简 历
李沙，女，博士，教授，硕士生导师。1997年于华中科技大学同济医学院药学院（原同济医科大学药学院）获药物化学硕士学位，2002年于北京大学医学部药学院攻读药剂学博士学位，2002~2003年于香港理工大学应用生物及化学科技学系作博士后研究。先后于华中科技大学同济医学院药学院药剂系任讲师、副教授，于暨南大学药学院药剂学教研室任副教授、教授。主要从事药剂学相关教学工作，先后新建暨南大学药学院《中药药剂学》和《中药药剂学实验》、药学院《物理药剂学》、国际学院药学专业《Pharmaceutics》和《Pharmaceutics Experiments》五门本科课程。先后主讲与承担本科生药剂学(中文及国际学院全英教学)、中药药剂学、物理药剂学、生物药剂学与药物动力学、生物药物制剂学理论课与实验课教学工作，以及药学院硕士研究生《药剂学概论》和博士研究生《药剂学研究进展》、国际学院硕士研究生《Pharmaceutical Preparation Technology》的教学工作。现任广东省药学会药剂学专委会委员、广东省药学会制药工程专委会委员、广东省生物医学工程学会药品食品智能制造工程分会委员、中国老年学和老年医学学会老年骨科分会基础学组委员。主持并承担国家、省、市等各级科研项目近二十项，以第一作者或通讯作者在国内外本专业重要学术期刊上发表论文近50篇，申请专利7项，授权2项。
研究方向：
新型微粒药物传递系统、缓释与控释制剂、常规制剂研发与一致性评价、药动学等方面的研究工作。
主持科研项目：
广东省自然科学基金：新型苯基哌嗪喹唑啉类P-gp抑制剂与阿霉素共载Nanocell的构建及逆转肿瘤多药耐药的研究
广州市科技计划项目：抗癌药物传递系统ALG-NC的研究
广东省科技计划项目：黄酮类化合物知母宁的提取、分离与纯 化工艺研究
广州市科技计划项目产学研协同创新重大专项：固体口服药物一致性评价部分关键共性技术研究子课题
广州市科技计划项目产学研协同创新重大专项：具有抗炎抗氧化及舒张呼吸道平滑肌双重作用的治疗哮喘候选一类新药ANT014的临床前研究子课题
“重大新药创制”科技重大专项项目—新药研究开发关键技术研究项目：口服调释微丸制剂国际化关键技术子课题负责人
近三年代表性文章：
Ouyang Jiabi, Yang Mohui, Gong Tian, Ou Jinlai, Tan Yani, Zhang Zhen, Li Sha*. Doxorubicin-loading core-shell pectin nanocell: A novel nanovehicle for anticancer agent delivery with multidrug resistance reversal. PLoS One. 2020,15(6):e**.
Ouyang Jiabi, Wang Xingli, Yang Mohui, Tan Yani, Zhang Zhen, Li Sha*. Preparation and Drug Release Mechanism of Time Controlled Explosive Pulsatile Tablets with Ethylcellulose Coating. J Pharm Biomed Sci. 2020,10(4):81-90.
Li Huirou, Liang Zhiyan, Wang Kaiyu, Ouyang Jiabi, Yang Mohui, Lu Weiqi, Xiang Menghua, You Jiayi, Jiang Jie, Li Sha*. Tissue distribution study on apocynin nitrone derivative AN-1 after intravenous administration. J Pharm Biomed Sci. 2019,9(6):62-71.
Chen Yangyang, Ye Qiumian, Gong Tian, Kuang Jianyuan, Li Sha*. Preparation of doxorubicin-loading sodium alginate nanoparticles and its anticancer activity in HepG2 cells. J Pharm Biomed Sci 2018;08(05):79?83.
Huang Yu, Luo Rui, Fang Yiping, Li Sha *. Preliminary study on the feasibility of p53 gene delivery mediated by novel vectors constructed with CTS and PEI. J Pharm Biomed Sci. 2017;07(5): 177–185.
Gong Tian, Zhou Guifang, Ye Qiumian, Kuang Jianyuan, Ou Jinlai, Xu Zhenxia, Zhao Wen, Li Sha*. In vitro anticancer activity of doxorubicin-loading pectin nanoparticles. J Pharm Biomed Sci 2016;06(05): 366–370.
Feng Guoshuai,Zhang Zhijian,Bao Qingqing,Zhang Zaijun,Zhou Libing,Jiang Jie,Li Sha*. Protective Effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease. Biol Pharm Bull.2014,37(8):1301-1307.
Wang Kaiyu, Li Linlin, Song Yan, Ye Xiaocui, Fu Shaolian, Jiang Jie, Li Sha*. Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization: comparative pharmacokinetics of nitrone-apocynin and its parent apocynin in rats.PLoS One.2013,8(7):e70189.
Jiang Jie, Kang Hongjun, Song Xiaoliang, Huang Sichao, Li Sha*, Xu Jun.A Model of Interaction between Nicotinamide Adenine Dinucleotide Phosphate (NADPH) Oxidase and Apocynin Analogues by Docking Method. Int J Mol Sci. 2013,14(1):807-817.
Li Sha, Wang Xingli, Peng Kelong, Ma Zhiguo, Zhang Xiaoqi, Fu Shaolian, Li Xiaofei, Li Linlin, Hong Aihua, Jiang Jie. Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and its Pharmacokinetic Applications. Molecules. 2012,17(3): 2663-2674.
Yao Hui, Li Sha*, Yu Pei, Tang Xiaodan, Jiang Jie, Wang Yuqiang. Reaction Characteristics of Andrographolide and its Analogue AL-1 with GSH, as a Simple Chemical Simulation of NF-κB Inhibition. Molecules. 2012,17(1):728-739.
Li Sha, Chen Hainan, Wang Xingli, Wu Jianfeng, Jiang Jie, Wang Yuqiang. Pharmacokinetics study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats. European Journal of Drug Metabolism and Pharmacokinetics. 2011, 36(2):95-101.