个人简介

张在军，博士，研究员/教授，硕士/博士研究生导师。主要从事治疗心脑血管及神经退行性疾病创新药物的研究开发与作用机理研究。主持/参与完成1类化学新药临床前药效学评价5项，获批1类新药临床研究批文4件，4个新药进入II期临床研究。主持国家自然科学基金4项、国家“十三五”新药创制重大专项1项、广东省和广州市项目3项，横向项目3项，累计到位科研经费800万元。已发表论文100余篇，以(共同)第一或通讯作者在Hypertension, Brit J Pharmacol, Aging Cell等国际期刊发表论文50余篇 (影响因子>5分共10篇)，论文累计正面他引2100次，H指数24。3篇论文入选ESI高被引论文。申请发明专利20余项，获授权专利10项。广东省药理学会神经药理专业委员会委员、广东省生物医学工程学会药物食品智能制造工程分会委员和广东省抗衰老及神经调控专业委员会委员。SCI期刊American Journal of Alzheimer’s Disease and Other Dementias杂志编委，Neural Regeneration Research和Chinese Medicine杂志青年编委。
研究方向：神经药理学
代表性论文：
Chunhui Huang?, Jun Li?, Guiliang Zhang, Yingqi Lin, Caijuan Li, Xiao Zheng, Xichen Song, Bofeng Han, Baojian Guo, Zhuchi Tu, Jun Zhang, Yewei Sun, Yuqiang Wang,Zaijun Zhang*, Sen Yan*. TBN improves motor function and prolongs survival in a TDP-43^M337Vmouse model of ALS.Human Molecular Genetics.2021 Apr 30:ddab101. doi: 10.1093/hmg/ddab101.
Fangcheng Luo#; Liangmiao Wu#; Guoqing Xie; FangFang Gao; Zhixiang Zhang; Guangying Chen; Zheng Liu; Ling Zha; Gaoxiao Zhang; Yewei Sun*; Zaijun Zhang*; Yuqiang Wang. Dual-functional MN-08 Attenuated Pulmonary Arterial Hypertension through Vasodilation and Inhibition of Pulmonary Arterial Remodeling. Hypertension. 2021;77:1787–1798.
Liangmiao Wu?, Xinhua Zhou?, Yiwan Cao, Shing Hung MAK, Ling Zha, Ning Li, Zhiyang Su, Ziting Peng, Yifan Han, Yuqiang Wang, Maggie PuiMan Ho5, Yewei Sun, Gaoxiao Zhang*,Zaijun Zhang*, Xifei Yang*. Aging Cell.2021 May 6:e13371. doi: 10.1111/acel.13371.
Jing Wen?, Shangming Li?, Chengyou Zheng?, Fengjiao Wang, Yangwen Luo, Liangmiao Wu, Jie Cao, Baojian Guo, Pei Yu, Gaoxiao Zhang, Shupeng Li, Yewei Sun, *, Xifei Yang, *, Zaijun Zhang, *, Yuqiang Wang. Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice. Neuropharmacology. 2021, 182:108380.
Chunhui Huang, Sen Yan*, Zaijun Zhang*. Maintaining the balance of TDP-43, mitochondria, and autophagy: A promising therapeutic strategy for neurodegenerative diseases. Translational Neurodegeneration2020,30;9(1):40.
Chen H, Cao J, Zha L, Wang P, Liu Z, Guo B, Zhang G, Sun Y*, Zhang Z*, Wang Y. Neuroprotective and neurogenic effects of novel tetramethylpyrazine derivative T-006 in Parkinson's disease models through activating the MEF2-PGC1α and BDNF/CREB pathways. Aging, 2020, 24;12(14):14897-14917.
Luo F, Wu L, Zhang Z, Zhu Z, Liu Z, Guo B, Li N, Ju J, Zhou Q, Li S, Yang X, Mak S, Han Y, Sun Y, Wang Y, Zhang G, Zhang Z*.The Dual-Functional Memantine Nitrate MN-08 Alleviates Cerebral Vasospasm and Brain Injury in Experimental Subarachnoid Haemorrhage Models. Br J Pharmacol.2019 Sep;176(17):3318-3335.
Gaoxiao Zhang?, Tao Zhang?, Ning Li, Liangmiao Wu, Jianbo Gu, Cuimei Li, Chen Zhao, Wei Liu, Pei Yu, Yaohui Tang, Guo-yuan Yang, Yuqiang Wang, Yewei Sun*, Zaijun Zhang*. Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats. British Journal of Pharmacology 2018 Feb;175(3):517-531.
Baojian Guo?, Shengquan Hu?, Chengyou Zheng, Haitao Li, Hongyu Wang, Wei Cui, Shinghung Mak, Tony Chung-Lit Choi, Edmond Dik-Lung Ma, Yuqiang Wang, Simon Ming-Yuen Lee, Zaijun Zhang*, Yifan Han*.Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacology. 2017 Nov;126:12-24.
Xiaopeng Luo?, Yankun Yu?, Zongqin Xiang, Huisu Wu, Seeram Ramakrishna，Yuqiang Wang, Kwok-Fai So, Zaijun Zhang*, Ying Xu*. Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity. Journal of Neurochemistry2017 May;141(3):373-386.

科研项目:
1. 2021广东省粤澳科技创新联合资助项目 2021.03-2024.02, 100 万元
2. 2020国家自然科学基金 NSFC-FDCT 联合项目 ()，2021.01-2023.12, 150万元
3. 2020国家自然科学基金面上项目 (**)，2021.01-2024.12, 58万元
4. 2018国家自然科学基金面上项目 (**)，2019.01-2022.12, 55万元
5. 2018国家“十三五”新药创制重大专项 (2019ZX**)，2019.01-2020.12, 299.86 万元
6. 2013国家自然科学基金青年基金项目 (**)，2014.01-2016.12, 23万元
学术奖励:
国际中医药学会 第二届中华医药创新创业大赛 二等奖（2020年）
中国博士后基金-香港****学会香江****奖（2013年）