招生信息
教育背景
工作经历
教授课程
出版信息
科研活动
指导学生
基本信息
高亮男硕导中国科学院深圳先进技术研究院
电子邮件： liang.gao@siat.ac.cn
通信地址： 深圳市南山区学苑大道1068号中国科学院深圳先进技术研究院
邮政编码： 518055
研究领域
We are interested in the molecular and cellular functions of peripheral immune system in CNS injury and degenerative diseases, specially focus on infiltrating monocyte in mediating the immune response post ischemic stroke and inflammaging in the induction of AD. As immune response is a double-edged sword in neuronal death and regeneration post injury, understanding and fine tuning the balance between proinflammatory and anti-inflammatory responses provides new strategies for the relief of neural injury and promotion of regeneration. Aging is the key risking factor for neuronal degenerative diseases, accumulated distortions in the aged immune system lead to the interruption of immune niche in CNS and finally disturb the immune-protective effect of glial cells on neuronal survival. Thus, it is of great importance to find out the mechanism of inflammaging in the induction and progression of CNS degeneration.
Additionally, we will also investigate the role of neural circuitry regulations on immune system in homeostasis and immune disease progression. The innervation of sympathetic and parasympathetic nerves in immune organs provide controlling hubs for CSN in regulating immune activities. However, the detailed neural circuitry and molecular mechanisms of how CNS directing immune system still remains mysteries.
招生信息
We are always looking for motivated students who have good trainings in biology，zoology，medicine or other natural science background and willing to join us with great interest on neuroimmunology topics.招生专业
071006-神经生物学招生方向
神经免疫学教育背景
2009-10--2014-12德国海德堡大学博士2006-09--2009-06第二军医大学硕士2000-09--2004-06天津科技大学学士学历
博士学位
博士工作经历
工作简历
2015-01~2017-09,德国癌症研究中心,博士后教授课程
神经生物学基础出版信息
发表论文
（1）An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury,Frontiers in Molecular Neuroscience,2018,第3作者（2）Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion,eLife,2016,第1作者（3）Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice,The Journal of Experimental Medicine,2015,第1作者（4）Blocking P2X receptors can inhibit the injury-induced proliferation of olfactory epithelium progenitor cells in adult mouse,International Journal of Pediatric Otorhinolaryngology,2010,第1作者科研活动
科研项目
（ 1 ） 阿尔茨海默症的诊治方法研究, 参与,省级,2018-12--2022-12（ 2 ） 2019优青基金新引进启动项目, 主持,市地级,2020-01--2021-12（ 3 ） 深港脑科学创新研究院开放课题, 主持,省级,2019-01--2023-12参与会议
（1）Neutrophil slow rolling involves CD95 activation of integrin signaling2015-11-08指导学生
现指导学生徐帆硕士研究生071006-神经生物学
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