董 金堂Google Scholar ResearcherID

讲席教授 医学院
董金堂，南方科技大学医学院讲席教授，博士生导师。1984年获南开大学生物学学士，1989获中国协和医科大学、中国医学科学院理学博士。美国国立卫生研究院和约翰霍普金斯大学医学院博士后。美国弗吉尼亚大学医学院助理教授、副教授。美国埃默里大学医学院副教授、教授。承担过多项中国和美国的科研项目。在包括Science和Nature系列杂志在内的国际学术刊物上发表论文120多篇。获得过多项国内和国际奖励。担任中国和美国政府不同部门的各种科研和人才项目的评审。是多家国际学术刊物的副主编或编委。带领团队从事肿瘤发生发展的分子基础研究20多年，已经培养博士和博士后30余名。
个人简介董金堂教授于1989年获得协和医科大学（北京协和医学院）中国医学科学院理学博士学位。1990年至1996年在美国国立卫生研究院和约翰霍普金斯大学医学院从事博士后工作。1996年至2002年在美国尼亚大学医学院病理系, 生物化学和分子遗传学系担任助理教授、副教授。2002年起先后担任美国埃默里大学医学院肿瘤学和血液学系以及泌尿学系副教授、正教授，并曾担任科研副主任及Winship肿瘤中心癌症遗传学和表观遗传学项目共同主任。曾获得佐治亚癌症联盟杰出医生和科学家奖，美国国立卫生研究院院长奖，国家自然科学基金委****基金。
董金堂教授于2018年8月入职南方科技大学医学院，任讲席教授，为深圳市国家级领军人才。

个人简介

研究领域肿瘤发生发展的分子基础及其转化应用研究：董金堂教授课题组利用遗传学、生物化学、细胞生物学、分子生物学、组织病理学等各种研究手段和各种肿瘤模型，了解前列腺癌发生和演进的生物学机制，并探索机制方面的发现在肿瘤检测和治疗方面的应用。

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教学生物医学专业硕士博士生：肿瘤生物学；生物医学专业本科生：医学遗传学。

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学术成果 查看更多通讯或第一作者论文目录：
(1)Dong JT, Luo XM (1993) Arsenic-induced DNA-strand breaks associated with DNA-protein crosslinks in human fetal lung fibroblasts. Mutat Res 302:97-102.
(2)Dong JT, Luo XM (1994) Effects of arsenic on DNA damage and repair in human fetal lung fibroblasts. Mutat Res 315:11-15.
(3)Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268:884-886.
(4)Dong JT, Zhou CN, Luo XM (1995) Induction of preneoplastic lesions by sodium arsenite in human fetal respiratory epithelia in organ culture. Environ Res 68:39-43.
(5)Dong JT, Suzuki H, Pin SS, Bova GS, Schalken JA, Isaacs WB, Barrett JC, Isaacs JT (1996) Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss. Cancer Res 56:4387-4390.
(6)Dong JT, Isaacs WB, Barrett JC, Isaacs JT (1997) Genomic organization of the human KAI1 metastasis-suppressor gene. Genomics 41:25-32.
(7)Dong JT, Sipe TW, Hyytinen ER, Li CL, Heise C, McClintock DE, Grant CD, Chung LW, Frierson HF, Jr. (1998) PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. Oncogene 17:1979-1982.
(8)Hyytinen ER, Frierson HF, Boyd JC, Chung LWK, Dong JT (1999) Three distinct regions of allelic loss at 13q14, 13q21-22, and 13q33 in prostate cancer. Gene Chromosome Cancer 25:108-114.
(9)Hyytinen ER, Frierson HF Jr, Sipe TW, Li CL, Degeorges A, Sikes RA, Chung LW, Dong JT (1999) Loss of heterozygosity and lack of mutations of the XPG/ERCC5 DNA repair gene at 13q33 in prostate cancer. Prostate. 41(3): 190-195.
(10)Dong JT, Chen C, Stultz BG, Isaacs JT, Frierson HF, Jr. (2000) Deletion at 13q21 is associated with aggressive prostate cancers. Cancer Res 60:3880-3883.
(11)Chen C, Brabham W, Stultz BG, Frierson HFJ, Barrett JC, Sawyers CL, Isaacs JT, and Dong JT (2001) Defining a common region of deletion at 13q21 in human cancers. Genes Chromosomes Cancer 31:333-344.
(12)Chen C, Frierson HFJ, Haggerty PF, Theodorescu D, Gregory CW, Dong JT (2001) An 800 kb region of deletion at 13q14 in human prostate and other carcinomas. Genomics 77:135-144.
(13)Dong JT, Li CL, Sipe TW, Frierson HF, Jr. (2001) Mutation of PTEN/MMAC1 in primary prostate cancers from Chinese patients. Clin Cancer Res 7:304-308.
(14)Dong JT, Boyd JC, Frierson HF, Jr. (2001) Loss of heterozygosity at 13q14 and 13q21 in high grade prostate cancer. Prostate 49:166-171.
(15)Hyytinen ER, Saduut R, Chen C, Lindsay Paull L, Koivisto PA, Vessella RL, Frierson HF, Dong JT (2002) Defining the Region(s) of Deletion at 6q16-q22 in Human Prostate Cancer. Genes Chromosomes Cancer 34:306-312.
(16)Chen C, Bhalala HV, Qiao H, and Dong JT (2002) A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. Oncogene 21:6567-6572.
(17)Chen C, Hyytinen ER, Sun X, Helin HJ, Koivisto PA, Frierson HF, Vessella RL, and Dong JT (2003) Deletion, mutation, and loss of expression of the KLF6 tumor suppressor gene in a subset of prostate cancer. Am J Pathol 162:1349-1354.
(18)Chen C, Bhalala HV, Vessella RL, and Dong JT (2003) KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate 55:81-88.
(19)Chen C, Zhou Y, Zhou Z, Sun X, Otto KB, Uht RM, and Dong JT (2004) Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells. Gene 330:133-142.
(20)Chen C, Sun X, Ran Q, Wilkinson KD, Murphy TJ, Simons JW, and Dong JT (2005) Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene 24:3319-3327, 2005.
(21)Sun X, Frierson HF, Chen C, Li C, Ran Q, Otto KB, Cantarel BL, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, and Dong JT (2005) Frequent somatic mutations of the ATBF1 transcription factor in human prostate cancer. Nat Genet37: 407-412.
(22)Chen C, Guo P, Sun X, Dong XY, Sethi P, Cheng X, Zhou J, Ling J, Simons JW, Lingrel JB, and Dong JT (2005) KLF5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J Biol Chem 280:41553-41561.
(23)Chen C, Benjamin MS, Sun X, Otto KB, Guo P, Dong XY, Bao Y, Zhou Z, Cheng X, Simons JW &Dong JT (2006). KLF5 promotes cell proliferation and tumorigenesis through gene regulation in the TSU-Pr1 human bladder cancer cell line. Int J Cancer 118:1346-1355.
(24)Sun X, Chen C, Vessella RL, and Dong JT (2006) Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancer. Prostate 66:660-666.
(25)Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX, Chung LW, Zhou W, and Dong JT (2006) FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting AR signaling in prostate cancer. Cancer Res 66:6998-7006.
(26)Chen C, Sun X, Guo P, Dong XY, Sethi P, Zhou W, Zhou Z, Petros J, Frierson HF, Vessella RL, Atfi A, and Dong JT (2007) Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene 26: 2386-2394.
(27)Sun X, Zhou Y, Otto KB, Wang M, Chen C, Zhou W, Subramanian K, Vertino PM, and Dong JT (2007) Infrequent mutation of ATBF1 in human breast cancer. J Cancer Res Clin Oncol 133:103-5.
(28)Dong XY, Rodriguez C, Guo P, Sun X, Talbot JT, Zhou W, Petros J, Li Q, Vessella RL, Kibel AS, Stevens VL, Calle EE, and Dong JT (2008) SnoRNA U50 is a candidate tumor suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum Mol Genet 17:1031-142.
(29)Chen L, Zhu Z, Sun X, Dong XY, Wei J, Gu F, Sun YL, Zhou J, Dong JT, and Fu L (2009) Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. Breast Cancer Res Tt 116:471-8.
(30)Guo P, Zhao KW, Dong XY, Sun X, and Dong JT (2009) Acetylation of KLF5 alters the assembly of P15 transcription factors in TGFbeta-mediated induction in epithelial cells. J Biol Chem 284:18184-93.
(31)Dong XY, Guo P, Boyd J, Sun X, Li Q, Zhou W, and Dong JT (2009) Implication of snoRNA U50 in human breast cancer. J Genet Genomics 36:447-54.
(32)Guo P, Dong XY, Zhao KW, Sun X, Li Q, and Dong JT (2009) Opposing effects of KLF5 on the transcription of Myc in epithelial proliferation in the context of TGFbeta. J Biol Chem 284:28243-28252.
(33)Guo P, Dong XY, Zhao KW, Sun X, Li Q, and Dong JT (2010) Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. Int J Cancer 126:81-89.
(34)Dong XY, Sun X, Guo P, Li Q, Sasahara M, Ishii Y, and Dong JT (2010) ATBF1 inhibits ER function by selectively competing with AIB1 for binding to ER in ER-positive breast cancer cells. J Biol Chem 285:32801-32809.
(35)Wang XX, Fu L, Li X, Wu X, Zhu Z, Fu L, and Dong JT (2011) Somatic mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary breast cancers. Path Onc Res 17:429-433.
(36)Zhao KW, Sikriwal D, Dong X, Guo P, Sun X &Dong JT (2011). Estrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells. Biochem J437:323-333.
(37)Dong XY, Guo P, Sun X, Li Q, and Dong JT (2011) Estrogen upregulates ATBF1 transcription but causes its protein degradation in ER-positive breast cancer cells. J Biol Chem 286:13879-13890.
(38)Zhang Z, Zhang B, Li W, Fu L, Fu L, Zhu Z, and Dong JT (2011) Epigenetic silencing of miR-203 upregulates SNAI2 and contributes to the invasiveness of malignant breast cancer cells. Genes Cancer 2:782-791.
(39)Su D, Fu X, Fan S, Wu X, Wang XX, Fu L, Dong XY, Ni JJ, Zhu Z, and Dong JT (2012) Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am J Pathol 180:1189-201.
(40)Wu X, Zhu Z, Li W, Fu X, Su D, Fu L, Zhang Z, Luo A, Sun X, and Dong JT (2012) Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer. Breast Cancer Res 14:R73.
(41)Dong XY, Fu X, Fan S, Guo P, Su D, and Dong JT (2012) Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. Biochem J 444:581-590.
(42)Sun X, Fu X, Li J, Xing C, Martin D, Zhang H, and Dong JT (2012) Heterozygous deletion of Atbf1 by the Cre-loxP system in mice causes preweaning mortality. Genesis 50(11):819-827.
(43)Li M, Fu X, Ma G, Sun X, Dong XY, Nagy T, Xing C, Li J, and Dong JT (2012) Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling. PLoS ONE 7(12):e51283.
(44)Li M, Zhao D, Ma G, Zhang B, Fu X, Zhu Z, Fu L, Sun X, and Dong JT (2012) Upregulation of ATBF1 by progesterone-PR signaling and its functional implication in mammary epithelial cells. Biochem Biophys Res Commun 430(1):358-363.
(45)Sun X, Li J, Sica G, Fan SQ, Wang Y, Chen Z, Muller S, Chen ZG, Fu X, Dong XY, Guo P, Shin DM, and Dong JT (2012) Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma.. Head Neck 35:1007-1014, 2013.
(46)Xing C, Fu X, Sun X, Guo P, Li M, and Dong JT (2013) Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. PLoS ONE 8:e65538.
(47)Xing C, Fu X, Sun X, and Dong JT (2013) Lack of an additive effect between the deletions of Klf5 and Nkx3-1 in mouse prostatic tumorigenesis. J Genet Genomics 40:315-318.
(48)Zhang B, Zhang Z, Xia S, Xing C, Ci X, Li X, Zhao R, Tian S, Ma G, Zhu Z, Fu L, and Dong JT (2013) KLF5 activates miR-200 transcription to maintain epithelial characteristics and prevent induced EMT in epithelial cells. Mol Cell Biol33：4919-4935.
(49)Sun X, Li J, Dong FN, and Dong JT (2014) Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. PLoS ONE 9:e92746.
(50)Zhang Z, Zhu Z, Zhang B, Li W, Li X, Wu X, Wang L, Fu L, Fu L, and Dong JT (2014) Frequent mutation of rs** and its association with PVT1 expression and cell proliferation in breast cancer. J Genet Genom 41:187-195.
(51)Li X, Zhang B, Wu Q, Ci X, Zhao R, Zhang Z, Xia S, Su D, Chen J, Ma G, Fu L, and Dong JT (2014) Interruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells. Int J Cancer 136(3):536-546.
(52)Sun X, Fu X, Li J, Xing C, Frierson HF, Wu H, Ding X, Ju T, Cummings RD, Dong JT (2014)Deletion of atbf1/zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways. Neoplasia. 16(5):377-89.
(53)Xing C, Ci X, Sun X, Fu X, Zhang Z, Dong EN, Hao ZZ, and Dong JT (2014) Klf5 deletion promotes Pten deletion-initiated luminal type mouse prostate tumors via multiple oncogenic signaling pathways. Neoplasia 16(11):883-899.
(54)Ci X, Xing C, Zhang B, Zhang Z, Ni JJ, Zhou W, and Dong JT (2015) KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1alpha accumulation. Mol Cancer 14:91 (15 pages).
(55)Sun X, Xing C, Fu X, Li J, Zhang B, Frierson HFJ, and Dong JT (2015) Additive effect of Zfhx3/Atbf1 and Pten deletion on mouse prostatic tumorigenesis. J Genet Genomics 42(7):373-82.
(56)Zhang B, Zhao R, He Y, Fu X, Fu L, Zhu Z, Fu L, and Dong JT (2015) Micro RNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR. Oncotarget 7(5):5702-5714.
(57)Luo A, Su D, Zhang X, Qi L, Fu L, and Dong JT (2016) Estrogen-estrogen receptor signaling suppresses the transcription of ERRF in breast cancer cells. J Genet Genomics 43:565-567.
(58)Zhao D, Ma G, Zhang X, He Y, Li M, Han X, Fu L, Dong XY, Nagy T, Zhao Q, Fu L, and Dong JT (2016) Zinc finger homeodomain factor Zfhx3 is essential for mammary lactogenic differentiation by maintaining prolactin signaling activity. J Biol Chem 291:12809-12820.
(59)Luo A, Zhang X, Fu L, Zhu Z, and Dong JT (2016) Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells. J Genet Genomics 43:677-685.
(60)Qi L, Zhang B, Zhang S, Ci X, Wu Q, Ma G, Luo A, Fu L, King JL, Nahta R, and Dong JT (2017) ERRF sensitizes ERBB2-positive breast cancer cells to lapatinib treatment likely by attenuating MCL1 and ERBB2 expression. Oncotarget 8:36054-36066.
(61)Tao R, Zhang B, Li Y, King JL, Tian R, Xia S, Schiavon CR, and Dong JT (2018) HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation. Biochem Biophys Res Commun 500:777-782.
(62)Gao A, Sun T, Ma G, Cao J, Hu Q, Chen L, Wang Y, Wang Q, Sun J, Wu R, Wu Q, Zhou J, Liu L, Hu J*, Dong JT*, and Zhu Z* (2018) LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERalpha pathway. Nat Commun 9(1):4180. (* Corresponding author)
(63)King JL, Zhang B, Li Y, Li KP, Ni JJ, Saavedra HI, and Dong JT (2018) TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer. Oncogenesis 7:69.
(64)Wu Q, Fu C, Li M, Li J, Li Z, Qi L, Ci X, Ma G, Gao A, Fu X, Jun A, Na A, Liu M, Li Y, King JL, Fu L, Zhang B, &Dong JT (2018) CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival, and tumor growth. Int. J. Cancer 144: 582-594.
(65)Luo A, Zhang K, Zhao Y, Zhu Z, Fu L, and Dong JT (2018) ZNF121 interacts with ZBRK1 and BRCA1 to regulate their target genes in mammary epithelial cells. FEBS Open Bio 8:1943-1952.
(66)Hu Q, Zhang B, Chen R, Fu C, A J, Fu X, Li J, Fu L, Zhang Z, and Dong JT (2019) ZFHX3 is indispensable for ERbeta to inhibit cell proliferation via MYC downregulation in prostate cancer cells. Oncogenesis 8:28 (15 pages).
(67)Zhao D, Han X, Huang L, Wang J, Zhang X, Jeon JH, Zhao Q, and Dong JT (2019) Transcription factor ZFHX3 regulates calcium influx in mammary epithelial cells in part via the TRPV6 calcium channel. Biochem Biophys Res Commun 519:366-371.
(68)Guo P, Xing C, Fu X, He D, and Dong JT (2019) Ras inhibits TGFbeta‐induced KLF5 acetylation and transcriptional complex assembly via regulating SMAD2/3 phosphorylation in epithelial cells. J Cell Biochem 120:In press.





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董金堂课题组招聘博士后及研究助理
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