邢少军
学院： 基础医学院
专业： 免疫与病原生物学
职称： ****
简介： 邢少军（Shaojun Xing），博士，深圳大学医学部****。获深圳市孔雀计划（B类）资助。主要研究围绕T细胞的发育及功能调节，从分子、细胞、动物及人体等不同水平结合多种学科开展工作。主要学术贡献：1.基础免疫方面：首次直接鉴定转录因子TCF1/LEF1对组蛋白的表观修饰功能，发现转录因子的表观修饰功能，研究成果发表在Nature Immunology 杂志，被F1000prime引用并推荐；发现wnt信号转录抑制因子TLE能够调控CD8+T细胞的正常发育及维持其外周稳定；证明TCF1/LEF1在体内维持Foxp3+调节性T细胞的功能。研究结果分别于2018年和2019年发表在Journal of Experimental Medicine杂志。2.感染与免疫方面，系统分析特异性CD8+ T细胞在感染过程中表观修饰及调控的动态变化，鉴定及发现增强子及超级增强子的动态变化特点，并预测阶段特异的转录调控网络。研究结果发表在Immunity杂志；揭示TCF1/ LEF1对滤泡辅助性T细胞（Tfh）分化的调节机制，成果发表在Nature Immunology杂志。3.临床免疫方面：阐明HIV感染不同阶段患者外周CD4+FoxP3+调节性T细胞与HIV感染疾病进展及抗病毒治疗的相关性，揭示疾病进展对调节性T细胞稳态的影响。成果发表在艾滋病专业杂志JAIDS及免疫学杂志Immunology。
目前实验室主要研究方向：（1）?获得性免疫细胞（T细胞）在病原感染、肿瘤发生等疾病状态下的免疫应答及表观修饰研究；（2）wnt信号通路转录因子（TCF1/LEF1）及其调控因子在免疫细胞发育及辅助性T细胞亚群（如调节性T细胞、滤泡调节性T细胞）免疫应答中的调控作用；（3）HDAC抑制剂在T细胞分化及功能中的作用机制。
代表性成果?
??Xing S#, Gai K#, Li X, Shao P, Zeng Z, Zhao X, Zhao X, Chen X, Paradee WJ, Meyerholz DK, Peng W*, Xue HH* Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells. J Exp Med 2019 Mar 5. pii: jem.**. doi: 10.1084/jem.**.
??Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan et al Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018; 9: 5452. doi: 10.1038/s41467-018-07853-z PMCID: PMC**
??Shaojun Xing, Peng Shao, Fengyin Li et al. Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med 2018 July 25, 215(7) DOI: 10.1084/jem.** IF=10.79
??Jiao Y-M#, Yang H-G#, Huang H-H, Tu B, Xing S-J, Mao L, Xia W, He R, Zhang J-Y, Xu R-N, Jin L, Shi M, Xu Z, Qin E-Q, Wang X-C, Wu H, Ye L and Wang F-S (2017) Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5??CD8+ T Cells during Chronic HIV Infection. Front. Immunol. 8:1786. doi: 10.3389/fimmu.2017.01786
??Shan Q#, Zeng Z#, Xing S, Li F, Hartwig SM,et al . The transcription factor Runx3 guards cytotoxic CD8(+)effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017 Jun 12. doi: 10.1038/ni.3773. PubMed PMID:**. IF=21.506
??Jodi A. Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng et al Differential requirements for Tcf1 long isoforms in CD8+ and CD4+ T cell responses to acute viral infection. J Immunol. 2017 Aug 1; 199(3): 911–919. doi: 10.4049/jimmunol.** PMCID: PMC**
??Zhe Xu#, Shaojun Xing#, Qiang Shan et al Cutting Edge: beta-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017 Mar 27. pii: **. doi: 10.4049/jimmunol.**. PMID: ** IF=4.856 (co-first author).
??Bing He#, Shaojun Xing#, Changya chen et al CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections. Immunity. 2016 Dec 20;45(6):1341-1354. PMID:** IF=22.845 (co-first author).
??Shaojun Xing#, Fengyin Li#, Zhouhao Zeng#, Yunjie Zhao, Shuyang Yu, et al Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity. Nat Immunol. 2016 Jun;17(6):695-703. PMID: ** IF=21.506 (F1000 prime recommended by Salvatore Spicuglia )
??Yu S#, Li F#, Xing S et al Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors. J Biol Chem. 2016 May 20;291(21):11148-60. PMID: ** IF=4.125
??Yang Q, Li F, Harly C, Xing S, Ye L, et al TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol. 2015 Oct;16(10):1044-50. doi: 10.1038/ni.3248. Epub 2015 Aug 17. PMID: ** IF=21.506 (commentary by Kaye J.)
??Choi YS#, Gullicksrud JA#, Xing S et al LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6 Nat Immunol. 2015 Sep;16(9):980-90. PMID:** IF=21.506 (cited by Nature, commentary by Masato Kubo)
??Fu J, Zhang Z, Zhou L, Qi Z, Xing S, et al Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma. Hepatology. 2013 Jul;58(1):139-49. doi: 10.1002/hep.26054. Epub 2013 Feb 15. PMID: ** IF=13.246 (commentary by Gyongyi Szabo)
??Xing S#, Fu J#, Zhang Z et al Increased turnover of FoxP3high regulatory T cells is associated with hyperactivation and disease progression of chronic HIV-1 infection. J Acquir Immune Defic Syndr. 2010 Aug;54(5):455-62. PMID: ** IF=3.935
??Jiao Y#, Fu J#, Xing S, et al The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors. Immunology. 2009 Sep;128(1 Suppl):e366-75. PMID:** IF=3.701