研究领域
招生信息
教育背景
工作经历
专利与奖励
出版信息
科研活动
基本信息
洪伟男中国科学院深圳先进技术研究院
电子邮件： wei.hong@siat.ac.cn
通信地址： 广东省深圳市南山区学苑大道1068号
邮政编码： 518055
研究领域
1. 神经退行性疾病研究模型；
2. 阿尔茨海默症的细胞和分子机制解析；
3. 阿尔茨海默症的治疗药物和生物标志物开发。
招生信息
招生专业
071006-神经生物学071010-生物化学与分子生物学071009-细胞生物学招生方向
阿尔茨海默症研究模型、发生机制和诊疗策略教育背景
2009-09--2014-06武汉大学博士2005-09--2009-06武汉大学学士工作经历
2014-11~2019-10, 哈佛大学医学院,博士后
专利与奖励
深圳市海外高层次人才，2020出版信息
发表论文
（1）PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins,Acta Neuropathologica,2020,第3作者（2）ImKTx96, a peptide blocker of the Kv1. 2 ion channel from the venom of the scorpion Isometrus maculates,Peptides,2020,通讯作者（3）PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity,Brain Research,2019,第2作者（4）A vicious cycle of beta amyloid-dependent neuronal hyperactivation,Science,2019,第3作者（5）Identification of neurotoxic cross-linked amyloid-beta dimers in the Alzheimer's brain,Brain,2019,第2作者（6）Diffusible, highly bioactive oligomers represent a critical minority of soluble Abeta in Alzheimer's disease brain,Acta Neuropathologica,2018,第1作者（7）An in vitro paradigm to assess potential anti-Abeta antibodies for Alzheimer's disease,Nature Communications,2018,第3作者（8）Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1,Theranostics,2018,第3作者（9）Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo,Journal of Neuroscience,2018,第5作者（10）Human Brain-Derived Abeta Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP,Journal of Neuroscience,2017,第3作者（11）A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA,Mol Ther Nucleic Acids,2016,第3作者（12）A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro,Toxins,2016,第3作者（13）A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro,J Biol Chem,2015,第1作者（14）Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery,Small,2015,第6作者（15）Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1,Antiviral Research,2014,第1作者（16）Sj7170, a unique dual-function peptide with a specific alpha-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom,J Biol Chem,2014,第4作者（17）Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus,Biomaterials,2013,第1作者（18）The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods,Nature Communications,2013,其他（合作组作者）（19）Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae,J Proteomics,2013,第6作者（20）Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4alpha in vitro and in vivo,J Biol Chem,2012,第2作者（21）Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses,Peptides,2011,第5作者（22）A new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV,Peptides,2011,第6作者科研活动
科研项目
（ 1 ） 非人灵长类动物模型分析, 主持,院级,2020-05--2020-12参与会议
（1）Identification of neurotoxic cross-linked Aβ heterodimers in Alzheimer's disease brain第48届神经科学学会年会(SFN)2018-11-07（2）Diffusible Alzheimer’s disease brain-derived Aβ disrupts synaptic plasticity第47届神经科学学会年会(SFN)2017-11-152013 © 中国科学院大学，网络信息中心.
