基本介绍

个人简介：

“****”特聘教授，中山大学副校长兼中山医学院院长。1986年毕业于中山医科大学临床医学专业毕业，获医学学士学位。1986－1991年就读中山医科大学与中国预防医学科学院北京病毒学研究所（CAPM－BIV）病毒基因工程国家重点实验室联合培养研究生，获医学博士学位。1991－1993年任CAPM-BIV病毒基因工程国家重点实验室助理研究员。1993年前往美国匹兹堡癌症研究所接受博士后训练，并于1997年在该所担任研究助理教授（ResearchAssistantProfessor，非独立职位）。2000年起受聘于匹兹堡大学医学院病理系，任助理教授(AssistantProfessor，独立职位)，一直在美国从事医学分子病毒学、分子肿瘤学和细胞生物学的教学与科研，研究领域主要为病毒致病与致癌、以及肿瘤发生发展的分子机制，并讲授医学生“MolecularPathogenesisofInfectiousDiseases”和博士生“Angiogenesis:PhysiologyandPathologicalSignificance”课程。2005年受聘为“****”特聘教授，全职归国到中山医学院工作。黎孟枫教授近年在中山大学主要致力于阐明肿瘤发生与病毒感染、炎症过程的关系，以及相关的信号控制机理，主要学术重点是NF-κB信号通路所涉及的新调控分子及其工作机制，以及由此产生的生物学效应和在肿瘤、病毒性疾病上的临床意义，最近发现了NF-κB的激活与多种病毒感染相关基因之间的相互作用，以及miRNA对NF-κB激活的表观遗传学调控作用，深入研究了这些相互作用的生物学意义。作为上述调控网络的理论意义的延伸，还研究了NF-κB调控分子在病毒感染和肿瘤恶化中的临床意义，并在此基础上寻找病毒感染和恶性肿瘤诊断、预后判定新分子标志物及治疗新靶点。上述研究的部分结果最近发表在CancerResearch.,Oncogene,JournalofPathology,AmericanJournalofPathology,ClinicalCancerResearch等期刊上。

学术论著与教材：

近三年发表的学术论文：

1.JunLi,NuZhang,LiBingSong,WenTingLiao,Li-LiJiang,LiYunGong,WuJH,JieYuan,HuiZhongZhang,MuShenZeng,MengfengLi*.Astrocyteelevatedgene-1IsaNovelPrognosticMarkerforBreastCancerProgressionandOverallPatientSurvival.ClinicalCancerResearch.14(11):3319-3326,2008.

2.JunLi,Hong-YuGuan,Li-YunGong,Li-BingSong,NuZhang,JuehengWu,JieYuan,Yi-JieZheng,Zheng-SongHuang,*MengfengLi.ClinicalSignificanceofSphingosineKinase-1ExpressioninHumanAstrocytomasProgressionandOverallPatientSurvival.Clin.CancerRes.14(21):6996-7003,2008.

3.JLi,LYang,LSong,HXiong,LWang,XYan,JYuan,JWu,MengfengLi*.Astrocyteelevatedgene-1isaproliferationpromoterinbreastcancerviasuppressingtranscriptionalfactorFOXO1.Oncogene,28(36):3188-3196,2009.

4.JunLi,LiangYu,HuizhongZhang,JuehengWu,JieYuan,XiaoxiLi*,MengfengLi*.Down-regulationofpescadilloinhibitsproliferationandtumorigenicityofbreastcancercells.CancerScience,100(12):2255-2260,2009.[Epub2009Aug25].

5.Li-BingSong,JunLi,Wen-TingLiao,YanFeng,Chun-PingYu,Li-JuanHu,Qing-LiKong,Li-HuaXu,XingZhang,Wan-LiLiu,Man-ZhiLi,LingZhang,Tie-BangKang,Li-WuFu,Wen-LinHuang,Yun-FeiXia,SaiWahTsao,MengfengLi,VimlaBand,HamidBand,Qing-HuaShi,Yi-XinZeng,andMu-ShengZeng*.ThepolycombgroupproteinBmi-1repressesthetumorsuppressorPTENandinducesepithelial-mesenchymaltransitioninhumannasopharyngealepithelialcells.JournalofClinicalInvestigation,119(12):3226-3236,2009.

6.FanLiu,QingLi,HongYang,Xiao-LingCai,Xue-KuiXia,Sheng-PingChen,MengfengLi,Zhi-GangShe∗andYong-ChengLin*.StructureelucidationofthreediphenyletherderivativesfromthemangroveendophyticfungusSBE-14fromtheSouthChinaSea.MagneticResonanceinChemistry.47:453–455,2009.

7.WenLi,Chun-PingYu,Jin-tangXia,LingZhang,Gui-XiangWeng,Hai-qingZheng,Qing-liKong,Li-juanHu,Mu-ShengZeng,Yi-xinZeng,MengfengLi,JunLi*,andLi-BingSong*.SphingosineKinase1IsAssociatedwithGastricCancerProgressionandPoorSurvivalofPatients.ClinCancerRes.15:1393-1399,2009.

8.FanLiu,Xiao-LingCai,HongYang,Xue-KuiXia,Zhi-YongGuo,JieYuan,MengfengLi,Zhi-GangShe,Yong-ChengLin*.TheBioactiveMetabolitesoftheMangroveEndophyticFungusTalaromycessp.ZH-154IsolatedfromKandeliacandel(L.)Druce.PlantaMedica,75:1–4,2009.

9.JunLi,HengZhang,JuehengWu,HongyuGuan,JieYuan,ZhengsongHuang,MengfengLi*.PrognosticSignificanceofIntegrin-linkedkinase1OverexpressioninAstrocytoma.InternationalJournalofCancer,126(6):1436-1444,2010.[Epub2009Oct15].

10.JunLi,Li-YunGong,Li-BingSong,Li-LiJiang,Li-PingLiu,JuehengWu,JieYuan,Jun-ChaoCai,MianHe,LanWang,MushengZeng,Shi-YuanCheng*,MengfengLi*.OncoproteinBmi-1RendersApoptoticResistancetoGliomaCellsthroughActivationoftheIKK-NF-kBPathway.AmericanJournalofPathology176(2):699-709,2010.[Epub2009Dec24].

11.LipingLiu,JuehengWu,ZheYing,BaixueChen,LibingSong,JieYuan,JunLi^*,MengengLi^*.Astrocyteelevatedgene-1(AEG-1)UpregulatesMatrixMetalloprotease-9andInducesHumanGliomaInvasion.CancerResearch,70(9):3750-3759,2010.[Epub2010Apr13].

12.XuChen,JuehengWu,HanningLiu,ZhenjianHe,MinghuiGu,NingWang,JiandaMa,JiepingHu,LeiXia,HaipengHe,JieYuan,JunLi,LuyuanLi,MengfengLi*,XunZhu*.ApproachestoefficientproductionofrecombinantangiogenesisinhibitorrhVEGI-192andcharacterizationofitsstructureandantiangiogenicfunction.ProteinScience.19(3):449-57.2010.

13.Gui’eXie,XunZhu,QingLi,ZhenjianHe,JuehengWu,JunLi,YongchengLin,MengfengLi,ZhigangShe*,JieYuan*.SZ-685C,amarineanthraquinone,asapotentapoptosisinducerwithanticanceractivitythroughsuppressingtheAkt/FOXOpathway.BritishJournalofPharmacology,159(3):689-697,2010.[Epub2010Jan28].

14.LibingSong*,LanWang,JunLi,HuapingXiong,JuehengWu,MenfengLi*.Sam68UpregulationCorrelateswith,andItsDownregulationInhibits,ProliferationandTumorigenicityofBreastCancerCells.JournalofPathology,222(3):227–237,2010.[EpubonlineJuly27,2010].【CommentedinthesameissueofJournalofPathologybyDavidJElliottandPrabhakarRajan:TheroleoftheRNA-bindingproteinSam68inmammarytumourigenesis.222:223–226,2010.】

15.XiaofanDing,LifangJiang,ChangwenKe,ZhanYang,ChunliangLei,KaiyuanCao,JunXu,LinXu,XingfenYang,YonghuiZhang,PingHuang,WeijunHuang,XunZhu,ZhenjianHe,LipingLiu,JunLi,JieYuan,JuehengWu,XiaopingTang^*,MengfengLi^*.Aminoacidsequenceanalysisandidentificationofmutationsunderpositiveselectioninhemagglutininof2009influenzaA(H1N1)isolates.VirusGenes,41:329–340,2010.【Epub2010Aug31,DOI10.1007/s11262-010-0526-z】.

16.HongyuGuan,HengZhang,JuehengWu,JieYuan,ZhengsongHuang*andMengfengLi*.IKBKEisoverexpressedingliomaandcontributestoresistanceofgliomacellstoapoptosisviaactivatingNF-κB.JournalofPathology.JournalofPathology,223:436–445.2011

17.LibingSong^*,HuapingXiong,JunLi,WengtingLiao,LanWang,JuehengWu,MenfengLi^*.Sphingosinekinase-1EnhancesResistancetoApoptosisthroughActivationofPI3K/Akt/NF-κBPathwayinHumanNon-smallCellLungCancer.AcceptedbyClinicalCancerResearch.2011

18.HongyuGuan,JunchaoCai,NuZhang,JuehengWu,JieYuan,JunLiandMengfengLi*.Sp1isupregulatedinhumanglioma,promotesMMP-2-mediatedcellinvasionandpredictspoorclinicaloutcome.AcceptedbyInternationalJournalofCancer.2011.

学术兼职：

其他：

主持在研基金项目：

1.微小RNA与肿瘤，973课题

2.海洋来源的抗肿瘤候选药物SZ-685C的研究，国家新药科技重大专项

3.广东省传染病病原谱流行规律研究（监测平台），国家传染病科技重大专项

4.原癌基因AEG-1诱导乳腺癌早期转移的分子机制，国家自然科学基金面上项目

5.驱动脑胶质瘤血管新生的新机制：AEG-1激活的信号转导，国家自然科学基金面上项目