthesis of (S)-(+)-Imperanene, Effective Use of Regio- and Enantioselective Intramolecular Carbon?Hydrogen Insertion Reactions Catalyzed by Chiral Dirhodium(II) Carboxamidates. J. Org. Chem.?2002, 67, 2954-2959.
2001年
124. Michael P. Doyle,* Iain M. Phillips, and?Wenhao Hu, A New Class of Chiral Lewis Acid Catalysts for Highly Enantioselective Hetero-Diels-Alder Reactions: Exceptionally High Turnover Numbers from Dirhodium(II) Carboxamidates, J. Am. Chem. Soc.?2001, 123, 5366-5367.
125. Michael P. Doyle,* and?Wenhao Hu, A New Enantioselective Synthesis of Milnacipran and an Analogue by Catalytic Asymmetric Cyclopropanation, Adv. Synth. Catal.?2001, 343, 299-302.
126. Michael P. Doyle,* and?Wen-Hao Hu, Enantiocontrol in Macrocycle Formation from Catalytic Metal Carbene Transformations, Chin. J. Chem.?2001, 19, 22-29.
127. Michael P. Doyle*,?Wenhao Hu, and Daren J. Timmons, Epoxides and Aziridines from Diazoacetates via Ylide Intermediates, Org. Lett.?2001, 3, 933-935.
128. Michael P. Doyle,*?Wenhao Hu, and Daren J. Timmons, Highly Stereoselective Syntheses of Five- and Seven-Membered Ring Heterocycles from Ylides Generated by Catalytic Reactions of Styryldiazoacetates with Aldehydes and Imines. Org. Lett.?2001, 3, 3741-3744.
129. Michael P. Doyle,* and?Wenhao Hu, Macrocycle formation from catalytic metal carbene transformations, Synlett?2001, 9, 1364-1370.
130. Michael P. Doyl,*?Wenhao Hu, Iain M. Phillips, Christopher J. Moody, Adrian G. Pepper, ?and Alexandra M. Z. Slawinc, Reactivity Enhancement for Chiral Dirhodium(II) Tetrakis(Carboxamidates), Adv. Synth. Catal.?2001, 343, 112-117.
2000年
131. Michael P. Doyle,*?Wenhao Hu, and Iain M. Phillips, A New Approach to Macrocyclization via Alkene Formation in Catalytic Diazo Decomposition: Synthesis of Patulolides A and B, Org. Lett.?2000, 2, 1777-1779.
132. Michael P. Doyle,* Simon B. Davies, and?Wenhao Hu, Dirhodium(II) Tetrakis[methyl 2-oxaazetidine-4-carboxylate]:? A Chiral Dirhodium(II) Carboxamidate of Exceptional Reactivity and Selectivity, Org. Lett.2000, 2, 1145-1147.
133. Michael P. Doyle,*?Wenhao Hu, Brant Chapman, Alan B. Marnett, Chad S. Peterson, Justin P. Vitale, and Sarah A. Stanley, Enantiocontrolled Macrocycle Formation by Catalytic Intramolecular Cyclopropanation, J. Am. Chem. Soc.?2000, 122, 5718-5728.
134. Michael P. Doyle,* Simon B. Davies, and?Wenhao Hu, Optimization of enantiocontrol in cis-selective cyclopropanation reactions catalyzed by dirhodium(II) tetrakis[alkyl 2-oxaazetidine-4(S)-carboxylates], Chem. Commun.?2000, 867-868.
135. Michael P. Doyle,* and?Wenhao Hu, Reactivities and selectivities in macrocyclic addition reactions with diazoacetates using copper(I) and rhodium(II) catalysts, Tetrahedron Lett.?2000, 41, 6265-6269.
136. Michael P. Doyle,* and?Wenhao Hu, Selectivity in Reactions of Allyl Diazoacetates as a Function of Catalyst and Ring Size from γ-Lactones to Macrocyclic Lactones, J. Org. Chem.?2000, 65, 8839-8847.
137.?Wenhao Hu, Ming Yan, Chak-Po Lau, S. M. Yang, Albert S. C. Chan,* Yaozhong Jiang, and Aiqiao Mi, A Highly Effective Rhodium Spirocyclic Phosphinite Catalyst for the Asymmetric Hydrogenation of Enamides, Tetrahedron Lett.?2000, 41, 973-976.
1999年
138. Michael P. Doyl,* Brant J. Chapman,?Wenhao Hu, Chad S. Peterson, M. Anthony McKervey, and Concepción F. Garcia, Catalytic Intramolecular Addition of Metal Carbenes to Remote Furans, Org. Lett.?1999, 1, 1327-1329.
139. Qing-hua Fan, Chang-yu Ren, Chi-hung Yeung,?Wen-hao Hu, and Albert S. C. Chan*, Highly Effective Soluble Polymer-Supported Catalysts for Asymmetric Hydrogenation, J. Am. Chem. Soc.?1999, 121, 7407-7408.
1998年
140. Aiqiao Mi, Rongliang Lou, Yaozhong Jiang, Jingen Deng, Yong Qin, Fangmin Fu, Zhi Li,?Wenhao Hu, and Albert S. C Chan*, Novel Chiral Aminophosphine Phosphinite Ligand and Its Application in Homogenous Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Derivatives, Synlett.?1998, 8, 847-848.
141. Xiao-Ming Feng, Liu-Zhu Gong,?Wen-Hao Hu, Zhi Li, Wei-Dong Pan, Ai-Qiao Mi, and Yao-Zhong Jiang, Chiral Schiff Base Ti(OR)4 Complexes Catalyzed Asymmetric Trimethylsilylcyanation of Aldehydes, Chem. J. Chinese U.?1998, 19, 1416-1421.
142.?Wenhao Hu, Chih-Chiang Chen, Guoping Xue, and Albert S. C. Chan*, Synthesis of (?)-(4R,5R)-4,5-bis[di-3′-(2′,6′-dimethoxypyridyl)phosphinomethyl]-2,2-dimethyl-1,3-dioxolane and its application in the Rh-catalyzed asymmetric hydrogenation reactions, Tetrahedron-Asymmetry,?1998, 9, 3241-3246.
143. Yao-Zhong Jiang,* Minga Yan, Jian Sun,?Wen-Hao Hu, Zhi Li, Ai-Qiao Mi, and Albert S. C. Chan, Chinese Journal of Chemistry?1998, 16, 258-263.
1997年
144. Albert S. C. Chan,*?Wenhao Hu, Cheng-Chao Pai, and Chak-Po Lau, Yaozhong Jiang,* Aiqiao Mi, Ming Yan, Jian Sun, Rongliang Lou, and Jingen Deng, Novel Spiro Phosphinite Ligands and Their Application in Homogeneous Catalytic Hydrogenation Reactions, J. Am. Chem. Soc.?1997, 119, 9570-9571.
145. Yaozhong Jiang, Liuzhu Gong, Xiaoming Feng,?Wenhao Hu, Weidong Pan, Zhi Li, and Aiqiao Mi, Salen-Ti(OR)4 complex catalysed trimethylsilylcyanation of aldehydes, Tetrahedron?1997, 53, 14327-14338.
1996年
146. Weidong Pan, Xiaoming Feng, Liuzhu Gong,?Wenhao Hu, Zhi Li, Aiqiao Mi, and Yaozong Jiang, Chiral salen-titanium complexes-efficient catalysts for asymmetric trimethyl silylcyanation of benzaldehyde, Synlett.?1996, 6, 337-338.
147. Tay-Yuan Chau, Hsaio-Chi Lin, and?Wenhao Hu, Complete Diastereofacial Selective Cycloaddition of New Sulfinyl Dienophiles (Ss)- and (Rs)-(-)Menthyl α-(2-Methoxyphenylsulfoxyl)acylate with Anthracene Under Chelation Control, Synthetic Commun.?1996, 26, 1867-1874.
1995年
148. Yaozhong Jiang, Xiangge Zhou,?Wenhao Hu, Lanjun Wu, and Aiqiao Mi, Asymmetric catalytic trimethylsilylcyanation of benzaldehyde by novel Ti(IV)-chiral schiff base complexes, Tetrahedron-Asymmetry?1995, 6, 405-408
149. Albert S. C. Chan, Chi-Ching Lin, Jian Sun,?Wenhao Hu, Zhi Li, Weidong Pan, Aiqiao Mi, Yaozhong JiangTsang-Miao Huang, Teng-Kuei Yang, Jyh-Horung Chen, Yu Wang, and ?Gene-Hsiang Lee, Synthesis of spiro[4.4]nonane-1,6-diols via the hydrogenation of spiro[4.4]nonane-1,6-dione: the profound effect of hydrogenating agents, Tetrahedron-Asymmetry?1995, 6, 2953-2959.
?1994年
150. Guilan Liu,?Wenhao Hu, Yuzi Ma, Yaozhong Jiang, and Teng-Kuei Yang, Asymmetric Oxidative Coupling Reaction of Imine Carbanions via (+)-Camphor Chiral Template, Synthetic Commun.?1994, 24, 3115-3122.
1991年
151. Yaozhong Jiang,?Wenhao Hu, Jingen Deng, and Liuzhu Gong, TiCl(Oipr)3-promoted asymetric coupling reaction of D-camphor ketamine anion, Synthetic Commun.?1991, 21, 1755-1761.
1990年
152. Yaozhong Jiang, Jingen Deng, Wenhao Hu, Liuzhu Gong, and Aiqiao Mi, stereoselective synthesis of α-alkyl-2-furfurylamines via D-camphor ketamine intermediate, Synthetic Commun.?1990, 20, 3077-3083.
相关成果
·发表专利
?申请国内外发明专利103余项，其中有32项专利已获授权。
代表性授权专利
1.?胡文浩，江俊，管晓渝，郭鑫，马晓初，刘顺英；一种多取代茚醇衍生物的制备方法；专利号：ZL1.1。
2.?胡文浩，昝力，厉铭，黄海峰，周静，张霞，杨琍苹；一种3，3'-二取代-3-羟基双吲哚酮衍生物及其制备方法和应用；专利号：ZL7.0。
3.?胡文浩，石炜，段月娇，钱宇，厉铭，杨琍苹；含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法；专利号：ZL6.9。正在申请国际专利?PCT/CN2010/000268，已授权。
4.?胡文浩，徐新芳，郭新，邱林，周静，杨琍苹；一种合成多芳基取代噁唑烷的方法；专利号：ZL2.0。
5.?胡文浩，史滔达，郭震球，杨琍苹；一种制备α-羟基-β-氨基丙酸乙酯衍生物的方法；专利号：ZL 7.X。
6.?胡文浩，朱映光，翟昌伟，岳永力，杨琍苹；一种二氢吡咯衍生物的制备方法；专利号：ZL2.X。
代表性申请专利
1.?胡文浩，翟昌伟，马超群，荆常诚，邢栋；一种螺[吡咯啉基-3,2’-氧化吲哚]衍生物及其合成方法和应用；申请号：8.3。
2.?胡文浩，马明亮，席间备，吕思莹，王文科，章雄文，方艳芬；一种咪唑并吡啶骨架结构的新化合物的合成及应用；申请号：5.2。
3.?胡文浩，周俊，张丹，邢栋，刘顺英；?硫酸化岩藻-半乳四糖及其制备方法和应用；申请号：3.4。
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