吴健苹 生物医药研究院 研究副教授 wuji@sustc.edu.cn



教育经历
2001 – 2006西澳大利亚大学机械与化工学院生物工程博士
1983 – 1987昆明理工大学机械工程学院机械工程学士


工作经历
2018-
南方科技大学生物医学工程系副教授
澳大利亚科廷大学土木和机械工程学院兼职高级研究员,博士生导师
西澳大利亚大学病理学和检验医学学院兼职研究员
2015 -2018
澳大利亚科廷大学土木和机械工程学院高级研究员, 博士生导师, 三维成像和生物工程实验室副主管
西澳大利亚大学病理学和检验医学学院兼职研究员
2012 - 2015
澳大利亚科廷大学土木和机械工程学院研究员, 博士生导师, 三维成像和生物工程实验室副主管
西澳大利亚大学病理学和检验医学学院兼职研究员
2011 - 2012
西澳大学机械与化学工程学院三维图像实验室研究员, 博士生导师, 和实验室主管
2006 - 2011
澳大利亚国家卫生和医学研究员, 博士生导师,西澳大学机械与材料工程学院三维图像实验室实验室副主管
1995 - 2000
西澳大学机械与材料工程学院三维图像实验室研究助理
1987 - 1994
中国有色金属工业总公司昆明贵金属研究所机械工程师


交叉研究领域
生物医学工程
微创伤诊图像诊断技术
3D成像开发和应用
成像分析和处理
肌肉骨骼系统功能障碍机理
关节软骨，肌腱和韧带微构件的机械功能
耳鼻咽喉科，听力和行为科学


所获荣誉
2017 - 2019 National Health and Medical Research Council (NHMRC) Development Grant (associate investigator), project title: Superior surgical fixation using a novel orthopaedic expandable fastener, $414,000
2011 – 2014 Australian Research Council, Linkage Awarded $840,000 from the ARC and $667,633 from Orthocell, EBonz, and Sir Charles Gairdner Hospital as an Australian Research Council Linkage grant for the project title: Bioengineered bioscaffolds for Achilles tendinopathy treatment” in partnership with UWA, University of Auckland and Griffith University. (Intensively participated in writing the grant and the only named research fellow in the grant), total $1,507,633.
2006 - 2010 NHMRC Industry Fellowship (sole investigator), project title: Developing confocal arthroscopy for in vivo visualizing the internal microstructure of articular cartilage for assessing early osteoarthritis, $362,000.
2010 UWA Research Development Award (sole investigator), project title: Studying Altered Mechanical Behaviour of Articular Cartilage in Relation to Disruption of the Articular Surface and the Collagen Matrix, $13,500.
2007 UWA Research Grant Scheme (sole investigator), project title: The Role of the Surface of Articular Cartilage in Maintaining Cartilage Matrix Integrity and Healthy Joints”, $25,000.
2006 Travel Grant Award, ANZORS.
2003 Travel Award, International Society of Biomechanics.
2001 - 2005 A PhD scholarship (UPA) with stipend & Dr Julian Hunka top up Scholarship, UWA.
1993 Award for Scientific and Innovative Achievement (Non-Ferrous Metal Industry Cooperation of China, formerly the Ministry of Mining and Metallurgy of China).
Citation: “this award was given to those who have made a great contribution in developing science and technology in China”.


代表文章
1. JP Wu*, BJ Swift, T Becker, A Squelch, YC Zheng, J Xu, MH Zheng, A Wang, W Xue, XL Zhao, D Lloyd and TB Kirk, High resolution studying the 3D collagen fibrillar matrix in Achilles tendons without tissues labelling and dehydrating, J. Microscopy, 266 (3), 2017, 273-287. (Cover page of the issue). (corresponding author)
2. X Pan, JP Wu*, GT Allison, J Rubenson, MH Zheng, D Lloyd, B Gardiner, A Wang and TB Kirk, The three dimensional microstructural network of elastin, collagen and cells in Achilles tendons. J. Orthopaedic Research, 35 (6), 2017, 1203-1214. (corresponding author)
3. Z Xu, Y Zhang, Q Hu, Q Tang, J Xu, JP Wu, T B Kirk, D Ma, W Xue, Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery, Materials Science and Engineering C, 71, 2017, 965-972.
4. Q Lin, Y Yang, Q Hu, Z Guo, T Liu, J Xu, J Wu, T B Kirk, D Ma, W Xu E, Injectable supramolecular hydrogel formed from α-cyclodextrin and PEGylated arginine-functionalized poly(L-lysine) dendron for sustained MMP-9 shRNA plasmid delivery, Acta Biomaterialia, 49, 2017, 456-471.
5. Y Gu, Y Guo, C Wang, J Xu, J Wu, TB Kirk, D Ma and W Xue, A Polyamidoamne dendrimer functionalized graphene oxide for DOX and MMP-9 shRNA plasmid co-delivery, Materials Science and Engineering C, 70 (Pt 1), 2017, 572-585.
6. KY Wang, JP Wu, R Days, TB Kirk and XZ Hu, Characterizing depth dependent refractive index of articular cartilage subjected to mechanical wear or enzymic degeneration, J. Biomedical Optics, 21 (9), 2016, 095002, doi:10.1117/1.JBO.21.9.095002.
7. A Hayes, K Easton, PT Devanaboyina, JP Wu, TB Kirk and D Lloyd, Structured white light scanning of rabbit Achilles tendon, J. Biomechanics, 49 (15), 2016, 3753-3758.
8. X Zhou, Q Zheng, C Wang, J Xu, JP Wu, TB Kirk, D Ma and W Xue. Star-shaped amphiphilic hyerbranched polyclycerol-conjugated with dendritic poly (L-lysine) for the co-delivery of decetaxel and MMP-9 siRNA in cancer therapy. ACS Applied Materials & Interfaces, 8 (20), 2016, 12609-12619.
9. Q Hu, Y Zhang, C Wang, J Xu, JP Wu, Z Liu and W Xue, Hemocompatibility evaluation in vitro of methoxy ployethyleneglyco-polycaprolactone copolymer solutions, J. Biomedical Materials Research (Part A), 104 (3), 2016, 802-812.
10. JP Wu*, M Walton, A Wang, P Anderson, T Wang, TB Kirk and MH Zheng, The development of confocal arthroscopy as optical histology for rotator cuff tendinopathy, J. Microscopy, 259 (3), 2015, 1-7. (corresponding author)
11. XJ Duan, JP Wu, B Swift and TB Kirk, Texture analysis of the 3D collagen network and automatic classification of the physiology of articular cartilage, J. Computer Methods in Biomechanics and Biomechanical Engineering, 18(9), 2015, 931-943.
12. X Yang, D Teguh, JP Wu, B He, TB Kirk, S Qin, S Li, H Chen, W Xue, B Ng, S M Chim, J Tickner & J Xu, Protein kinase C delta null mice exhibit structural alterations in articular surface, intra-articular and subchondral compartments, Arthritis Research & Therapy, 17(1), 2015, 1-8.
13. Bo He, JP Wu, Thomas B Kirk, John A Carrino, Chuan Xiang and Jiake Xu, High resolution measurements of the multilayer ultrastructure of articular cartilage and their translational potential, Arthritis Research & Therapy, 2014, 16: 205.
14. KY Wang, JP Wu and TB Kirk, Depth dependent refractive index of normal and early degenerated articular cartilage, J. Biomedical Optics, 2013, 18 (10): 105003.
15. B He, JP Wu, J Xu; R E Day and T B Kirk, Microstructural and compositional features of the fibrous and hyaline cartilage on the medical tibial plateau imply a unique role for the hopping locomotion of kangaroos, PLOS One, 2013.
16. XJ Duan, JP Wu and TB. Kirk, Rotated Hough Filtering for Automatically Distinguishing the Collagen Bundles in the Most Superficial Layer of Articular Cartilage, The IEEE J. Biomedical and Health Informatics, 17 (5): 922-927, 2013.
17. B He, JP Wu, HH Chen, TB. Kirk and J Xu, Elastin fibers display a versatile microfibril network in articular cartilage depending on the mechanical microenvironments. J. Orthopaedic Research, 2013, 1-9.
18. B He, JP Wu, SM Chim, J Xu and TB Kirk, Microstructural analysis of collagen and elastin fibres in the kangaroo articular cartilage reveals a structural divergence depending on its local mechanical environment. Osteoarthritis and Cartilage. 2013, 21 (1): 237-245.
19. JP Wu*, KY Wang, XJ Duan and TB Kirk, Minimally invasive techniques for diagnosis of early musculoskeletal disorders, Clinical and Experimental Pharmacology and Physiology (Supplement), 2013.
20. K Wang, JP Wu, R Days and TB Kirk, Utilizing confocal microscopy to measure refractive index of articular cartilage. J. Microscopy. 2012, 248 (3): 281-291.
21. D Smolinski, CW Jones, JP Wu, K Miller, TB Kirk, MH Zheng. Confocal arthroscopic assessment of osteoarthritis in situ. J. Arthroscopy and Related Surgery. 2008, 24: 423-429.
22. JP Wu*, TB Kirk. Study of altered mechanical properties of articular cartilage in relation to the collagen network. J. Advanced Materials Research. 2008, 41-42: 9-14. (corresponding author)
23. JP Wu*, TB Kirk and MH Zheng. Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique. J. Orthopaedic Surgery and Research. 2008, 3: 29-. (corresponding author)
24. JP Wu, TB Kirk. 3D Study of microstructure of articular cartilage for development of real time histology for articular cartilage. J. Tissue Engineering (supplement). (ISSN 1076-3279, Mary Ann Liebert, Inc. publishers, New York).
25. JP Wu*, TB Kirk, Z Peng, MH Zheng and K Miller. Quantitative characterizing the collagen orientation in the superficial zone for studying early degenerative changes in articular cartilage. J. Musculoskeletal Research. 2006, Volume 10: 1-12. (corresponding author)
26. JP Wu, Kirk TB, Z Peng, MH Zheng and K Miller. Utilization of two-dimensional Fast Fourier Transform and power spectral analysis for assessment of early degeneration of articular cartilage. J. Musculoskeletal Research. 2005, Volume 9: 1-13.
27. CW Jones, D Smolinski, JP Wu, C Willers, K Miller, TB Kirk and MH Zheng. Quantification of chondrocyte morphology by confocal arthroscopy. J. Musculoskeletal Research. 2004; Volume 4: 145-154.
28. CW Jones, A Keogh, D Smolinski, JP Wu, TB Kirk and MH Zheng. Histological assessment of the chondral and connective tissues of the knee by a confocal arthroscope. J. Musculoskeletal Research. 2004; Volume 8: 75-86.
29. JP Wu, TB Kirk and MH Zheng. Assessment of three-dimensional architecture of collagen fibres in the superficial zone of bovine articular cartilage. J. Musculoskeletal Research. 2004; Volume 8: 169-179.
30. D Smolinski, JP Wu, CW Jones, MH Zheng, LJ O’Hara, K Miller and TB Kirk. The confocal arthroscope as cartilage optical biopsy tool. Osteoarthritis & Cartilage (supplement A). 2003; Volume (11); p111.


联系方式
wujp@sustech.edu.cn
+86**