个人简介

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职称：教授
学科专业：药理学
研究方向：
1、抗肿瘤化合物筛选，活性及机制研究；
2、肿瘤相关蛋白功能及信号传导通路方面的研究；
3、基于蛋白-蛋白相互作用的靶标的发现和研究
电子邮箱：qiqikc@jnu.edu.cn
个人简介：
致力于细胞生物学和肿瘤药理学领域的研究。发表SCI收录论文74篇，其中包括国际知名在PNAS, Oncogene, JMC等在内的第一/通讯论文21篇（总影响因子达到109.102， 2020年公布）。研究成果获得国际同行的广泛关注和高度肯定。现已是包括Cancer Research， Biochemical Pharmacology, Molecular Pharmacology, Journal of Molecular Medicine 在内的28家SCI收率杂志的特邀审稿人。

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学习科研经历

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2018.6-至今，暨南大学医学院药理系 教授
2016.11-2018.5，埃默里大学医学院药理系化学生物学研发中心 Instructor (美国)
2015.3-2016.10，埃默里大学医学院药理系化学生物学研发中心Research Associate (美国)
2010.8-2015.2，埃默里大学医学院病理和实验医学系博士后(美国)
2009.8-2010.7，西弗吉尼亚大学医学院生理系伦道夫玛丽巴布癌症中心博士后(美国)
2006-2009，中国药科大学, 药理学博士学位
2003-2006，中国药科大学, 药理学硕士学位
1999-2003，郑州大学, 药学学士学位

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主要论文

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1.Yao W, Lin S, Su J, Cao Q, Chen Y, Chen J, Zhang Z, Hashimoto K, Qi Q, Zhang JC. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Transl Psychiatry. 2021 Feb 24;11(1):140. (Corresponding author)
2.Xu M, Qi Q, Men L, Wang S, Li M, Xiao M, Chen X, Wang S, Wang G, Jia H, Liu C. Berberine protects Kawasaki disease-induced human coronary artery endothelial cells dysfunction by inhibiting of oxidative and endoplasmic reticulum stress. Vascul Pharmacol. 2020 Apr;127:106660. (Co-first author)
3.Li X, Tang X, Su J, Xu G, Zhao L, Qi Q. Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid. Biochem Pharmacol. 2019 Sep 9;169:113635. (Corresponding author)
4.Qi Q, Obianyo O, Du Y, Fu H, Li S, Ye K. Blockade of asparagine endopeptidase inhibits cancer metastasis. J Med Chem. 2017 Sep 14;60(17):7244-7255.
5.Qi Q, Kang SS, Zhang S, Baker SJ, Fu H, Brat DJ, Ye K. Co-amplification of Phosphoinositide 3-kinase enhancer A and Cyclin-dependent kinas 4 Triggers Glioblastoma Progression. Oncogene. 2017 Aug 10;36(32):4562-4572.
6.Qi Q, Li DY, Luo HR, Guan KL, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7255-60.
7.Qi Q, He K, Liu X, Pham C, Meyerkord C, Fu H. Ye K. Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion, and colony formation. Oncogene. 2013 Feb 21;32(8):1030-40.
8.Qi Q, Liu X, Daniel Brat, Ye K. Merlin sumoylation is required for its tumor suppressor activity. Oncogene. 2014 Oct 9;33(41):4893-903.
9.He K, Qi Q, Chan CB, Xiao G, Liu X, Tucher-Burden C, Wang L, Mao H, Lu X, McDonald, F, Luo H, Fan Q, Weiss W, Sun S, Brat D, Wang L, Mao H, Fu H, Tao H, Ye K. Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2. Science signal. 2013 Jul 9;6(283):ra55. (Co-first author)
10.Qi Q, He K, Yoo MH, Chan CB, Liu X, Zhang Z, Olson JJ, Xiao G, Wang L, Mao H, Fu H, Tao H, Ye K. Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases. J Biol Chem. 2012 Feb 24;287(9):6113-27.
11.Qi Q, Lu N, Li C, Zhao J, Liu W, You Q, Guo Q. Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells. Mol Carcinog. 2015 Jun;54 Suppl 1:E13-25.
12.Qi Q, Gu H, Yang Y, Lu N, Zhao J, Liu W, Ling H, You QD, Wang X, Guo Q. Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. J Mol Med. 2008 Dec;86(12):1367-77.
13.Qi Q, Lu N, Wang XT, Gu HY, Yang Y, Liu W, Li C, You QD, Guo QL. Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. Biochem Cell Biol. 2008 Oct;86(5):386-95.
14.Qi Q, You Q, Gu H, Zhao L, Liu W, Lu N, Guo Q. Studies on the toxicity of gambogic acid in rats. J Ethnopharmacol. 2008 May 22;117(3):433-8.
15.Li C, Lu N, Qi Q, Li F, Ling Y, Chen Y, Qin Y, Li Z, Zhang H, You Q, Guo Q. Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway. Biochem Pharmacol. 2011 Dec 15;82(12):1873-83. (Co-first author)

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获奖及荣誉

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Acta Pharmacologica Sinica （A1-1区）突出贡献奖，2020
Acta Pharmacologica Sinica 突出贡献奖，2018
Acta Pharmacologica Sinica 突出贡献奖，2016

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学术著作

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《肿瘤药理学》编委 2008，北京，化学工业出版社

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学术兼职

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专业学会服务
中国抗癌协会抗癌药物专业委员会青年委员会 副主任委员
广东省药理学会肿瘤药理学专业委员会 常委
广东省抗癌协会抗肿瘤药物专业委员会 委员
专业学会会员
美国癌症研究协会， AACR
国际化学生物学学会， ICBS
中国细胞生物学学会，CSCB
中国药理学会，CNPHARS
中国生物化学与分子生物学会，CSBMB
受邀评审专家
国家自然科学基金
广东省自然科学基金
学术杂志编委
《Molecular and Cellular Biochemistry》(IF:2.883);
《中国临床药理学与治疗学》
担任28家国际专业杂志特邀审稿人
Cancer Research; Acta Pharmaceutica Sinica B; Cell Death & Disease; Free Radical Biology and Medicine; Journal of Experimental & Clinical Cancer Research; Laboratory Investigation; Journal of Molecular Medicine; Journal of Cellular and Molecular Medicine; Biochemical Pharmacology; Frontiers in Pharmacology; Molecular Pharmacology; Food and Chemical Toxicology; Investigational New Drugs; BMC Cancer; Toxicology; Acta Pharmacologica Sinica; Basic &Clinical Pharmacology & Toxicology; OncoTargets and Therapy; Journal of Cellular Biochemistry; European Journal of Pharmacology; PLOS One; Molecular and Cellular Biochemistry; Pharmacological Reports; Cancer Management and Research; Oncology Letters; Journal of Oncology; Neoplasma; Molecular Medicine Reports;