黄郑炜，男，博士，中共党员，副教授，暨南大学“青蓝****”。2020年毕业于中山大学药学院药剂学专业，获理学博士学位，导师为国家特聘专家吴传斌教授。2015年获中山大学理学学士学位及优秀毕业生称号。本人专业方向为药剂学，主要从事纳米药物递送系统创制领域的研究。近年来参与各级科研项目7项，其中国家自然科学基金项目5项。相关研究成果已发表多篇论文，其中以本人为第一作者、共同第一作者或共同通讯作者身份的研究论文共20篇。



研究方向

肺部吸入纳米制剂、纳米制剂的体内命运、纳米制剂-生物分子相互作用

参与科研项目

国家自然科学基金面上项目，**，可控晶格的动态智能液晶系统用于软组织缺损修复及其机制研究，在研，参与
广东省基础与应用基础研究基金项目，2020A，用于慢性伤口的溶致液晶递药系统：可控有序晶格结构及其对多肽药物的稳定机制，在研，参与
国家自然科学基金青年基金项目，**，基于星形聚赖氨酸的可溶性微针贴片构建及其用于高效治疗皮肤感染的研究，在研，参与
国家自然科学基金面上项目，**，溶致液晶关节腔递药系统及其对关节保护机制的研究，在研，参与
国家自然科学基金青年基金项目，**，干粉吸入剂可控多孔化载体的成型机制及其增效机理研究，已结题，参与
国家自然科学基金面上项目，**，干粉吸入剂二元载体表面微结构的定向构建及其增效机理的研究，已结题，参与
高校基本科研业务费——中山大学青年教师培育项目，16ykpy23，多孔/微粗糙甘露醇载体的形成机制及其在干粉吸入剂中的应用，已结题，参与

主要学术成果
(A) 代表性论著
Z. Huang, Y. Huang, W. Wang, F. Fu, W. Wang, S. Dang, C. Li, C. Ma, X. Zhang, Z. Zhao, X, Pan*, C. Wu. Relationship between particle size and lung retention time of intact solid lipid nanoparticle suspensions after pulmonary delivery. J Control Release. 2020; 325: 206-222.
Z. Huang, Y. Huang*, C. Ma, X. Ma, X. Zhang, L. Lin, Z. Zhao, X. Pan**, C. Wu. Endotracheal aerosolization device for laboratory investigation of pulmonary delivery of nanoparticle suspensions: In vitroand in vivovalidation. Mol Pharmaceut. 2018; 15: 5521-5533.
Z. Huang, L. Lin, C. Goverin, H. Liu, L. Wang, Q. Zhou, M. Lu*, C. Wu. Dry powder inhaler formulations of poorly water-soluble itraconazole: A balance between in-vitrodissolution and in-vivodistribution is necessary. Int J Pharm. 2018; 551: 103-110.
W. Wang?, Z. Huang?, Y. Li, W. Wang, J. Shi, F. Fu, Y. Huang*, X. Pan, C. Wu**. Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study.Acta Pharm Sin B. 2020; Accepted Manuscript.
C. Zhou?, Z. Huang?, Y. Huang?, B. Wang, P. Yang, Y. Fan, A. Hou, B. Yang, Z. Zhao, G. Quan, X. Pan*, C. Wu. In-situgelation of rhEGF-containing liquid crystalline precursor with good cargo stability and system mechanical properties: A novel delivery system for chronic wounds treatment. Biomater Sci. 2019; 7: 995-1010.
(B) 其他英文论著
F. Fu?, Z. Huang?, W. Wang, W. Wang, X. Ma, L. Wang, Y. Huang*, P. Hu, X. Pan, C. Wu**. Interaction between bovine serum albumin and Solutol^?HS 15 micelles: A two-stage and concentration-dependent process. J Drug Deliv Sci Tec. 2021; Accepted Manuscript.
S. Lei?, F. Fu?, Z. Huang*, Y. Huang, P. Hu, X. Pan**. Nanostructure of DiR-loaded solid lipid nanoparticles with potential bioimaging functions. AAPS Pharmscitech. 2020; Accepted Manuscript.
W. Wang?, Z. Huang?, K. Xue, J. Li, W. Wang, J. Ma, C. Ma, X, Bai, Y. Huang*, X. Pan**, C. Wu. Development of aggregation-caused quenching probe-loaded pressurized metered-dose inhalers with fluorescence tracking potentials. AAPS Pharmscitech. 2020; Accepted Manuscript.
Z. Huang?, C. Ma?, M. Wu?, X. Li, C. Lu, X. Zhang, X. Ma, Y. Yang, Y. Huang*, X. Pan**, C. Wu. Exploring the drug-lipid interaction of weak-hydrophobic drug loaded solid lipid nanoparticles by isothermal titration calorimetry. J Nanopart Res. 2020; 22(3): 1-14.
Y. Huang?, Z. Huang?, M. Wu, Y. Liu, X. Zhang, Z. Zhao, C. Ma, X. Bai, H. Liu, L. Wang, X. Pan, C. Wu. Modified-release oral pellets for duodenum delivery of doxycycline hyclate. Drug Develop Res. 2019; 80: 958-969.
C. Ma?, W. Wang?, Z. Huang?, X. Chen, W. Ye, K. Pan, R. Ma, K. Xue, S. Cai, Y. Huang, X. Pan, C. Wu. Effect of the cargo lipophilicity on powder micromeritics properties of drug loaded solid lipid microparticles. J Drug Deliv Sci Tec. 2019; 51: 614-620.
Z. Huang, M. Wu, C. Ma, X. Bai, X. Zhang, Z. Zhao, Y. Huang*, X. Pan, C. Wu. Spectroscopic quantification of surfactants in solid lipid nanoparticles. J Pharm Innov. 2019; pp1-8.
Y. Yang?, Z. Huang?, X. Zhang, J. Li, Y. Huang*, W. Chen, X. Pan**, C. Wu. Development of paroxetine hydrochloride single layer controlled-release tablets based on 3²factorial design. Pharmaceutics. 2018; 10(243): 1-19.
C. Ma?, H. Fu?, Z. Huang?, X. Chen, L. Hu, X. Ma, Y. Huang*, X. Pan, C. Wu. Pharmacokinetics and pharmacodynamics evaluation on risperidone-containing microsphere fabricated by ultra-fine particle processing system. Powder Technol. 2019; 358: 13-19.
Y. Huang?, Z. Huang?, X. Zhang, Z. Zhao, X. Zhang, K. Wang, C. Ma, C. Zhu, X. Pan*, C. Wu. Chitosan-based binary dry powder inhaler carrier with nanometer roughness for improving in vitroand in vivoaerosolization performance. Drug Deliv Transl Re. 2018; 8: 1274-1288.
Z. Zhao?, Z. Huang?, X. Zhang, Y. Huang*, Y. Cui, C. Ma, G. Wang, T. Freeman, X. Lu, X. Pan, C. Wu**. Low density, good flowability cyclodextrin-raffinose binary carrier for dry powder inhaler: Anti-hygroscopicity and aerosolization performance enhancement. Expert Opin Drug Del. 2018; 15(5): 443-457.
Z. Huang?, Han Wu?, B. Yang, L. Chen, Y. Huang, G. Quan, C. Zhu, X. Li, X. Pan*, C. Wu. Anhydrous reverse micelle nanoparticles: New strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers. Drug Deliv. 2017; 24(1): 527-538.
Z. Huang, X. Chen, H. Fu, X. Wen, C. Ma, J. Zhang, C. Wu, Y. Huang*, X. Pan**, C. Wu.Formation mechanism and in vitroevaluation of risperidone-containing PLGA microspheres fabricated by ultrafine particle processing system. J Pharm Sci. 2017; 106(11): 3363-3371.
(C) 中文论著
黄郑炜, 黄莹, 潘昕, 吴传斌,等. 基于文献计量学的荧光探针显像发展近况研究:以Web of Science和CNKI为例. 今日药学. 2019; 29(9): 392-396.
黄郑炜, 黄莹, 潘昕, 李革, 陈航平, 吴传斌,等. β-胡萝卜素营养乳剂稳定化机理研究. 今日药学. 2017; 27(4): 244-247.

会议报告
2018.12,中国广州:2018第十二届中国药物制剂大会.“Drug-lipid interaction in weak-hydrophobic drug loaded solid lipid nanoparticles”.
2018.06,中国广州:2018年第十三届AAPS中新亚洲药学论坛.“Correlation between drug-lipid interaction and phase solubility for preformulation of hydrophilic drug loaded solid lipid nanoparticles”.
2016.11,中国广州:2016全国吸入给药联盟学术论坛.“基于反相胶束纳米粒系统的压力定量吸入剂研究”.