胡命豪
学院： 药学院
专业： 药物化学
职称： 副教授

简介： 胡命豪，药学博士，长聘副教授，硕士生导师。长期致力于靶向特殊核酸二级结构G-四链体的小分子化合物的开发，主要包括：（1）开发具有新型化学骨架、具有较大成药潜力的先导化合物；（2）开发靶向G-四链体结构的功能性小分子化合物；（3）探究G-四链体小分子配体在难治性肿瘤、耐药性肿瘤上的应用。在Nucleic Acids Res.，J. Med. Chem.，Eur. J. Med. Chem.，Anal. Chem.等国际知名期刊上发表多篇研究性论文。主讲本科《药物化学》等课程。
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办公室：深圳大学丽湖校区药学院A1-508
办公电话：**
邮箱：@qq.com；humhao1229@szu.edu.cn
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教育与工作经历
1. 2008.09–2012.06，中山大学药学院，药学专业，获学士学位
2. 2012.09–2017.06，中山大学药学院，药物化学专业，获博士学位
3. 2017.07–2021.01，深圳大学医学部药学院，助理教授
4. 2021.01–至今，深圳大学医学部药学院，长聘副教授
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主持项目
1. 国家自然科学基金（青年项目），**，2019.01–2021.12，21万元，主持
2. 广东省自然科学基金（博士启动），2018A，2018.01–2020.12，10万元，主持
3. 深圳市科技计划（自由探索），20**6158，2018.03–2020.03，33万元，主持
4. 广东省医学科研基金，A**，2019.07–2021.06，1万元，主持
5. 深圳大学新进教师科研启动项目，2018.01–2022.12，20万元，主持
6. 深圳大学医学部青年教师项目，2018/2019/2020，25万元，主持
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发表论文（# 表示共同第一作者，* 表示通讯作者）
16. Wang, X.^#; Yu, B.-Y.^#; Lin, J.-H.; Yan, Y.; Hu, M.-H.* Development of a near-infrared fluorescent ligand that visualizes and stabilizes G-quadruplexes by decorating the triphenylamine scaffold. Sens. Actuators B Chem., 2021, 330, 129391.
15. Hu, M.-H.* Pyrazine-based G-quadruplex fluorescent probes: transformation between aggregation-induced emission and disaggregation-induced emission via slight variations in structures. Sens. Actuators B Chem., 2021, 328, 128990.
14. Hu, M.-H.*; Yu, B.-Y.; Wang, X.; Jin, G.Drug-like biimidazole derivatives dually target c-MYC/BCL-2 G-quadruplexes and inhibit acute myeloid leukemia. Bioorg. Chem., 2020, 104, 104264.
13. Hu, M.-H.*; Chen, X. New fluorescent light-up quinoxalines differentiate between parallel and nonparallel G-quadruplex topologies using different excitation/emission channels. Chem. Commun., 2020, 56, 4168–4171.
12. Wu, T.-Y.; Huang, Q.; Huang, Z.-S.; Hu, M.-H.*; Tan, J.-H.* A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg. Chem., 2020, 99, 103866.
11. Hu, M.-H.*; Lin, X.-T.; Liu, B; Tan, J.-H. Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere. Eur. J. Med. Chem., 2020, 186, 111891.
10. Hu, M.-H.*; Wu, T.-Y.; Huang, Q.; Jin, G.*New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription. Nucleic Acids Res., 2019, 47, 10529–10542.
9. Hu, M.-H.*; Chen, X; Tan, J.-H. Development of a multitasking fluorescent probe for differentiating G-quadruplex structures. Dyes Pigm., 2019, 170, 107560.
8. Hu, M.-H.^#; Zhou, J.^#; Luo, W.-H.; Chen, S.-B.; Huang, Z.-S.; Wu, R.*; Tan, J.-H.* Development of a smart fluorescent sensor that specifically recognizes the c-MYC G-quadruplex. Anal. Chem., 2019, 91, 2480–2487.
7. Hu, M.-H.^#; Wang, Y.-Q.^#; Yu, Z-Y; Hu, L-N; Ou, T.-M.; Chen, S.-B.*; Tan, J.-H.* Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex. J. Med. Chem., 2018, 61, 2447–2459.
6. Wang, Y.-Q.^#; Hu, M.-H.^#; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.* Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA. Sens. Actuators B Chem., 2018, 266, 187–194.
5. Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.*Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Res., 2017, 45, 1606–1618.
4. Hu, M.-H.^#; Guo, R.-J.^#; Chen, S.-B.; Huang, Z.-S.;Tan, J.-H.* Development of an engineered carbazole/thiazole orange conjugating probe for G-quadruplexes. Dyes Pigm., 2017, 137, 191–199
3. Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole. Biosens. Bioelectron., 2016, 83, 77–84.
2. Hu, M.-H.; Chen, S.-B.; Guo, R.-J.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.*Development of a highly sensitive fluorescent light-up probe for G-quadruplexes. Analyst, 2015, 140, 4616–4625.
1. Hu, M.-H.; Chen, X.; Chen, S.-B.; Ou, T.-M.; Yao, M.; Gu, L.-Q.; Huang, Z.-S.;Tan, J.-H.* A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology. Sci. Rep., 2015, 5, 17202.