王志刚
学院： 药学院
专业： 药物化学
职称： 助理教授

简介：
王志刚，2009年本科毕业于中国农业大学理科试验班。2017年博士毕业于香港城市大学生物与化学系，研究方向为药物化学。2017年加入深圳大学药学院，现为药物化学教研室助理教授，硕士生导师，南山区领航人才，深圳市海外高层次人才。主要从事新型铂类药物开发用以解决现有铂类抗肿瘤药物的毒副作用和耐药性问题。主讲本科《药物化学》、《波谱解析》课程。
?
办公室：深圳大学丽湖校区药学院A1-512
邮箱：wangzg@szu.edu.cn
?
研究方向
1.铂类金属抗肿瘤药物设计、合成及机理研究
2.无机纳米载体用于癌症的靶向治疗
3. 光激活化学药物
?
主持项目
1. 深圳大学新进教师科研启动项目，2018/01–2022/12，20万元，主持
2.深圳市海外高层次人才科研启动项目，2019/01–2022/12, 270万元，主持
?
近五年代表性论文（#表示共同第一作者，*表示通讯作者）
?
1.?? Tang, L.; Cai, D.; Qin, M.; Lu, S.; Hu, M. H.; Ruan, S.; Jin, G.*; Wang, Z.*, Oxaliplatin-Based Platinum(IV) Prodrug Bearing Toll-like Receptor 7 Agonist for Enhanced Immunochemotherapy. ACS Omega 2020,5 (1), 726-734.
2.?? Deng, Z.; Wang, N.; Liu, Y.; Xu, Z.; Wang, Z.; Lau, T.-C.; Zhu, G., A Photocaged, Water-Oxidizing, and Nucleolus-Targeted Pt(IV) Complex with a Distinct Anticancer Mechanism. J. Am. Chem. Soc. 2020.142, 8061;
3.?? Wang, Z.*; Wang, N.; Cheng, S.-C.; Xu, K.; Deng, Z.; Chen, S.; Xu, Z.; Xie, K.; Tse, M.-K.; Shi, P.; Hirao, H.; Ko, C.-C.; Zhu, G.*, Phorbiplatin, a Highly Potent Pt(IV) Antitumor Prodrug That Can Be Controllably Activated by Red Light. Chem 2019.5, 3151–3165.[News report inSZU News(in Chinese);X-MOL(in Chinese);ScienceDaily;Eurekalert;Phys.org;CityU_research(in Chinese); and many other local news]
4.?? Wang, Z.^#; Deng, Z. ^#; Zhu, G., Emerging platinum(IV) prodrugs to combat cisplatin resistance: from isolated cancer cells to tumor microenvironment. Dalton Transactions 2019,48 (8), 2536-2544.[Front Cover Article]
5.?? Wang, Z.; Zhu, G., DNA Damage Repair Pathways and Repair of Cisplatin-Induced DNA Damage. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier: 2018.
6.?? Wang, N.; Wang, Z.; Xu, Z.; Chen, X.; Zhu, G., A Cisplatin‐Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy. Angew. Chem. Int. Ed. 2018,57 (13), 3426-3430.
7.?? Yu, W. K.; Wang, Z.; Fong, C. C.; Liu, D.; Yip, T. C.; Au, S. K.; Zhu, G.; Yang, M., Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin‐induced DNA damage. Br. J. Pharmacol. 2017,174 (4), 302-313.
8.?? Yan, L.; Wang, Z.; Chen, X.; Gou, X.-J.; Zhang, Z.; Zhu, X.; Lan, M.; Chen, W.; Zhu, G.; Zhang, W., Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo. Chem. Commun. 2017,53 (15), 2339-2342.
9.?? Wang, Z.; Xu, Z.; Zhu, G., A platinum (IV) anticancer prodrug targeting nucleotide excision repair to overcome cisplatin resistance. Angew. Chem. Int. Ed. 2016,55 (50), 15564-15568.[VeryImportantPaper andBack Cover Article]
10. Wang, Z.; Ma, R.; Yan, L.; Chen, X.; Zhu, G., Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. Chem. Commun. 2015,51 (58), 11587-11590.