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中山大学深圳校区生物医学工程学院导师教师师资介绍简介-林旭东

本站小编 Free考研考试/2021-05-15


一、主要经历
2019.03-现在: 中山大学,生物医学工程,“****”副教授/硕导
2017.05-2019.02:香港城市大学,生物医学工程系,博士后
2013.03-2017.04:香港城市大学,生物医学工程系,博士
2008.09-2012.07:中山大学,微电子学,学士
二、学科方向
围绕生物医学传感器以及微纳芯片研制,将之应用于解决生物医学领域疾病诊断和治疗的难题
智能生物医学传感:开发基于微纳结构的生物医学传感技术,实现对复杂神经递质释放的快速,高灵敏度和高特异性的监测以及相关脑部疾病诊断;
高通量药物筛选系统:基于微流控技术和超快光学成像技术,设计开发高通量活体生物(斑马鱼)传感技术和平台,并结合人工智能技术进行靶向药物的精准筛选;
神经调控器件:基于多功能纳米材料,针对神经活动的体外/体内远程调控,用于脑科学研究以及脑疾治疗(比如深脑刺激)。
三、科研项目
1. 中国自然科学基金青年科学基金项目,“基于人工智能与大脑活动图谱的新型高通量药物筛选研究”,2020-2022(主持)。
2. 中山大学****启动基金项目,2019-2022 (主持)。
3. 中国自然科学基金面上项目,“基于金刚石纳米阵列的小分子核糖核酸检测技术及其在高通量原位分析神经细胞异质性的应用”,2019-2022(参与)。
2. 深圳市科技创新委员会基础研究学科布局项目,“基于高通量全脑活动图谱映射的脑疾病药物筛选研究”,2019-2021(参与)。
3. 深圳市科技创新委员会基础研究自由探索项目,“基于纳米上转换技术的无线光遗传学调控系统的研究与应用”, 2018-2019(参与)。
四、论著发明
代表性论文:
1. Xudong Lin, Xin Duan, Claire Jacobs, Jeremy Ullmann, Chung-Yuen Chan, Siya Chen, Shuk-Han Cheng, Wen-Ning Zhao, Annapurna Poduri, Xin Wang*, Stephen J. Haggarty* & Peng Shi*. “High-throughput brain activity mapping and machine learning as foundation for systems neuropharmacology”, Nature Communications, 9(1), 5142, (2018). (IF: 12.353)
2. Xudong Lin, Xian Chen, Wenchong Zhang, Qinghai Liao, Peilin Fang, Xi Chen, Jufang He, Ming Liu,Feng Wang*, Peng Shi*. “Core–Shell–Shell Upconversion Nanoparticles with Enhanced Emission for Wireless Optogenetic Inhibition”, Nano Letters, 18 (2), pp 948–956 (2018). (IF: 12.08)
3. Ying Wang, Xudong Lin, Xi Chen, Xian Chen, Zhen Xu, Wenchong Zhang, Qinghai Liao, Xin Duan, Xin Wang, Ming Liu, Feng Wang, Jufang He, Peng Shi*. “Tetherless Near-infrared Control of Brain Activity in Behaving Animals Using Fully Implantable Upconversion Microdevices”, Biomaterials, 142, 136-148 (2017, Co-first). (IF: 10.273)
其他论文
1. Kai Xie, Naixiang Wang, Xudong Lin, Zixun Wang, Xi Zhao, Peiling Fang, Haibing Yue, Junhwi Kim, Jing Luo, Shaoyang Cui, Feng Yan*, Peng Shi*. “Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo”, Elife, e50345, (2020). (IF: 7.551)
2. Chong Wang, Haibing Yue, Wei Huang, Xudong Lin, Xiaoqiong Xie, Zhi He, Xiao He, Sanbiao Liu, Lu Bai Bingheng Lu, Yen Wei, Min Wang*. “Cryogenic 3D printing of heterogeneous scaffolds with gradient mechanical strengths and spatial delivery of osteogenic peptide/TGF-β1 for osteochondral tissue regeneration”, Biofabrication, 12(2), (2020, co-first). (IF: 7.236)
3. Lu, Haojian, Yuanyuan Yang, Xudong Lin, Peng Shi, and Yajing Shen. "Low-Invasive Cell Injection based on Rotational Microrobot." Advanced Biosystems, ** (2019).
4. Xudong Lin, Ying Wang, Xian Chen, Runhuai Yang, Zixun Wang, Jingyu Feng, Haitao Wang, King W. C. Lai, Jufang He, Feng Wang*, Peng Shi*. “Multiplexed Optogenetic Stimulation of Neurons with Spectrum-Selective Upconversion Nanoparticles”, Advanced Healthcare Materials, 6(17): **(2017). (IF: 6.27)
5. Xudong Lin, Shiqi Wang, Xudong Yu, Zhuguo Liu, Fei Wang, Wai Tsun Li, Shuk Han Cheng, Qiuyun Dai, and Peng Shi*. “High-throughput Mapping of Brain-wide Activity in Awake and Drug-responsive Vertebrates”, Lab on a Chip, 15(3):680-9 (2015). (IF: 6.914)
6. Xudong Lin, Vincent W. T. Li, Siya Chen, Chung-Yuen Chan, Shuk-Han Cheng, and P. Shi*. “Autonomous system for cross-organ investigation of ethanol-induced acute response in behaving larval zebrafish”, Biomicrofluidics, 10, 024123 (2016). (IF: 2.535)
7. Xu Bingzhe, Lin Xudong, Li Wei, Wang Zixun, Zhang Wenchong, Shi Peng*. “Cell Generator: A Self-sustaining Bio-hybrid System Based on Energy Harvesting from Engineered Cardiac Micro-tissues”, Advanced Functional Materials, ** (2017). (IF: 13.325)
8. Ma Lili, Lin Xudong, Li Cai, Xu Zoufeng, Chan Chun-Yin, Tse Man-Kit, Shi Peng, Zhu Guangyu*. "A Cancer Cell-Selective and Low-Toxic Bifunctional Heterodinuclear Pt (IV)-Ru (II) Anticancer Prodrug." Inorganic chemistry, 57(5), 2917-2924 (2018). (IF: 4.700)
9. Wei Li, Zhen Xu, Bingzhe Xu, Chung Yuen Chan, Xudong Lin, Ying Wang, Ganchao Chen, Zhigang Wang, Qiuju Yuan, Guangyu Zhu, Hongyan Sun, Wutian Wu, and Peng Shi*. “Investigation of the Subcellular Neurotoxicity of Amyloid-β Using a Device Integrating Microfluidic Perfusion and Chemotactic Guidance”, Advanced Healthcare Materials, ** (2017). (IF: 5.110)
10. Yu Gao, Chon U Chan, Qiushi Gu, Xudong Lin, Wencong Zhang, Chen Loong Yeo, Astrid Marlies Alsema, Manish Arora, Seow Khoon Chong, Peng Shi, Claus-Dieter Ohl and Chenjie Xu. “Controlled nanoparticle release from stable magnetic microbubble oscillations”, NPG Asia Materials, 8, e260 (2016). (IF: 7.208)
11. Wei Li, Rongcong Luo, Amol D. jadhav, Zicong Zhang, Xudong Lin, Li Yan, Xianfeng Chen, Jufang He, Chia-Hung Chen, P. Shi*, “Remote Modulation of Neural Activities via Near-infrared Triggered Release of Biomolecules”, Biomaterials, 65: 76-85 (2015). (IF: 8.806)
12 Jinfeng Zhang, Yu-Chuan Liang, Xudong Lin, Xiaoyue Zhu, Li Yan, Shengliang Li, Xia Yang, Guangyu Zhu, Andrey L. Rogach, Peter K. N. Yu, Peng Shi, Lung-Chen Tu, Chia-Ching Chang, Xiaohong Zhang, Xianfeng Chen, O Wenjun Zhang, and Chun-Sing Lee*. “Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo”, ACS Nano, 9(10), 9741-9756 (2015). (IF: 13.709)
13. Qiang Ju, Xian Chen, Fujin Ai, Dengfeng Peng, Xudong Lin, Wei Kong, Peng Shi, Guangyu Zhu and Feng Wang. “An upconversion nanoprobe operating in the first biological window”, J. Mater. Chem. B, 3, 3548-3555 (2015). (IF: 4.776)
14. Wei Li, Zhen Xu, Xudong. Lin, Rongcong Luo, Chia-Hung Chen, Peng Shi*, “NeuroArray: A Universal Interface for Patterning and Interrogating Neural Circuitry with Single Cell Resolution”, Scientific Reports, 4:4784 (2014). (IF: 4.122)
授权专利
1. US Patent Application, No. 14/705,128 (381); Systems and Methods for Automated Handling of Live Organisms.
2. US Patent Application, No. 15/695,372; Wireless Optogenetic Device and Associated Radiation System.
3. US Patent Application, No. 16/127,471; A method and a system for analyzing neuropharmacology of a drug.
五、主讲课程
《生物医学传感器》
六、联系方式
1、地址:广东省广州市中山大学(大学城)工学院B523室
2、邮箱:linxd37@mail.sysu.edu.cn;linxud@hotmail.com;


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