个人简历


汕头大学医学院，博士，副研究员，硕士生导师。研究方向：人胚胎干细胞。主持并完成了中国博士后科学基金“去唾液酸糖蛋白受体在乙肝病毒感染人精子过程中的作用” (No. ) 、国家自然基金青年基金“乙肝表面蛋白HBs 诱导人精子线粒体膜电位丧失的分子机制”(No.**)以及国家自然基金委－英国医学理事会中英干细胞国际合作项目“应用人胚胎干细胞建立HBV 和HCV 体外研究模型”（No. ）等课题。成功的应用人胚胎干细胞定向分化获得的肝脏细胞建立肝炎病毒感染模型的研究，为深入研究肝炎性病毒和宿主之间的相互作用提供了强有力的支持。相关成果发表在Human Reproduction、Stem Cell Reports等杂志上。现主持在研国家自然基金面上项目2项（No. **, **）。成果发表在Stem Cell Reports、Human Reproduction等专业期刊上。担任过中国环境诱变剂学会活性氧生物学效应专业委员会委员，汕头市遗传学会秘书、理事，中国遗传学会会员，中国环境与诱变剂协会会员，美国化学学会杂志J AGRIC FOOD CHEM 审稿人，British Journal of Pharmacology 审稿人。现在读硕士3人，合作指导博士后3人。


研究论文


1. Zhou X, Shi H, Yang S, Sun P. An efficient rapid system for assaying HBx-mediated transactivation. Biotechnol Lett 2017;39:1091-1099.
2. Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, et al. Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports 2016;7:43-54.
3. Zhou X, Sun P, Lucendo-Villarin B, Angus AG, Szkolnicka D, Cameron K, Farnworth SL, et al. Modulating innate immunity improves hepatitis C virus infection and replication in stem cell-derived hepatocytes. Stem Cell Reports 2014;3:204-214.
4. Sun P, Zheng J, She G, Wei X, Zhang X, Shi H, Zhou X. Expression pattern of asialoglycoprotein receptor in human testis. Cell Tissue Res 2013;352:761-768.
5. Cheng J, Guo S, Chen S, Mastriano SJ, Liu C, D'Alessio AC, Hysolli E, et al. An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis. Cell Rep 2013;5:471-481.
6. Zhou XL, Sullivan GJ, Sun P, Park IH. Humanized murine model for HBV and HCV using human induced pluripotent stem cells. Arch Pharm Res 2012;35:261-269.
7. Zhou XL, Sun PN, Bucheli P, Huang TH, Wang D. FT-IR methodology for quality control of arabinogalactan protein (AGP) extracted from green tea (Camellia sinensis ). J Agric Food Chem 2009;57:5121-5128.
8. Zhou XL, Sun PN, Huang TH, Xie QD, Kang XJ, Liu LM. Effects of hepatitis B virus S protein on human sperm function. Hum Reprod 2009;24:1575-1583.
9. Zhou X, Wang D, Sun P, Bucheli P, Li L, Hou Y, Wang J. Effects of soluble tea polysaccharides on hyperglycemia in alloxan-diabetic mice. J Agric Food Chem 2007;55:5523-5528.
10. Zhou XL, Shen W, Zhuge J, Wang ZX. Biochemical properties of a thermostable phytase from Neurospora crassa. FEMS Microbiol Lett 2006;258:61-66.


主要的科研项目