个人简介

---

职称：研究员
学科专业：发育生物学
研究方向：血管及血液系统发育
电子邮箱：rainyblue_1999@126.com
个人简介：兰雨博士，暨南大学医学部基础医学院研究员，博士生导师。中国生理学会血液生理学专业委员会青年委员。研究方向：血管及血液系统发育。作为负责人先后承担国家重点研发计划课题1项、国家自然科学基金项目4项。发表SCI收录论文22篇（IF=217），第一/通讯作者研究论文发表在Cell Stem Cell、Developmental Cell、Cell Research、Circulation Research、Blood等杂志。论文引用800余次，3篇第一/通讯作者论文被F1000推荐。科研成果《TGF-β/Smad信号通路维持组织稳态的生理功能和机制》获得2012年国家自然科学奖（二等，排名第4）。

---

学习科研经历

---

2017.01–至今，暨南大学医学部基础医学院，研究员
2011.09–2016.07，军事医学科学院生物工程研究所，副研究员
2008.01–2011.09，军事医学科学院生物工程研究所，助理研究员
2007.07–2007.12，海军总医院，主治医师
2003.08-2007.06，军事医学科学院，遗传学，博士学位
2001.07–2003.07，海军总医院，主治医师
1998.08-2001.06，第二军医大学，内科学，硕士学位
1995.08–1998.07，海军总医院，医师
1990.08-1995.07，第三军医大学，临床医学，学士学位

---

主要论文

---

10篇代表性论文（共同第一作者#，通讯作者*）。
1. Yu Lan*. Procr+ stem cells: from vessel to blood. National Science Review, 2017;4:523-4 (IF=8.843)
2. Hui Ye#, Xiaobo Wang#, Zongcheng Li, Fan Zhou, Xianlong Li, Yanli Ni, Weijing Zhang, Fuchou Tang, Bing Liu*, and Yu Lan*. Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence. Cell Research, 2017;27(8):1065-8 (IF=15.606 Recommended by FACULTY of 1000*)
3. Peng Zhang#, Siyuan Hou#, Jicheng Chen#, Jishuai Zhang, Fuyu Lin, Renjie Ju, Xuan Cheng, Xiaowei Ma, Yao Song, Youyi Zhang, Minsheng Zhu, Jie Du, Yu Lan*, and Xiao Yang*. Smad4 deficiency in smooth muscle cells initiates the formation of aortic aneurysm. Circulation Research, 2016;118(3):388-99 (IF=13.965)
4. Jicheng Chen#, Ning Hou#, Chong Zhang, Yan Teng, Xuan Cheng, Zhenhua Li, Jie Ren, Jian Zeng, Rui Li, Wei Wang, Xiao Yang*, and Yu Lan*. Smooth muscle Hgs deficiency leads to impaired esophageal motility. International Journal of Biological Sciences, 2015;11(7):794-802 (IF=3.982)
5. Yu Lan#,*, Wenyan He#, Zhuan Li, Yu Wang, Jun Wang, Jiao Gao, Weili Wang, Tao Cheng, Bing Liu*, and Xiao Yang*. Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation. Blood, 2014;123(14):2161-71 (IF=10.452)
6. Jun Wang, Youliang Wang, Yu Wang, Ying Ma, Yu Lan*, and Xiao Yang*. Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium. Journal of Biological Chemistry, 2013;288(15):10418-26 (IF=4.6)
7. Zhuan Li#, Yu Lan#, Wenyan He, Dongbo Chen, Jun Wang, Fan Zhou, Yu Wang, Huayan Sun, Xianda Chen, Chunhong Xu, Sha Li, Yakun Pang, Guangzhou Zhang, Liping Yang, Lingling Zhu, Ming Fan, Aijia Shang, Zhenyu Ju, Lingfei Luo, Yuqiang Ding, Wei Guo, Weiping Yuan, Xiao Yang*, and Bing Liu*. Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell, 2012;11(5):663-75 (IF=25.315 Recommended by FACULTY of 1000**; Highlighted by Nature CHINA)
8. Fangfei Li#, Yu Lan#,*, Youliang Wang#, Jun Wang, Guan Yang, Fanwei Meng, Hua Han, Anming Meng, Yaping Wang, and Xiao Yang*. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Developmental Cell, 2011;20(3):291-302 (IF=14.030 Previewed article in Developmental Cell; Recommended by FACULTY of 1000*)
9. Wen-Yan He#, Yu Lan#, Hui-Yu Yao#, Zhuan Li, Xiao-Yan Wang, Xiu-Sen Li, Ji-Yan Zhang, Yu Zhang, Bing Liu*, and Ning Mao*. Interleukin-3 promotes hemangioblast development in mouse aorta-gonad-mesonephros region. Haematologica, 2010;95(6):875-83 (IF=6.532)
10. Yu Lan, Bing Liu, Huiyu Yao, Fangfei Li, Tujun Weng, Guan Yang, Wenlong Li, Xuan Cheng, Ning Mao, and Xiao Yang*. Essential role of endothelial Smad4 in vascular remodeling and integrity. Molecular and Cellular Biology, 2007;27(21):7683-92 (IF=6.420)

---

获奖及荣誉

---

1、中国遗传学会青年优秀论文奖，2014.07
2、国家自然科学二等奖（排名第4），2012.12
3、全国优秀博士学位论文提名论文，2009.09
4、全军优秀博士学位论文，2008.11
5、中国遗传学会青年优秀论文奖，2007.08

---

学术兼职

---

中国生理学会血液生理学专业委员会青年委员

---