李凯
研究员
lik@sustech.edu.cn
个人主页


李凯，现任南方科技大学生物医学工程系研究员，博士生导师。主要研究方向为新型分子探针与纳米探针的开发及其在肿瘤诊疗与再生医学中的应用。李博士于2011年在新加坡国立大学获得博士学位，对共轭聚合物纳米微粒作为新型荧光探针在生物医学方面的应用做了系统的研究，并获得了国家优秀自费留学生奖学金。随后加入新加坡科技研究局材料与工程研究院任研究科学家，2013年获得新加坡科技研究局年轻研究员职业发展奖，2015-2017年作为访问****加入斯坦福大学医学院分子影像中心进行合作研究。李博士在相关研究领域有着多年的学术积累，开发的新型荧光纳米微粒及细胞示踪剂被Nature杂志以‘The nanolight revolution is coming’为专题进行过报道，迄今申请PCT专利4项，授权新加坡专利1项，共发表学术论文70余篇，被包括Nature, Science Translational Medicine, Chemical Reviews, Chemical Society Reviews在内的学术期刊引用超过6,500次(Web of Science)，其中单篇引用超过100次的论文13篇，当前H-index为42。
教育背景
1999年-2003年 北京化工大学材料科学与工程学院 本科
2004年-2006年 忠南国立大学高分子工学系 硕士
2008年-2011年 新加坡国立大学化学与生物分子系 博士
工作经历
2018年-至今 南方科技大学生物医学工程系 研究员
2015年-2017年 斯坦福大学医学院分子影像中心 访问****
2011年-2018年 新加坡科研局材料工程研究院 研究科学家, PI
荣誉及奖励
2016年 世界分子影像大会Travel Award
2015年 新加坡科技研究局International Fellowship
2013年 新加坡科技研究局年轻研究员职业发展奖
2011年 教育部优秀自费留学生奖学金
2008年 新加坡国立大学校长奖学金
2004年 韩国科技财团优秀外国留学生奖学金
2003年 北京地区高校优秀毕业生
代表论文
1. Jen-Shyang Ni,? Xun Zhang,? Guang Yang, Tianyi Kang, Xiangwei Lin, Menglei Zha, Yaxi Li, Lidai Wang, Kai Li*. Photoinduced nonadiabatic decay-guided molecularmotor triggers effective photothermal conversion for hyperthermia cancer therapy. Angew. Chem. Int. Ed. 2020, doi: 10.1002/ange. (?contributed equally).
2. Jen-Shyang Ni,? Tianliang Min,? Yaxi Li, Menglei Zha, Pengfei Zhang, Chun Loong Ho, Kai Li.* Planar AIEgens with Enhanced Solid-State Luminescence and ROS-Generation for Multidrug-Resistant Bacteria Treatment. Angew. Chem. Int. Ed. 2020, doi: 10.1002/anie. (?contributed equally).
3. Jen-Shyang Ni,? Yaxi Li,? Wentong Yue, Bin Liu,* Kai Li.* Nanoparticle-based cell trackers for biomedical applications. Theranostics 2020, 10, 1923-1947. (?contributed equally).
4. Qiyao Li,? Ying Li,? Tianliang Min,? Junyi Gong, Lili Du, David Lee Phillips, Junkai Liu, Jacky W. Y. Lam, Herman H. Y. Sung, Ian D. Williams, Ryan T. K. Kwok, Chun Loong Ho, Kai Li, Jianguo Wang,* Ben Zhong Tang.* Time‐dependent photodynamic therapy for multiple targets: a highly efficient AIE‐active photosensitizer for selective bacterial elimination and cancer cell ablation. Angew. Chem. Int. Ed. 2019, doi: 10.1002/anie. (?contributed equally).
5. Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J. Abilez, Dan Ding, Sarah C. Heilshorn, Kai Li.* An in vivo miRNA delivery system for restoring infarcted myocardium. ACS Nano 2019, 13, 9880-9894.
6. Xulei Qin, Haodong Chen, Huaxiao Yang, Haodi Wu, Xin Zhao, Huiyuan Wang, Tony Chour, Evgenios Neofytou, Dan Ding, Heike Daldrup-Link, Sarah C. Heilshorn, Kai Li,* Joseph C. Wu,* Photoacoustic imaging of embryonic stem cell-derived cardiomyocytes in living hearts with ultrasensitive semiconducting polymer nanoparticles. Adv. Funct. Mater. 2018, 28, **.
7. Heqi Gao, Xiaoyan Zhang, Chao Chen, Kai Li,* Dan Ding.* Unity makes strength: how aggregation-induced emission luminogens advance the biomedical field. Adv. Biosys. 2018, 2, ** (Invited Review).
8. Kai Li,* Hossein Nejadnik, Heike E. Daldrup-Link,* Next generation superparamagnetic iron oxide nanoparticles for cancer theranostics. Drug Discov. Today 2017, 22, 1421-1429 (Invited Review).
9. Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu,* Kai Li,* Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun. 2016, 52, 2752-2755 (*corresponding author).
10. Guorui Jin, Duo Mao, Pingqiang Cai, Rongrong Liu, Nikodem Tomczak, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding,* Bin Liu,* Kai Li,* Conjugated polymer nanodots as ultrastable long-term trackers to understand mesenchymal stem cell therapy in skin regeneration. Adv. Funct. Mater. 2015, 25, 4263-4273 (Frontispiece Story).
11. Jie Liu, Kai Li,* Bin Liu,* Far-red/near-infrared conjugated polymer nanoparticles for long-term in-situ monitoring of liver tumor growth. Adv. Sci. 2015, 2, **.
12. Kai Li, Bin Liu, Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. Chem. Soc. Rev. 2014, 43, 6570-6597.
13. Dan Ding,? Duo Mao,? Kai Li,? Xiaomin Wang, Wei Qin, Rongrong Liu, David Shunzhong Chiam, Nikodem Tomczak, Zhimou Yang, Ben Zhong Tang, Deling Kong, Bin Liu (?contributed equally), Precise and long-term tracking of adipose-derived stem cells and their regenerative capacity via superb bright and stable organic nanodots. ACS Nano 2014, 8, 12620-12631.
14. Wei Qin,? Kai Li,? Guangxue Feng, Min Li, Zhiyong Yang, Bin Liu, Ben Zhong Tang, Bright and photostable organic fluorescent dots with aggregation-induced emission characteristics for noninvasive long-term cell imaging. Adv. Funct. Mater. 2014, 24, 635-643 (?contributed equally).
15. Guangxue Feng,? Kai Li,? Jie Liu, Dan Ding, Bin Liu, Bright single-chain conjugated polymer dots embedded nanoparticles for long-term cell tracing and imaging. Small 2014, 10, 1212-1219 (?contributed equally).
16. Kai Li, Wei Qin, Dan Ding, Nikodem Tomczak, Junlong Geng, Rongrong Liu, Jianzhao Liu, Xinhai Zhang, Hongyu Liu, Bin Liu, Ben Zhong Tang, Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci. Rep. 2013, 3, 1150 (Highlighted by Nature News).
17. Kai Li, Zhenshu Zhu, Zujin Zhao, Nikodem Tomczak, Pingqiang Cai, Rongrong Liu, Jie Liu, Wei Qin, Yong Hu, Xiaodong Chen, Ben Zhong Tang, Bin Liu, Organic dots with aggregation-induced emission (AIE dots) characteristics for dual-color cell tracing. Chem. Mater. 2013, 25, 4181-4187.
18. Kai Li, Dan Ding, Da Huo, Kan-Yi Pu, Ngo Nguyen Phuong Thao, Yong Hu, Zhi Li, Bin Liu, Conjugated polymer based nanoparticles as dual-modal probes for targeted in vivo fluorescence and magnetic resonance imaging. Adv. Funct. Mater. 2012, 22, 3107-3115.
19. Kai Li, Yutao Liu, Kan-Yi Pu, Si-Shen Feng, Ruoyu Zhan, Bin Liu, Polyhedral oligomeric silsesquioxanes-containing conjugated polymer loaded PLGA nanoparticles with Trastuzumab (Herceptin) functionalization for HER2-positive cancer cell detection. Adv. Funct. Mater. 2011, 21, 287-294 (Inside Front Cover Story).
20. Kai Li, Jie Pan, Si-Shen Feng, Arthur Wenqing Wu, Kan-Yi Pu, Yutao Liu, Bin Liu, Generic strategy of preparing fluorescent conjugated polymer-loaded poly(dl-lactide-co-glycolide) nanoparticles for targeted cell imaging. Adv. Funct. Mater. 2009, 19, 3535-3542 (Frontispiece Story).