科　　室：转化医学研究中心
职　　称：研究员
导师资格：博士生导师
最高学历：博士




医疗/科研特长：
长期从事慢性免疫病研究，在艾默里大学和斯坦福大学工作期间，发现了自身免疫病病人免疫细胞中ATM蛋白主导的DNA 损伤修复通路的缺陷可导致免疫细胞修复功能的缺失,免疫系统长期处于增殖压力下，最终导致免疫衰老和自身免疫识别的异常。此发现从一定程度改变了传统上人们对自身免疫病的认识。在美国耶鲁大学医学院工作期间，深入研究了表观遗传修饰酶--SUMO特异性蛋白酶（SENP1），并首次证明了NEMO的SUMO化特异性增强胰岛脂肪细胞炎性细胞介素的分泌，进而导致自发性糖尿病，从而首次揭示SENP1作为敏感基因在糖尿病发病中的作用。相关结果分别发表在J .Exp Med.，Nature Communication，Nature Review Rheumatology，PNAS，EMBO MM, Journal of Autoimmunity. Arthritis & rheumatism., Frontiers in Immunology等国际著名的医学杂志。并被美国临床免疫学会（FOCIS），美国免疫学会（AAI），美国类风湿学会（ACR）邀请作大会报告。此外还拥有斯坦福大学技术许可证明1项，美国专利1项及国内专利2项。
研究方向：临床免疫学及肿瘤免疫
主要教育和工作经历：
沈阳药科大学 药学 学士
沈阳药科大学 药理 硕士
中科院研究生院 细胞生物学 博士
2002.8-2007.3 中科院动物所 助理研究员
2006.4-2009.12 艾默里大学（Emory） 博士后
2009.12-2011.6 斯坦福大学（Stanford）博士后
2011.4-2012.4 斯坦福大学（Stanford）研究助理
2012.8-2016.3 耶鲁大学（Yale） 副研究员
2016.4-至今 中山大学 研究员
社会兼职：
论著：
1 Qiao Su^#, jun Jing^#, Wuguo Li, Jianda Ma, Xueling zhang, Zongren Wang, Zhongyang Zhou, Lie Dai*, Lan Shao*, Impaired Tip60-mediated Foxp3 acetylation attenuates regulatory T cell development in rheumatoid arthritis, Journal of Autoimmunity, 2019, 100, 27-29. (IF: 7.54)
2 Jian‐Da Ma, Jun Jing, Jun‐Wei Wang, Ying-Qian Mo, Qian‐Hua Li, Jian‐Zi Lin, Le‐Feng Shao L *#, Pierre Miossec, Lie Dai# . Activation of the PGC‐1β/NFATc‐1 Pathway in Circulating Osteoclast Precursors Associated with Bone Destruction in Rheumatoid Arthritis. Arthritis & rheumatism. 2019 Aug;71(8):1252-1264.(IF: 9.02)
3 Shao L * DNA damage response signals transduce stress from rheumatoid arthritis risk factors into T cell dysfunction. Frontiers in immunology. Frontiers in immunology. 2018, December, Vol: 9:3055
4 张雪玲，李武国，周仲洋，郑漫妮，邵兰*. T 细胞代谢异常对类风湿关节炎发生发展影响。中华风湿病学杂志. 2018, 22(11), 114-116.1
5 Shao L, Feng BY, Zhou HJ, Ji WD, Wang Min* The role of adipose derived inflammatory cytokines in type 1 diabetes (2016). Adipocyte 17 Mar 2016:1-5. (IF: 3.55)
6 邵兰，冯博雅, 张钰莹, 周焕娇，纪卫东，王敏(2016).脂肪组织与Ⅰ型糖尿病。千人生物2016, 3(1), 1-6。
7 Shao L, Zhou HJ, Zhang HF, Wang Min (2015). SENP1-mediated NEMO deSUMOyation in the adipocyte limits inflammatory responses and type 1 diabetes progression. Nat. Commun. 2015, Nov 24. (IF: 12.12)
8 Shao L, Goronzy JJ, Weyand CM (2010). Inhibition of the DNA repair enzyme DNA-PKcs restores T cell survival in rheumatoid arthritis. EMBO Molecular Medicine. 2010 2 (10):415-27. (IF: 11.549)
9 Goronzy JJ, Shao L, Weyand CM (2010). New insights into Rheumatoid Arthritis. Rheumatic Disease Clinics of North America. 2010 36 (2). 297-310. (IF: 3.34)
10 Shao L, Fujii H, Goronzy JJ, Weyand CM (2009). Deficiency of the DNA repair enzyme ATM in Rheumatoid Arthritis. J.Exp.Med. 2009 Jun; 8; 206(6): 1435-49. (IF: 11.9)
11 Weyand CM, Fujii H, Shao L, Goronzy JJ (2009).Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol. 2009 5, 583-588. (IF: 18.68)
12 Fujii H, Shao L, Goronzy JJ, Weyand CM (2009). Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11): 4360-5. (IF: 9.81)
13 Shao L, Li QH, Wang J, Tan Z (2005). Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis. Cancer Biol Ther. 2005; 4(3):336-41.(IF: 3.63)
14 Shao L, Li QH, Tan Z (2004). L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004, 324(2): 931-936.(IF: 2.4)
15 Yang F, Yang JP, Li QH, Shao L (2003). Strand breaks in telomeres in Hela cells. Acta Zoology Sinica. 2003, 49 (6): 873-877.
16 Shao L, Huang Q, Li QH (2003). Regulation effect of insulin on metabolic dysfunction of diabetic rats. Chinese Journal of Zoology. 2003, 38(2): 23-27.
17 Shao L, Li QH, Huang Q (2002). Effect of insulin on oxidative damage in liver of diabetic rats. Chinese Journal of Zoology. 2002, 37(5): 28-31.
18 Jiao XM, Li QH, Xu M, Li LJ, Shao L (2002). Fusion of Ehrlich′s ascites cell plasma membrane with liposomes driven by transmembrane pronton efflux: effect of calcium ions and liposome phospholipid composition. Acta Zoologica Sinica. 2002, 48 (5): 660-666.
19 Huang Q, Shao L, Jiang H (2001). Effect of insulin on oxygen free radicals and oxidative phosphorylation in liver mitochondrial of diabetic rats. Acta. Pharmacol. Sina. 2001, 22(5): 455-458. (IF:2.496)
20 Shao L, Yu QH, Huang Q (2001). The effect of Houttuyninum on cellular immunological function in splenectomy animals. Chinese Pharmacological Bullitin.2001, 17(1): 51-54.
21 Shao L,Yu QH (2000). The effect of Houttuyninum on immunological function in mice treated with cyclophosphamide. Journal of Shenyang Pharmacoeuticel University. 2000, 17(2): 133-135.
22 Shao L,Yu QH (1999). The effect of Houttuyninum on immunological function in splenectomy animals. Journal of Shenyang Pharmacoeuticel University. 1999, 16(3): 209-211.
23 Shao L,Yu QH (1998). The Improving Effect of Decoction of Coptis and Its Extract on Intelligence.Journal of Shenyang Pharmacoeuticel University. 1998, 15 (1): 35~37.
24 Ye FG, Yu QH, Shao L (1998). Antioxidant Activity of Calculus Borisfor Lipid. China Journal of Traditional Chinese Medicine and Pharmacy. 1998, 13 (2): 69.
25 Yu QH, Zhang YF, Shao L (1997). The role of Immune regulation of Chinese Medicine. Medical Journal of Liaoning. 1997, 11(6): 299-301.
专利
1 Weyand CM, Goronzy JJ, Shao L. Improving Immune System Function in conditions characterized by elevated double strand breaks (U.S. Patent Application Serial No. 13/205,001, issued data 12/6/2016).
2 Zhao Y, Xie W, Shao L. A tetramer combined with SARS Antigen Peptide, its preparation and use (No. 7).
其他主要工作成绩：
中山大学附属第一医院 2015高影响因子奖
美国免疫学年会大会奖（AAI 2010）
美国临床免疫学年会大会奖 (FOCIS 2009)