个人简介


沈建新,生理学教授，博士，汕头大学医学院机能学实验室主任，汕头大学医学院生理学教研室副主任。主要从事生理学和机能学实验的教学和研究工作，熟悉普通电生理技术、膜片钳技术、胞内钙成像技术和数据的编程管理和处理分析系统的构建和应用，曾主持国家自然科学基金项目3项和省级研究项目多项，独立或合作发表SCI论文二十多篇，为一项国家发明专利和三项实用新型专利的第一发明人，另有一项国家发明专利正在申请中。指导大创项目多项，指导大学生参加全国性实验创新设计大赛并获奖多项。入选2015年广东省”扬帆计划”培养高层次人才项目。主持或参加校内或校外教学研究项目多项。每年给本科生授课约160学时，给研究生授课约80学时。


SCI收录论文(#共同第一作者，*通讯作者或共同通讯作者)


1 Xia, K. K., Shen, J. X.*, Huang, Z. B., Song, H. M., Gao, M., Chen, D. J., Zhang, S. J. & Wu, J. Heterogeneity of cannabinoid ligand-induced modulations in intracellular Ca(2+) signals of mouse pancreatic acinar cells in vitro. Acta Pharmacol Sin, doi:10.1038/s41401-018-0074-y (2018).
2 Xia, K., Ma, Z., Shen, J., Li, M., Hou, B., Gao, M., Zhang, S. & Wu, J. The 2-aminoethoxydiphenyl borate analog, DPB161 blocks store-operated Ca(2+) entry in acutely dissociated rat submandibular cells. Oncotarget 8, 61551-61560, doi:10.18632/oncotarget.18623 (2017).
3 Wu, J., Liu, Q., Tang, P., Mikkelsen, J. D., Shen, J., Whiteaker, P. & Yakel, J. L. Heteromeric alpha7beta2 Nicotinic Acetylcholine Receptors in the Brain. Trends Pharmacol Sci 37, 562-574, doi:10.1016/j.tips.2016.03.005 (2016).
4 Huang, Z., Wang, H., Wang, J., Zhao, M., Sun, N., Sun, F., Shen, J., Zhang, H., Xia, K., Chen, D., Gao, M., Hammer, R. P., Liu, Q., Xi, Z., Fan, X. & Wu, J. Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca(2+) oscillations in mouse pancreatic acinar cells. Sci Rep 6, 29757, doi:10.1038/srep29757 (2016).
5 Wu, J., Gao, M., Shen, J. X., Qiu, S. F. & Kerrigan, J. F. Mechanisms of intrinsic epileptogenesis in human gelastic seizures with hypothalamic hamartoma. CNS Neurosci Ther 21, 104-111, doi:10.1111/cns.12348 (2015).
6 Shen, J. & Wu, J. Nicotinic Cholinergic Mechanisms in Alzheimer's Disease. Int Rev Neurobiol 124, 275-292, doi:10.1016/bs.irn.2015.08.002 (2015).
7 Liu, Q., Kuo, Y. P., Shen, J., Lukas, R. J. & Wu, J. Roles of nicotinic acetylcholine receptor beta subunit cytoplasmic loops in acute desensitization and single-channel features. Neuroscience 289, 315-323, doi:10.1016/j.neuroscience.2014.12.016 (2015).
8 Ma, L. Y., Wu, C., Jin, Y., Gao, M., Li, G. H., Turner, D., Shen, J. X., Zhang, S. J., Narayanan, V., Jentarra, G. & Wu, J. Electrophysiological phenotypes of MeCP2 A140V mutant mouse model. CNS Neurosci Ther 20, 420-428, doi:10.1111/cns.12229 (2014).
9 Ma, L., Turner, D., Zhang, J., Wang, Q., Wang, M., Shen, J., Zhang, S. & Wu, J. Deficits of synaptic functions in hippocampal slices prepared from aged mice null alpha7 nicotinic acetylcholine receptors. Neurosci Lett 570, 97-101, doi:10.1016/j.neulet.2014.04.018 (2014).
10 Huang, Z. B., Wang, H. Y., Sun, N. N., Wang, J. K., Zhao, M. Q., Shen, J. X., Gao, M., Hammer, R. P., Jr., Fan, X. G. & Wu, J. Congo red modulates ACh-induced Ca(2+) oscillations in single pancreatic acinar cells of mice. Acta Pharmacol Sin 35, 1514-1520, doi:10.1038/aps.2014.94 (2014).
11 Wu, J., Gao, M., Shen, J. X., Shi, W. X., Oster, A. M. & Gutkin, B. S. Cortical control of VTA function and influence on nicotine reward. Biochem Pharmacol 86, 1173-1180, doi:10.1016/j.bcp.2013.07.013 (2013).
12 Shen, J. X., Qin, D., Wang, H., Wu, C., Shi, F. D. & Wu, J. Roles of nicotinic acetylcholine receptors in stem cell survival/apoptosis, proliferation and differentiation. Curr Mol Med 13, 1455-1464 (2013).
13 Liu, Q., Emadi, S., Shen, J. X., Sierks, M. R. & Wu, J. Human alpha4beta2 nicotinic acetylcholine receptor as a novel target of oligomeric alpha-synuclein. PLoS One 8, e55886, doi:10.1371/journal.pone.** (2013).
14 Jin, Y., Su, Q. X., Shen, J. X., Marks, M. J. & Wu, J. Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors. CNS Neurosci Ther 19, 721-723, doi:10.1111/cns.12138 (2013).
15 Shen, J. X.* & Yakel, J. L. Functional alpha7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices. J Mol Neurosci 48, 14-21, doi:10.1007/s12031-012-9719-3 (2012).
16 Liu, Q., Huang, Y., Shen, J., Steffensen, S. & Wu, J. Functional alpha7beta2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid beta peptides. BMC Neurosci 13, 155, doi:10.1186/1471-2202-13-155 (2012).
17 Kimura, R., Ma, L. Y., Wu, C., Turner, D., Shen, J. X., Ellsworth, K., Wakui, M., Maalouf, M. & Wu, J. Acute exposure to the mitochondrial complex I toxin rotenone impairs synaptic long-term potentiation in rat hippocampal slices. CNS Neurosci Ther 18, 641-646, doi:10.1111/j.1755-5949.2012.00337.x (2012).
18 Zheng, C., Yang, K., Liu, Q., Wang, M. Y., Shen, J., Valles, A. S., Lukas, R. J., Barrantes, F. J. & Wu, J. The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors. J Pharmacol Exp Ther 335, 401-408, doi:10.1124/jpet.110.171108 (2010).
19 Tu, B., Gu, Z., Shen, J. X., Lamb, P. W. & Yakel, J. L. Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. J Neurosci 29, 10436-10448, doi:10.1523/JNEUROSCI.2580-09.2009 (2009).
20 Shen, J. X. & Yakel, J. L. Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system. Acta Pharmacol Sin 30, 673-680, doi:10.1038/aps.2009.64 (2009).
21 Shen, J. X., Tu, B. & Yakel, J. L. Inhibition of alpha 7-containing nicotinic ACh receptors by muscarinic M1 ACh receptors in rat hippocampal CA1 interneurones in slices. J Physiol 587, 1033-1042, doi:10.1113/jphysiol.2008.167593 (2009).
22 Poisik, O. V., Shen, J. X., Jones, S. & Yakel, J. L. Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata. J Physiol 586, 1365-1378, doi:10.1113/jphysiol.2008.149963 (2008).
23 Shen, J. X. Isoprenaline enhances local Ca2+ release in cardiac myocytes. Acta Pharmacol Sin 27, 927-932, doi:10.1111/j.1745-7254.2006.00383.x (2006).
24 Wang, S. Q., Wei, C., Zhao, G., Brochet, D. X., Shen, J., Song, L. S., Wang, W., Yang, D. & Cheng, H. Imaging microdomain Ca2+ in muscle cells. Circ Res 94, 1011-1022, doi:10.1161/01.RES..68447.A1 (2004).
25 Shen, J. X., Wang, S., Song, L. S., Han, T. & Cheng, H. Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes. Biophys J 86, 182-190, doi:10.1016/S0006-3495(04)74095-3 (2004).



专利清单（均为第一发明人）


1. Simple, hand-operated three-D positioning apparatus and its making method. National Invention Patent of PRC. Patent No: 3.2 （approved on Nov 11, 2009） (一种简易手动三维定位操纵仪及其制造方法，国家发明专利，专利号： 3.2)（授权公告日：2009-11-11）
2. One type of chamber for integrated neuro-muscular experiments. Utility Model Patent of PRC. Patent No: ZL 2007 2 **.6 （approved on Feb 27, 2008）（一种神经肌肉综合实验标本盒， 实用新型专利，专利号：ZL 2007 2 **.6）（授权公告日：2008-2-27）
3. 一种适用于荧光显微成像的暗室. 实用新型专利（专利号： ZL 2011 2 **.6）（授权公告日：2012-5-30）
4. 多电极神经标本盒，实用新型专利，专利号：ZL 2017 2 **.1， 沈建新等，中华人民共和国国家知识产局权，2018-1-23授权
5. 正申报发明专利1项: 申请号2.3, 神经干单-双相动作电位同时记录研究实验方法, 2019年8月5日提交申请


主要科研项目（均为负责人）


1. Fund from National Natural Science Foundation of China (**) (2005-2007) (国家自然科学基金项目，已结题)
2. Fund from Natural Science Foundation of Guangdong Province, PRC (**) (2005-2007) （广东省自然科学基金项目，已结题）
3. Fund from Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (SRF for ROCS, SEM.) (2005-)（ 教育部留学回国人员科研启动基金，已结题）
4. Fund from National Natural Science Foundation of China (**) (2012-2015) (国家自然科学基金项目，已结题，65万)，海马脑片星形胶质细胞含a7亚基尼古丁受体的功能性研究。
5. Fund from National Natural Science Foundation of China () (2013-2013) (国家自然科学基金项目，已结题， 2.5万)，尼古丁受体的功能研究：进展及研究方法。



作为主讲教师之一讲授的主要课程







主要的教学研究与教学改革课题