吴光耀
学院： 深圳大学总医院
专业： 影像医学与核医学
职称： 主任医师/教授
简介：
吴光耀，博士，新加坡国立大学博士后；硕士和博士研究生导师。曾任湖北省医学会放射学分会第八届副主委，第九届常委，湖北省抗癌协会放射学分会常委，中国针灸学会影像学分会第一届委员、第二届常委，中华放射学会分子影像学组委员；湖北省医学会数字学分会第一、二届委员，湖北省预防医学会委员。担任国家自然科学基金委网评专家，科技部重点研发计划网评和会评专家（2015?2018）。
主要从事功能磁共振成像（fMRI/DKI、DTI、IVIM-DWI/in vivo和in vitro HRMAS ¹HMRS/VBM-MRI）； 超极化气体¹²⁹Xe肺部成像与大数据分析； 肿瘤定量成像及肿瘤血管生成DCE-MRI、DCE-CT 及DCE PET成像；基于磁共振成像影像组学与高分辨磁共振波谱代谢组学研究。获国家科技部、国家自然基金委等科研基金资助，总经费达800万元。以第一作者或通讯作者在AJR、AJNR等国际期刊发表高水平学术论文58篇。
科研项目
1.项目主持人?国家自然基金-面上项目，2012-2015年国家自然基金项目，编号：**，；
2.国家重大科研仪器设备研制专项-子课题负责人， 2012-2017年国家自然基金委，第五课题组长，编号：**
3.项目主持人?湖北省****基金，2009-2010年，编号2009CDA071
4.项目主持人?国家自然基金-青年基金编号：2009-2010年，编号**
5.科技部-国家重点研发计划，子课题负责人，2016-2020年，编号2016YFC**
6.项目主持人?深圳市科创委面上项目?基于多模态磁共振脑血流及血脑屏障定量评估对阿尔茨海默病早期（MCI）及超早期(SCD) 患者的诊断及机制的应用研究2020-2023年?编号JCYJ20**3552
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?代表性成果（近五年代表作5-10篇）
1?Li J, Wu G*, Wen Z, Zhang J, Lei H, Gui X, Lin F. White Matter Development is Potentially Influenced in Adolescents with Vertically Transmitted HIV Infections: A Tract-Based Spatial Statistics Study. AJNR Am J Neuroradiol. 2015 Nov;36(11):2163-9. doi: 10.3174/ajnr.A4417. Epub 2015 Jul 30.?
2?Zhu L, Wu G*, Zhou X, Li J, Wen Z, Lin F. Altered spontaneous brain activity in patients with acute spinal cord injury revealed by resting-state functional MRI. PLoS One. 2015, 13;10(3):e**. doi: 10.1371/journal.pone.**. eCollection 2015.
3 Wu G*, Yang S, Zhu L, Lin F. Altered spontaneous brain activity in heavy smokers revealed by regional homogeneity.?Psychopharmacology (Berl). 2015 Jul;232(14):2481-9.
4 Lin F, Wu G*, Zhu L, Lei H. Altered brain functional networks in heavy smokers. Addict Biol. 2015 Jul;20(4):809-19.
5?Wen Z, Zhang J, Li J, Dai J, Lin F, Wu G*. Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson's Disease: A Short-Term Regional Homogeneity fMRI Study. PLoS One. 2016 Jun 16;11(6):e**. doi: 10.1371/journal.pone.**. eCollection 2016.
6?Lv YG, Kang L, Wu G*. Fluorosis increases the risk of postmenopausal osteoporosis by stimulating interferon γ.Biochem Biophys Res Commun. 2016 Oct 14;479(2):372-379. doi: 10.1016/j.bbrc.2016.09.083. Epub 2016 Sep 17.
7 Fen Xing, Ning Tu, Tong San Koh, Guangyao Wu*. MR diffusion kurtosis imaging predicts malignant potential and the histological type of meningioma. Eur J Radiol. 2017 Oct;95:286-292. doi: 10.1016/j.ejrad.2017.08.019. Epub 2017 Aug 22 (IF2.843)
8?Wang P, Thapa D, Wu G*, Sun Q, Cai H, Tuo F. A study on diffusion and kurtosis features of cervical cancer based on non-Gaussian diffusion weighted model. Magn Reson Imaging. 2018 Apr;47:60-66. doi: 10.1016/j.mri.2017.10.016. Epub 2017 Nov 2.
9 Li J, Gao L, Wen Z, Zhang J, Wang P, Tu N, Lei H, Lin F, Gui X, Wu G*. Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents. Sci Rep.?2018 Jan 19;8(1):1182. doi: 10.1038/s41598-018-19290-5. ?
10?Wang X, Tu N, Qin T, Xing F, Wang , Wu G*. Diffusion Kurtosis Imaging Combined With DWI at 3-T MRI for Detection and Assessment of Aggressiveness of Prostate Cancer. AJR Am J Roentgenol. 2018 Aug 7:W1-W8. doi: 10.2214/AJR.17.19249. ?IF3.161
11 Thapa D, Wang P, Wu G*, Wang X, Sun Q. A histogram analysis of diffusion and perfusion features of cervical cancer based on intravoxel incoherent motion magnetic resonance imaging. Magn Reson Imaging. 2019,55:103-111.?
12?Liu Z, Wang C, Wu G*, Cheng J. MRI analysis of hydrogel-loaded apatinib for local therapy of hepatocellular carcinoma model in nude mice.Biochem Biophys Res Commun. 2019 Feb 5;509(2):529-534. IF2.705
13?Li Y, Guo W, Su X, Lu N, Wu G*, Ou-Yang L, Dang M, Tao J, Teng Z. Facile preparation of near-infrared fluorescence and magnetic resonance dual-modality imaging probes based on mesoporous organosilica nanoparticles. J Colloid Interface Sci. 2019 15;539:277-286.
14?Tu N, Zhong Y, Wang X, Xing F, Chen L, Wu G*. Treatment?Response?Prediction of Nasopharyngeal?Carcinoma?Based on Histogram?Analysis of Diffusional?Kurtosis?Imaging. AJNR Am J Neuroradiol. 2019, 40(2):326-333. IF 3.256
15 Wang K, Cheng J, Wang Y, Wu G*. Renal cell carcinoma: preoperative evaluate the grade of histological malignancy using volumetric histogram analysis derived from magnetic resonance diffusion kurtosis imaging.?Quant Imaging Med Surg. 2019 Apr;9(4):671-680. doi: 10.21037/qims.2019.04.14. ??