个人简介


杨小骏，教授，神经科学中心常务副主任，博士生导师。2006年获得武汉大学微生物学专业博士学位。2006-2009年美国匹兹堡大学医学院博士后。2010-2014年在第三军医大学历任副研究员，研究员。2014年起受聘为汕头大学医学院神经科学中心研究员。任广东省肿瘤转移专业委员会委员。国家自然科学基金、广东省重点研发计划、广东省自然科学基金项目评审专家。主持国家自然科学基金3项，广东省自然科学基金1项，参与国家自然科学基金重点项目，重大项目各1项。主要研究方向为恶性胶质瘤发病机制，已发表SCI论文30余篇，其中以第一/通讯作者在Journal of Neuroscience, Cell Death & Disease, FASEB Journal, International Journal of Cancer等主流SCI期刊发表论文14篇。



代表性研究论文(#共同第一作者，*通讯作者或共同通讯作者)


1. Pei Liu, Chenchen Zhu, Juanjuan Luo, Sheng Lan, Dongsheng Su, Qiongjin Wang, Zhe Wei, Wei Cui, Chuan Xu* and Xiaojun Yang*. Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma. The FASEB Journal 2019 (In press)
2. Barash U, Spyrou A, Liu P, Vlodavsky E, Zhu CC, Luo JJ, Su DS, Ilan N, Forsberg-Nilsson K, Vlodavsky I* and Yang XJ*. Heparanase promotes glioma progression via enhancing CD24 expression. International Journal of Cancer 2019; 145(6):1596-1608.
3. Juan-Juan Luo, Wan-Ping Bian, Yi Liu, Hai-Yang Huang, Qian Yin, Xiao-Jun Yang*, De-Sheng Pei*. Crispr/Cas9-based genome engineering of zebrafish using a seamless integration strategy. The FASEB Journal 2018; 32(9):5132-5142. (Cover Story)
4. Lihui Wang*, Xiaoyu Dong, Yong Ren, Juanjuan Luo, Pei Liu, Dongsheng Su, Xiaojun Yang*. Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. Cell Death & Disease 2018; 9(2):129.
5. Juan-Juan Luo, Dong-Sheng Su, Shao-Lin Xie, Yi Liu, Pei Liu, Xiao-Jun Yang*, De-Sheng Pei*. Hypersensitive assessment of aryl hydrocarbon receptor transcriptional activity using a novel truncated cyp1a promoter in zebrafish. The FASEB Journal 2018; 32(5):2814-2826.
6. Xiaojun Yang*, Jinling Fu, Xiangyun Wei*. Expression patterns of zebrafish nocturnin genes and the transcriptional activity of the frog nocturnin promoter in zebrafish rod photoreceptors. Molecular Vision 2017; 23:1039-1047.
7. Zhaoheng Duan, Haochuan Wang, Dongmei Zhao, Xiaoxin Ji, Min Song, Xiaojun Yang*, Wei Cui*. Cooperatively transcriptional and epigenetic regulation of sonic hedgehog overexpression drives malignant potential of breast cancer. Cancer Science 2015; 106(8):1084-1091.
8. Xiaojun Yang#*, Wei Cui#, Shicang Yu, Chuan Xu, Guilai Chen, Ai Gu, Tingting Li, Xia Zhang and Xiuwu Bian*. A synthetic dl-nordihydroguaiaretic acid (Nordy), inhibits angiogenesis, invasion and proliferation of glioma stem cells within a zebrafish xenotransplantation model. PLoS ONE 2014; 15(9):e85759.
9. Xiaojun Yang, Wei Cui, Ai Gu, Chuan Xu, Shicang Yu, Tingting Li, Youhong Cui, Xia Zhang, Xiuwu Bian*. A Novel Zebrafish Xenotransplantation Model to Glioma Stem Cell Invasion. PLoS ONE 2013; 16(4):e61801.
10. Xiaojun Yang, Guilai Chen, Shicang Yu, Chuan Xu, Tingting Li, Shicang Yu, Ai Gu, Jiangjie Duan, Chen Qian, Youhong Cui, Xia Zhang, Xiuwu Bian*. TGF-β1 Enhances Tumor-induced Angiogenesis via JNK Pathway throughout up-regulation of macrophage development in an Improved Zebrafish Embryo/Xenograft Glioma Model. International Immunopharmacology 2013; 15:191–198.
11. Xiaojun Yang, Jian Zou, Lance Davidson, Willi Halfter, Xiangyun Wei*. Stepwise establishment of apicobasal polarity by Lin7c and other polarity determinants defines the bilateral symmetry of vertebrate neural tube. Journal of Neuroscience 2009; 16:29(37):11426-11440. (Cover Story)


主持科研项目


1. L1CAM/CD24/heparanase信号轴调控恶性胶质瘤发生和侵袭转移机制研究（国家自然科学基金面上项目，**，2019.1-2022.12）
2. Hsc70介导的L1核转运机制及其在肿瘤发生、侵袭转移中的生物学功能研究（国家自然科学基金面上项目，**，2016.1-2019.12）
3. 肿瘤干细胞斑马鱼模型的建立及其在肿瘤血管生成分子机制研究中的应用（国家自然科学基金青年项目，**）
4. 胶质瘤转基因斑马鱼模型的建立及其在胶质瘤发生、发展分子机制研究中的应用（广东省自然科学基金面上项目，2015A，2015.8-2018.8）