黄玲,女,1983年生。中山大学药学院讲师。主要研究方向为药物设计、合成与活性研究。
联系方式:HuangL72@mail.sysu.edu.cn
学习与工作经历
2000.09-2004.06:中南大学药学院,药学专业,获学士学位
2004.07-2006.08:广州万方健医药有限公司,新药研发
2006.09-2011.06:中山大学药学院,药物化学专业,获博士学位
2011.06至今:中山大学药学院讲师
研究方向
1)手性药物新合成工艺研究
2)多靶点抗阿尔茨海默病药物分子设计合成及活性研究
3)抗哮喘/慢性阻塞性肺病的药物分子设计合成及活性研究
科研项目(均为参与者)
1)国家自然科学基金项目:亚胺衍生物与有机金属试剂的不对称加成反应研究(项目号:20472116,2005-2007)
2)广州市科技攻关项目:新型手性配体的合成及在抗哮喘药物合成中的应用(项目号:2007Z3-E4141,2006-209)
3)国家自然科学基金项目:手性多靶点抗哮喘药物分子设计合成与活性研究(项目号:20972198,2010-2012)
发表论文(2006~2011)
1)LingHuang,JuntaoLiu,WenjunShan,BaoLiu,AndingShi,XingshuLi.Theasymmetricsynthesisof(R,R)-formoterolviatransferhydrogenationwithpolyethyleneglycolboundRhcatalystinPEG2000andwater.Chirality.2010,22(2),206-211.
2)LingHuang,AndingShi,FengHe,XingshuLi.Synthesis,biologicalevaluation,andmolecularmodelingofberberinederivativesaspotentacetylcholinesteraseinhibitors.Bioorganic&MedicinalChemistry.2010,18(3),1244-1251.
3)LingHuang,ZonghuaLuo,FengHe,JingLu,XingshuLi.Synthesisandbiologicalevaluationofanewseriesofberberinederivativesasdualinhibitorsofacetylcholinesteraseandbutyrylcholinesterase.Bioorganic&MedicinalChemistry.2010,18(12),4475-4484.
4)LingHuang,ZonghuaLuo,FengHe,AndingShiFangfeiQinandXingshuLi.Berberinederivatives,withsubstitutedaminogroupslinkedatthe9-position,asinhibitorsofacetylcholinesterase/butyrylcholinesteraseBioorganic&MedicinalChemistryLetters.2010,20(22),6649–6652.
5)AndingShi,LingHuang,ChuanjunLu,FengHe,XingshuLi.Synthesis,biologicalevaluationandmolecularmodelingofnoveltriazole-containingberberinederivativesasacetylcholinesteraseandβ-amyloidaggregationinhibitors.Bioorganic&MedicinalChemistry,2011,19(7):2298-2305.
6)ChuanjunLu,ZonghuaLuo,LingHuang,XingshuLi.TheRu-catalyzedenantioselectivepreparationofchiralhalohydrinsandtheirapplicationinthesynthesisof(R)-clorprenalineand(S)-sotalol.Tetrahedron:Asymmetry.2011,22(7),722-727.
7)Wen-JunShan,LingHuang,QiZhou,Fan-ChaoMeng,Xing-ShuLi.Synthesis,biologicalevaluationof9-N-substitutedberberinederivativesasmultifunctionalagentsofantioxidant,inhibitorsofacetylcholinesterase,butyrylcholinesteraseandamyloid-βaggregation.EuropeanJournalofMedicinalChemistry.Doi:10.1016/j.ejmech.2011.09.051
8)JuntaoLiu,DiZhou,XianJia,LingHuang,XingshuLi,AlbertS.C.Chan.Aconvenientsynthesisof(R)-SalmeterolviaRh-catalyzedasymmetrictransferhydrogenation.Tetrahedron:Asymmetry.2008,19(15),1824-1828.
9)BaoLiu,LingHuang,JuntaoLiu,YaoZhong,XingshuLi,AlbertS.C.ChanChiralCu(II)complexcatalyzedenantioselectiveadditionofphenylacetylenetoN-arylarylimines.Tetrahedron:Asymmetry.2007,18(24),2901-2904.
10)BaoLiu,JuntaoLiu,XianJia,LingHuang,XingshuLi,AlbertS.C.ChanThesynthesisofchiralN-tosylatedaminoimineligandsandtheirapplicationinenantioselectiveadditionofphenylacetylenetoimines.Tetrahedron:Asymmetry.2007,18(9),1124-1128.
11)黄玲,刘宝,黎星术,抗哮药物(R,R)福莫特罗的不对称合成研究,2007年全国药物化学学术研讨会论文集