许宝山
副研究员 博士生导师


导师简介

中山大学“****二期”引进人才
[学位/学历]
理学学士 (中国农业大学生物学院，生物科学)
理学博士（中国农业大学生物学院，生理学，师从夏国良教授）
[学术简历]
2008-2011年，博士后研究员，美国路易斯安那州立大学健康科学中心 ?
2011-2016年，资深博士后研究员，美国斯托沃斯医学研究所 ? ?
2016年12月起，副研究员，博士生导师，中山大学****引进人才。中山大学光华口腔医学院?附属口腔医院，中山大学口腔医学研究所，广东省口腔医学重点实验室
本人综合运用Ribosome profiling、Droplet digital PCR和分子生物学、发育和细胞生物学、生物化学等一系列技术手段，围绕着人类口腔重要疾病的基础医学机制开展了一系列开拓性研究，分别在口腔颅颌面遗传性疾病和发育畸形的分子机制和治疗靶点、核糖体DNA拷贝数变异决定口腔癌症化疗敏感性、哺乳动物雷帕霉素靶蛋白mTOR信号通路在肿瘤治疗中的作用机制等方面取得了显著的成果。相关工作发表在Proc Natl Acad Sci U S A、Cell Reports、PLoS Genetics、Human Molecular Genetics、Carcinogenesis、Free Radical Biology and Medicine、Laboratory Investigation等重要期刊上。根据科学引文索引（SCI-EXPANDED）数据库的最新文献检索报告，至今共发表SCI研究论文31篇（IF≥6分的论文7篇），论文影响因子总和为135.33分，累计他引次数589次；其中申报人以第一（含并列）作者发表研究论文13篇（IF≥5分的论文5篇），累计影响因子52.093分，累计他引次数313次，单篇第一作者论文他引次数最高90次，H指数为17。由于本人在口腔疾病研究中获得的突出成果，至今在国际学术研讨会上受邀进行会议报告4次。同时，申报人以独立PI身份主持美国Cornelia de Lange Syndrome (CdLS) Foundation科研基金1项，以项目组第二完成人身份承担美国Cornelia de Lange Syndrome (CdLS) Foundation和March of dimes (MOD) Foundation科研基金2项。
[研究方向]
1.颅颌面部组织发育畸形与缺损的修复和重建研究，主要围绕口腔颅颌面部发育缺陷的遗传基础，以及颅颌面软组织修复和再生的细胞和分子机制展开研究。
2.肿瘤发生发展的蛋白翻译调控机理研究，重点围绕癌症早期诊断、肿瘤分化的分子分型、新型生物标志物的发现，以及重要信号蛋白和小分子代谢产物新功能的阐述和新药靶分子的功能性验证。
[主持课题]
1.中山大学****科研启动基金，2016/12-2021/12，在研，主持，120万元。
2.美国Cornelia de Lange综合症基金会科研基金项目“Targeting translation in Cornelia de Lange Syndrome human cells with L-leucine”，2014/9-2015/8，已结题，主持，3750美元。
3.美国March of Dimes出生缺陷基金会发现和转化医学研究基金项目“L-leucine as a potential therapy for Cornelia de Lange Syndrome”，2014/6-2017/5，已结题，第二完成人，235000美元。
4.美国Cornelia de Lange综合症基金会2013-2014年科研基金项目“Treatment of Zebrafish Models for CdLS with L-leucine”，2013/9-2014/8，已结题，第二完成人，5000美元。
5.国家自然科学基金面上项目“促减数分裂甾醇合成酶CYP51基因沉默对卵母细胞减数分裂恢复作用机理的研究”，2006/01-2008/12，已结题，第四完成人，28万元。
6.国家自然科学基金面上项目“心钠肽在输卵管中的分泌调节及其对受精的作用和机理”，2007/01-2009-12，已结题，第五完成人，26万元。
7.国家自然科学基金青年项目“利用RNA干扰技术治疗小鼠高胆固醇血症的研究”，2008/01-2010/12，已结题，第二完成人，18万元。
[发表论文]
1.Baoshan Xu, Hua Li, John M. Perry, Vijay Pratap Singh, Jay Unruh, Zulin Yu, Musinu Zakari, William McDowell, Linheng Li, Jennifer L. Gerton*. ?Ribosomal DNA copy number can be lost in cancer. PLoS Genetics. 2017 Jun 22;13(6):e**. (IF: 6.661)（Highlighted feature in the Scientist Magazine）.
2. ?Baoshan Xu, Kenneth K. Lee, Lily Zhang, Jennifer L. Gerton*. ?Stimulation of mTORC1 with L-leucine Rescues Defects Associated with Roberts Syndrome. PLOS Genetics. 2013 Oct; 9(10):e**. (IF: 6.661) （Highlighted feature in the Science News Site Science Daily）.
3.Baoshan Xu, Nenja Sowa, Maria E. Cardenas, Jennifer L. Gerton*. ?L-leucine partially rescues translational and developmental defects associated with zebrafish models of Cornelia de Lange syndrome. Human Molecular Genetics, 2015 Mar 15; 24 (6):1540-1555. (IF: 5.985)
4.Baoshan Xu, Karin Zueckert, Madelaine Gogol, and Jennifer L. Gerton*. ?L-leucine stimulation of mTORC1 partially rescues transcription and translation in Roberts Syndrome. BMC Genomics, 2016 Jan 5;17(1):25. (IF: 3.867)
5.Baoshan Xu#, Sujuan Chen#(Co-first author), Yan Luo, Zi Chen, Lei Liu, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Long Chen*, Shile Huang*. ?Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLOS ONE, 2011, April 22; 6(4) e19052. (IF: 3.057)
6.Baoshan Xu, Shuai Lu, Jennifer L. Gerton*. Roberts syndrome-a deficit in acetylated cohesin at heterochromatic regions leads to nucleolar dysfunction. Rare Diseases, 2014 Jan., e27743.
7.Baoshan Xu#, Chao Wang#(Co-first author),, Jie Yang, Ping Tai, Bo Zhou, Guoliang Xia*, Meijia Zhang*. Silencing of Mouse hepatic lanosterol 14alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by Short-term treatment of siRNA. Biological & Pharmaceutical Bulletin, 2008, June, 31(6):1182-1191. (IF: 1,574)
8.Xiuzhen Han#, Baoshan Xu#(Co-first author), Christopher S. Beevers, Yoshinobu Odaka, Long Chen, Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Shile Huang*. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. Carcinogenesis. 2012 Apr.; 33(4):868-875. (IF: 4.874)
9.Chen Long#, Baoshan Xu#(Co-first author), Lei Liu, Yan Luo, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Shile Huang*. Cadmium induction of reactive oxygen species activates mTOR pathway, leading to neuronal cell death. FREE RADICAL BIO. MED., 2011 Mar 1; 50(5):624-632. (IF: 5.784)
10.Long Chen#, Baoshan Xu#(Co-first author), Lei Liu, Yan Luo, Jun Yin, Hongyu Zhou, Wenxing Chen, Tao Shen, Xiuzhen Han, Shile Huang*. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest., 2010 May 90(5): 762-773. (IF: 4.202)
11.Shaoxiao Wang, Baoshan Xu, Liangchun Liou, Qun Ren, Shile Huang , Yan Luo , Zhaojie Zhang, Stephan N Witt*. Alpha-Synuclein Disrupts Stress Signaling by Inhibiting Polo-like Kinase Cdc5/Plk2. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16119-24. (IF: 9.423)
12.Kobe C. Yuen, Baoshan Xu, Ian D. Krantz, Jennifer L. Gerton*. NIPBL controls RNA biogenesis to prevent activation of the stress kinase PKR. Cell Reports, 2016 Jan 5;14(1):93-102. (IF: 7.87)
13.Sujuan Chen#, Yijiao Xu#, Baoshan Xu#(Co-first author), Min Guo, Zhen Zhang, Lei Liu, Hongwei Ma, Zi Chen, Yan Luo, Shile Huang*, Long Chen*. Cadmium-elevated intracellular free Ca2+ activates MAPK and mTOR signaling by CaMKII phosphorylation leading to apoptosis of neuronal cells. J Neurochem. 2011 Dec; 119(5):1108-18. (IF: 3.842)
14.Chao Wang#, Baoshan Xu#(Co-first author), Bo Zhou, Cheng Zhang, Jie Yang, Hong Ouyang, Gang Ning, Meijia Zhang, Jianzhong Shen, Guoliang Xia*. Reducing CYP51 inhibits FSH-induced resumption of mouse oocyte meiosis in vitro. J Lipid Res., 2009 Nov. 50(11): 2164-2172. (IF: 4.368)
15.Hua Zhang#, Baoshan Xu#(Co-first author), Huirong Xie, Bo Zhou, Hong Ouyang, Gang Ning, Ge Li, Meijia Zhang*, Guoliang Xia*. Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial folliclepool in mouse fetal ovary. Molecular Reproduction and Development, 2009, May, 76(5): 514-521. (IF: 2.141)
16.Long Chen*, Baoshan Xu, Lei Liu, Chunxiao Liu, Yan Luo, Xin Chen, Mansoureh Barzegar, Jun Chung, Shile Huang*. Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. Oncotarget. 2015 Mar 30;6(9):7136-50. (IF: 5.008)
17.Yoshinobu Odaka, Baoshan Xu, Yan Luo, Tao Shen, Chaowei Shang, Yang Wu, Hongyu Zhou, Shile Huang*. Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells. Carcinogenesis. 2014 Jan; 35(1):192-200. (IF: 4.874)
18.Tania Bose, Kenneth K. Lee, Shuai Lu, Baoshan Xu, Bethany Harris, Brian Slaughter, Jay Unruh, Alexander Garrett, William McDowell, Andrew Box, Hua Li, Allison Peak, Sree Ramachandran, Chris Seidel, Jennifer L. Gerton*. Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells. PLoS Genetics. 2012 Jun; 8(6):e**. (IF: 6.661)
19.Xiufen Chen, Bo Zhou, Jun Yan, Baoshan Xu, Ping Tai, Junxia Li, Shiming Peng, Meijia Zhang*, Guoliang Xia*. Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced porcine cumulus–oocyte complexes meiotic resumption. Journal of Endocrinology, 2008, May, 197, 409-419. (IF: 4.498)
20.Xiaoming Song, Ping Tai, Jun Yan, Baoshan Xu, Xiufen Chen, Hong Ouyang, Meijia Zhang, Guoliang Xia*. Expression and regulation of lanosterol 14α-demethylase in mouse embryo and uterus during the peri-implantation period. Reproduction, Fertility and Development, 2008, Oct. 23, 20(8): 964–972. (IF: 2.135)
21.Gang Ning, Hong Ouyang, Songbo Wang, Xiufen Chen, Baoshan Xu, Jiange Yang, Hua Zhang, Meijia Zhang*, Guoliang Xia*. 3',5'-Cyclic Adenosine Monophosphate Response Element Binding Protein Up-Regulated Cytochrome P450 Lanosterol 14 α -Demethylase Expression Involved in Follicle-Stimulating Hormone-Induced Mouse Oocyte Maturation. Molecular Endocrinology, 2008, July, 22 (7): 1682-1694. (IF: 3.432)
22.Liu Lei, Yan Luo, Long Chen, Tao Shen, Baoshan Xu, Wenxing Chen, Hongyu Zhou, Xiuzhen Han, Shile Huang*. Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol. Chem., 2010 Dec. 3, 285(49), 38362-38373. (IF: 4.258)
23.Wenxing Chen, Yan Luo, Lei Liu, Hongyu Zhou, Baoshan Xu, Xiuzhen Han, Tao Shen, Zhijun Liu, Yin Lu, Shile Huang*. Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb Phosphorylation. Cancer Prev Res., 2010 Aug, 3(8): 1015-1025. (IF: 3.887)
24.Yong Joo Lee, Elodie Burlet, Shaoxiao Wang, Baoshan Xu, Shile Huang, Floyd J. Galiano, Stephan N. Witt*. Triclabendazole protects yeast and mammalian cells from oxidative stress: Identification of a potential neuroprotective compound. Biochem Biophys Res Commun. 2011 Oct 14; 414(1):205-8. (IF: 2.371)
25.Yan Luo, Hongyu Zhou, Lei Liu, Tao Shen, Wenxing Chen, Baoshan Xu, Xiuzhen Han, Fangfang Zhang, Rona S.Scott, J.Steve Alexander, Antoine Alam, Shile Huang*.The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene 2011 May 5, 30(18): 2098-2107. (IF: 7.932)
26.Guankun Mao, Junxia Li, Fenghua Bian, Yingying Han, Meng Guo, Baoshan Xu, Meijia Zhang, Guoliang Xia*. Gap junction-mediated cAMP movement between oocytes and somatic cells. Frontiers in Bioscience E5, January 1, 2013, 755-767. ?(IF: 2.484)
27.Lei Liu, Long Chen, Yan Luo, Wenxing Chen, Hongyu Zhou, Baoshan Xu, Xiuzhen Han, Tao Shen, Shile Huang*. Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway. PLOS ONE, 2010, May 11; 5(5):e10578. (IF: 3.057)
28.Hongyu Zhou, Tao Shen, Yan Luo, Lei Liu, Wenxing Chen, Baoshan Xu, Xiuzhen Han, Jia Pang, Chantal A. Rivera, Shile Huang*. The antitumor activity of the fungicide ciclopirox. Int. J Cancer, 2010 Nov 15;127(10):2467-2477. (IF: 5.531)
29.Xiaoming Song, Hong Ouyang, Ping Tai, Xiufen Chen, Baoshan Xu, Jun Yan, Guoliang Xia, Meijia Zhang*. Stage-specific Expression of Lanosterol 14 α -Demethylase in Mouse Oocytes in Relation to Fertilization and Embryo Development Competence. Asian-Aust. J. Anim. Sci., 2009, Mar., 22(3): 319-327.
30.Jiange Yang, Maoyong Fu, Songbo Wang, Xiufen Chen, Gang Ning, Baoshan Xu, Yuzhen Ma, Meijia Zhang, Guoliang Xia*. An antisense oligodeoxynucleotide to LH receptor attenuates FSH-induced oocyte maturation in mice. Asian-Aust. J. Anim. Sci., 2008 July, 21(7), 972-979.
31.Chao Wang#, Huirong Xie#, Xiaoming Song, Gang Ning, Jun Yan, Xiufen Chen, Baoshan Xu, Hong Ouyang, Guoliang Xia* ?Lanosterol 14α-demethylase expression in mice ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro, Theriogenology, 2006, Sep.15, 66(5): 1156-1164. ?(IF: 1.838)
[获奖及学术荣誉]
1. ?美国Cornelia de Lange Syndrome Foundation 2014-2015年基础科学奖
2. ?美国细胞生物学学会（ASCB）第50周年学术年会旅行奖 ? ?
3. ?美国科学促进协会（AAAS）2011-2013年卓越科学项目奖
[社会兼职]
1. International Association for Dental Research（IADR）会员
2. American Society for Cell Biology（ASCB） 会员
3. The American Physiological Society （APS）会员
4. American Society for Investigative Pathology （ASIP）会员
5. American Association for the Advancement of Science （AAAS）会员
6. 多个SCI期刊特邀/长期审稿人，包括：International Journal of Cancer，Toxicological Sciences，Toxicology Letters，Acta Pharmacologica Sinica，Asian Journal of Andrology，Journal of cell death，Theriogenology, Reproductive Biology and Endocrinolog, Molecular and Cellular Biochemistry，
International Journal of Molecular Sciences，Chinese Journal of Cancer Research
[联系方式]
地 址：广州市中山二路74号，中山大学（北校区）口腔医学研究所（510080）
电 话：
E-mail：xubsh3@mail.sysu.edu.cn ?