科　　室：转化医学研究中心
职　　称：研究员
导师资格：博士生导师
最高学历：博士




医疗/科研特长（限400字内）：
主要以斑马鱼为模式动物研究人类重要疾病相关基因的功能。以第一/共第一、通讯/共通讯发表多篇SCI论文，其中2篇论文获得Faculty of 1000推荐。

研究方向：疾病基因鉴定与斑马鱼模型构建及功能研究

主要教育和工作经历：
2000年12月获博士学位。2001年到2011年期间，先后在新加坡分子和细胞生物学研究院（IMCB）从事博士后研究和担任研究员、资深研究员工作，主要以模式生物拟南芥、斑马鱼为研究对象，研究机体器官发育的分子机理。2011年12月，作为中山大学“****”引进人才到本院工作，建立了斑马鱼疾病模式动物公共平台，开展人类疾病相关易感基因的致病机制研究。



社会兼职：
广东省精准医学应用学会疾病模型分会第一届委员会副主任委员。
中国实验动物学会水生实验动物专业委员会委员。

论著：
YangS^#,Emelyanov A, You MS, Sin M, Korzh V*. Camel regulatesdevelopment of the brain ventricular system. Cell Tissue Res. 2020 Sep 9. doi:10.1007/s00441-020-03270-1.
Rong D^#, Wang C^#,Zhang X^#, Wei Y, Zhang M, Liu D, Farhan H, Momen Ali SA, Liu Y, Adam T, Guo W, Wang Y, OjimaI*, Yang S*, Wang H*. A noveltaxane, difluorovinyl-ortataxel, effectively overcomes paclitaxel-resistance inbreast cancer cells. Cancer Letters, 2020, 491:36–49.
Zhang W^#, Zhang S^#, Guan W^#, Huang Z, Kong J, Huang C, Wang H*, Yang S*. Poly C BindingProtein 1 Regulates p62/SQSTM1 mRNA Stability and Autophagic Degradation toRepress Tumor Progression. Frontiers in Genetics. 2020 Aug 14;11:930. doi:10.3389/fgene.2020.00930. eCollection 2020.
Li H^#, Zhang M^#, Wei Y, Haider F, Lin Yi, Guan W, Liu Y,Zhang S, Yuan R, Yang X, Yang S* and Wang H*. SH3BGRL confers innate drug resistance in breastcancer by stabilizing HER2 activation on cell membrane. Journal of Experimental& Clinical Cancer Research, 2020, ePub, doi.org/10.1186/s13046-020-01577-z.
Lin J^#, Liang J, Wen J, Luo M, Li J, Sun X, Xu X, Li J, Wang D,Wang J, Chen H, Lai R, Liang F, Li C, Ye F, Zhang J, Zeng J,Yang S*, Sheng W*. Mutations ofRNF213areresponsible for sporadic cerebral cavernous malformation and lead to amulberry-like cluster in zebrafish. Journal of Cerebral Blood Flow and Metabolism, 2020, Apr 4:271678X**. doi:10.1177/**X**.
Wang J^#,Guo X,Wang D,Yang S*. Expression patterns of pcbpgene family members during zebrafish embryogenesis. Gene Expr Patterns. 2020Jan 31; 35:119097. doi: 10.1016/j.gep.2020.119097.
Zhang M^#, Wei Y, Liu Y, Guan W, Zhang X, Kong J, Li H, Yang S*, Haihe Wang*, MetastaticPhosphatase PRL-3 induces Ovarian Cancer Stem Cell Subpopulation throughPhosphatase-independent Deacetylation Modulations. iScience 2020 Jan24;23(1):100766. doi: 10.1016/j.isci.2019.100766.
Shi H^#, Li H^#,Yuan R^#, Guan W, Zhang X, Zhang S, Zhang W, Tong F, Li L, Song Z,Wang C, Yang S*., Wang H*.. PCBP1depletion promotes tumorigenesis through attenuation of p27 ^Kip1mRNA stability and translation. Journal ofExperimental & Clinical Cancer Research, 2018, 37：187.ePub，doi:10.1186/s13046-018-0840-1.
Li L^#, Shi H^#,Zhang M, Guo X, Tong F, Zhang W, Zhou J, Wang H*, Yang S*. Upregulation of metastasis-associated PRL-3 initiateschordoma in zebrafish. International Journal of Oncology, 2016,48(4):1541-1552.
TongF^#, Zhang M, Guo X, Shi H, Guan W, Wang H* and Yang S*. Expression patterns of SH3BGRfamily members in zebrafish development. Development Genes and Evolution 2016,226(4): 287-295.
ZhangW^#, Shi H^#, Zhang M, Liu B, Mao S, Li L, Tong F, Liu G, Yang S*, Wang H*. Poly C bindingprotein 1 represses autophagy through downregulation of LC3B to promote tumorcell apoptosis in starvation. International Journal of Biochemistry and CellBiology. 2016, 73: 127-136.
Yang S^#, Aw SS, Chang Q, Korzh S, Korzh V*, and Peng J*.Depletion of Bhmt elevates sonic hedgehog transcript levels to promotepancreatic islet development in zebrafish, Endocrinology, 2011:152(12):4706-4717.
KorzhS, Winata CL, Zheng W, Yang S, YinA, Ingham P, Gong Z*. The interaction ofepithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladderdevelopment. Developmental Biology, 2011,359：262–276.
Yang S ^#,Puah CS, Xie L, Jiang L, Zhang X, Chen L, Ye D*. Over-expression of TPD1 altersthe cell fates in the arabidopsis carpel and tapetum via genetic Interactionwith EMS1/EXS. Plant Physiology, 2005, 139: 186-191.
Jiang L^#, Yang S^#,Xie L, Puah CS, Yang W, Sundaresan V, Ye D*. VANGUARD1 encodes a pectin methylesterase that enhances pollen tube growth in theArabidopsis style and transmitting tract. Plant Cell, 2005, 17: 584-596.(Faculty of 1000 推荐).
YangS ^#, Xie L, Mao H, Puah CS, Yang W, JiangL, Ye D*. 2003. Tapetum determinant 1 gene is required for cell specializationin the Arabidopsis anther. Plant Cell, 15: 2792-2804. (Faculty of 1000推荐).

专著：

其他主要工作成绩（比如获奖情况）：