权桂兰，女，博士，副教授，硕士生导师。中国药学会药剂专业委员会青年候补委员、亚洲药学杂志AJPS青年编委、广东省药学会药用辅料专业委员会委员。2010年毕业于中山大学药学院，获学士学位。分别于2013、2016年毕业于中山大学药剂学专业，师从吴传斌教授，获理学硕士、博士学位。2016年7月进入中山大学药学院担任副研究员，2019年11月加入暨南大学药学院。
主持国家自然科学基金、广东省自然科学基金，广东省中医药局、广东省重点领域研发计划子课题等项目各1项。在J Control Release，Theranostics，ACS Appl Mater Inter,Acta Pharm Sin B等本领域权威杂志发表论文50余篇，第一/通讯作者30篇（中科院1区/Top期刊10篇，中科院2区10篇，入选ESI高被引论文1篇，期刊封面论文4篇）。申请发明专利14项，授权5项，其中1项实现产业转化。担任中国科学院教材建设专家委员会规划教材《药学导论》编委。应邀在中国药物制剂大会、中国药学大会和岭南国际药学大会等学术会议报告10次。曾获2019年中国产学研合作创新成果奖一等奖、2018年中国药学会优秀青年药剂学奖、2017年广东省科学技术二等奖、2016年中国产学研合作创新成果奖二等奖、2015年美国AAPS礼来奖（亚洲3人）。

研究方向：
可溶微针经皮给药系统
基于新型多孔载体（介孔硅、金属有机骨架）的药物递送系统

主持科研项目：
[1] 国家自然科学基金青年基金项目（项目编号：**）
[2] 广东省自然科学基金-博士启动项目（项目编号: 2018A）
[3] 广东省中医药局专项资金面上项目（项目编号: **）
[4]广东省重点领域研发计划项目新药创制专项子课题（项目编号：2019B）
[5] 暨南大学第四层次引进人才科研配套经费（项目编号：/）

代表性论文：
[1]M Chen#, G Quan#,Y Sun, D Yang, X Pan*, C Wu*. Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery. J Control Release, 2020, 325: 163-175.(中科院1区，药剂学顶刊)
[2] M Chen#, G Quan#, T Wen, P Yang, W Qin, H Mai, Y Sun, C Lu, X Pan*, C Wu*. Cold to hot: binary cooperative microneedle array-amplified photoimmunotherapy for eliciting antitumor immunity and the abscopal effect. ACS Appl Mater Inter, 2020, Doi.org/10.1021/acsami.0c05090.(中科院1区，封面论文)
[3] W Qin#, G Quan#, Y Sun, M Chen, P Yang, D Feng, T Wen, X Hu, X Pan, C Wu. Dissolving microneedles with spatiotemporally controlled pulsatile release nanosystem for synergistic chemo-photothermal therapy of melanoma. Theranostics, 2020, 10(18): 8179-8196.(中科院1区).
[4] Y Zhou#, B Niu#, B Wu, S Luo, J Fu, Y Zhao, G Quan*, X Pan, C Wu*. A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility. Acta Pharm Sin B, 2020, Doi.org/10.1016/j.apsb.2020.07.018(中科院1区).
[5]B Wu, J Fu, Y Zhou, S Luo, Y Zhao, G Quan*, X Pan*, C Wu. Tailored core-shell dual metal-organic frameworks as a versatile nanomotor for effective synergistic antitumor therapy. Acta Pharm Sin B, 2020, Doi.org/10.1016/j.apsb.2020.07.025 (中科院1区).
[6] Y Zhou, Y Zhao, B Niu, Q Luo, Y Zhang, G Quan*, X Pan, C Wu*. Cyclodextrin-based metal-organic frameworks for pulmonary delivery of curcumin with improved solubility and fine aerodynamic performance. Int J Pharma, 2020, 588,119777.(Top期刊)
[7] S Wei, G Quan*, C Lu, X Pan*, C Wu. Dissolving microneedles integrated with ph-responsive micelles containing AIEgen with ultra-photostability for enhancing melanoma photothermal therapy. Biomaterials Science, 2020, online. (中科院2区)
[8] Q Wu, D Feng, Z Huang, M Chen, D Yang, X Pan, C Lu*, G Quan*, C Wu. Supersaturable organic-inorganic hybrid matrix based on well-ordered mesoporous silica to improve the bioavailability of water insoluble drugs. Drug delivery,2020, online. (中科院2区)
[9] C Lu, T Wen*, M Zheng, D Liu,G Quan*, X Pan, C Wu. Poly(ethylene glycol) crosslinked multi-armed poly(l-lysine) with encapsulating capacity and antimicrobial activity for the potential treatment of infection-involved multifactorial diseases. Pharmaceutics, 2020, 12, 47.(中科院2区)
[10] S Lin#, G Quan#, A Hou, P Yang, T Peng, Y Gu, W Qin, R Liu, X Ma, X Pan*, H Liu, L Wang, C Wu*. Strategy for hypertrophic scar therapy: Improved delivery of triamcinolone acetonide using mechanically robust tip-concentrated dissolving microneedle array. J Control Release, 2019, 306: 69-82.(中科院1区，药剂学顶刊)
[11] A Hou^#,G Quan^#, B Yang, C Lu, M Chen, D Yang, L Wang, H Liu, X Pan*, C Wu*. Rational design of rapidly separating dissolving microneedles for precise drug delivery by balancing the mechanical performance and disintegration rate. Adv Healthc Mater, 2019, 8, **. (中科院1区，内页封面论文)
[12] B Wu, J Fu, Y Zhou, Y Shi, J Wang, X Feng, Y Zhao, G Zhou, C Lu*, G Quan*, X Pan, C Wu. Metal–organic framework-based chemo-photothermal combinational system for precise, rapid and efficient antibacterial therapeutics. Pharmaceutics2019, 11, 463. (中科院2区，封面论文)
[13] C Lu#, G Quan#, M Su, A Nimmagadda, W Chen, M Pan, P Teng, F Yu, X Liu, L Jiang, W Du, W Hu, F Yao, X Pan, C Wu,* D Liu,* J Cai*. Molecular architecture and charging effects enhance the in vitro and in vivo performance of multi-arm antimicrobial agents based on star-shaped poly(L-lysine), Advanced therapeutics, 2019, 2, **. (封面论文)
[14] Y Zhou, S Luo, B Niu, B Wu, J Fu, Y Zhao, V Singh, C Lu,G Quan*, X Pan, J Zhang, C Wu*. Ultramild one-step encapsulating method as a modular strategy for protecting humidity-susceptible metal-organic frameworks achieving tunable drug release profiles. ACS Biomater Sci Eng, 2019, 5: 5180-5188. (中科院2区)
[15] T Wen, B Niu, Q Wu, Y Zhou, X Pan, G Quan*, C Wu. Fenofibrate solid dispersion processed by hot-melt extrusion: elevated bioavailability and its cell transport mechanism. Curr Drug Deliv, 2019, 16:538-547.
[16] C Liu^#, L Lin^#, Z Huang, Q Wu, J Jiang, L Lv, X Yu, G Li*,G Quan*, C Wu. Novel inhalable ciprofloxacin dry powders for bronchiectasis therapy: mannitol-silk fibroin binary microparticles with high-payload and improved aerosolized properties.AAPS PharmSciTech, 2019, 20:85.
[17] H Chen^#, B Wu^#, M Zhang, P Yang, B Yang, W Qin, Q Wang, X Wen, M Chen,G Quan*, X Pan, C Wu. A novel scalable fabrication process for the production of dissolving microneedle arrays. Drug Deliv Transl Re, 2019, 9:240-248.
[18] Y Zhou^#, G Quan^#, QWu, X Zhang, B Niu, B Wu, Y Huang, X Pan*, C Wu*. Mesoporous silica nanoparticles for drug and gene delivery. Acta Pharm Sin B. 2018, 8(2):165-177.(中科院1区, ESI高被引论文)
[19] Q Zhang, C Xu, S Lin, H Zhou, G Yao, H Liu, L Wang, X Pan, G Quan*, C Wu. Synergistic immunoreaction of acupuncture-like dissolving microneedles containing thymopentin at acupoints in immune-suppressed rats. Acta Pharm Sin B, 2018, 8(3):449-457.(中科院1区)
[20] Y Zhou^#, Q Fang^#, B Niu, B Wu, Y Zhao, G Quan*,X Pan*, C Wu. Comparative studies on amphotericin B nanosuspensions prepared by a high pressure homogenization method and an antisolvent precipitation method. Colloid Surface B. 2018, 172:372-379.(中科院2区)
[21] D Feng, T Peng, Z Huang, V Singh, Y Shi, T Wen, M Lu, G Quan*, X Pan*, C Wu. Polymer–surfactant system based amorphous solid dispersion: precipitation inhibition and bioavailability enhancement of itraconazole. Pharmaceutics 2018, 10(2), 53.(中科院2区)
[22] B Niu, Y Zhou, T Wen, G Quan*, V Singh, X Pan*, C Wu. Proper functional modification and optimized adsorption conditions improved the DNA loading capacity of mesoporous silica nanoparticles, Colloid Surface A. 2018, 548:98-107.
[23] A Hou, L Li, Y Huang, V Singh, C Zhu, X Pan, G Quan*, C Wu. Fragmented particles containing octreotide acetate prepared by spray drying technique for dry powder inhalation. Drug Deliv Transl Re, 2018, 8:693-701.
[24]Z Zhan, X Zhang, J Huang, Y Huang, Z Huang, X Pan, G Quan*, H Liu, L Wang, C Wu. Improved gene transfer with functionalized hollow mesoporous silica nanoparticles of reduced cytotoxicity. Materials2017, 10(7), 731; doi:10.3390/ma**.
[25] G Quan, B Niu, V Singh, Y Zhou, C Wu, X Pan*, C Wu*.Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement.Int J Nanomed. 2017,12:8801-8811.(中科院2区)
[26] G Quan,Q Wu, X Zhang, Z Zhan, C Zhou, B Chen, Z Zhang, G Li, X Pan*, C Wu*. Enhancing in vitro dissolution and in vivo bioavailability of fenofibrate by solid self-emulsifying matrix combined with SBA-15 mesoporous silica. Colloid Surface B, 2016, 141: 476-482.(中科院2区)
[27] G Quan, X Pan, Z Wang, Q Wu, G Li, L Dian, B Chen*, C Wu*. Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery. J Nanobiotech. 2015,13:7.(中科院2区)

申请/授权发明专利：
[1]吴传斌，陈宝，王周华，权桂兰. 一种中空介孔二氧化硅微球及其制备方法和用途. 专利号 ZL 3.3，授权并转让
[2] 吴传斌，冯地桑，潘昕，权桂兰，黄莹，陈航平. 固体分散体及其制备方法和应用. 专利号ZL 4.0 授权
[3] 吴传斌，林师麒，权桂兰，潘昕，蔡炳贞，侯嫒琳，杨佩佩. 胸腺五肽可溶性微针及其制备方法. 专利号ZL 8.7 授权
[4] 吴传斌，牛博艺，吴巧利，权桂兰，潘昕. 非诺贝特固体分散体及其制备方法和应用. 专利号0.X 授权
[5] 吴传斌，湛正文，权桂兰，潘昕，陈航平. 中空介孔二氧化硅纳米粒、纳米载体及其制备方法. 专利号1.0 授权
[6] 吴传斌，陈明龙，权桂兰，潘昕，杨佩佩，覃宛冰. 一种用于经皮递送难溶性药物的胶束复合凝胶微针的制备. 专利号2.8
[7] 吴传斌，罗苏兰，吴碧湲，牛博艺，周奕先，权桂兰. 环糊精-金属有机骨架材料复合微球及其制备方法. 专利号4.0
[8] 吴传斌，杨佩佩，覃宛冰，权桂兰，潘昕. 核壳结构微针及其制备方法. 专利号4.2
[9] 吴传斌，侯嫒琳，权桂兰, 杨蓓蓓，潘昕. 快速分离型可溶性微针及其制备方法.专利号5.8
[10] 吴传斌，林师麒，侯嫒琳，杨佩佩，顾宇琨，权桂兰. 曲安奈德可溶性微针及其制备方法. 专利号0.6
[11] 吴传斌，侯嫒琳，潘昕，权桂兰，黄莹，李露，陈航平. 醋酸奥曲肽干粉吸入制剂及其制备方法. 专利号4.4
[12] 吴传斌，王倍，张晓旭，潘昕，权桂兰，陈航平. 三元基因传递系统的冻干制剂及其制备方法. 专利号7.4
[13] 吴传斌，林师麒，权桂兰，潘昕，陈航平. 固体自乳化制剂及其制备方法. 专利号6.8
[14] 吴传斌，顾宇琨，潘昕，黄莹，权桂兰，朱春娥. 溶瘤病毒立方液晶前体注射剂及其制备方法. 专利号3.3

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