陈泽涛
研究员 博士生导师


导师简介

[学位/学历]
2005-2010 ?中山大学光华口腔医学院?本科
2010-2012 ?中山大学光华口腔医学院?七年制硕士?（口腔种植学）
2012-2015 ?澳大利亚昆士兰科技大学?博士
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[学术简历]
就职于中山大学光华口腔医学院?附属口腔医院，任研究员、主治医师（口腔种植科），博士生导师。现任中山大学科学研究院基地处副处长，广东省牙颌系统修复重建技术与材料工程技术研究中心副主任。入选国家海外高层次人才计划、广东省****科学基金项目、广东省珠江人才计划青年拔尖人才项目。
2012年毕业于中山大学光华口腔医学院，获口腔临床医学（种植学）硕士学位。2015年毕业于澳大利亚昆士兰科技大学，取得博士学位。从事口腔种植相关医教研工作，聚焦软硬组织再生修复的免疫机制及其调控研究，成果发表于Advanced Functional Materials，ACS Nano，Materials Today等。共发表SCI学术论文37篇，累计影响因子达268.079，通讯10篇，第一/并列第一16篇，一作/通讯发表大于10分的SCI学术论文7篇。参编外语专著1部（The Immune Response to Implanted Materials and Devices）。申请专利2项，参与获批专利1项。主持包括ITI Research Grant, The Osteology Foundation Research Grant在内的国际项目4项，国家自然科学基金在内的项目5项。
? ??教学方面，参与口腔种植学的教学工作，并致力于推动口腔基础研究的教学改革与实践。主编《口腔基础研究导论》（人民卫生出版社，2020，ISBN: 978-7-117-29325-9）。从2016年起，作为学院“科创育才”协会指导教师与学生科联合连续举办四届“口腔科研训练营”，探索以第二课堂形式培养学生创新基础研究能力，并初步建立口腔创新基础研究能力的教学评价体系；2020年作为课程负责人与教学科联合创建“口腔基础研究导论”课程，将创新基础研究能力的培养融入第一课堂。从口腔基础研究课程的建立与实践、教材的编写、到教学评价体系的构建，这一系列的教学改革工作获得了2项省级及3项校级教学类项目支持。
[研究方向]
1.?? ?口腔软硬组织再生修复过程的免疫调控机制
2.?? ?口腔生物材料的免疫调控性能
3.?免疫智能口腔生物材料的研发及其在口腔软硬组织再生修复中的应用
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[主持课题]
教学类项目：
1.?? ?2020-2022年，中山大学本科教学质量工程类项目
2.?? ?2020-2021年，广东省高校青年教师高等教育学研究课题
3.?? ?2019-2019年，中山大学研究生教育创新计划项目
4.?? ?2019-2020年，广东省高等教育教学研究和改革项目（综合类项目，第二参与人）
5.?? ?2018-2019年，中山大学本科教学质量工程类项目
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科研类项目：
1.?? ?2018-2020年，国家自然科学基金青年基金
2.?? ?2018-2021年，广东省****科学基金项目
3.?? ?2017-2022年，广东省珠江人才计划青年拔尖人才项目
4.?? ?2017-2019年，中山大学青年教师培育项目
5.?? ?2016-2018年，中山大学****启动基金
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国际项目：
1.?? ?2019-2020年，The ?Osteology Foundation, Young Researcher Grant (18-016)
2.?? ?2018-2020年，ITI Research Grant，Small Grant 2017 (1267_2017)
3.?? ?2016-2017年，The Osteology Foundation, Young ?Researcher Grant (15-004)
4.?? ?2015-2016年，The Prince Charles Hospital Foundation，New Investigator Gran t (NI2015-102)
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[发表论文（近三年）]
基础研究：
1.?? ? ?Runheng ?Liu^#, Shoucheng Chen^#, Peina Huang, Guanqi Liu, Pu Luo, ?Zhipeng Li, Yin Xiao, Zhuofan Chen*,?Zetao ?Chen*. Immunomodulation-based strategy for improving soft tissue and ?metal implant integration and its implications in the development of metal ?soft tissue materials.. Advanced Functional Materials, 2020, accepted. (IF: ?15.621)
2.?? ? ?Guanqi ?Liu^#, Xiaoshuang Wang^#, Xuan Zhou^#, Linjun ?Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang*, Zhuofan Chen*,?Zetao Chen*. Modulating the ?cobalt dose range to manipulate multisystem cooperation in bone environment: ?a strategy to resolve the controversies about cobalt use for orthopedic ?applications. Theranostics, 2020, 10(3), 1074-1089. (IF: 8.063)
3.?? ? ?Lingling ?Chen^#, Guanqi Liu^#, Jinyan Wu, Xuan Zhou, Yiming Zhao,?Zetao Chen*, Zhengmei Lin*, ?Yin Xiao. Multi-faceted effects of mesenchymal stem cells (MSCs) determined ?by immune microenvironment and their implications on MSC/biomaterial-based ?inflammatory disease therapy. Applied Materials Today, 2020, 18, 100458. (IF: ?8.013)
4.?? ? ?Zetao Chen^#, ?Rahul Madathiparambil Visalakshan^#, Jia Guo^#, Fei Wei, ?Linjun Zhang, Lingling Chen, Zhengmei Lin*, Krasimir Vasilev*, Yin Xiao*. ?Plasma deposited poly-oxazoline nanotextured surfaces dictate ?osteoimmunomodulation towards ameliorative osteogenesis. Acta Biomaterialia, ?2019, 15: 568-581 (IF: 6.638)
5.?? ? ?Guanqi ?Liu^#, Yuanlong Guo^#, Linjun Zhang^#, ?Xiaoshuang Wang, Runheng Liu, Peina Huang, Yin Xiao, Zhuofan Chen*,?Zetao Chen*. A standardized ?rat burr hole defect model to study maxillofacial bone regeneration. Acta Biomaterialia, ?2019, 86:456-60 (IF: 6.638)
6.?? ? ?Shiyu ?Wu^#, Binbin Xia^#, Sui Mai^#, Zhicai Feng, ?Xiaoshuang Wang, Yudong Liu, Runheng Liu, Zhipeng Li, Yin Xiao*, Zhuofan ?Chen*,?Zetao Chen*. Sodium ?fluoride under dose range of 2.4-24 μM, a promising osteoimmunomodulatory ?agent for vascularized bone formation. ACS Biomaterials Science & ?Engineering, 2019, 5 (2): 817–830. (IF 4.511)
7.?? ? ?Wei ?Qiao^#, Runheng Liu^#, Zhipeng Li, Xin Luo, Baoxin Huang, ?Quan Liu,?Zetao Chen, James ?Kit Hon Tsoi, Richard Yu Xiong Su, Kenneth M.C. Cheung, Jukka Matinlinna*, ?Kelvin Yeung*, Zhuofan Chen*. Contribution of the in situ release of ?endogenous cations from xenograft bone driven by fluoride incorporation ?toward enhanced bone regeneration. Biomaterials Science, 2018, 6: 2951-64 (IF ?5.251)
8.?? ? ?Fei ?Wei^#, Guanqi Liu^#, Yuanlong Guo, Ross Crawford,?Zetao Chen*, Yin Xiao*. Blood ?prefabricated hydroxyapatite/tricalcium phosphate induces ectopic ?vascularized bone formation via modulating the osteoimmune environment. ?Biomaterials Science, 2018, 6(8):2156-71 (IF 5.251)
9.?? ? ?Runheng ?Liu^#, Yixiong Lin^#, Jinying Lin^#, Linjun ?Zhang, Xueli Mao, Baoxin Huang, Yin Xiao, Zhuofan Chen*,?Zetao Chen*. Blood prefabrication subcutaneous small ?animal model for the evaluation of bone substitute materials. ACS ?Biomaterials Science & Engineering, 2018, 4(7):2516-2527 (IF ?4.511)
10.??Zetao Chen^#, ?Lingling Chen^#, Runheng Liu^#, Yixiong Lin, Shoucheng ?Chen, Shifeier Lu, Zhengmei Lin, Zhuofan Chen*, Chengtie Wu*, Yin Xiao*. The osteoimmunomodulatory ?property of barrier collagen membrane and its manipulation via coating ?nanometer-sized bioactive glass to improve guided bone regeneration. ?Biomaterials Science, 2018, 6(5):1007-19 (IF 5.251)
11.??Runheng ?Liu^#, Wei Qiao^#, Baoxin Huang,?Zetao Chen, Jinghan Fang, Zhipeng Li*, Zhuofan Chen*, ?Fluorination enhances osteogenic capacity of porcine hydroxyapatite, Tissue ?Engineering Part A, 2018, 24(15-16):1207-17 (IF 3.616)
12.??Shoucheng ?Chen^#, Yuanlong Guo^#, Runheng Liu^#, Shiyu ?Wu, Jinghan Fang，?Baoxin Huang, ?Zhipeng Li, Zhuofan Chen*,?Zetao ?Chen*. Tuning surface properties of bone biomaterials to manipulate ?osteoblastic cell adhesion and the signaling pathways for the enhancement of ?early osseointegration. Colloids and Surfaces B: Biointerfaces, 2018, 164: ?58-69. (IF: 3.973)
13.??Zetao Chen^#, ?Shengwei Han^#, Mengchao Shi, Guanqi Liu, Zhuofan Chen, Jiang ?Chang, Chengtie Wu*, Yin Xiao*. Immunomodulatory effects of mesoporous silica ?nanoparticles on osteogenesis: from nanoimmunotoxicity to nanoimmunotherapy. ?Applied Materials Today, 2018, 10: 184-93. (IF: 8.013)
14.??Zetao Chen^#, Akash ?Bachhuka^#, Fei Wei, Xiaoshuang Wang, Guanqi Liu, Krasimir Vasilev*, ?Yin Xiao*. Nanotopography-based strategy on the precise manipulation of ?osteoimmunomodulation in bone regeneration. Nanoscale, 2017, 9: 18129-52. (IF: ?6.970)
15.??Mengchao ?Shi^#, Lunguo Xia^#,?Zetao ?Chen, Fang Lv, Huiying Zhu, Fei Wei, Shengwei Han, Jiang Chang, Yin ?Xiao*, Chengtie Wu*. Europium-doped mesoporous silica nanosphere as an immune-modulating ?osteogenesis/angiogenesis agent. Biomaterials, 2017, 144: 176-87. (IF: ?10.273)
16.??Xufang ?Zhang^#, Qingpiao Chen^#, Jianwei Liu, Qi Wei,?Zetao Chen, Xueli Mao*. ?Parthenolide promotes differentiation of osteoblasts through Wnt/β-catenin ?signaling pathway in inflammatory environment. Journal of Interferon and ?Cytokine Research, 2017, 37(9): 406-414. (IF:1.774)
17.??Zetao Chen^#, ?Akash Bachhuka^#, Shengwei Han, Fei Wei, Shifeier Lu, Rahul ?Visalakshan, Krasimir Vasilev*, Yin Xiao*. Tuning chemistry and topography of ?nanoengineered surfaces to manipulate immune response for bone regeneration ?applications. ACS Nano, 2017, 11(5): 4494-506. (IF 13.903)
18.??Gaojie ?Yang^#, Haoming Liu^#, Xixi Hu,?Zetao Chen,?Thor Friis, Jianglin Wang, Yin Xiao*, Shengmin ?Zhang*. Bio-inspired hybrid nanoparticles promote vascularized bone ?regeneration in a morphology-dependent manner. Nanoscale, 2017, 9: 5794-805. ?(IF ?6.970)
19.??Shengwei ?Han,?Zetao Chen*, Pingping ?Han, Qingang Hu, Yin Xiao*. Activation of macrophages by lipopolysaccharide ?for assessing the immunomodulatory property of biomaterials. Tissue ?Engineering Part A, 2017, 23 (19-20): 1100-9. (IF 3.616)
20.??Zetao Chen^#, ?Siyu Ni^#, Shengwei Han, Ross Crawford, Shifeier Lu, Fei Wei, Jiang ?Chang, Chengtie Wu*, Yin Xiao*. Nanoporous microstructures mediate ?osteogenesis by modulating the osteo-immune response of macrophages. ?Nanoscale. 2017, 9: 706-18. (IF 6.970)
临床研究：
21.??Yudong ?Liu^#,Qifan Liu^#, Zhipeng Li, Aneesha ?Acharya, Danying Chen,?Zetao Chen, ?Nikos Mattheos, Zhuofan Chen*, Baoxin Huang*. Long noncoding RNA and mRNA ?expression profiles in peri-implantitis versus periodontitis. Journal of ?periodontal research, 2019, accepted. (IF: 2.613)
22.??Rachana ?Shrestha#, Xin Liu#, Shoucheng Chen, Zhipeng Li,?Zetao Chen, Edmond H. N. Pow，Zhuofan Chen*, ?Baoxin Huang*. Correlation of anterior overbite with root position and buccal ?bone thickness of maxillary anterior teeth: a CBCT study. Surgical and ?Radiologic Anatomy. 2019,41(8):935-942. (IF:1.039)
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[参编教材与论著]
1.?? ? ??主编《口腔基础研究导论》，人民卫生出版社，2020，ISBN: ?978-7-117-29325-9
2.?? ? ?参编英文专著'The Immune ?Response to Implanted Materials and Devices',?by ?editor Bruna Corradetti, Springer-Verlag, 2017. ISBN: 978-3-319-45431-3. Zetao ?Chen, Chengtie Wu, Yin Xiao. 'Convergence of osteoimmunology and ?immunomodulation for the development and assessment of bone biomaterials.'
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[获奖及学术荣誉]
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1.?? ??2019/2018中山大学光华口腔医学院本科教学优秀教师奖，二等奖
2.?? ??AIDE - Young Australia China Alumni ?of the Year Award of the ACAA and TOEFL? - 2018 Australia China ?Alumni Awards, finalist.
3.?? ??2017全国口腔生物医学学术年会优秀青年研究奖三等奖
4.?? ??2017年IADR中国分会********奖比赛二等奖
5.?? ??中华口腔医学会科研管理专委会年会2017国际口腔医学青年科学家论坛明日之星奖
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[社会兼职]
1.?? ?广东省青年联合会第十一届委员会委员
2.?? ?中华口腔医学会第三届口腔生物学专业委员会委员
3.?? ?广东省口腔医学会第三届口腔种植学专委会委员
4.?? ??中国生物材料学会青年委员会第二届委员会委员
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[联系方式]
地?址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）
电?话：
传?真：
E-mail：ztchensysu@163.com