理学博士，教授、博士生导师，********、国家****科学基金获得者、新世纪百千****才工程国家级人选、全国创新争先奖获得者、广东省南粤百杰。1983年7月毕业于南京药学院(现中国药科大学)中药学专业，获学士学位；1983年8月?1988年10月在安徽中医药高等专科学校任教；1988年11月?1997年7月在中国药科大学天然药物化学教研室任教，先后任讲师、副教授；1997年8月?2001年10月在香港科技大学化学系学习，获博士学位；2001年12月起任中国药科大学教授、博士生导师；2002年8月?2015年11月先后担任暨南大学中药及天然药物研究所常务副所长，中药系主任，药学院副院长、院长。2014年10月起任暨南大学副校长。
长期从事中药和天然药物活性成分、天然产物化学生物学、创新药物研发等研究工作。先后主持了国家重点研发计划、国家自然科学基金重点项目、国家自然科学基金-广东联合基金重点项目、国家重大科技专项和科技支撑计划、教育部****创新团队、广东省珠江人才计划首批本土创新科研团队、广东省重点领域研发计划、广东省和广州市重大科技专项等科研项目40余项。已发表研究论文800余篇，其中在JACS、Angew Chem Int Ed、J Clin Invest、Mol Psychiatry、Chem Sci、J Med Chem、Org Lett、J Nat Prod等SCI收录杂志发表论文500余篇，2014-2018年连续被列入Elsevier中国高被引****榜单，获授权国内外发明专利40余项，获一类和五类中药新药临床研究批件各1项；以第一完成人获国家科技进步奖二等奖1项、广东省科学技术奖一等奖2项，并获中国产学研合作创新成果一等奖2项、中国专利优秀奖1项；主编著作1部，参编著作11部；主要成果之一“中药和天然药物的三萜及其皂苷成分研究与应用”入选2017中国十大医学进展。讲授了多门本科生和研究生课程，培养硕士和博士研究生180余名。
现兼任国家药典委员会委员、中国药学会理事及广东省药学会副理事长、中国药学会中药和天然药物专业委员会副主任委员、广东省学位委员会委员、广东省政协常委委员、九三学社中央委员及广东省委副主委，以及《现代中药研究与实践》杂志主编、Chemistry & Biodiversity和Journal of Asian Natural Products Research等10余种国内外专业学术期刊编委。获第二届全国创新争先奖、中国药学发展奖、国务院政府特殊津贴、广东省丁颖科技奖，并获全国模范教师、全国优秀科技工作者称号。

主要研究方向：
1. 中药及天然药物活性成分研究
2. 活性天然产物的化学生物学研究
3. 中药及天然药物来源的创新药物研究

代表性论文：
Wu ZL, Zhao BX, Huang XJ, Tang GY, Shi L, Jiang RW, Liu X, Wang Y*, Ye WC*. Suffrutines A and B: a pair of Z/Eisomeric indolizidine alkaloids from the roots of Flueggea suffruticosa. Angewandte Chemie, International Edition, 2014, 53, 5796?5799.
Cheng MJ, Zhong LP, Gu CC, Zhu XJ, Chen B, Liu JS, Wang L*, Ye WC*, Li C-C*. Chuang-Chuang Li. Asymmetric total synthesis of bufospirostenin A. Journal of the American Chemical Society, 2020,142, 12602?12607.
Ma N, Hu J, Zhang ZM, Liu WY, Huang MH, Fan YL, Yin XF, Wang J*, Ding K*, Ye WC*, Li ZQ*. 2H-azirine-based reagents for Chemoselective Bioconjugationat carboxyl residues inside live cells. Journal of the American Chemical Society, 2020,142, 6051?6059.
Chen MF, Lei XP, Shi CZ, Huang MH, Li XB, Wu BJ, Li ZQ, Han WL, Du B, Hu JY, Nie QL, Mai WQ, Ma N, Xu NH, Zhang XY, Fan CL, Hong AH, Xia MH, Luo LP, Ma AD, Li HH, Yu Q, Chen HR*, Zhang DM*, Ye WC*. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. The Journal of Clinical Investigation, 2017, 127, 3689?3701.
Guo D, Peng Y, Wang L, Sun X, Wang X, Liang C, Yang X, Li S, Xu J, Ye WC*, Jiang B*, Shi L*. Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Molecular Psychiatry, 2019, doi:10.1038/s41380-019-0472-7.
Yao N, Wang CR, Liu MQ, Li YJ, Chen WM, Li ZQ, Qi Q, Lu J-J, Fan CL, Chen MF, Qi M, Li XB, Hong J, Zhang DM*, Ye WC*. Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth. Signal Transduction and Targeted Therapy,2020,5, 214.
Cheng MJ, Cao JQ, Yang XY, Zhong LP, Hu LJ, Lu X, Hou BL, Hu YJ, Wang Y, You XF, Wang L*, Ye WC*, Li CC*. Catalytic asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B and callistrilones A, C, D, E. Chemical Science, 2017, 34, 2413?2421.
Lei XP, Chen MF, Huang MH, Li XB, Shi CZ, Zhang D, Luo LP, Zhang YW, Ma N, Chen HR, Liang HF, Ye WC*, Zhang DM*. Desacetylvinblastine monohydrazide disrupts tumor vessels by promoting VE-cadherin internalization. Theranostics, 2018, 8, 384?398.
Wu ZL, Huang XJ, Hu LJ, Zhang WY, Xie QJ, Jiang RW, Wang Y*, Ye WC*. Absolute configurations and stereochemical inversion mechanism of epimeric Securinegaalkaloids from Flueggea suffruticosa. Organic Letters, 2020,22, 3673?3678.
Gu JH, Wang WJ, Chen JZ, Liu JS, Li NP, Cheng MJ, Hu LJ, Li CC*, Ye WC*, Wang Lei*. Leptosperols A and B, two cinnamoylphloroglucinol-sesquiterpenoid hybrids from Leptospermum scoparium: structural elucidation and biomimetic synthesis. Organic Letters, 2020,22, 1796?1800.
Cheng MJ, Yang XY, Cao JQ, Liu C, Zhong LP, Wang Y, You XF, Li CC*, Wang L*, Ye WC*. Isolation, structure elucidation, and total synthesis of myrtuspirone A from Myrtus communis. Organic Letters, 2019, 21, 1583?1587.
Song JG, Su JC, Song QY, Huang RL, Tang W, Hu LJ, Huang XJ, Jiang RW, Li YL, Ye WC*, Wang Y*. Cleistocaltones A and B, antiviral phloroglucinol-terpenoid adducts from Cleistocalyx operculatus. Organic Letters, 2019, 21, 9579?9583.
He QF, Wu ZL, Huang XJ, Zhong YL, Li MM, Jiang RW, Li YL, Ye WC*, Wang Y*. Cajanusflavanols A-C, three pairs of flavonostilbene enantiomers from Cajanus cajan. Organic Letters, 2018, 20, 876?879.
Zhang W, Xu W, Wang GY, Gong XY, Li NP, Wang L*, Ye WC*. Gelsekoumidines A and B: two pairs of Atropisomeric Bisindolealkaloids from the Roots of Gelsemium elegans. Organic Letters, 2017, 19, 5194?5197.
Cao JQ, Huang XJ, Li YT, Wang Y, Wang L*, Jiang RW, Ye WC*. Callistrilones A and B, triketone-phloroglucinol-monoterpene hybrids with a new skeleton from Callistemon rigidus. Organic Letters, 2016, 18, 120?123.
Liu C, Ang S, Huang XJ, Tian HY, Deng YY, Zhang DM, Wang Y, Ye WC*, Wang L*. Meroterpenoids with new skeletons from Myrtus communisand structure revision of myrtucommulone K. Organic Letters, 2016, 18, 4004?4007.
Li XL, Zhao BX, Huang XJ, Zhang DM, Jiang RW, Li YJ, Jian YQ, Wang Y*, Li YL*, Ye WC*. (+)- and (-)- Cajanusine, a pair of new enantiomeric stilbene dimers with a new skeleton from the leaves of Cajanus cajan. Organic Letters, 2014, 16, 224?227.
Zhao BX, Wang Y*, Zhang DM, Huang XQ, Bai LL, Yan Y, Chen JM, Lu TB, Wang YT, Zhang QW*, Ye WC*. Virosaines A and B, two new birdcage-shaped securinega alkaloids with an unprecedented skeleton from Flueggea virosa. Organic Letters, 2012, 14, 3096?3099.
Shao M, Wang Y, Jian YQ, Huang XJ, Zhang DM, Tang QF, Jiang RW, Sun XG, Lv ZP, Zhang XQ, Ye WC*. Guadial A and psiguadials C and D, three unusual meroterpenoids from Psidium guajava. Organic Letters, 2012, 14, 5262?5265.
Wang CQ, Wang L, Fan CL, Zhang DM, Huang XJ, Jiang RW, Bai LL, Shi JM, Wang Y, Ye WC*. Ilelic Acids A and B, two unusual triterpenes with a seven-membered ring from Ilex latifolia. Organic Letters, 2012, 14, 4102?4105.
Zhao BX, Wang Y, Zhang DM, Jiang RW, Wang GC, Shi JM, Huang XJ, Chen WM, Che CT, Ye WC*. Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa. Organic Letters, 2011, 13, 3888?3891.
Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC*. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Organic Letters, 2010, 12, 5040?5043.
Zhang J, Song M, Ao Y-L, Li Y, Zou X-Y, Xu J, Wang Y, Zhang D, Zhang X-Q*, Ye W-C*. Alstolarines A and B, two unusual monoterpenoid indole alkaloids with acetal moiety from Alstonia scholaris. Organic Chemistry Frontier,2020, doi:10.1039/D0QO00751J.
Luo SL, Hu LJ, Huang XJ, Su JC, Shao XH, Wang L, Xu HH, Li CC, Wang Y*,Ye WC*. Discovery and biomimetic synthesis of a phloroglucinol-terpene adduct collection from Baeckea frutescensand its biogenetic origin insight. Chemistry – A European Journal, 2020, 26, 11104?11108.
Deng LJ, Wang LH, Peng CK, Li YB, Huang MH, Chen MF, Lei XP, Qi M, Cen Y, Ye WC*, Zhang DM*, Chen WM*. Fibroblast activation protein α activated tripeptide bufadienolide antitumor prodrug with reduced cardiotoxicity.Journal of Medicinal Chemistry, 2017, 60, 5320?5333.
Chen M, Wang W-J, Li N-P, Zeng H-H, Guo H, Jiang R-W, Wang L*, Ye W-C*. Myrcaulones A–C, unusual rearranged triketone–terpene adducts from Myrciaria cauliflora.Journal of Natural Products,2020,83, 2410?2415.
Li SG, Huang XJ, Li MM, Liu Q, Liu H, Wang Y*, Ye WC*. Multiflorumisides A-G, dimeric stilbene glucosides with rare coupling patterns from the roots of Polygonum multiflorum. Journal of Natural Products, 2018, 81, 254?263.
Liu H, Wu ZL, Huang XJ, Peng Y, Huang X, Shi L, Wang Y*, Ye WC*. Evaluation of diarylheptanoid-terpene adduct enantiomers from Alpinia officinarumfor Neuroprotective Activities. Journal of Natural Products, 2018, 81, 162?170.
Liu F, Tian H-Y, Huang X-L, Wang W-J, Li N-P, He J, Ye W-C*, Wang L*. Xanthchrysones A-C: rearranged phenylpropanoyl-phloroglucinol dimers with unusual skeletons from Xanthostemon chrysanthus. The Journal of Organic Chemistry 2019,84, 15355?15361.
Zhang DM, Xu HG, Wang L, Li YJ, Sun PH, Wu XM, Wang GJ, Chen WM, Ye WC*. Betulinic acid and its derivatives as potential antitumor agents. Medicinal Research Reviews, 2015, 35, 1127?1155.

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